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Intra-abdominal ectopic bronchogenic cyst with a mucinous neoplasm harboring a GNAS mutation: A case report

World Journal of Clinical Cases 2022年第24期10卷 8709-8717页

作者： Takashi Murakami Hiroaki Shimizu Kazuto Yamazaki Hiroyuki Nojima Akihiro Usui Chihiro Kosugi KiyohikoShuto Shuntaro Obi Takahisa Sato Masato Yamazaki keiji koda Department of Surgery Teikyo University Chiba Medical CenterIchihara 299-0111ChibaJapan Department of Pathology Teikyo University Chiba Medical CenterIchihara 299-0111ChibaJapan Department of Internal Medicine Teikyo University Chiba Medical CenterIchihara 299-0111ChibaJapan

BACKGROUND Bronchogenic cysts are congenital cysts caused by abnormal sprouting from the ventral foregut during fetal *** usually occur in the mediastinum or lung,but there are very rare cases of ectopic bronchogenic cysts that develop in the abdominal cavity.A unique intra-abdominal ectopic bronchogenic cyst with a mucinous neoplasm that was producing carcinoembryonic antigen(CEA),harboring a GNAS mutation,is *** present case may contribute to clarifying the mechanism of tumorigenesis and malignant transformation of ectopic bronchogenic *** SUMMARY In 2007,a man in his 50s was incidentally found to have an intra-abdominal cystic mass,8 cm in *** resection was recommended,but he preferred to remain under *** 2020,his serum CEA level increased to 26.7 ng/mL,and abdominal computed tomography showed a 15 cm×12 cm,multifocal,cystic mass located predominantly on the lesser curvature of the *** malignancy could not be ruled out,he finally underwent surgical ***,the cystic wall was lined by ciliated columnar epithelium,accompanied by bronchial gland-like tissue,bronchial cartilage,and smooth *** of the cyst consisted of atypical columnar epithelium with an MIB-1 index of 5%and positive for ***,a GNAS mutation(p.R201C)was detected in the atypical epithelium,leading to a diagnosis of an ectopic bronchogenic cyst with a low-grade mucinous *** patient is currently undergoing outpatient follow-up without *** An extremely rare case of an abdominal bronchogenic cyst with a low-grade mucinous neoplasm harboring a GNAS mutation was reported.

关键词： Congenital,hereditary,and neonatal diseases and abnormalities Ectopic bronchogenic cyst Abdominal neoplasms GNAS mutation Carcinoembryonic antigen Case report

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Connexin 26 correlates with Bcl-xL and Bax proteins expression in colorectal cancer

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World Journal of Gastroenterology 2005年第10期11卷 1544-1548页

作者： Luiza Kanczuga-koda Stanislaw Sulkowski Mariusz koda Elzbieta Skrzydlewska Mariola Sulkowska Department of Pathology Department of Analytical Chemistry

AIM: To evaluate of Cx26 in correlation with Bcl-xL and Bax proteins in colorectal cancer. METHODS: Immunohistochemical staining using specific antibodies was performed to evaluate the protein expression of Cx26, Bax and Bcl-xL in 152 colorectal cancer samples and the correlations among studied proteins as well as the relationships between the expression of Cx26, Bax, Bcl-xL and clinicopathological features were analyzed. RESULTS: Both normal epithelial cells and carcinoma cells expressed Cx26, Bax and Bcl-xL, but Cx26 in cancer cells showed aberrant, mainly cytoplasmic staining. Expression of Cx26, Bax and Bcl-xL was observed in 55.9%, 55.5% and 72.4% of evaluated colorectal cancers respectively. We found the positive correlation between Cx26 and Bax expression (r= 0.561, P<0.0001), Cx26 and Bcl-xL (P=0.409, P<0.0001) as well as between Bax and Bcl-xL (P=0.486, P<0.0001). Association of Cx26, Bax and Bcl-xL expression with histological G2 grade of tumors was noted (P<0.005, P<0.001 and P<0.002 respectively). CONCLUSION: Cytoplasmic presence of Cx26 and its association with apoptotic markers could indicate a distinct role from physiological functions of Cx26 in cancer cells and it could suggest that connexins might be a target point for modulations of apoptosis with therapeutic implications.

关键词： Cx26 Bcl-xL Bax Apoptosis Colorectal cancer Immunohistochemistry

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Locally infiltrative inflammatory fibroid polyp of the ileum:report of a case showing transmural proliferation

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Gastroenterology Report 2018年第2期6卷 144-148,I0003页

作者： Shogo Tajima Kenji koda Department of Pathology Shizuoka Saiseikai General HospitalShizuokaJapan and 2Department of PathologyFujieda Municipal General HospitalShizuokaJapan

Morphologically,an inflammatory fibroid polyp(IFP)is usually centred in the *** of an IFP to the subserosa with destruction of the muscularis propria is exceedingly ***,we describe a 70-year-old woman who presented with right lower abdominal pain but was finally diagnosed with an ***-enhanced computed tomography revealed a target-like structure with a hypovascular mass at the leading edge,which was consistent with intussusception due to a *** surgery,the resected specimen displayed a mass measuring 4×3×3 cmthat was protruding into the ***,the mass was centred in the submucosa,extending up to the mucosal surface and down to the subserosa and *** muscularis mucosae and muscularis propria were destroyed focally.A PDGFRA gene mutation in exon 2(1837_1851 del)that was found in this case,as well as a highly infiltrative growth pattern,strongly supported the neoplastic nature of IFP.

关键词： inflammatory fibroid polyp transmural proliferation subserosa serosa

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Lipid peroxidation and antioxidant status in colorectal cancer

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World Journal of Gastroenterology 2005年第3期11卷 403-406页

作者： Elzbieta Skrzydlewska Stanislaw Sulkowski Mariusz koda Bogdan Zalewski Luiza Kanczuga-koda Mariola Sulkowska Department of Analytical Chemistry Department of Pathology Department of General Surgery

AIM: Reactive oxygen species (ROS) can induce carcinogenesis via DNA injury. Both enzymatic and non-enzymatic parameters participate in cell protection against harmful influence of oxidative stress. The aim of the present study was to assess the levels of final lipid peroxidation products like malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) in primary colorectal cancer. Moreover, we analysed the activity of main antioxidative enzymes, superoxide dismutase (Cu, Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GSSRG-R) and the level of non-enzymatic antioxidants (glutathione, vitamins C and E). METHODS: Investigations were conducted in 81 primary colorectal cancers. As a control, the same amount of sample was collected from macroscopically unchanged colon regions of the most distant location to the cancer. Homogenisation of specimens provided 10% homogenates for our evaluations. Activity of antioxidant enzymes and level of glutathione were determined by spectrophotometry. HPLC revealed levels of vitamins C and E and served as a method to detect terminal products of lipid peroxidation in colorectal cancer. RESULTS: Our studies demonstrated a statistically significant increase in the level of lipid peroxidation products (MDA-Adc. muc.-2.65±0.48 nmol/g, Adc.G3-2.15±0.44 nmol/g, clinical IV stage 4.04±0.47 nmol/g, P<0.001 and ***. -0.44±0.07 nmol/g, Adc.G3-0.44±0.10 nmol/g, clinical IV stage 0.52±0.11 nmol/g, P<0.001) as well as increase of Cu,Zn-SOD (***.-363±72 U/g, Adc.G3-318?8 U/g, clinical IV stage 421±58 U/g, P<0.001), GSH-Px (***. -2143±623 U/g, Adc.G3-2005±591 U/g, clinical IV stage 2467±368 U/g, P<0.001) and GSSG-R (***.-880±194 U/g, Adc.G3-795±228 U/g, dinical IV stage 951±243 U/g, P<0.001) in primary tumour comparison with normal colon (MDA-1.39±0.15 nmol/g, HNE-0.29±0.03 nmol/g, Cu, Zn-SOD-117±25 U/g, GSH-Px-1723±189 U/g, GSSG-R-625±112 U/g) especially in mucinous and G3-grade adenocarcinomas as we

关键词： Colorectal cancer Lipid Peroxidation Oxidative Stress Carcinogenesis

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Monocyte-to-lymphocyte ratio as a prognostic factor in peripheral whole blood samples of colorectal cancer patients

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World Journal of Gastroenterology 2020年第31期26卷 4639-4655页

作者： Katarzyna Jakubowska Mariusz koda Małgorzata Grudzinska Luiza Kanczuga-koda Waldemar Famulski Department of Pathomorphology Comprehensive Cancer CentreBialystok 15027Poland Department of General Pathomorphology Medical University of BialystokBialystok 15027Poland Department of Medical Pathomorphology Medical University of BialystokBialystok 15027Poland

BACKGROUND Colorectal cancer is the third most common malignancy ***,it is critically important to identify new useful markers that can be easily obtained in routine *** is a crucial issue in the pathogenesis and development of *** To evaluate the prognostic value of absolute monocyte count,monocyte to lymphocyte ratio(MLR),the combination of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio(NLR-PLR),and combined platelet and neutrophilto-lymphocyte ratio(PLT-NLR)in peripheral blood samples of patients with colorectal cancer undergoing *** We conducted a retrospective study of 160 patients with colorectal cancer who underwent surgery,and 42 healthy *** status of absolute monocyte count,MLR,NLR-PLR and PLT-NLR was calculated on the basis of blood samples obtained before and after *** factors were examined in correlation with the type of tumour growth,tumour size,histological type,percentage of mucinous component,grade of malignancy,Tumour-Node-Metastasis stage,venous,lymphatic and perineural invasion of cancer cells,status of lymph node invasion and the presence of cancer cell *** Kaplan-Meier method and the long-rank test were used to compare survival *** determine independent prognostic factors,univariate and multivariate Cox proportional hazards regression models were *** The PLT-NLR status was correlated with tumour size and the presence of perineural invasion(P=0.015;P=-0.174,P=0.037).Moreover,high NLR-PLR and PLR-NLR ratios in the blood samples obtained after surgery were positively associated with histological type of cancer and percentage of the mucinous component(NLR-PLR:P=0.002;P=0.009;PLR-NLR status:P=0.002;P=0.007).The analysis of 5-year disease-free survival showed that the MLR of whole blood obtained after surgery[HR=2.903,95%CI:(1.368-6.158),P=0.005]and the status of lymph node metastasis[HR=0.813,95%CI:(0.653-1.013),P=0.050]were inde

关键词： Monocyte count Monocyte to lymphocyte ratio Platelet Neutrophil-tolymphocyte ratio Colorectal cancer Prognosis

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Classification of Spectra of Emission Line Stars Using Machine Learning Techniques

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International Journal of Automation and computing 2014年第3期11卷 265-273页

作者： Pavla Bromová Petr koda Jaroslav Vázn Faculty of Information Technology Brno University of Technology Astronomical Institute of the Academy of Sciences of the Czech Republic

Advances in the technology of astronomical spectra acquisition have resulted in an enormous amount of data available in world-wide telescope archives. It is no longer feasible to analyze them using classical approaches, so a new astronomical discipline,astroinformatics, has emerged. We describe the initial experiments in the investigation of spectral line profiles of emission line stars using machine learning with attempt to automatically identify Be and B[e] stars spectra in large archives and classify their types in an automatic manner. Due to the size of spectra collections, the dimension reduction techniques based on wavelet transformation are studied as well. The result clearly justifies that machine learning is able to distinguish different shapes of line profiles even after drastic dimension reduction.

关键词： Be star stellar spectrum feature extraction dimension reduction discrete wavelet transform classification support vector machines(SVM) clustering.

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Sampling lattices in semi-grand canonical ensemble with autoregressive machine learning

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npj Computational Materials 2022年第1期8卷 588-597页

作者： James Damewood Daniel Schwalbe-koda Rafael Gómez-Bombarelli Department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA02319USA

Calculating thermodynamic potentials and observables efficiently and accurately is key for the application of statistical mechanics simulations to materials ***,naive Monte Carlo approaches,on which such calculations are often dependent,struggle to scale to complex materials in many state-of-the-art disciplines such as the design of high entropy alloys or multi-component *** address this issue,we adapt sampling tools built upon machine learning-based generative modeling to the materials space by transforming them into the semi-grand canonical ***,we show that the resulting models are transferable across wide ranges of thermodynamic conditions and can be implemented with any internal energy model U,allowing integration into many existing materials *** demonstrate the applicability of this approach to the simulation of benchmark systems (AgPd,CuAu) that exhibit diverse thermodynamic behavior in their phase ***,we discuss remaining challenges in model development and promising research directions for future improvements.

关键词： canonical thermodynamic directions

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Proteolytic-antiproteolytic balance and its regulation in carcinogenesis

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World Journal of Gastroenterology 2005年第9期11卷 1251-1266页

作者： Elzbieta Skrzydlewska Mariola Sulkowska Mariusz koda Stanislaw Sulkowski Department Department of Pathology

Cancer development is essentially a tissue remodeling process in which normal tissue is substituted with cancer tissue. A crucial role in this process is attributed to proteolytic degradation of the extracellular matrix (ECM). Degradation of ECM is initiated by proteases, secreted by different cell types, participating in tumor cell invasion and increased expression or activity of every known class of proteases (metallo-, serine-, aspartyl-, and cysteine) has been linked to malignancy and invasion of tumor cells. Proteolytic enzymes can act directly by degrading ECM or indirectly by activating other proteases, which then degrade the ECM. They act in a determined order, resulting from the order of their activation. When proteases exert their action on other proteases, the end result is a cascade leading to proteolysis. Presumable order of events in this complicated cascade is that aspartyl protease (cathepsin D) activates cysteine proteases (e.g. cathepsin B) that can activate pro-uPA. Then active uPA can convert plasminogen into plasmin. Cathepsin B as well as plasmin are capable of degrading several components of tumor stroma and may activate zymogens of matrix metalloproteinases, the main family of ECM degrading proteases. The activities of these proteases are regulated by a complex array of activators, inhibitors and cellular receptors. In physiological conditions the balance exists between proteases and their inhibitors. Proteolytic-antiproteolytic balance may be of major significance in the cancer development. One of the reasons for such a situation is enhanced generation of free radicals observed in many pathological states. Free radicals react with main cellular components like proteins and lipids and in this way modify proteolytic-antiproteolytic balance and enable penetration damaging cellular membrane. All these lead to enhancement of proteolysis and destruction of ECM proteins and in consequence to invasion and metastasis.

关键词： Proteases Protease inhibitors Reactive oxygen species

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Bounded derived categories of very simple manifolds

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Science China Mathematics 2011年第8期54卷 1741-1750页

作者： OGUISO keiji Department of Mathematics Graduate School of ScienceOsaka University Korea Institute for Advanced Study

A non-representable cohomological functor of finite type of the bounded derived category of coherent sheaves of a compact complex manifold of dimension greater than one with no proper closed subvariety is given explic... 详细信息

关键词： derived category cohomological functor very simple manifold

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A simple remark on a flat projective morphism with a Calabi-Yau fiber

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Science China Mathematics 2011年第8期54卷 1751-1756页

作者： OGUISO keiji Department of Mathematics Graduate School of ScienceOsaka University Korea Institute for Advanced Study

If a K3 surface is a fiber of a flat projective morphisms over a connected noetherian scheme over the complex number field,then any smooth connected fiber is also a K3 *** this,Professor Nam-Hoon Lee asked if the same is true for higher dimensional Calabi-Yau *** shall give an explicit negative answer to his question in each dimension greater than or equal to three as well as a proof of his initial observation.

关键词： flat projective morphism Hilbert scheme Calabi-Yau manifold

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