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Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C

World Journal of Gastroenterology 2016年第27期22卷 6224-6234页

作者： Takafumi Saito Masahiro Sugimoto Kazuo Okumoto Hiroaki Haga Tomohiro Katsumi kei mizuno Taketo Nishina Sonoko Sato Kaori Igarashi Hiroko Maki Masaru Tomita Yoshiyuki Ueno Tomoyoshi Soga Department of Gastroenterology Yamagata University School of Medicine Institute for Advanced Biosciences Keio University

AIM: To clarify the characteristics of metabolite profiles in virus-related hepatocellular carcinoma (HCC) patients using serum metabolome ***: The serum levels of low-molecular-weight metabolites in 68 patients with HCC were quantified using capillary electrophoresis chromatography and mass spectrometry. Thirty and 38 of the patients suffered from hepatitis B virus-related HCC (HCC-B) and hepatitis C virus-related HCC (HCC-C), ***: The main metabolites characteristic of HCC were those associated with glutathione metabolism, notably 13 γ-glutamyl peptides, which are by-products of glutathione induction. Two major profiles, i.e., concentration patterns, of metabolites were identified in HCC patients, and these were classified into two groups: an HCC-B group and an HCC-C group including some of the HCC-B cases. The receiver operating characteristic curve for the multiple logistic regression model discriminating HCC-B from HCC-C incorporating the concentrations of glutamic acid, methionine and γ-glutamyl-glycine-glycine showed a highly significant area under the curve value of 0.94 (95%CI: 0.89-1.0, P < 0.0001).CONCLUSION: The serum levels of γ-glutamyl peptides, as well as their concentration patterns, contribute to the development of potential biomarkers for virus-related HCC. The difference in metabolite profiles between HCC-B and HCC-C may reflect the respective metabolic reactions that underlie the different pathogeneses of these two types of HCC.

关键词： Metabolome Hepatocellular carcinoma γ -glutamyl peptides Glutathione Oxidative stress

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Changes in reaction time, coefficient of variance of reaction time, and autonomic nerve function in the mental fatigue state caused by long-term computerized Kraepelin test workload in healthy volunteers

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World Journal of Neuroscience 2012年第2期2卷 113-118页

作者： Daisuke Kuratsune Seiki Tajima Junichi Koizumi Kouzi Yamaguti Tetsuya Sasabe kei mizuno Masaaki Tanaka Naoko Okawa Hideki Mito Hirokazu Tsubone Yasuyoshi Watanabe Masayasu Inoue Hirohiko Kuratsune Clinical Center for Fatigue Science Graduate School of Medicine Osaka City University Osaka Japan Department of Biochemistry and Molecular Pathology Graduate School of Medicine Osaka City University Osaka Japan Department of Comparative Pathophysiology Veterinary Medical Sciences Graduate School of Agricultural & Life Science The University of Tokyo Tokyo Japan Department of Physiology Graduate School of Medicine Osaka City University Osaka Japan Division of Materials Science and Chemical Engineering Yokohama National University Yokohama Japan Faculty of Health Science for Welfare Kansai University of Welfare Sciences Kasiwara Japan Hyogo Children’s sleep and development medical research center Kobe Japan RIKEN Center for Molecular Imaging Science MI R&D Center Kobe Japan

Fatigue is a common sense caused by crushing labor, stressful social events and various illnesses. It is usually judged by their subjective symptoms, but it should be evaluated in an objective perspective. Here we show that the decrease of working efficiency and sympathetic hyperactivity are associated with mental fatigue state caused by prolonged mental workload. Recently we made a new mental fatigue model of healthy volunteers caused by long-term computerized Kraepelin test (CKT) workload. CKT is our new software for automatically checking the calculation capability, with which it is easy to determine the reaction time (RT), coefficient of variance of reaction time (CV), and accuracy of the answers (AC) during tasks. We put 24 healthy volunteers into the fatigue state by subjecting them to 120 minutes’ CKT workload, and then studied the changes in fatigue sensation, RT, CV, and AC before and after the CKT workload. The fatigue sensation, RT, and CV were clearly increased by the fatigue-inducing task and recovered during the resting period. We also studied the changes in autonomic nerve activity by using heart rate variability analysis. The low/high frequency component ratio (LF/HF) was signifi-cantly increased by the fatigue-inducing task and decreased by resting, suggesting that mental stress causes a relatively sympathetic nerve activity-dominant state. Therefore, our new fatigue model involving a long-term CKT workload is a good mental fatigue model to provide much information about the fatigue state simultane-ously, and the increase of RT, CV, and proportion of sympathetic activity (LF/HF) are associated with mental fatigue state. These might be useful objective biomarkers or evaluating a mental fatigue state.

关键词： Fatigue Computerized Kraepelin Test Reaction Time Accuracy of the Answers Autonomic Nerve Activity

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Heterogeneous Round-Trip Trading and the Emergence of Volatility Clustering in Speculation Game

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Journal of Systems Science & Complexity 2022年第1期35卷 221-244页

作者： KATAHIRA kei CHEN Yu Faculty of Engineering Information and SystemsUniversity of TsukubaTennodai 1-1-1TsukubaIbaraki 305-8573Japan Research Fellow of Japan Society for the Promotion of Science Japan. Graduate School of Frontier Sciences The University of Tokyo5-1-5 KashiwanohaKashiwa-shiChiba-ken 277-8563Japan.

This study is a detailed analysis of Speculation Game,a simple agent-based model of financial markets,in which the round-trip trading and the dynamic wealth evolution with variable trading volumes are *** of herding behavior,the authors find that the heterogeneous holding periods in round-trip trades can contribute to the emergence of volatility *** particular,the spontaneous redistribution of market wealth through repetitions of round-trip trades with non-uniform horizons can widen the wealth disparity and establish the Pareto distribution of the capital *** a result,the intermittent placements of relatively big orders from endogenously emerged rich traders can bring on large fluctuations in price *** data are used to support the scenario derived from the model.

关键词： Financial stylized facts heterogeneity Pareto’s law round-trip trading wealth distribution

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An overview of the contribution of acupuncture to thyroid disorders

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Journal of Integrative Medicine 2018年第6期16卷 375-383页

作者： Fung-kei Cheng Hong Kong China

Thyroid dysfunction, affecting people of all ages, not only damages human growth and energy metabo- lism but is also comorbid with other illnesses such as cardiovascular disease, kidney disease and gastroin- testinal disorders. With the increasing acceptance of alternative and complementary therapies, acupuncture, a traditional Chinese medical practice, has also been employed to address this problem. Analysing 29 clinical projects that were retrieved from 29 major digital databases and include 1757 patients aged 7-79 years from China, Italy, Korea, Macedonia and Russia, this narrative review offers an overview of the efficacy, and evaluated the safe and cost-effective use of acupuncture against hyper- thyroidism, hypothyroidism and thyroid-relevant illnesses. Findings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination ther- apy. In addition to showing the role of acupuncture as an alternative and complementary medicine or as an adjunctive therapy for curative and rehabilitative purposes, more well-designed researches are needed to achieve reliable data.

关键词： Acupuncture Alternative and complementary medicine Endocrine system Integrative medicine Traditional Chinese medicine Thyroidism

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Ultrasonic vibrating system design and tool analysis

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中国有色金属学会会刊：英文版 2009年第B9期19卷 225-231页

作者： kei-Lin KUO Department of Vehicle Engineering National Taip ei University of Technology

The applications of ultrasonic vibrations for material removal processes exist predominantly in the area of vertical processing of hard and brittle materials. This is because the power generated by vertical vibrating oscillators generates the greatest direct penetration, in order to conduct material removal on workpieces by grains. However, for milling processes, vertical vibrating power has to be transformed into lateral (horizontal) vibration to produce the required horizontal cutting force. The objective of this study is to make use of ultrasonic lateral transformation theory to optimize processing efficiency, through the use of the finite element method for design and analysis of the milling tool. In addition, changes can be made to the existing vibrating system to generate best performance under consistent conditions, namely, using the same piezoelectric ceramics.

关键词：超声振动系统分析工具设计有限元分析方法超声波振动材料去除垂直振动硬脆材料

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CT-maximum intensity projection is a clinically useful modality for the detection of gastric varices

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World Journal of Gastroenterology 2005年第47期11卷 7515-7519页

作者： Toru Ishikawa Takashi Ushiki Ken-ichi mizuno Tadayuki Togashi Kouji Watanabe kei-ichi Seki Hironobu Ohta Toshiaki Yoshida keiko Takeda Tomoteru Kamimura Department of Gastroenterology Saiseikai Niigata Second HospitalNiigataJapan Department of Radiology Saiseikai Niigata Second HospitalNiigataJapan

AIM： To evaluate the efficacy of CT-maximum intensity projection （CT-MIP） in the detection of gastric varices and their infiowing and outflowing vessels in patients with gastric varices scheduled to undergo balloonoccluded retrograde transvenous obliteration （B-RTO）. METHODS： Sixteen patients with endoscopically confirmed gastric varices were included in this study. All patients were evaluated with CT-MIP using threedimensional reconstructions, before and after B-RTO. RESULTS： CT-MIP clearly depicted gastric varices in 16 patients （100%）, the left gastric vein in 6 （32.5%）, the posterior gastric vein in 12 （75.0%）, the short gastric veins in 13 （81.3%）, gastrorenal shunts in 16 （100%）, the hemiazygos vein （HAZV） in 4 （25.0%）, the pericardiophrenic vein （PCPV） in 9 （56.3%）, and the left inferior phrenic vein in 9 patients （56.3%）. Although flow direction itself cannot be determined from CT-MIP, this modality provided clear images of the inflowing and the outflowing vessels. Moreover, in one patient, short gastric veins were not seen on conventional angiographic portography images of the spleen, but were clearly revealed on CT-MIP. CONCLUSION： We suggest that CT-MIP should be considered as a routine method for detecting and diagnosing collateral veins in patients with gastric varices scheduled for B-RTO. Furthermore, CT-MIP is more useful than endoscopy in verifying the early therapeutic effects of B-RTO.

关键词： Gastric varices CT-MIP, Portal hypertension

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The thermal conductivity of the Earth's core and implications for its thermal and compositional evolution

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National Science Review 2021年第4期8卷 18-20页

作者： Kenji Ohta kei Hirose Department of Earth and Planetary Sciences Tokyo Institute of Technology Earth-Life Science Institute Tokyo Institute of Technology Department of Earth and Planetary Science The University of Tokyo

The thermal conductivity of iron alloys is a key to understanding the mechanism of convection in the Earth’s liquid core and its thermal history. The Earth’s magnetic field is formed by a dynamo action that requires...

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Improved rate-distortion optimized video coding using non-integer bit estimation and multiple Lambda search

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Frontiers of Computer Science 2016年第1期10卷 157-166页

作者： Sio kei IM Mohammad Mahdi GHANDI MPI-QMUL Information Systems Research Centre Macao Polytechnic Institute Macao China Department of Electronic Systems Engineering University of Essex Colchestey CO4 3SQ UK

Many modern video encoders use the Lagrangian rate-distortion optimization （RDO） algorithm for mode deci- sions during the compression procedure. For each encoding stage, this approach involves minimizing a cost, which is a function of rate, distortion and a multiplier called Lambda. This paper proposes to improve the RDO process by applying two modifications. The first modification is to increase the ac- curacy of rate estimation, which is achieved by computing a non-integer number of bits for arithmetic coding of the syntax elements. This leads to a more accurate cost computation and therefore a better mode decision. The second modification is to search and adjust the value of Lambda based on the char- acteristics of each coding stage. For the encoder used, this paper proposes to search multiple values of Lambda for the intra-4x4 mode decision. Moreover, a simple shift in Lambda value is proposed for motion estimation. Each of these modi- fications offers a certain gain in RDO performance, and, when all are combined, an average bit-rate saving of up to 7.0% can be achieved for the H.264/AVC codec while the same concept is applicable to the H.265/HEVC codec as well. The extra added complexity is contained to a certain level, and is also adjustable according to the processing resources available.

关键词： rate distortion optimization Lambda adjust-ment non-integer bit estimation H.264/AVC H265/HEVCvideo coding

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Rotary ultrasonic-assisted milling of brittle materials

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中国有色金属学会会刊：英文版 2012年第S3期22卷 793-800页

作者： KUO kei-lin TSAO Chung-chen Department of Vehicle Engineering National Taipei University of Technology Department of Automation Engineering Tahua Institute of Technology

In order to improve the machining efficiency of ultrasonic milling,the easiest and most effective approach was started with the improvement of tool *** main objective of this research was to utilize rotary ultrasonic machining (RUM's) effectiveness in removing brittle materials to extend the applications of this independent,innovative manufacturing method (self-driving rotary ultrasonic machining),and to experimentally investigate its milling application on brittle *** designed tool was used in the conjunction with previously established RUM machine tools,and glass was selected as workpiece for *** interrelationship between feed rate and depth of cut was *** measuring the surface roughness of workpiece,the overall efficacy of utilizing RUM for milling was evaluated and *** assisted milling results in the reduction of milling resistance,which leads to a greater process rate.

关键词： rotary ultrasonic ultrasonic assisted milling brittle material

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Mass balance of saline lakes considering inflow loads of rivers and groundwater: the case of Lake Issyk-Kul, Central Asia

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Journal of Arid Land 2021年第12期13卷 1260-1273页

作者： kei SAITOH Rysbek SATYLKANOV Kenji OKUBO Beppu Geothermal Research Laboratory Institute for Geothermal SciencesGraduate School of ScienceKyoto UniversityOita 8740903Japan Tien Shan High Mountain Research Center Institute of Water Problem and Hydropower of National Academy of Sciences of Kyrgyz RepublicBishkek 720033Kyrgyzstan Graduate School of Environmental and Life Science Okayama UniversityOkayama 7008530Japan

This study aimed to elucidate the influence of inflow water on the salinity concentration process of a saline lake and the mass balance of Lake Issyk-Kul,a tectonic saltwater lake in *** on the survey results and meteorological data from 2012 to 2015,we analyzed the dissolved chemical composition loads due to water ***,we discussed the relationship between the increase in salinity and water inflow into the *** the water quality analysis data,we used the tank model to estimate the river inflow and analyze the loads by the L-Q *** groundwater loads were then estimated from the average annual increase in salinity of the lake over a period of 30 *** results suggest that Lake Issyk-Kul was temporarily freshened between about AD 1500 and 1800 when an outflowing river existed,and thereafter,it became a closed lake in AD 1800 and continued to remain a saline lake until *** chemical components that cause salinization are supplied from the rivers and groundwater in the catchment area,and when they flow into the lake,Ca^(2+),HCO_(3)−and Mg^(2+)precipitate as CaCO_(3) and MgCO_(3).These compounds were confirmed to have been left on the lakeshore as *** model analysis showed that 1.67 mg/L of Ca^(2+)and Mg^(2+)supplied from rivers and groundwater are precipitated as evaporite and in other forms per *** the other hand,salinity continues to remain in the lake water at a rate of 27.5 mg/L per *** are the main causes of increased salinity in Lake *** Na^(+)and Cl^(-)are considered to be derived from geothermal water,they will continue to flow in regardless of the effects of human ***,as long as these components are accumulated in Lake Issyk-Kul as a closed lake,the salinity will continue to increase in the future.

关键词： groundwater geothermal water mass balance salinity saline lake L-Q curve

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