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Clinical applications of 5-aminolevulinic acid-mediated fluorescence for gastric cancer

World Journal of Gastroenterology 2015年第29期21卷 8769-8775页

作者： Tsutomu Namikawa Tomoaki Yatabe keiji inoue Taro Shuin Kazuhiro Hanazaki Department of Surgery Kochi Medical School Nankoku Department of Anesthesiology Kochi Medical School Nankoku Department of Urology Kochi Medical School Nankoku

5-aminolevulinic acid(ALA) is a naturally occurring amino acid that is a protoporphyrin IX(Pp IX) precursor and a next-generation photosensitive substance. After exogenous administration of ALA, Pp IX specifically accumulates in cancer cells owing to the impaired metabolism of ALA to Pp IX in mitochondria, which results in a red fluorescence following irradiation with blue light and the formation of singlet oxygen. Fluorescence navigation by photodynamic diagnosis(PDD) using ALA provides good visualization and detection of gastric cancer lesions and is a potentially valuable diagnostic tool for gastric cancer for evaluating both the surgical resection margins and extension of the lesion. Furthermore, PDD using ALA might be used to detect peritoneal metastases during preoperative staging laparoscopy, where it could provide useful information for the selection of a therapeutic approach. Another promising application for this modality is in the evaluation of lymph node metastases. Photodynamic therapy(PDT) using ALA to cause selective damage based on the accumulation of a photosensitizer in malignant tissue is expected to be a non-invasive endoscopic treatment for superficial early gastric cancer. ALA has the potential to be used not only as a diagnostic agent but also as a therapeutic drug, resulting in a new strategy for cancer diagnosis and therapy. Here, we review the current use of PDD and PDT in gastric cancer and evaluate its future potential beyond conventional modalities combined with a light energy upconverter, a light-emitting diode and nearinfrared rays as light sources.

关键词： Fluorescence imaging 5-aminolevulinic acid Photodynamic diagnosis Photodynamic therapy Gastric cancer

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5-ALA-mediated photodynamic treatment Induces caspase-dependent and-Independent cell death in human histiocytic lymphoma cell line U937

5-ALA-mediated photodynamic treatment Induces caspase-depend...

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21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology

作者： Kozo Utsuml Masataka Uchida Hirofumi Fujita Toshihiko Utsumi keiji inoue Junzo Sasaki Okayama University Graduate School of Medicine DentistryPharmaceutical Sciences Graduate School of Medicine Yamaguchi University Medical School Kochi University

＜正＞The photodynamic treatment（PDT） using 5-aminolevulinic acid（ALA） is one of the new therapeutic modalities for malignant *** mechanism of cell damage induced by ALA-mediated PDT is not fully *** treatment of human histiocytic lymphoma U937 cell line cultures by ALA-based PDT resulted in apoptotic cell death,chromatin condensation,phos-

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Oxidation behavior and improvement in nonflammability of LPSO-type Mg–Zn–Y–Sr alloy

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Journal of Magnesium and Alloys 2024年第2期12卷 742-749页

作者： Shin-ichi inoue Kazumasa Iwanaga Yoshihito Kawamura Magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Department of Materials Science Graduate School of Science and TechnologyKumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

Mg_(97)Zn_(1)Y_(2)alloys with high ignition temperatures were developed by adding *** addition of Sr resulted in the formation of a uniform and thin Y_(2)O_(3)***–Zn–Y alloys containing at least 0.25 at.%Sr exhibited ignition temperatures of 1270–1320 *** a result of EDS measurement,Sr was found to be concentrated in the Y_(2)O_(3)*** addition,a mixed film of MgO and Sr O formed on the outer layer in the 1.5 at.%Sr-containing Mg_(97)Zn_(1)Y_(2)*** findings suggest that the uniform and thin Y_(2)O_(3)film that maintains high soundness at high temperatures was formed owing to valence control and the formation of a protective outer oxide film.

关键词： Magnesium alloy Yttrium Strontium High-temperature oxidation Nonflammability

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Case of plasmablastic lymphoma of the sigmoid colon and literature review

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World Journal of Gastroenterology 2015年第24期21卷 7598-7603页

作者： Tomoko Haramura Masashi Haraguchi Junji Irie Shinichiro Ito Hirotaka Tokai Kazumasa Noda Masachika Kitajima Shigeki Minami keiji inoue Yuya Sasaki Koichi Oshima Susumu Eguchi Department of Surgery Nagasaki Harbor Medical Center City Hospital Department of Pathology Nagasaki Harbor Medical Center City Hospital Department of Pathology Kurume University Department of Surgery Nagasaki University Graduate School of Biomedical Sciences

Plasmablastic lymphoma(PBL) is a rare form of nonHodgkin's lymphoma that is associated with human immunodeficiency virus(HIV) infection. Although PBL is most commonly observed in the oral cavity of HIV-positive patients, it can also be observed at extra-oral sites in HIV-negative patients. This report represents an unusual case of HIV-negative PBL that occurred in the sigmoid colon. This patient had a history of systemic lupus erythematosus and an underlying immunosuppressive state from long term steroid therapy. The lymphoma cells were positive for CD138, kappa light chain restriction and Epstein-Barr virus and negative for CD20/L26, CD3, CD79 a, UCHL1(CD45RO) and cytokeratin(AE1/AE3). The patient died approximately 2 mo after the operation. In the present paper, we review cases of PBL of the colon in HIVnegative patients.

关键词： Plasmablastic lymphoma Sigmoid colon Humanimmunodeficiency virus-negative Immunosuppressive state Extra-oral site

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Continued Diagnostic Difficulties in Preoperatively Differentiating Lipiodized Oil and Residual Metallic Material: A Case Report

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Case Reports in Clinical Medicine 2016年第4期5卷 125-129页

作者： Masashi Haraguchi Shinichiro Ito Kohei Kotera Aya Fukushima Toshio Fukuda Hirotaka Tokai Kazumasa Noda Masataka Hirabaru Toshiyuki Adachi Nobuhiro Tada keiji inoue Shinya Onizuka Shigeki Minami Department of Surgery Nagasaki Harbor Medical Center City Hospital Nagasaki Japan Department of Obstetrics and Gynecology Nagasaki Harbor Medical Center City Hospital Nagasaki Japan Department of Radiology Nagasaki Harbor Medical Center City Hospital Nagasaki Japan

Retained foreign objects in the abdomen and pelvis are serious clinical problems yet the imaging required can present difficulties. Prolonged retention of lipiodized oil used for hysterosalpingography over years is very rare. However, lipiodized oil had previously been misdiagnosed as residual metallic material. We are reporting a case in which the latest computed tomography (CT) equipment seemed inadequate for obtaining a clear pre-operative diagnosis. Here, we describe the case of a 33-year-old Japanese female whose pelvis had contained retained lipiodized oil that had been suspected as residual metallic material. The preoperative diagnosis was very difficult and included three-dimensional computed tomography (3D-CT) of unclear results despite expectations of resolution. By laparoscopic surgery, we removed a cyst of approximately 2 cm containing a yellowish oily fluid. Postoperatively, we demonstrated that the fluid was lipiodized oil. A postoperative experiment to attempt distinguishing lipiodized oil from metal through gemstone spectral CT imaging did not offer clarity either. Distinguishing between retained lipiodized oil and metallic material in the abdominal cavity may still present unexpected difficulties even with the latest medical equipments.

关键词： Lipiodized Oil Hysterosalpingography Residual Metallic Material

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Does There Exist the Applicability Limit of PDE to Describe Physical Phenomena?—A Personal Survey of Quantization, QED, Turbulence

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World Journal of Mechanics 2024年第6期14卷 97-142页

作者： Atsushi inoue Department of Mathematics Tokyo Institute of Technology Tokyo Japan

What does it mean to study PDE (Partial Differential Equation)? How and what to do “to claim proudly that I’m studying a certain PDE”? Newton mechanic uses mainly ODE (Ordinary Differential Equation) and describes nicely movements of Sun, Moon and Earth etc. Now, so-called quantum phenomenum is described by, say Schrödinger equation, PDE which explains both wave and particle characters after quantization of ODE. The coupled Maxwell-Dirac equation is also “quantized” and QED (Quantum Electro-Dynamics) theory is invented by physicists. Though it is said this QED gives very good coincidence between theoretical1 and experimental observed quantities, but what is the equation corresponding to QED? Or, is it possible to describe QED by “equation” in naive sense?

关键词： Superspace Grassmann Variables Hamilton-Jacobi Equation Quantization

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In-situ study of the microstructure evolution during tension of a Mg-Y-Zn-Al alloy processed by rapidly solidified ribbon consolidation technique

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Journal of Magnesium and Alloys 2024年第5期12卷 2024-2040页

作者： Jeno Gubicza Kristián Máthis Péter Nagy Péter Jenei Zoltán Hegedus Andrea Farkas Jozef Vesely Shin-ichi inoue Daria Drozdenko Yoshihito Kawamura Department of Materials Physics Faculty of ScienceEotvos Loránd UniversityPázmány P.sétány 1/ABudapest H-1117Hungary Department of Physics of Materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116 Praha 2Czech Republic Deutsches Elektronen-Synchrotron DESY Notkestr.85Hamburg 22603Germany Magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

Mg-Y-Zn-Al alloys processed by rapidly solidified ribbon consolidation(RSRC)technique exhibit an exceptional mechanical performance indicating promising application *** material has a bimodal microstructure consisting of fine recrystallized and coarse non-recrystallized grains with solute-rich stacking faults forming cluster arranged layers(CALs)and nanoplates(CANaPs),or complete long period stacking ordered(LPSO)*** order to reveal the deformation mechanisms,in-situ synchrotron X-ray diffraction line profile analysis was employed for a detailed study of the dislocation arrangement created during tension in Mg-0.9%Zn-2.05%Y-0.15%Al(at%)*** uncovering the effect of the initial microstructure on the mechanical performance,additional samples were obtained by annealing of the as-consolidated specimen at 300 and 400℃ for 2 *** heat treatment at 300℃ had no significant effect on the initial microstructure,its evolution during tension and,thus,the overall deformation behavior under tensile *** the other hand,annealing at 400℃ resulted in a significant increase of the recrystallized grains fraction and a decrease of the dislocation density,leading to only minor degradation of the mechanical *** maximum dislocation density at the failure of the samples corresponding to the plastic strain of 10-25% was estimated to be about 16-20×10^(14)m^(-2).The diffraction profile analysis indicated that most dislocations formed during tension were of non-basal and pyramidal types,what was also in agreement with the Schmid factor values revealed independently from orientation *** was also shown that the dislocation-induced Taylor hardening was much lower below the plastic strain of 3% than above this value,which was explained by a model of the interaction between prismatic dislocations and CANaPs/LPSO plates.

关键词： Mg-Zn-Y-Al alloy Long period stacking ordered(LPSO)phase Cluster arranged nanoplates(CANaPs) Annealing Tension Dislocation density Hardening

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Association of Omega-3 Polyunsaturated Fatty Acids with Sarcopenia in Liver Cirrhosis Patients with Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 613-624页

作者： Akitoshi Sano Jun inoue Eiji Kakazu Masashi Ninomiya Mio Tsuruoka Kosuke Sato Masazumi Onuki Satoko Sawahashi Keishi Ouchi Atsushi Masamune Division of Gastroenterology Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Liver Disease The Research Center for Hepatitis and ImmunologyNational Center for Global Health and MedicineIchikawaChibaJapan

Background and Aims:Sarcopenia is associated with the prognosis of patients with liver cirrhosis and hepatocellular carcinoma(HCC).Given their diverse physiological activities,we hypothesized that plasma fatty acids might influence the progression of *** study aimed to clarify the association between fatty acids and sarcopenia in cirrhotic patients with ***:In this singlecenter retrospective study,we registered 516 cases and analyzed 414 cases of liver cirrhosis and *** skeletal muscle mass index was measured using a transverse computed tomography scan image at the third lumbar *** cutoff value for sarcopenia followed the criteria set by the Japan Society of *** acid concentrations were measured by gas ***:Fatty acid levels,particularly omega-3(n-3)polyunsaturated fatty acid(PUFA),were lower in patients with poor liver function(Child-Pugh grade B/C)and were negatively correlated with the albumin-bilirubin score(p<0.0001).The prognosis of HCC patients with low PUFA levels was significantly *** the different fatty acid fractions,only n-3 PUFAs significantly correlated with skeletal muscle mass index(p=0.0026).In the multivariate analysis,the n-3 PUFA level was an independent variable associated with sarcopenia(p=0.0006).Conclusions:A low level of n-3 PUFAs was associated with sarcopenia in patients with liver cirrhosis and HCC.

关键词： Liver cirrhosis Hepatocellular carcinoma Sarcopenia Skeletal Muscle Fatty Acids Omega-3 polyunsaturated fatty acids

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Injuries and illness of athletes at the Tokyo 2020 Olympic and Paralympic summer games visiting outside facilities

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Sports Medicine and Health Science 2024年第1期6卷 48-53页

作者： Shuji Sakanashi Hideharu Tanaka Hiroyuki Yokota Yasuhiro Otomo Tomohiko Masuno Kousuke Nakano Junichi inoue Manabu Sugita Takahiko Tokunaga Nagisa Kato Tomoya Kinoshi Hironori inoue Hiroto Numata Koshi Nakagawa Ryo Sagisaka Shota Tanaka Tetsuya Miyamoto Takao Akama The Tokyo Organising Committee of the Olympic and Paralympic Games TokyoJapan Department of Sports Medicine Kokushikan University TokyoJapan Graduate School of Emergency Medical System Kokushikan UniversityTokyoJapan Research Institute of Disaster Management and EMS Kokushikan University TokyoJapan Graduate School of Health and Medical Science Nippon Sports Science UniversityJapan Tokyo Medical and Dental University Hospital Trauma and Acute Critical Care CenterTokyoJapan Graduate School of Medicine Nippon Medical UniversityTokyoJapan Saitama City Hospital Emergency DepartmentSaitamaJapan Graduate School of Medicine Juntendo UniversityTokyoJapan Emergency Lifesaving Academy Tokyo TokyoJapan Nippon Medical School Musashikosugi Hospital Emergency and Critical Care CenterKnagawaJapan Department of Integrated Science and Engineering for Sustaiable Society Chuo UniversityJapan Faculty of Sport Sciences Waseda UniversitySaitamaJapan National Hospital Organization Disaster Medical Center TokyoJapan

This study aimed to identify the reasons for transferring athletes to local medical facilities during the Olympic and Paralympic *** on 567 injuries and other illnesses of athletes treated at the on-site clinics were collected from the Tokyo 2020 Organizing *** these,84 athletes who required outpatient care during the Games were registered for this *** the Olympic and Paralympic Games,66(8.3/1000)and 18(7.2/1000)athletes,respectively,consulted external medical *** the Olympic Games,the reasons for these visits included 48 cases(72.7%)of injuries,13(19.7%)cases of illnesses,and 5(7.6%)cases of heat stroke illness(HSI).Of these patients,56(84.9%)were treated as outpatients and 10(15.1%)were hospitalized,while three of these patients required hospitalization for>7 *** the other hand,in the Paralympics Games,there were 7(38.8%)cases of injuries,9(50.0%)other illnesses,1(5.6%)case of HSI,and 1(5.6%)other cases,of which 11(61.1%)were treated as outpatients and 7(38.9%)were hospitalized,but none was hospitalized for>7 *** accounted for 70%of the total cases at the 2021 Olympic Games,but only three(0.05%)were severe cases that required hospitalization for more than 1 *** contrast,in the Paralympic Games,other illnesses accounted for approximately half of the total *** study provides details on the extent of injuries and other illnesses that were transferred to outside facilities,which has not been documented in previous games.

关键词： Olympic games Paralympic games Sports injuries Illness Heat-related illness 2020 Tokyo

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Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?

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World Journal of Gastroenterology 2024年第10期30卷 1368-1376页

作者： Nobukazu Agatsuma Takahiro Utsumi Yoshitaka Nishikawa Takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka Takahiro inoue Yuki Nakanishi Takahiro Shimizu Mikako Ohno Akane Fukushima Takeo Nakayama Hiroshi Seno Department of Gastroenterology and Hepatology Kyoto University Graduate School of MedicineKyoto 606-8507Japan Department of Gastroenterology and Hepatology Japanese Red Cross Wakayama Medical CenterWakayama 640-8558Japan Department of Health Informatics Kyoto University School of Public HealthKyoto 606-8501Japan Institute for Advancement of Clinical and Translational Science(iACT) Kyoto University HospitalKyoto 606-8507Japan Medical Support Section Medical Affairs DivisionKyoto University HospitalKyoto 606-8507Japan

BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor *** efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside *** identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less *** the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related *** To clarify the stage at CRC diagnosis based on diagnostic *** We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two *** diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and *** early-stage was defined as Stages 0 or *** and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up *** adjusted covariates were age,sex,and tumor *** Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,*** the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,*** symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening gro

关键词： Colorectal neoplasms Cancer registry Diagnostic route Cancer screening Stage at diagnosis

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