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建筑学报 2008年第11期 85-92页

作者：迫庆一郎

北京设计师广场和济南自由城项目有些共同的地方，他们都是小户型的公寓，而且都建在街面上，是商业设施与公寓复合的设施。以下是二者的一些共通点。

关键词：设计师广场自由济南市商业设施小户型公寓

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螺旋银川某高级男装服装会所

室内设计与装修 2013年第7期 106-110页

作者： keiichiro sako Satomi NAGAOKA 薇拉

说起店铺设计的要义，倒是可以仔细地划分为几个方面：招牌设计、门店设计、橱窗设计、外部照明和壁面照明等。这些细小的方面组合在一起构成的空间，是体现店面整体概念、档次和个性的根本。现代风格的店面设计，总是能够给人以时尚的... 详细信息

说起店铺设计的要义，倒是可以仔细地划分为几个方面：招牌设计、门店设计、橱窗设计、外部照明和壁面照明等。这些细小的方面组合在一起构成的空间，是体现店面整体概念、档次和个性的根本。现代风格的店面设计，总是能够给人以时尚的气息。设计师根据业主不同的要求和品牌的特色，来完成对于一个空间的定义。由sako建筑设计工社的这间位于银川I的店铺包含了5个品牌、2个鞋子专柜以及贵宾室。

关键词：银川橱窗设计螺旋会所男装外部照明店面设计现代风格

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浪漫一身

现代装饰 2007年第7期 132-135页

作者： keiichiro sako（设计） Nobutoshi Hara（设计） Jiao Jian（摄影） SKSK Architects 不详

“浪漫一身”是在中国拥有500家分店的服装品牌。业主在委托设计师做内装改造设计的同时，对于自身的服装品牌形象也制定了向更精炼方向转型的目标。设计师对于此品牌的“新生”的构思，和“鸡蛋”本身所具寓意“诞生、未来、发展”是... 详细信息

“浪漫一身”是在中国拥有500家分店的服装品牌。业主在委托设计师做内装改造设计的同时，对于自身的服装品牌形象也制定了向更精炼方向转型的目标。设计师对于此品牌的“新生”的构思，和“鸡蛋”本身所具寓意“诞生、未来、发展”是互相吻合的。

关键词：浪漫服装品牌改造设计品牌形象设计师业主

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北京冲击

城市建筑 2011年第1期8卷 71-76页

作者：迫庆一郎 sako建筑设计工社

北京冲击位于北京市丰台区看丹桥西南角，占地面积1．7hm2．总建筑面积10．3万m2．由4栋23层、26层高层酒店式公寓塔楼及大型综合商业组成。立面由黑白灰三基色组成．使建筑好像是黑白盒子的堆积．成为西南四环地标性建筑。开放式社区内、

关键词：北京市建筑面积酒店式公寓占地面积型综合三基色开放式西南

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“北京主义”的实验地

现代装饰 2008年第1期 68-75页

作者： Yoko FUJII Hiroaki SAWAMURA Bo XU Misae Hiromatsu（摄影） keiichiro sako（迫庆一郎）（设计） Yoko Fujii（设计）不详 Beijing NDC Studio Inc.

设计师广场项目位于北京市丰台区看丹桥西南角，占地面积17949平方米，总建筑面积99206平方米，由4栋23或26层高层塔式酒店公寓及大型综合商业组成。

关键词：北京市实验主义占地面积建筑面积设计师型综合平方

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浙江金华八咏大厦

城市建筑 2011年第6期8卷 115-118页

作者：迫庆一郎藤井洋子 sako建筑设计工社

该项目位于浙江省金华市经济开发区,是浙江八咏公路工程有限公司的办公楼和酒店楼。由于位于经济开发区的入口,委托方提出要使这个项目成为标志性的建筑。预计到周边是一组皇冠式的圆顶建筑,我们设计两个简约到极致的体块。

关键词：浙江金华经济开发区大厦圆顶建筑公路工程金华市浙江省办公楼

An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads:Experimental studies and molecular dynamics analysis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2669-2684页

作者： Jamie Anne Lugtu-Pe Xuning Zhang sako Mirzaie Hao Han R.Chang Nour AL-Mousawi Kuan Chen Yongqiang Li Anil Kane Daniel Bar-Shalom Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company Inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Thermo Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution ***,most new chemical entities exhibit poor water solubility,and hence are exempt from such *** combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,particularly within the dosage ***,we explored the potential of an emerging,non-leachable terpolymer nanoparticle(TPN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid dispersion(CRASD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)*** to conventional pore former,polyvinylpyrrolidone(PVP),TPN-containing membranes exhibited superior structural integrity,less crystal formation at the CRASD bead surface,and greater extent of celecoxib ***-atom molecular dynamics analyses revealed that in the presence of TPN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to *** work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CRASD.

关键词： Controlled release amorphous solid dispersion Poorly soluble drug Internal recrystallization Membrane-reservoir coated beads Molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer interactions

Pericarditis in Cardiology at a Regional Hospital

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World Journal of Cardiovascular Diseases 2024年第9期14卷 581-587页

作者： Coulibaly Souleymane Traoré Djénébou Konaté Massama B. A. Hamidou Oumar Guindo Aissata Yves Roland Koumaré Sidibé Samba sako Mariam Sanogo Alpha Kodio Aniéssa Mahamadou Yaya Kéita Diakité Mamadou Menta Ichaka Department of Cardiology CHU Point G Bamako Mali Department of Internal Medicine CHU Point G Bamako Mali Mali Hospital Medical Department Bamako Mali Department of Cardiology Gabriel Tour University Hospital Bamako Mali Department of Cardiology Nianankoro Fomba Hospital Sgou Mali

Introduction: Pericarditis is an inflammation of the pericardium with or without pericardial fluid effusion. Its prevalence is difficult to determine given the many forms that are not symptomatic. In Africa, its prevalence was 6.3% in Gabon in 2020 and 7.2% in Mali in 2022. In Europe, an Italian study estimates the incidence of acute pericarditis at 27.7 cases per 100,000 people per year. In another study conducted in Finland over a period of 9 years, the incidence of pericarditis requiring hospitalisation was 3.32 cases per 100,000 people per year. The aim of our study was to describe the clinical and paraclinical characteristics of pericarditis observed in the cardiology department of the regional hospital in Mali. Methodology: This was a single centre cross-sectional study from 30 January 2018 to 30 June 2020 in the cardiology department of the Ségou regional hospital. All consenting patients, regardless of age or sex hospitalised in the department for pericarditis confirmed on cardiac ultrasound were included. Data were collected using an individual patient follow-up form recording sociodemographic, clinical, biological, electrocardiographic and echocardiographic data, as well as the course of the disease. Results: Out of 879 patients hospitalized, the hospital frequency was 7.28%. Females predominated, with a sex ratio of 0.42. More than half the patients were aged 45 or younger (59.4%). The mean age of patients was 41.8 ± 18.1 years. Cardiovascular risk factors were dominated by hypertension and smoking (46.9% and 12.5% respectively). The reasons for consultation were dyspnoea (84.3%), chest pain (54.7%), cough (71.9%) and fever (34.4%). Physical signs included muffled heart sounds (76.6%), tachycardia (70.3%), pericardial friction (17.2%) and signs of peripheral stasis in 53.1% of cases. We observed elevated C-reactive protein (CRP) in 57.8% of cases, hypercreatininaemia in 37.5% and positive HIV serology in 3.1%. The major radiographic signs were cardiomegal

关键词： Pericarditis Epidemiology Clinic Nianankoro Fomba Hospital Ségou

Therapeutic Compliance of Hypertensive Patients Followed in Ambulatory in the Cardiology Department of Kati University Hospital

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World Journal of Cardiovascular Diseases 2024年第5期14卷 333-342页

作者： Boubacar Sonfo Coumba Thiam Mariam sako Massama Konaté Youssouf Camara Mamadou Touré Boubacar Diarra Diakaridja Sacko Samba Sidibé Bassan Diarra Hamidou Camara Asmaou Keita Konimba Diarra Hamidou Oumar Bâ Ibrahima Sangaré Youssouf Guindo Sanoussi Daffe Daouda Fofana Souleymane Coulibaly Ichaka Menta Department of Cardiology University Hospital Bocar Sidy Sall Kati Mali Department of Cardiology University Hospital of Point G Bamako Mali Department of Cardiology Mali Hospital Bamako Mali Department of Cardiology University Hospital Mother-Child Luxembourg Bamako Mali Department of Cardiology University Hospital Gabriel Tour&#233 Bamako Mali Department of Cardiology Kayes Hospital Kayes Mali

Introduction: High blood pressure is a major public health problem worldwide due to its frequency and cardiovascular complications. Adherence to treatment for chronic diseases is a global problem. The aim was to study therapeutic adherence in hypertensive patients followed in ambulatory. Materials and Methods: This was a cross-sectional, descriptive study with prospective recruitment that took place from July 1 to December 31, 2022 (6 months) in the cardiology department of the university hospital of Kati. The variables studied were sociodemographic data, cardiovascular risk factors, comorbidities, the possession of insurance and compliance (the Girerd questionnaire was used to assess adherence). Results: A total of 1182 patients were consulted, including 887 for hypertension, a frequency of 75%. Fifty-six patients were included in the study. The average age was 58.18 ± 13.25 years with extremes of 30 and 80 years. There was a female predominance (75%) with a sex ratio of 0.3. The majority of patients lived in urban areas (89.3%). Out-of-school patients accounted for 44.6%, more than half of patients or 55.4% had no income, patients with medical coverage accounted for 67.9% of cases. The main risk factors were physical inactivity (25%) followed by smoking 14.3%. More than 71% of patients had a compliance problem and the main reasons were forgetting to take the drug with 73.2%, followed by delayed treatment of 50% and drug discontinuation of 28.6%. Conclusion: Compliance is a real challenge and a major public health issue. This study allowed us to find a real problem of compliance in our hypertensive patients. There was a statistically significant relationship between drug adherence and forgetting to take the drug and drug discontinuation.

关键词： Hypertensive Therapeutic Adherence University Hospital of Kati

Acute Coronary Syndrome of Young Subjects at the Luxembourg Mother-Child University Hospital in Bamako

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World Journal of Cardiovascular Diseases 2024年第3期14卷 157-165页

作者： Mamadou Toure Mariam Dagnogo Massama Konate Mariam sako Daouda Fofana Hamma Sankare Almou A. Diall Modibo Doumbia Baba I. Diarr Mady Sow Abdoul Wahhab Terra Coumba A. Thiam Boubacar Sonfo Boubacar Diarra Asmaou Keita Ousmane Traore Hamidou O. Ba Ichaka Menta Cardiology Department CHU-Mother Child Bamako Mali Cardiology Department CHU-Gabriel Tour&#233 Bamako Mali Faculty of Medicine University of Sciences Technics and Technologies of Bamako Bamako Mali Center Andre FESTOC Department of Cardiac Surgery of Bamako Mali Bamako Mali

Introduction: Acute coronary syndrome is often the first event of coronary disease of young subjects. Objective: To study sociodemographic, clinical, paraclinical, therapeutic and evolutionary aspects of acute coronary syndrome of young subjects. Patients and Methods: Descriptive cross-sectional study with prospective recruitment from October 01, 2020 to March 31, 2022. Were included all patients admitted for acute coronary syndrome whose age was less or equal to 45 years and who had undergone coronary angiography at the Mother-Child University Hospital on Luxembourg from Bamako. Results: During the study period, we collected 60 patient files out of 198. These 60 patient files met our inclusion criteria. Hospital frequency was 30.30%. Average age of patients was 40.43 ± 3.9 years. Sex ratio M/F was 5.3. Main cardiovascular risk factor was smoking tobacco (23.42%), followed by dyslipidemia (13.92%). Functional signs were dominated by angina 62% followed by dyspnea 25.3%. Persistent ST-segment elevation on electrocardiogram was present in 76.4%. Left ventricular systolic dysfunction was present in 26.5%. Time to first medical contact was more than 12 hours in 62.7% of cases. Radial approach was adopted in 94% of cases. Coronary angiography was pathological in 85% (n = 51) of cases. Lesions were single-vessel disease in 47.1% and culprit artery was anterior interventricular in 51% of cases. Dual anti-platelet aggregation was aspirin and ticagrelor in 91.8% of cases. Angioplasty was performed in all patients who had significant abnormalities at coronary angiography. In-hospital mortality was 3.9%. Conclusion: Acute coronary syndromes exist in young Africans with a male predominance. Main cardiovascular risk factor is smoking tobacco. Coronary lesions are single vessel disease in the majority of case. Most of patients meet medical team after 12 hours. Time to first medical contact is a main challenge in our country.

关键词： Acute Coronary Syndrome Young Subjects Coronary Angiography CHU Luxembourg Bamako