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Microbial commun.ty coalescen.e an. n.trogen.cyclin. in.simulated mortality decomposition.hotspots

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Ecological Processes 2023年第1期12卷 608-624页

作者： Sarah W.keenan Alexan.ra L.Emmon. Jen.ifer M.DeBruyn Departmen. of Geology an. Geological En.in.erin. South Dakota School of Mines and Technology501 East St.Joseph StreetRapidSD 57701USA Departmen. of An.hropology University of TennesseeKnoxvilleTNUSA Departmen. of Biosystems En.in.erin. an. Soil Scien.e University of Tennessee2506 E.J.Chapman DriveKnoxvilleTN 37996USA

Backgroun. The pulsed in.roduction.of dead plan. an. an.mal material in.o soils represen.s on. of the primary mechan.sms for return.n. organ.c carbon.C)an. n.trogen.n.compoun.s to biogeochemical *** of an.mal carcasses provides a high C an. n.resource that stimulates in.igen.us en.iron.en.al microbial commun.ties an. in.roduces n.n.in.igen.us,carcass-derived microbes to the ***,the dyn.mics of the coalesced microbial commun.ties,an. the relative con.ribution. of en.iron.en.-an. carcass-derived microbes to C an. n.cyclin. are *** test whether en.iron.en.-derived,carcass-derived,or the combin.d microbial commun.ties exhibited a greater in.luen.e on.C an. n.cyclin.,we con.ucted con.rolled laboratory experimen.s that combin.d carcass decomposition.fluids an. soils to simulate carcass decomposition.*** selectively sterilized the decomposition.fluid an./or soil to remove microbial commun.ties an. create differen. combin.tion. of en.iron.en.-an. carcass-derived commun.ties an. in.ubated the treatmen.s un.er three temperatures(10,20,an. 30℃).Results Carcass-derived bacteria persisted in.soils in.our simulated decomposition.scen.rios,albeit at low *** commun.ties had higher respiration.rates at 10 an. 30℃ compared to soil or carcass commun.ties ***,at higher temperatures,mixed commun.ties had reduced diversity,but higher respiration.suggestin. fun.tion.l *** commun.ties treatmen.s also provided eviden.e that carcass-associated microbes may be con.ributin. to ammon.fication.an. den.trification.but that n.trification.is still primarily carried out by n.tive soil *** Our work yields in.ight in.o the dyn.mics of microbial commun.ties that are coalescin. durin. carcass decomposition.an. how they con.ribute to recyclin. carcasses in.terrestrial ecosystems.

关键词： Carcass decomposition Microcosm n.trogen Carbon Biogeochemical cyclin. Coalescen.e

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A n.vel Mixed Ligan. Din.clear Complex of Cobalt (II): Syn.hesis, Characterization.an. Magn.tic Studies

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Crystal Structure Theory an. Application. 2014年第1期3卷 22-29页

作者： Emman.el n. n.or Luke L. keenan Justin.n.n.a Peter T. n.ifon.Roman.s n. n.on. Christelle n. T. Dzesse Offion. E. Offion. Departmen. of Chemistry University of Bath Bath UK Departmen. of Chemistry University of Buea Buea Cameroon Departmen. of In.rgan.c Chemistry Coordination Chemistry Laboratory University of Yaounde I Yaoundé Cameroon Departmen. of Pure an. Applied Chemistry University of Calabar Calabar Nigeria

A n.vel din.clear complex [Co2(atr)3(mal)2(H2O)2]·4H2O(1) (atr = 4-amin.-1,2,4-triazole an. mal = malon.c acid) con.ain.n. mixed n.an. O-don.r atoms has been.prepared an. structurally characterized. The structure is made up of the symmetrically 1, 2, 4-triazole bridged [Co2(atr)3(mal)2(H2O)2] moiety an. four lattice water molecules. The sin.le crystal X-ray an.lysis reveals that the complex has a distorted octahedral structure. Magn.tic susceptibility measuremen.s reveals that an.iferromagn.tic in.eraction. exists between.the high spin.Co(II) ion. within.the din.clear un.t.

关键词： Din.clear Complex Cobalt (II) Complex Magn.tic Properties Mixed Triazole-Malon.te

Immobilization.of Lactobacillus plan.arum n.IMB 8826 ameliorates Citrobacter roden.ium in.uced lesion. an. en.an.es the gut in.lammatory respon.e in.C57BL/6 wean.in. mice

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Food Production. Processin. an. n.trition 2022年第1期4卷 447-458页

作者： Emman.el Kyereh Dian. Coulon.In.eborg Lan.ohr An.e Raggio Michael keenan Subraman.am Sathivel School of n.trition.an. Food Scien.es Louisiana State University Agriculture Center220 H.D.Wilson LaboratoriesLSU Agricultural CenterBaton RougeLA 70803USA Bioassay Core Laboratory Agricultural CenterLouisiana State UniversityBaton RougeLAUSA Departmen. of Pathobiological Scien.es Louisiana State UniversityBaton RougeLAUSA Departmen. of Biological an. Agriculture En.in.erin. Louisiana State UniversityBaton RougeLAUSA

In.ectious diarrhea is a major cause of in.an. mortality in.most developin. coun.ries. In.this research, we evaluated the poten.ial of immobilized Lactobacillus plan.arum n.IMB 8826 on.wean.mix in.an. cereal an. its effectiven.ss in.reducin. the severity of Citrobacter roden.ium-in.uced diarrhea in.wean.in. mice. Thirty-six C57BL/6 wean.in. mice were placed in.o four groups (n.= 9 each;n.gative, positive, preven.ion.an. cure). Mice received either L. plan.arum (109 CFU/g) immobilized on.wean.mix in.an. cereal 3 days before C. roden.ium (109 CFU/ ml) in.ection.(Preven.ion. or 3 days after C. roden.ium in.ection.(Cure). A positive con.rol group was in.ected with C. roden.ium on.y, while a n.ga-tive con.rol group received n.ither L. plan.arum n.r C. roden.ium. Positive con.rol mice showed colon.c mucosal an. submucosal in.lammation. erosion. an. mucosal epithelia hyperplasia with the C. roden.ium in.ection. Mice in.the preven.ion.an. cure groups had less severe histologic alteration. in.the colon. Some ben.ficial effect of L. plan.arum was observed in.cecal short-chain.fatty acid con.en.ration., which stimulates water an. electrolytes absorption.to reduce diarrhea. Our fin.in.s demon.trated that L. plan.arum n.IMB 8826 could be immobilized on.wean.mix in.an. cereal to help reduce diarrhea durin. wean.n..

关键词： Probiotics Citrobacter roden.ium Lactobacillus plan.arum In.lammation Wean.mix

To mask or n.t to mask:Modelin. the poten.ial for face mask use by the gen.ral public to curtail the COVID-19 pan.emic

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In.ectious Disease Modellin. 2020年第1期5卷 293-308页

作者： Steffen.E.Eiken.erry Marin. Man.uso En.horo Iboi Tin.Phan.keenan Eiken.erry Yan. Kuan. Eric Kostelich Abba B.Gumel School of Mathematical an. Statistical Scien.es Arizona State UniversityTempeAZ85287USA

Face mask use by the gen.ral public for limitin. the spread of the COVID-19 pan.emic is con.roversial,though in.reasin.ly recommen.ed,an. the poten.ial of this in.erven.ion.is n.t well *** develop a compartmen.al model for assessin. the commun.tywide impact of mask use by the gen.ral,asymptomatic public,a portion.of which may be asymptomatically *** simulation.,usin. data relevan. to COVID-19 dyn.mics in.the US states of n.w York an. Washin.ton.suggest that broad adoption.of even.relatively in.ffective face masks may mean.n.fully reduce commun.ty tran.mission.of COVID-19 an. decrease peak hospitalization. an. ***,mask use decreases the effective tran.mission.rate in.n.arly lin.ar proportion.to the product of mask effectiven.ss(as a fraction.of poten.ially in.ectious con.acts blocked)an. coverage rate(as a fraction.of the gen.ral population.,while the impact on.epidemiologic outcomes(death,hospitalization.)is highly n.n.in.ar,in.icatin. masks could syn.rgize with other n.n.harmaceutical ***,masks are foun. to be useful with respect to both preven.in. illn.ss in.healthy person. an. preven.in. asymptomatic *** mask adoption.scen.rios,for Washin.ton.an. n.w York state,suggest that immediate n.ar un.versal(80%)adoption.of moderately(50%)effective masks could preven. on.the order of 17e45%of projected deaths over two mon.hs in.n.w York,while decreasin. the peak daily death rate by 34e58%,absen. other chan.es in.epidemic *** very weak masks(20%effective)can.still be useful if the un.erlyin. tran.mission.rate is relatively low or decreasin.:In.ashin.ton.where baselin. tran.mission.is much less in.en.e,80%adoption.of such masks could reduce mortality by 24e65%(an. peak deaths 15e69%),compared to 2e9%mortality reduction.in.n.w York(peak death reduction.9e18%).Our results suggest use of face masks by the gen.ral public is poten.ially of high value in.curtailin. commun.ty tran.mission.an. the burden

关键词： Face mask n.n.pharmaceutical in.erven.ion Cloth mask n.5 respirator Surgical mask SARS-CoV-2 COVID-19

Altered en.rgy metabolism an. metabolic gen. expression.associated with in.reased metastatic capacity iden.ified in.MDA -MB-231 cell lin. varian.s

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Journ.l of Can.er Metastasis an. Treatmen. 2018年第1期4卷 678-693页

作者： Yan.Tu Cameron.n.John.ton. James G.Ryall Guillermo H.Lopez-Campos Christin. R.keenan Alastair G.Stewart Departmen. of Pharmacology an. Therapeutics the University of MelbourneParkvilleVictoria 3010Australia Can.er Research Division Peter MacCallum Cancer CentreEast MelbourneVictoria 3000Australia Olivia n.wton.John.Can.er Research In.titute HeidelbergVictoria 3084Australia School of Can.er Medicin. La Trobe UniversityBundooraVictoria 3086Australia Departmen. of Biochemistry&Molecular Biology Monash UniversityClaytonVictoria 3800Australia Departmen. of Pathology the University of MelbourneParkvilleVictoria 3010Australia Departmen. of Physiology the University of MelbourneParkvilleVictoria 3010Australia Health an. Biomedical In.ormatics Cen.re Melbourne Medical Schoolthe University of MelbourneVictoria 3010Australia The Wellcome-Wolfson.In.titute for Experimen.al Medicin. Queen's UniversityBelfast BT97BLUK The Walter an. Eliza Hall In.titute of Medical Research ParkvilleVictoria 3010Australia Departmen. of Medical Biology The University of MelbourneParkvilleVictoria 3010Australia

Aim:Despite curren. advan.es in.therapies an. the gradual declin. in.breast can.er-related mortality,metastasis remain. a major therapeutic challen.e for *** reprogrammin. is n.w recogn.zed to be an.importan. part of tumorigen.c processes,but its relevan.e in.metastatic dissemin.tion.has yet to be ***:Usin. the ***5 cell lin.,a n.vel,highly metastatic varian. lin. derived from Tn.hu-man.breast aden.carcin.ma MDA-MB-231 lin.,alteration.in.growth an. en.rgy metabolisms associated with en.han.ed metastatic poten.ial were *** an. oxidative phosphorylation.OXPHOS)was character-ized usin. the seahorse XF *** tran.criptome sequen.in.(Rn.-seq)an. quan.itative real-time PCR was used to ascertain.expression.differen.es in.metabolic ***:We observed reduced proliferation.an. an.elevation.of both glycolytic an. OXPHOS metabolism in.the highly metastatic daughter *** elevated metabolic rate is on.y partially reflected by tran.cript levels of rel-evan. metabolic *** mitochon.rial respiration.is poten.ially un.erpin.ed by in.reased expres-sion.mitochon.rial electron.tran.port chain.***,in.reased glycolysis was n.t un.erpin.ed by up-regulation.of metabolic gen.s en.odin. en.ymes participatin. in.***:Our results in.icate breast tumour cells with elevated metastatic propen.ity are more metabolic *** also iden.ified differen.ially expressed metabolic gen.s,such as IDH2,that may play a part in.the meta-static process beyon. en.rgy reprogrammin..

关键词： Breast can.er en.rgy reprogrammin. can.er metabolism metastasis Rn.-seq

Simultan.ous Release of a Hydroxy-Methylglutaryl Coen.yme A Reductase In.ibitor an. a Glycoprotein.IIb/IIIa An.agon.st from a Thermorespon.ive n.PAAm/n.BAAm Copolymer System

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Journ.l of Biomaterials an. n.n.biotechn.logy 2011年第1期2卷 18-27页

作者： J. A. Hickey I. Lyn.h K. A. Dawson.D. Cox A. K. keenan 不详

While deploymen. of in.racoron.ry sten.s has been.shown.to reduce resten.sis, sten.in. can.also damage the en.othelial mon.layer lin.n. the vessel wall, leadin. to possible in.sten. thrombosis. Local drug delivery from sten. surfaces represen.s a mean. of deliverin. therapeutic doses of drug directly to the target site. The aim of this study was to elute fluvastatin. which can.in.ibit vascular smooth muscle cell proliferation. an. xemilofiban. which preven.s platelet adhesion.an. aggregation. together in.bioactive con.en.ration. from the same copolymer system. Combin.d elution.from thermorespon.ive n.isopropylacrylamide (n.PAAm)/n.tert-butylacrylamide (n.BAAm)-derived copolymer systems was achieved usin. microgels (n.PAAm/n.BAAm 65/35 wt/wt) ran.omly dispersed in.85/15 matrices. Fluvastatin.elution.from 5 mm films over a 14-day period showed in.tial burst release, which leveled off. Of the total in.orporated (8.33 ± 0.21 n.ol, n.4), 68.5 % was eluted durin. this period. Xemilofiban.release was measured in.terms of its ability to in.ibit platelet adhesion. usin. a microfluidic system. To in.estigate the in.luen.e of location.an. hydrophobicity on.elution.of bioactivity, three separate systems were employed. While elution.of an.i-adhesive activity from the system con.ain.n. xemilofiban.loaded matrices was more dramatic in.the short term, a more sustain.d level of in.ibition.was achieved when.xemilofiban.had been.in.orporated in.o microgels. All samples in.estigated for an.i-adhesive activity also decreased human.coron.ry artery smooth muscle cell proliferation. Therefore xemilofiban.has poten.ial as an.agen. for preven.in. in.sten. thrombosis. Our study has demon.trated the feasibility of usin. this n.vel matrix/microgel system to regulate simultan.ous release of both agen.s in.bioactive con.en.ration..

关键词： Fluvastatin Xemilofiban n.paam/n.baam Microgels Local Drug Delivery

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从洋中脊到俯冲带的快速转换

矿物岩石地球化学通报 2017年第1期36卷 91-91页

作者： keenan T E En.arn.ción.J Buchwaldt R Fern.n.ez D Mattin.on.J Rasozan.mparan. C Luetkemeyer P B 夏群科

板块俯冲是地球上最基本的也是最明显的板块构造过程,但是新的俯冲带从哪里形成以及如何形成,目前都还没有很好的地质限定。海洋扩张中心虽然是板块构造系统中最薄弱的部分之一,但是由于新形成的海洋岩石圈的浮力作用,以前都认为它不容... 详细信息

板块俯冲是地球上最基本的也是最明显的板块构造过程,但是新的俯冲带从哪里形成以及如何形成,目前都还没有很好的地质限定。海洋扩张中心虽然是板块构造系统中最薄弱的部分之一,但是由于新形成的海洋岩石圈的浮力作用,以前都认为它不容易参与俯冲。

关键词：俯冲带圣路易斯大学板块构造浮力作用洋中脊岩石圈板块俯冲扩张中心变质作用力学性质

A Review of the Impact of Covid-19 on.the Male Gen.to-Urin.ry Tract

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Case Reports in.Clin.cal Medicin. 2023年第6期12卷 149-158页

作者： Georgios Kallin.kas James n. Tsoporis Diomidis Kozyrakis An.stasios Zarkadas Vasileios Kon.tan.in.poulos Dimitrios Bozios Despoin. Mitilin.ou Kon.tan.in.s Safioleas Pan.giotis Filios Athan.sios Filios Evan.elos Rodin.s Gerasimos Vlassopoulos Ioan.is Gerzelis Departmen. of Urology Konstantopouleion-Patesion Hospital Nea Ionia Athens Greece keenan Research Cen.re for Biomedical Scien.e Unity Health Toronto Ontario Canada

In.roduction.an. Objectives: Sin.e its adven. in.2019, Coron. Virus Disease 19 (Covid-19) has chan.ed everyday life in.man. un.receden.ed ways. With the availability of Covid-19 vaccin.s, clin.cal practice has stepped gradually towards its everyday routin.. The clin.cian. however, n.eds to address such con.ern. as “Can.Covid-19 presen. with urin.ry tract symptoms predomin.n.ly?”, “Can.the urin.ry tract develop lon.-term Covid-19 symptoms?”, “Can.Covid-19 vaccin.s/drug therapy cause male in.ertility?” Methods: This min.-review of the curren. literature has been.carried out by searchin. the Pubmed database. Results an. Con.lusion.: Our literature review suggests that there is in.ufficien. eviden.e to con.lude a sign.fican. impact on.the urin.ry tract from Covid-19 in.ection. There is supportin. eviden.e that mRn. an.i-SARS-CoV-2 vaccin.s are safe for male gon.ds. Research to further support these con.lusion. is required.

关键词： Covid-19 SARS-Co2 Urin.ry Tract Male Subfertility

基底神经节和规则支配性语言在血管性和变性疾病中的作用

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 12-13页

作者： Lon.worth C.E. keenan S.E. Barker R.A. L.K. Tyler 郭俊 Cen.re for Speech an. Lan.uage Dept. of Experimental Psychology University of Cambridge Cambridge CB23EB United Kingdom

The Declarative/Procedural Model of Pin.er, Ullman.an. colleagues claims that the basal gan.lia are part of a fron.o-striatal procedural memory system which applies grammatical rules to combin. morphemes (the smallest mean.n.ful un.ts in.lan.uage) in.o complex words (e.g. talk-ed, talk-in.). We tested this claim b y in.estigatin. whether striatal damage or loss of its dopamin.rgic in.ervation.is reliably associated with selective regular past ten.e deficits in.patien.s wi th subcortical cerebrovascular damage, Parkin.on.s disease or Hun.in.ton.s dis *** focused on.past ten.e morphology sin.e this allows us to con.rast the re gular past ten.e (jump-jumped), which is rulebased,with the irregular past ten. e (sleep-slept), which is n.t We used elicitation.an. primin. tasks to test pat ien.s’ability to comprehen. an. produce in.lected forms. We foun. n. eviden.e o f a con.isten. association.between.striatal dysfun.tion.an. selective impairmen. of regular past ten.emorphology, suggestin. that the basal gan.lia are n.t esse n.ial for processin. the regular past ten.e as a sequen.e of morphemes, either i n.comprehen.ion.or production. in.con.rast to the claims of the Declarative/Proc edural Model. All patien. groups showed n.rmal activation.of seman.ic an. morpho logical represen.ation. in.comprehen.ion. despite difficulties suppressin. seman.tically appropriate altern.tives when.tryin. to in.lect n.vel verbs. This is con.sisten. with previous reports that striatal dysfun.tion.spares automatic activat ion.of lin.uistic in.ormation. but disrupts later lan.uage processes that requir e in.ibition.of competin. altern.tives.

关键词：基底神经节变性疾病支配性纹状体多巴胺能帕金森病亨廷顿舞蹈症程序模式功能障碍记忆系统