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Numerical Study on Nonlinear Sound Propagation for Parametric Array

Journal of Flow Control, Measurement & Visualization 2014年第3期2卷 120-124页

作者： kei fujisawa Department of Ocean Technology Policy and Environment University of Tokyo Tokyo Japan

This paper presents the numerical study on the nonlinear sound propagation for the parametric array using the compressible form of Navier-Stokes equations combined with the mass and energy conservation equations and the state equation. These governing equations are solved by finite difference time domain (FDTD) based method. The numerical result is shown for the parametric sound propagation in the near field of the sound source in cylindrical coordinate. The result indicates the generation of low-frequency unsteady beat by the interaction of two frequency sound waves in the near field, which grows to a difference frequency sound in the far field.

关键词： Numerical Simulation Nonlinear Sound Propagation Parametric Array FDTD

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Nonlinear Acoustic Shadow Method to Reduce Reverberation Artifact

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Journal of Flow Control, Measurement & Visualization 2016年第2期4卷 49-55页

作者： kei fujisawa Akira Asada Department of Ocean Technology Policy and Environment The University of Tokyo Tokyo Japan Institute of Industrial Science The University of Tokyo Tokyo Japan

A novel technique for reducing reverberation artifact in acoustic shadow imaging using nonlinear ultrasound interaction, called nonlinear acoustic shadow method, has been developed and experimentally studied. In this technique, the conventional acoustic shadow method is modified by using the secondary wave generated by nonlinear interaction of two primary sound waves emitted from parametric array. Either conventional or nonlinear acoustic shadow imaging is carried out for aluminum square cylinder and the size of the shadow is compared. The result shows that the nonlinear acoustic shadow method reduces reverberation artifact inside the square cylinder and has better accuracy in the size measurement than conventional acoustic shadow method.

关键词： Acoustic Shadow Method Reverberation Artifact Nonlinear Ultrasound Parametric Array Secondary Wave

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First cases of MPV17 related mitochondrial DNA depletion syndrome with compound heterozygous mutations in p.R50Q/p.R50W:a case report

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Hepatoma Research 2020年第1期6卷 1-10页

作者： Shuichiro Umetsu Ayano Inui Sohya Kobayashi Masaru Shimura Tomoko Uehara Hajime Uchida Rie Irie Tsuyoshi Sogo Haruki Komatsu Takako Yoshioka kei Murayama Kenjiro Kosaki MureoKasahara Tomoo fujisawa Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama City Tobu HospitalKanagawa 230-0012Japan Department of Metabolism Chiba Children’s HospitalChiba 266-0007Japan Center for Medical Genetics Keio University School of MedicineTokyo 160-8582Japan Department of Transplantation Surgery National Center for Child Health and DevelopmentTokyo 157-8535Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Department of Pediatrics Toho University Sakura Medical CenterChiba 285-8741Japan Department of Pathology National Center for Child Health and DevelopmentTokyo 157-8535Japan

Mutations in MPV17 lead to severe mitochondrial DNA depletion syndrome(MTDPS).All known p.R50W variants in MPV17 are *** homozygous variant p.R50Q in MPV17 among patients with Navajo neurohepatopathy is known to allow longer survival,although heterozygous variants p.R50Q have not been *** is the first clinical report in compound heterozygosity MPV17 mutation(p.R50W/p.R50Q).Three siblings were admitted due to multiple hepatic nodules;none presented neurological ***,they suffered from severe hypoglycemia and cyclic *** diagnosis of MPV17-related MTDPS was confirmed by detection of a compound heterozygous MPV17 mutation(p.R50W/p.R50Q),and striking reduction of hepatic mitochondrial *** patient developed pediatric-onset of hepatocellular ***,all patients survived for extended periods,including two patients who received liver transplantation,which contrasted the high mortality rate associated with p.R50W mutations,as previously *** p.R50Q mutation might be associated with longer survival and improved liver transplantation outcomes.

关键词： Mitochondrial DNA depletion syndrome MPV17 compound heterozygous mutation liver transplantation

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The Efficacy and Safety of Yokukansankachimpihange for Treating Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: An Open-Label Pilot Study

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Advances in Alzheimer's Disease 2018年第4期7卷 141-152页

作者： Ryutaro Arita Tetsuhiro Yoshino Miwako Ohgishi Takuya Hamaguchi Yuko Horiba Kaori Sawai kei Funaki Hajime Tabuchi Mizuki Oka Takahito Yoshizaki Kenji Watanabe Masaru Mimura Center for Kampo Medicine School of Medicine Keio University Tokyo Japan Department of Neuropsychiatry School of Medicine Keio University Tokyo Japan Department of Neurology School of Medicine Keio University Tokyo Japan Faculty of Environmental and Information Study Keio University Fujisawa Japan

Previous clinical trials have demonstrated the efficacy of yokukansan, a traditional Japanese medicine, for the treatment of behavioral and psychological symptoms of dementia (BPSD). However, less evidence is available for the treatment of BPSD with yokukansankachimpihange (YKSCH), which consists of yokukansan and two additional herbal ingredients. The present study was conducted to investigate the efficacy and safety of YKSCH for treating BPSD in patients with Alzheimer’s disease (AD). We enrolled outpatients with mild-to-moderate AD who exhibited BPSD and obtained a Neuropsychiatric Inventory (NPI) score of >3 including subscale scores for “agitation”, “anxiety”, “irritability”, and “sleep and night-time behavior change”. A daily YKSCH dose of 7.5 g was administered for 12 weeks with concomitant administration of anti-dementia medication. BPSD was evaluated using the NPI at baseline and every 4 weeks during the intervention. We also examined apathy using the Japanese translation of the Apathy Scale, the short version of the Japanese version of the Zarit Caregiver Burden Interview, and the Modified Crichton Rating Scale for Predicting Activities of Daily Living. Cognitive dysfunction was evaluated using the Mini Mental State Examination and the AD Assessment Scale-Cognitive (Japanese version). Five participants were enrolled. The NPI total score tended to decrease between the baseline and 8-week evaluations during the YKSCH intervention (Wilcoxon signed rank test, P = 0.063). In terms of the NPI subscale scores, “apathy”, “agitation”, “delusions”, and “sleep and night-time behavior change” decreased after the intervention in those who exhibited each symptom at baseline. There were no significant differences in the other scores examined. No serious adverse events were observed. YKSCH could ameliorate BPSD in patients with mild-to-moderate AD with agitation, anxiety, irritability, and sleep and night-time behavior change, and it was well-tolerated.

关键词： Alzheimer’s Disease Behavioral and Psychological Symptoms of Dementia Yokukansankachimpihange Kampo Medicine Apathy Neuropsychiatric Inventory

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