检索结果-南通市图书馆

矿物岩石地球化学通报 2017年第1期36卷 91-91页

作者： keenan t e encarnación J Buchwaldt R Fernandez D Mattinson J Rasozanamparany C Luetkemeyer P B 夏群科

板块俯冲是地球上最基本的也是最明显的板块构造过程,但是新的俯冲带从哪里形成以及如何形成,目前都还没有很好的地质限定。海洋扩张中心虽然是板块构造系统中最薄弱的部分之一,但是由于新形成的海洋岩石圈的浮力作用,以前都认为它不容... 详细信息

板块俯冲是地球上最基本的也是最明显的板块构造过程,但是新的俯冲带从哪里形成以及如何形成,目前都还没有很好的地质限定。海洋扩张中心虽然是板块构造系统中最薄弱的部分之一,但是由于新形成的海洋岩石圈的浮力作用,以前都认为它不容易参与俯冲。

关键词：俯冲带圣路易斯大学板块构造浮力作用洋中脊岩石圈板块俯冲扩张中心变质作用力学性质

维普期刊数据库

Free vibration and transient response of double curved beams connected by intermediate straight beams

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-tALOOKOLAeI H.GHANDVAR e.JUMAeV S.KHAtIR t.CUONG-Le School of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for engineering Application and technology Solutions Ho Chi Minh City Open University

this paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. the strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. the curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. the accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词： Kinetic energy

A study of real-world micrograph data quality and machine learning model robustness

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2021年第1期7卷 1463-1473页

作者： Xiaoting Zhong Brian Gallagher keenan eves emily Robertson t.Nathan Mundhenk t.Yong-Jin Han Materials Science Division Lawrence Livermore National LaboratoryLivermoreCAUSA Center for Applied Scientific Computing Lawrence Livermore National LaboratoryLivermoreCAUSA Defense technologies engineering Division Lawrence Livermore National LaboratoryLivermoreCAUSA Computational engineering Division Lawrence Livermore National LaboratoryLivermoreCAUSA

Machine-learning(ML)techniques hold the potential of enabling efficient quantitative micrograph analysis,but the robustness of ML models with respect to real-world micrograph quality variations has not been carefully *** collected thousands of scanning electron microscopy(SeM)micrographs for molecular solid materials,in which image pixel intensities vary due to both the microstructure content and microscope instrument *** then built ML models to predict the ultimate compressive strength(UCS)of consolidated molecular solids,by encoding micrographs with different image feature descriptors and training a random forest regressor,and by training an end-to-end deep-learning(DL)*** show that instrument-induced pixel intensity signals can affect ML model predictions in a consistently negative *** a remedy,we explored intensity normalization *** is seen that intensity normalization helps to improve micrograph data quality and ML model robustness,but microscope-induced intensity variations can be difficult to eliminate.

关键词： instrument image eliminate

Perceptions of the effectiveness of Advanced Practice Nurses on a neurosurgery unit in a Canadian tertiary Care Centre:A pre-and-post implementation design

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2018年第2期5卷 138-143页

作者： Alanna M.keenan erin e.Mutterback Kristi M.Velthuizen Monika e.Pantalone Kira L.Gossack-keenan the Ottawa Hospital OttawaOntarioCanada University of Ottawa OttawaOntarioCanada McMaster University HamiltonOntarioCanada

Objectives:A framework for the advanced practice nurse(APN)role was developed in our Canadian tertiary Care Centre,delineating five domains of advanced nursing practice:clinical practice,consultation,research,education and *** goal of this study was to evaluate perceptions of the effectiveness of the implementation of an innovative APN role on an in-patient Neurosurgery ***:A pre-and-post implementation design,incorporating both qualitative and quantitative data,was *** innovative APN role was implemented within the Neurosurgery program focusing on the clinical domain and required the successful candidates to be NP *** APN role was designed to improve patient flow,documentation,communication and patient and staff *** primary outcomes were measured:pre-implementation questionnaire(nurses),post-implementation questionnaire(nurses and residents)and number of pages to the on-call ***:Survey scores by nurses and residents indicated improvement across all aspects *** scores increased from 1.1 to 2.6,reflecting an overall statistically significant *** number of pages to the on-call resident also showed a ***:Perceptions of patient care delivery and professional collaboration improved following implementation of the APN *** indicated that APNs significantly impacted patient care and improved nurses and residents'job satisfaction.

关键词： Advanced practice nursing Delivery of health care Patient care team Pre-post tests Professional practice gaps

Do Systemic Infections Contribute to the Pathogenesis of Dementia?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第3期38卷 331-333页

作者： keenan Sterling Mengen Xing Weihong Song townsend Family Laboratories Department of PsychiatryThe University of British ColumbiaVancouverBCV6T 1Z3Canada Institute of Aging Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and Kangning HospitalThe Second Affiliated Hospital and Yuying Children’s HospitalWenzhou Medical UniversityWenzhou325035China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou325000China

With over 50 million people currently living with dementia and numbers expected to double every twenty years,the world is currently facing a dementia ***,a poor understanding of the etiology of dementia has resulted in the inability to develop any successful disease-modifying *** the past year,several researchers have highlighted the role of systemic infections in increasing the risk of developing *** findings are particularly troubling given the ongoing coronavirus 19(COVID-19)pandemic,adding yet another cause for concern over the long-term impact of COVID-19 on the public’s mental health.

关键词： adding etiology finding

Business Continuity Management,Operational Resilience,and Organizational Resilience:Commonalities,Distinctions,and Synthesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2023年第5期14卷 713-721页

作者： S.e.Galaitsi elizaveta Pinigina Jeffrey M.Keisler Gianluca Pescaroli Jesse M.keenan Igor Linkov US Army engineer Research and Development Center VicksburgMS39180USA College of Management University of Massachusetts BostonBostonMA02125USA Institute for Risk and Disaster Reduction University College LondonLondonWC1E 6BTUK School of Architecture Tulane UniversityNew OrleansLA70118USA

the concepts of business continuity management,operational resilience,and organizational resilience each refer to actions that businesses and organizations can take in anticipating and responding to ***,the existing definitions and usages are difficult to differentiate due to overlapping objectives,implementation processes,and *** article examines definitions and approaches for these three concepts and suggest a framework to operationalize methods and tools relevant to *** definitions emphasize three dyads:risk versus resilience;organizational processes versus assets;and normal operating conditions versus crisis *** these dyads to differentiate the concepts of business continuity management,operational resilience,and organizational resilience can support planners in clarifying objectives and identifying which approach will be most beneficial as businesses or organizations plan for and encounter *** article evaluates these concepts by examining illustrative examples of disruptions and responses.

关键词： Business continuity management Disruptions Operational resilience Organizational resilience

维普期刊数据库

the role of inflammasomes in human diseases and their potential as therapeutic targets

在线全文

学校读者我要写书评

暂无评论

Signal transduction and targeted therapy 2024年第2期9卷 479-508页

作者： Jing Yao keenan Sterling Zhe Wang Yun Zhang Weihong Song the National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053China townsend Family Laboratories Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Key Laboratory of Neurodegenerative Diseases Ministry of EducationBeijingP.R.China Zhejiang Clinical Research Center for Mental Disorders Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and The Affiliated Kangning HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325000China

Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune *** inflammasome complex has three major components:an upstream sensor molecule that is connected to a downstream effector protein such as caspase-1 through the adapter protein *** formation typically occurs in response to infectious agents or cellular *** active inflammasome then triggers caspase-1 activation,followed by the secretion of pro-inflammatory cytokines and pyroptotic cell *** inflammasome activation and activity contribute to the development of diabetes,cancer,and several cardiovascular and neurodegenerative *** a result,recent research has increasingly focused on investigating the mechanisms that regulate inflammasome assembly and activation,as well as the potential of targeting inflammasomes to treat various *** clinical trials are currently underway to evaluate the therapeutic potential of several distinct inflammasome-targeting ***,understanding how different inflammasomes contribute to disease pathology may have significant implications for developing novel therapeutic *** this article,we provide a summary of the biological and pathological roles of inflammasomes in health and *** also highlight key evidence that suggests targeting inflammasomes could be a novel strategy for developing new disease-modifying therapies that may be effective in several conditions.

关键词： inflam therapeutic potential

Microbial community coalescence and nitrogen cycling in simulated mortality decomposition hotspots

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ecological Processes 2023年第1期12卷 608-624页

作者： Sarah W.keenan Alexandra L.emmons Jennifer M.DeBruyn Department of Geology and Geological engineering South Dakota School of Mines and Technology501 East St.Joseph StreetRapidSD 57701USA Department of Anthropology University of TennesseeKnoxvilleTNUSA Department of Biosystems engineering and Soil Science University of Tennessee2506 E.J.Chapman DriveKnoxvilleTN 37996USA

Background the pulsed introduction of dead plant and animal material into soils represents one of the primary mechanisms for returning organic carbon(C)and nitrogen(N)compounds to biogeochemical *** of animal carcasses provides a high C and N resource that stimulates indigenous environmental microbial communities and introduces non-indigenous,carcass-derived microbes to the ***,the dynamics of the coalesced microbial communities,and the relative contributions of environment-and carcass-derived microbes to C and N cycling are *** test whether environment-derived,carcass-derived,or the combined microbial communities exhibited a greater influence on C and N cycling,we conducted controlled laboratory experiments that combined carcass decomposition fluids and soils to simulate carcass decomposition *** selectively sterilized the decomposition fluid and/or soil to remove microbial communities and create different combinations of environment-and carcass-derived communities and incubated the treatments under three temperatures(10,20,and 30℃).Results Carcass-derived bacteria persisted in soils in our simulated decomposition scenarios,albeit at low *** communities had higher respiration rates at 10 and 30℃ compared to soil or carcass communities ***,at higher temperatures,mixed communities had reduced diversity,but higher respiration,suggesting functional *** communities treatments also provided evidence that carcass-associated microbes may be contributing to ammonification and denitrification,but that nitrification is still primarily carried out by native soil *** Our work yields insight into the dynamics of microbial communities that are coalescing during carcass decomposition,and how they contribute to recycling carcasses in terrestrial ecosystems.

关键词： Carcass decomposition Microcosm Nitrogen Carbon Biogeochemical cycling Coalescence

维普期刊数据库

同方期刊数据库

Amyloidβ-based therapy for Alzheimer’s disease:challenges,successes and future

在线全文

学校读者我要写书评

暂无评论

Signal transduction and targeted therapy 2023年第7期8卷 3374-3399页

作者： Yun Zhang Huaqiu Chen Ran Li keenan Sterling Weihong Song National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina the Second Affiliated Hospital and Yuying Children’s Hospital Institute of AgingKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceWenzhou Medical UniversityWenzhouZhejiangChina townsend Family Laboratories Department of PsychiatryThe University of British ColumbiaVancouverBC V6T 1Z3Canada Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiangChina

Amyloidβprotein(Aβ)is the main component of neuritic plaques in Alzheimer’s disease(AD),and its accumulation has been considered as the molecular driver of Alzheimer’s pathogenesis and progression.Aβhas been the prime target for the development of AD ***,the repeated failures of Aβ-targeted clinical trials have cast considerable doubt on the amyloid cascade hypothesis and whether the development of Alzheimer’s drug has followed the correct course.

关键词： Alzheimer Aβ clinical

Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

translational Neurodegeneration 2022年第1期11卷 883-916页

作者： Lina Gao Yun Zhang keenan Sterling Weihong Song Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthCollege of PharmacyJining Medical UniversityJining 272067ShandongChina townsend Family Laboratories Department of PsychiatryThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijing 100053China Institute of Aging Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and The Affiliated Kangning HospitalWenzhou Medical UniversityWenzhou 325000ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 325001ZhejiangChina.

Synaptic abnormalities are a cardinal feature of Alzheimer’s disease(AD)that are known to arise as the disease progresses.A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a mechanistic link between amyloidβ(Aβ)and tau pathology and thus may serve as an obligatory relay of the cognitive impairment in ***-derived neurotrophic factors(BDNFs)play an important role in maintaining synaptic plasticity in learning and *** AD as a synaptic disorder,BDNF has attracted increasing attention as a potential diagnostic biomarker and a therapeutical molecule for *** depletion of BDNF has been linked with Aβaccumulation,tau phosphorylation,neuroinflammation and neuronal apoptosis,the exact mechanisms underlying the effect of impaired BDNF signaling on AD are still ***,we present an overview of how BDNF genomic structure is connected to factors that regulate BDNF *** then discuss the role of BDNF in AD and the potential of BDNF-targeting therapeutics for AD.

关键词： Brain-derived neurotrophic factor Alzheimer’s disease Amyloidβprotein tau protein Neuroinflammation Neuronal apoptosis