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Embodying Deeply Held Values in Education:Seeking a More Equitable World for Both Humans and Non-Humans

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ECNU Review of Education 2024年第2期7卷 241-251页

作者：林静 Shue-kei Joanna Mok Virginia Gomes Department of Counseling Higher Education and Special EducationCollege of Education3214 Benjamin BuildingUniversity of MarylandCollege ParkMD20742USA

Highlights In this article,we contend that the bedrock of an equitable world lies in the profound recognition of love as the fundamental force permeating the *** believe that love is built into the essence of who we *** posit that genuine progress toward an equitable world is elusive unless we place love,both for one another and for the natural world,at the core of our educational endeavors.

关键词： Embodied practices heart and spirit love and equity love as a cosmic force

Voices From the Industry:How EdTech Leaders Responded to the COVID-19 Pandemic

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ECNU Review of Education 2024年第2期7卷 420-441页

作者： Deoksoon Kim Katrina Borowiec Drina kei Yatsu Stanton Wortham Boston College Lynch School of Education and Human DevelopmentI40 Commonwealth AvenueChestnut HillMA02467-3800USA

Purpose Educational technology(“EdTech”)served a pivotal role in keeping schools functioning during the beginning of the COVID-19 *** is known about EdTech leaders’roles in shaping this *** study explores EdTech leaders’perspectives and backgrounds,their response to the pandemic,how they envision their roles as educators,and their perspectives about how technology facilitates educational ***/Approach/Methods This study uses a qualitative,phenomenological approach to understand how 11 EdTech leaders experienced the *** were recruited for interviews in summer 2021 via purposive sampling to include diverse backgrounds and *** were analyzed *** The findings show that a four-category typology can be used to describe EdTech leaders’diverse backgrounds and *** emphasized equity and open collaboration in their pandemic responses,by expanding access to their tools and adapting their products as users’needs *** leaders anticipate streamlined user experiences,improvements in online learning,and increased adoption of artificial intelligence and simulated learning ***/Value This study addresses a gap in the research concerning EdTech leaders’perspectives on their efforts to support educators and their experiences during the *** hope this study sparks additional research on EdTech leaders’experiences and roles in education.

关键词： Collaboration COVID-19 pandemic educational technology innovation leadership technology access

First cases of MPV17 related mitochondrial DNA depletion syndrome with compound heterozygous mutations in p.R50Q/p.R50W:a case report

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Hepatoma Research 2020年第1期6卷 1-10页

作者： Shuichiro Umetsu Ayano Inui Sohya Kobayashi Masaru Shimura Tomoko Uehara Hajime Uchida Rie Irie Tsuyoshi Sogo Haruki Komatsu Takako Yoshioka kei murayama Kenjiro Kosaki MureoKasahara Tomoo Fujisawa Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama City Tobu HospitalKanagawa 230-0012Japan Department of Metabolism Chiba Children’s HospitalChiba 266-0007Japan Center for Medical Genetics Keio University School of MedicineTokyo 160-8582Japan Department of Transplantation Surgery National Center for Child Health and DevelopmentTokyo 157-8535Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Department of Pediatrics Toho University Sakura Medical CenterChiba 285-8741Japan Department of Pathology National Center for Child Health and DevelopmentTokyo 157-8535Japan

Mutations in MPV17 lead to severe mitochondrial DNA depletion syndrome(MTDPS).All known p.R50W variants in MPV17 are *** homozygous variant p.R50Q in MPV17 among patients with Navajo neurohepatopathy is known to allow longer survival,although heterozygous variants p.R50Q have not been *** is the first clinical report in compound heterozygosity MPV17 mutation(p.R50W/p.R50Q).Three siblings were admitted due to multiple hepatic nodules;none presented neurological ***,they suffered from severe hypoglycemia and cyclic *** diagnosis of MPV17-related MTDPS was confirmed by detection of a compound heterozygous MPV17 mutation(p.R50W/p.R50Q),and striking reduction of hepatic mitochondrial *** patient developed pediatric-onset of hepatocellular ***,all patients survived for extended periods,including two patients who received liver transplantation,which contrasted the high mortality rate associated with p.R50W mutations,as previously *** p.R50Q mutation might be associated with longer survival and improved liver transplantation outcomes.

关键词： Mitochondrial DNA depletion syndrome MPV17 compound heterozygous mutation liver transplantation

Enhancing visible-light-driven NO oxidation through molecular‐level insights of dye-loaded sea sands

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Rare Metals 2024年第2期43卷 543-554页

作者： Yu-Han Li Bang-Fu Chen Sónia A.C.Carabineiro You-Yu Duan Ping Tan Wing-kei Ho Fan Dong Engineering Research Center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Key Laboratory of Catalysis and New Environmental MaterialsChongqing Technology and Business UniversityChongqing400067China Nanchang Institute of Technology Nanchang33044China LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de Lisboa2829-516CaparicaPortugal College of Physics and Center of Quantum Materials and Devices Chongqing UniversityChongqing401331China Department of Science and Environmental Studies The Education University of Hong KongHong Kong999077China

Natural minerals,abundant and easily obtained through simple physical processing,offer a cost-effective and environmentally friendly solution for dyeing wastewater disposal and air pollution *** study investigates the photocatalytic removal of NO using natural different types of dyes,loaded on natural sand,under visible light *** examining various coating concentrations of dyes and sand weights,we discovered that sand loaded with Rhodamine B(RhB)exhibits high activity for the photo-oxidation of NO.A combination results of X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared spectroscopy(FTIR)and thermogravimetric(TG)analyses confirm the presence of SiO_(2),CaCO_(3),Al_(2)O_(3)and iron oxides as the main components of the ***,studying RhB-loaded individual components reveals that CaCO_(3)plays a crucial role in enhancing the NO removal *** results and theoretical calculations demonstrate the establishment of a directional charge transfer channel from CaCO_(3)to RhB,facilitating the adsorption and activation of molecular NO and O_(2).This work not only promotes the utilization of natural mineral resources but also enriches the fields of environmental photochemistry and semiconductor photocatalysis.

关键词： Sand dyes Rhodamine B Photo-oxidation of NO Visible light illumination

Comparison of isotope-based linear and Bayesian mixing models in determining moisture recycling ratio

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Journal of Arid Land 2024年第6期16卷 739-751页

作者： XIAO Yanqiong WANG Liwei WANG Shengjie kei YOSHIMURA SHI Yudong LI Xiaofei Athanassios A ARGIRIOU ZHANG Mingjun Key Laboratory of Resource Environment and Sustainable Development of Oasis of Gansu Province College of Geography and Environmental ScienceNorthwest Normal UniversityLanzhou 730070China Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou 730000China Atmosphere and Ocean Research Institute University of TokyoKashiwa 277-8568Japan School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi'an 710021China Laboratory of Atmospheric Physics Department of PhysicsUniversity of PatrasPatras GR-26500Greece

Stable water isotopes are natural tracers quantifying the contribution of moisture recycling to local precipitation,i.e.,the moisture recycling ratio,but various isotope-based models usually lead to different results,which affects the accuracy of local moisture *** this study,a total of 18 stations from four typical areas in China were selected to compare the performance of isotope-based linear and Bayesian mixing models and to determine local moisture recycling *** the three vapor sources including advection,transpiration,and surface evaporation,the advection vapor usually played a dominant role,and the contribution of surface evaporation was less than that of *** the abnormal values were ignored,the arithmetic averages of differences between isotope-based linear and the Bayesian mixing models were 0.9%for transpiration,0.2%for surface evaporation,and–1.1%for advection,respectively,and the medians were 0.5%,0.2%,and–0.8%,*** importance of transpiration was slightly less for most cases when the Bayesian mixing model was applied,and the contribution of advection was relatively *** Bayesian mixing model was found to perform better in determining an efficient solution since linear model sometimes resulted in negative contribution *** test with two isotope scenarios indicated that the Bayesian model had a relatively low sensitivity to the changes in isotope input,and it was important to accurately estimate the isotopes in precipitation ***,the Bayesian mixing model should be recommended instead of a linear *** findings are useful for understanding the performance of isotope-based linear and Bayesian mixing models under various climate backgrounds.

关键词： moisture recycling stable water isotope linear mixing model Bayesian mixing model China

Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival

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World Journal of Gastroenterology 2024年第7期30卷 714-726页

作者： Pui-Yin Leung Wenjing Chen Anissa N Sari Poojitha Sitaram Pui-kei Wu Susan Tsai Jong-In Park Department of Biochemistry Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Pancreatic cancer is a leading cause of cancer-related *** activity of the epidermal growth factor receptor(EGFR)is often observed in pancreatic cancer,and the small molecule EGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug ***,erlotinib alone is ineffective and should be combined with other drugs to improve therapeutic *** previously showed that certain receptor tyrosine kinase inhibitors can increase mitochondrial membrane potential(Δψm),facilitate tumor cell uptake ofΔψm-sensitive agents,disrupt mitochondrial homeostasis,and subsequently trigger tumor cell *** has not been tested for this *** To determine whether erlotinib can elevateΔψm and increase tumor cell uptake ofΔψm-sensitive agents,subsequently triggering tumor cell ***Δψm-sensitive fluorescent dye was used to determine how erlotinib affectsΔψm in pancreatic adenocarcinoma(PDAC)cell *** viability of conventional and patient-derived primary PDAC cell lines in 2D-and 3D cultures was measured after treating cells sequentially with erlotinib and mitochondria-targeted ubiquinone(MitoQ),aΔψm-sensitive *** synergy between erlotinib and MitoQ was then analyzed using SynergyFinder *** preclinical efficacy of the twodrug combination was determined using immune-compromised nude mice bearing PDAC cell line *** Erlotinib elevatedΔψm in PDAC cells,facilitating tumor cell uptake and mitochondrial enrichment ofΔψm-sensitive *** triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses,while erlotinib pretreatment potentiated low doses of *** suggested that these drugs synergistically induced tumor cell *** with in vitro data,erlotinib and MitoQ combination suppressed human PDAC cell line xenografts in mice more effectively than single treatments of each *** Our findings suggest tha

关键词： Pancreatic cancer Erlotinib Mitochondria-targeted ubiquinone Mitochondria Combination therapy

Investigating ischemia and reperfusion-induced organ damage in severe cardiac arrest:A comprehensive proteomics perspective

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Journal of Pharmaceutical Analysis 2024年第3期14卷 427-430页

作者： Ju Yeon Lee Muhammad Shoaib Jin-Woong Choi Rishabh C.Choudhary Tai Yin Nara Yoon kei Hayashida Seunguk J.Baek Santiago J.Miyara Lance B.Becker Junhwan Kim Research Center of Bioconvergence Analysis Korea Basic Science InstituteCheongjuSouth Korea Bio-Analytical Science University of Science and TechnologyCheongjuSouth Korea Laboratory for Critical Care Physiology Feinstein Institutes for Medical ResearchManhassetNY11030USA Donald and Barbara Zucker School of Medicine at Hofstra/Northwell School of Medicine HempsteadNY11549USA Mathematics and Computer Science Adelphi UniversityGarden CityNY11530USA Department of Emergency Medicine North Shore University HospitalManhassetNY11030USA

Cardiac arrest(CA)is a life-threatening condition with complex pathophysiology and limited treatment *** gain deeper insights into the pathological state of vital organs,we employed a proteomics analysis in rodents to assess proteome alterations in the brain,heart,kidney,and liver using a rat model of *** brain displayed severe protein alterations in essential cellular pathways,including three major energy-generating pathways after CA,which worsened after resuscitation,resulting in the most significant overall protein changes among the ***,the liver,experiencing the most substantial protein alterations post-CA,demonstrated significant recovery,presenting the least protein changes post-resuscitation.

关键词： alterations organs damage

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探讨多模态大模型在高校智慧财务中的作用

市场周刊 2024年第17期37卷 96-99页

作者：张可莉合肥工业大学财务处安徽合肥230009

高校财务正处于向智慧财务转型的过程中,GPT-4等多模态大模型具备文字、图像的识别、理解和生成能力,将在高校智慧财务建设中发挥重要作用。文章通过文献调研法总结了大模型的基础能力,分析了大模型对高校财务的作用,提出了基于多模态... 详细信息

高校财务正处于向智慧财务转型的过程中,GPT-4等多模态大模型具备文字、图像的识别、理解和生成能力,将在高校智慧财务建设中发挥重要作用。文章通过文献调研法总结了大模型的基础能力,分析了大模型对高校财务的作用,提出了基于多模态大模型的高校财务风险评估与流程监督方法。从训练、部署和应用三个阶段分析了模型带来的潜在风险及应对措施,期望为多模态大模型在高校财务管理领域的应用提供借鉴。

关键词：多模态大模型高校智慧财务风险评估流程监督

低温下C4F7N/CO_(2)混合气体的绝缘特性与参数配置

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高电压技术 2024年第2期50卷 832-841页

作者：陶子林郑宇高克利朱太云刘伟周文俊武汉大学电气与自动化学院武汉430072 国网安徽省电力有限公司电力科学研究院合肥230000 中国电力科学研究院有限公司北京100192

为提出低温下满足液化温度和绝缘要求的C4F7N/CO_(2)混合气体的参数配置,研究了C4F7N/CO_(2)混合气体在低温下的绝缘特性。首先采用实验和计算得到了不同气压和混合体积比例下C4F7N/CO_(2)混合气体的液化温度,结果表明计算得到的液化温... 详细信息

为提出低温下满足液化温度和绝缘要求的C4F7N/CO_(2)混合气体的参数配置,研究了C4F7N/CO_(2)混合气体在低温下的绝缘特性。首先采用实验和计算得到了不同气压和混合体积比例下C4F7N/CO_(2)混合气体的液化温度,结果表明计算得到的液化温度与实验数据较为相符。其次开展不同温度下C4F7N/CO_(2)混合气体的工频击穿试验,获得了C4F7N/CO_(2)混合气体的击穿电压随温度的变化。结果表明:气体在液化阶段的击穿电压标准差为液化后的2~7倍,且液化后混合气体的绝缘性能出现显著下降。此时击穿电压只与温度有关,基本不受混合体积比例的影响。考虑混合气体设备的应用需求,分别以–25℃和–30℃为最低使用温度,提出了满足要求的C4F7N/CO_(2)混合气体参数配置方案,可为低温下C4F7N/CO_(2)混合气体的应用提供参考。

关键词： C4F7N/CO_(2)混合气体绝缘特性约化电场液化温度参数配置