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Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms

Asian Journal of Andrology 2008年第5期10卷 777-785页

作者： Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Akira yamada Kyogo Itoh Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo kei Matsuoka Departments of Urology Kurume University School of Medicine Kurume 830-0011 Japan Departments of Bio-statistics Kurume University School of Medicine Kurume 830-0011 Japan Departments of Immunology Kurume University School of Medicine Kurume 830-0011 Japan Research Laboratories Chlorella Industry Co Ltd Chikugo 833-0056 Japan Department of Forest and Forest Products Science Faculty of Agriculture Kyushu University Fukuoka 812-8582 Japan

Aim： To evaluate the safety and efficacy of an extract of Ganoderma lucidum that shows the strongest 5α-reductase inhibitory activity among the extracts of 19 edible and medicinal mushrooms by a double-blind, placebo-controlled, randomized and dose-ranging study in men with lower urinary tract symptoms （LUTS）. Methods： In this trial, we randomly assigned 88 men over the age of 49 years who had slight-to-moderate LUTS to 12 weeks of treatment with G. lucidum extract （6 mg once a day） or placebo. The primary outcome measures were changes in the International Prostate Symptom Score （IPSS） and variables of uroflowmetry. Secondary outcome measures included changes in prostate size, residual urinary volume after voiding, laboratory values and the reported adverse effects. Results： G. lucidum was effective and significantly superior to placebo for improving total IPSS with 2.1 points decreasing at the end of treatment （mean difference, -1.18 points; 95% confidence interval, -1.74 to -0.62; P 〈 0.0001）. No changes were observed with respect to quality of life scores, peak urinary flow, mean urinary flow, residual urine, prostate volume, serum prostate-specific antigen or testosterone levels. Overall treatment was well tolerated with no severe adverse effects. Conclusion： The extract of G. lucidum was well tolerated and improved IPSS scores. These results encouraged a further, large-scale evaluation of phytotherapy for a long duration using the extract of G. lucidum on men with LUTS.

关键词： lower urinary tract symptoms phytotherapy outcome randomized trial Ganoderma lucidum

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植物工厂岩棉块种苗移植机移植部件设计与试验

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农业机械学报 2024年第3期55卷 106-114页

作者：童俊华刘珂刘霓红孙良王小琴 NORUPIRI R Obedience 浙江理工大学机械工程学院杭州310018 浙江省种植装备技术重点实验室杭州310018 广东省现代农业装备研究所广州510630 农业农村部东南丘陵山地农业装备重点实验室杭州310018

目前植物工厂岩棉块种苗移植装备自动化程度低,作业时大多依赖于人工,劳动强度大,效率低。基于植物工厂水培叶菜种苗移植现状设计了一种二级变间距的高速移植部件,并配备有一种拨指式定植杯分离辅助机构。对移植手取苗过程中岩棉块种苗... 详细信息

目前植物工厂岩棉块种苗移植装备自动化程度低,作业时大多依赖于人工,劳动强度大,效率低。基于植物工厂水培叶菜种苗移植现状设计了一种二级变间距的高速移植部件,并配备有一种拨指式定植杯分离辅助机构。对移植手取苗过程中岩棉块种苗进行受力分析,为移植手设计提供依据;开展拨指式定植杯分离辅助机构落杯试验,为后续植苗至栽培槽孔的定植杯中奠定基础。搭建移植机构试验平台,以取苗深度、岩棉块含水率、移植部件横移速度、移植手升降速度、移植手夹苗间距为试验因素进行五因素三水平正交试验,通过方差分析各因素对移植成功率的影响。试验结果表明:当取苗深度为24 mm、岩棉块含水率为90%、移植部件横移速度为0.8 m/s、移植手升降速度为0.24 m/s、移植手夹苗间距为14 mm时,机构移植成功率为97.9%,移植速度为3132株/h,能够满足高速、高效、稳定的植物工厂岩棉块叶菜种苗移植机械化作业的技术需求。

关键词：移植机岩棉块种苗移植手植物工厂

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Deep-learning-based quality filtering of mechanically exfoliated 2D crystals

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npj Computational Materials 2019年第1期5卷 57-62页

作者： Yu Saito Kento Shin kei Terayama Shaan Desai Masaru Onga Yuji Nakagawa Yuki M.Itahashi Yoshihiro Iwasa Makoto yamada Koji Tsuda RIKEN Center for Advanced Intelligence Project(AIP) Tokyo 103-0027Japan Department of Computational Biology and Medical Sciences Graduate School of Frontier SciencesThe University of TokyoKashiwa 277-8561Japan Graduate School of Medicine Kyoto UniversityKyoto 606-8501Japan Quantum-Phase Electronics Center(QPEC)and Department of Applied Physics The University of TokyoTokyo 113-8656Japan RIKEN Center for Emergent Matter Science(CEMS) Wako 351-0198Japan Department of Intelligence Science and Technology Kyoto UniversityKyoto 606-8501Japan PRESTO Japan Science and Technology Agency(JST)4-1-8HonchoKawaguchi-shiSaitama 332-0012Japan National Institute for Materials Science(NIMS) Center for Materials Research by Information IntegrationTsukuba 305-0047Japan California NanoSystems Institute University of California at Santa BarbaraSanta BarbaraCA 93106USA

Two-dimensional(2D)crystals are attracting growing interest in various research fields such as engineering,physics,chemistry,pharmacy,and biology owing to their low dimensionality and dramatic change of properties compared to the bulk counter *** the various techniques used to manufacture 2D crystals,mechanical exfoliation has been essential to practical applications and fundamental ***,mechanically exfoliated crystals on substrates contain relatively thick flakes that must be found and removed manually,limiting high-throughput manufacturing of atomic 2D crystals and van der Waals ***,we present a deep-learning-based method to segment and identify the thickness of atomic layer flakes from optical microscopy *** carefully designing a neural network based on U-Net,we found that our neural network based on Unet trained only with the data based on realistically small number of images successfully distinguish monolayer and bilayer MoS2 and graphene with a success rate of 70–80%,which is a practical value in the first screening process for choosing monolayer and bilayer flakes of all flakes on substrates without human *** remarkable results highlight the possibility that a large fraction of manual laboratory work can be replaced by AI-based systems,boosting productivity.

关键词： crystals filtering attracting

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Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

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The thermal conductivity of the Earth's core and implications for its thermal and compositional evolution

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National Science Review 2021年第4期8卷 18-20页

作者： Kenji Ohta kei Hirose Department of Earth and Planetary Sciences Tokyo Institute of Technology Earth-Life Science Institute Tokyo Institute of Technology Department of Earth and Planetary Science The University of Tokyo

The thermal conductivity of iron alloys is a key to understanding the mechanism of convection in the Earth’s liquid core and its thermal history. The Earth’s magnetic field is formed by a dynamo action that requires... 详细信息

关键词： ELECTRICAL-RESISTIVITY HIGH-PRESSURE IRON ALLOYS SI NI

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Improved rate-distortion optimized video coding using non-integer bit estimation and multiple Lambda search

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Frontiers of Computer Science 2016年第1期10卷 157-166页

作者： Sio kei IM Mohammad Mahdi GHANDI MPI-QMUL Information Systems Research Centre Macao Polytechnic Institute Macao China Department of Electronic Systems Engineering University of Essex Colchestey CO4 3SQ UK

Many modern video encoders use the Lagrangian rate-distortion optimization （RDO） algorithm for mode deci- sions during the compression procedure. For each encoding stage, this approach involves minimizing a cost, which is a function of rate, distortion and a multiplier called Lambda. This paper proposes to improve the RDO process by applying two modifications. The first modification is to increase the ac- curacy of rate estimation, which is achieved by computing a non-integer number of bits for arithmetic coding of the syntax elements. This leads to a more accurate cost computation and therefore a better mode decision. The second modification is to search and adjust the value of Lambda based on the char- acteristics of each coding stage. For the encoder used, this paper proposes to search multiple values of Lambda for the intra-4x4 mode decision. Moreover, a simple shift in Lambda value is proposed for motion estimation. Each of these modi- fications offers a certain gain in RDO performance, and, when all are combined, an average bit-rate saving of up to 7.0% can be achieved for the H.264/AVC codec while the same concept is applicable to the H.265/HEVC codec as well. The extra added complexity is contained to a certain level, and is also adjustable according to the processing resources available.

关键词： rate distortion optimization Lambda adjust-ment non-integer bit estimation H.264/AVC H265/HEVCvideo coding

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Loss of Masticatory Function Affects Morphology of the Tooth Root in Rats

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Open Journal of Stomatology 2021年第1期11卷 37-54页

作者： Takamichi yamada kei Ogawa Takehiko Shimizu Department of Pediatric Dentistry Nihon University Graduate School of Dentistry at Matsudo Chiba Japan Department of Pediatric Dentistry Nihon University School of Dentistry at Matsudo Chiba Japan Nihon University Research Institute of Oral Science Chiba Japan

Masticatory hypofunction and soft food affect the tooth rows, occlusion, and jawbone. This study aimed to clarify the influence of tooth loss and a soft diet on morphology of the tooth root during the growth period. We divided 3-week-old Wistar rats into the following three groups: Hard diet group (rats raised on solid standard diet), Powder diet group (rats raised on powdered standard feed diet), and Extraction group (rats raised on powdered standard diet with maxillary molars extraction). Length, width, cross-sectional area, and volume of the root of the mandibular M1 and M2 were measured using micro-CT analysis. Non-decalcified thin-slice specimens of sagittal sections of the M1 were obtained at the age of 20 weeks, and the roots were observed. The root length of all roots in the Extraction group was significantly longer than that in the other groups. The root width and cross-sectional area at the apical side 1/4 of all roots in the Extraction group were significantly smaller than those in the other groups. The root volume of the M1 mesial root in the Extraction group was significantly smaller than that in the other groups. This study clarified that when masticatory stimulus in the immature teeth is reduced by the extraction of opposing teeth and a powder diet, the root length increases due to the promotion of cellular cementum addition at the apex, and the root width and cross-sectional area decrease due to the suppression of cellular cementum addition at the apical side 1/4 of the roots.

关键词： Rats Tooth Root Morphology Powder Diet Extraction of Molars Micro-CT

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Mass balance of saline lakes considering inflow loads of rivers and groundwater: the case of Lake Issyk-Kul, Central Asia

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Journal of Arid Land 2021年第12期13卷 1260-1273页

作者： kei SAITOH Rysbek SATYLKANOV Kenji OKUBO Beppu Geothermal Research Laboratory Institute for Geothermal SciencesGraduate School of ScienceKyoto UniversityOita 8740903Japan Tien Shan High Mountain Research Center Institute of Water Problem and Hydropower of National Academy of Sciences of Kyrgyz RepublicBishkek 720033Kyrgyzstan Graduate School of Environmental and Life Science Okayama UniversityOkayama 7008530Japan

This study aimed to elucidate the influence of inflow water on the salinity concentration process of a saline lake and the mass balance of Lake Issyk-Kul,a tectonic saltwater lake in *** on the survey results and meteorological data from 2012 to 2015,we analyzed the dissolved chemical composition loads due to water ***,we discussed the relationship between the increase in salinity and water inflow into the *** the water quality analysis data,we used the tank model to estimate the river inflow and analyze the loads by the L-Q *** groundwater loads were then estimated from the average annual increase in salinity of the lake over a period of 30 *** results suggest that Lake Issyk-Kul was temporarily freshened between about AD 1500 and 1800 when an outflowing river existed,and thereafter,it became a closed lake in AD 1800 and continued to remain a saline lake until *** chemical components that cause salinization are supplied from the rivers and groundwater in the catchment area,and when they flow into the lake,Ca^(2+),HCO_(3)−and Mg^(2+)precipitate as CaCO_(3) and MgCO_(3).These compounds were confirmed to have been left on the lakeshore as *** model analysis showed that 1.67 mg/L of Ca^(2+)and Mg^(2+)supplied from rivers and groundwater are precipitated as evaporite and in other forms per *** the other hand,salinity continues to remain in the lake water at a rate of 27.5 mg/L per *** are the main causes of increased salinity in Lake *** Na^(+)and Cl^(-)are considered to be derived from geothermal water,they will continue to flow in regardless of the effects of human ***,as long as these components are accumulated in Lake Issyk-Kul as a closed lake,the salinity will continue to increase in the future.

关键词： groundwater geothermal water mass balance salinity saline lake L-Q curve

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Spatiotemporal changes in antlerless proportion of culled Sika deer in relation to deer density

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Journal of Forestry Research 2022年第3期33卷 1095-1101页

作者： kei K.Suzuki Teruki Oka Masatoshi Yasuda Kyushu Research Center Forestry and Forest Products Research InstituteKumamoto860-0862Japan Shikoku Research Center Forestry and Forest Products Research InstituteKochi780-8077Japan

Population management of herbivores is widely applied to decrease damage to forests in the northern hemisphere. Culling more antlerless deer, including females and fawns, is an effective means of reducing the population and helps to improve management efficiency. To increase the efficiency of antlerless-biased culling, we assessed the spatiotemporal distribution of the antlerless ratio in culled sika deer (Cervus nippon) in relation to population density. We hypothesized that the antlerless ratio is higher at the center of the distribution than at the margins of the deer’s range, because dispersal processes differ according to sex and age: Young male deer first disperse into an unoccupied area, and then males may become established in the new area for approximately 10–15 years before the number of females increases. A statistical model revealed spatiotemporal changes in the antlerless ratio of culled sika deer. The change in the ratio basically fit the density distribution of the deer, which was estimated independently on the basis of fecal pellet count surveys. The antlerless ratio estimated from the model increased asymptotically as deer density rose. The results support our hypothesis and suggest that antlerless sika deer will be more easily culled at the center rather than at the margins of the distribution range. These findings should help to increase the efficiency of managing the deer via antlerless-biased culling.

关键词： Antlerless Culling Density Distribution Large herbivore Wildlife management

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Single-site surface-enhanced Raman scattering beyond spectroscopy

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Frontiers of physics 2016年第2期11卷 19-30页

作者： Mai Takas Satoshi Yasuda kei Murakoshi Department of Chemistry Faculty of Science Hokkaido University Sapporo Hokkaido 060-0810 Japan Graduate School of Engineering Muroran Institute of Technology Muroran 050-8585 Japan

Recent progress in the observation of surface-enhanced Raman scattering （SERS） is reviewed to examine the possibility of finding a novel route for the effective photoexcitation of materials. The importance of well-controlled SERS experiments on a single molecule at a single site is discussed based on the difference in the information obtained from ensemble SERS measurements using mul- tiple active sites with an uncontrolled number of molecules. A single-molecule SERS observation performed at a mechanically controllable breaking junction with a simultaneous conductivity mea- surement provides clear evidence of the drastic changes both in the intensity and in the Raman mode selectivity of the electromagnetic field generated by localized surface plasmon resonance. Careful con- trol of the field at a few-nanometer-wide gap of a metal nanodimer results in the modification of the selection rule of electronic excitation of an isolated single-walled carbon nanotube. The examples shown in this review suggest that a single-site SERS observation could be used as a novel tool to find, develop, and implement applications of plasmon-induced photoexcitation of materials.

关键词： surface-enhanced Raman scattering localized surface plasmon resonance metalnanostructure single-molecule observation single-walled carbon nanotube selection rule ofelectronic excitation

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