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WNT5A drives interleukin-6-dependent epithelial-mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis

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Burns & Trauma 2022年第1期10卷 200-215页

作者： Young In Lee Jung Eun Shim Jihee Kim Won Jai Lee Jae Woo Kim kee hyun nam Ju Hee Lee Department of Dermatology Severance HospitalCutaneous Biology Research InstituteYonsei University College of MedicineSeoul 03722Korea Bioinformatics Collaboration Unit Yonsei University College of MedicineSeoul 03722Korea Department of Plastic and Reconstructive Surgery Severance HospitalYonsei University College of MedicineSeoul 03722Korea Scar Laser and Plastic Surgery Center Yonsei Cancer HospitalYonsei University College of MedicineSeoul 03722Korea Department of Biochemistry and Molecular Biology Chronic Intractable Disease for Systems Medicine Research CenterYonsei University College of MedicineSeoul 03722Korea Department of Surgery Severance HospitalYonsei University College of MedicineSeoulKorea

Background:Keloid scarring is a fibroproliferative disease caused by aberrant genetic activation with an unclear underlying *** predisposition,aberrant cellular responses to environmental factors,increased inflammatory cytokines and epithelial-mesenchymal transition(EMT)phenomena are known as major *** this study,we aimed to identify the molecular drivers that initiate keloid ***:Bulk tissue RNA sequencing analyses of keloid and normal tissues along with ex vivo and in vitro tests were performed to identify the contributing genes to keloid *** animal model of inflammatory keloid scarring was reproduced by replication of a skin fibrosis model with intradermal bleomycin injection in C57BL/6 ***:Gene set enrichment analysis revealed upregulation of Wnt family member 5A(WNT5A)expression and genes associated with EMT in keloid ***,human keloid tissues and the bleomycin-induced skin fibrosis animal model showed significantly increased expression ofWNT5A and EMT *** activation of the interleukin(IL)-6/Janus kinase(JAK)/signal transducer and activator of transcription(STAT)pathway and subsequent elevation of EMT markerswas also observed in keratinocytes co-cultured withWNT5A-activated fibroblasts or keloid ***,WNT5A silencing and the blockage of IL-6 secretion via neutralizing IL-6 antibody reversed hyperactivation of the STAT pathway and EMT markers in ***,STAT3 silencing significantly reduced the EMT-like phenotypes in both keratinocytes and IL-6-stimulated ***:Intercellular communication via the WNT5A and STAT pathways possibly underlies a partial mechanism of EMT-like phenomena in keloid ***-6 secreted from WNT5A-activated fibroblasts or keloid fibroblasts activates the JAK/STAT signaling pathway in adjacent keratinocytes which in turn express EMT markers.A better understanding of keloid development and the

关键词： Keloid Wnt family member 5A Interleukin-6 JAK/STAT pathway Epithelial-mesenchymal transition Scar Epithelial mesenchymal transition

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Adult human neural stem cell therapeutics: Current developmental status and prospect

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World Journal of Stem Cells 2015年第1期7卷 126-136页

作者： hyun nam kee-Hang Lee Do-hyun nam Kyeung Min Joo Department of Neurosurgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 South Korea Samsung Advanced Institute for Health Sciences and Technology Samsung Medical Center Sungkyunkwan University Seoul 135-710 South Korea Department of Anatomy and Cell Biology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 South Korea

Over the past two decades, regenerative therapies using stem cell technologies have been developed for various neurological diseases. Although stem cell therapy is an attractive option to reverse neural tissue damage and to recover neurological deficits, it is still under development so as not to show significant treatment effects in clinical settings. In this review, we discuss the scientific and clinical basics of adult neural stem cells(a NSCs), and their current developmental status as cell therapeutics for neurological disease. Compared with other types of stem cells, a NSCs have clinical advantages, such as limited proliferation, inborn differentiation potential into functional neural cells, and no ethical issues. In spite of the merits of a NSCs, difficulties in the isolation from the normal brain, and in the in vitro expansion, have blocked preclinical and clinical study using a NSCs. However, several groups have recently developed novel techniques to isolate and expand a NSCs from normal adult brains, and showed successful applications of a NSCs to neurological diseases. With new technologies for a NSCs and their clinical strengths, previous hurdles in stem cell therapies for neurological diseases could be overcome, to realize clinically efficacious regenerative stem cell therapeutics.

关键词： Adult neural stem cell Neurological diseases Stem cell therapy Preclinical trial Clinical trial

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Reliability, Accuracy, and Use Frequency of Evaluation Methods for Amount of Tongue Coating

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Chinese Journal of Integrative Medicine 2019年第5期25卷 378-385页

作者： Su-Ryun Kim Dong-hyun nam Department of Biofunctional Medicine and Diagnosis College of Korean MedicineSangji UniversityWonju 26339Republic of Korea

Objective: To classify the evaluation methods for amount of tongue coating(TC) and investigate their reliability, accuracy, and frequency of use. Methods: Articles published from 1985 to 2015 were searched for evaluation methods for the amount of TC in PubMed and the Cochrane Library. Only clinical researches were included except protocol articles. The methods were classi?ed according to their characteristics. Results: Finally,113 articles were selected. The evaluation method for the amount of TC from the articles was classi?ed into 4 types: intuitive, specificative, computerized, and weighing TC. The reliability in the intuitive and specificative methods(κ=0.33–0.92) showed varying levels among the studies. In general, the amount of TC calculated by the speci?cative method(Spearman's r=0.68–0.80) was more strongly related to the directly measured value than to the value estimated by the computerized method(Pearson's r=0.442). The number of articles published on this topic has increased consistently, and the speci?cative method was the most frequently used. Despite the higher reliability of the computerized method, it has not been widely used. Conclusions: The high prevalence of the speci?cative method would continue in clinical practice because of its convenience and accuracy. However,to establish higher reliability, the limitation of the subjectivity of the assessors should be overcome through calibration training. In the computerized method, novel algorithms are needed to obtain a higher accuracy so that it can help the practitioners con?dently estimate the amount of TC.

关键词： tongue coating evaluation methods reliability accuracy frequency

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Polymer-based membranes for solvent-resistant nanofiltration:A review

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Chinese Journal of Chemical Engineering 2017年第11期25卷 1653-1675页

作者： Slow kee Lira Kunli Goh Tae-hyun Bae Rong Wang Singapore Membrane Technology Center Nanyang Environment and WaterResearch InstituteNanyang Technological UniversityI Cleantech Loop637141 SingaporeSingapore Nanyang Environment and Water Research Institute Interdisciplinary Graduate SchoolNanyang Technological University637141 SingaporeSingapore School of Chemical and Biomedical Engineenng Nanyang Technological University62 Nanyang Drive637459 SingaporeSingapore School of Civil and Environmental Engineering Nanyang Technological University50 NanyangAvenue639798 SingaporeSingapore

Separation of organic mixture is an inevitable process in most modern industrial processes. In the quest for a more sustainable and efficient separation, solvent-resistant nanofiltration(SRNF) has emerged as a promising answer. This is because SRNF is a membrane-based process which offers the key advantages of high efficacy and low energy intensity separation. In particular, polymer-based membranes can offer compelling opportunities for SRNF with unprecedented cost-effectiveness. As a result, intensive research efforts have been devoted into developing novel polymer-based membranes with solvent-resistant capacities as well as exploring potential applications in different types of industries. In this review, we aim to give an overview of the recent progress in the development of the state-of-the-art polymer-based membranes for SRNF in the first section. Emerging nanomaterials for mixed matrix and thin film nanocomposite membranes are also covered in this section. This is followed by a discussion on the current status of membrane engineering and SRNF membrane commercialization. In the third section, we highlight recent efforts in adopting SRNF for relevant industrial applications such as food, bio-refinery, petrochemical, fine chemical and pharmaceutical industries followed by separations of enantiomers in stereochemistry, homogeneous catalysis and ionic liquids. Finally, we offer a perspective and provide deeper insights to help shape future research direction in this very important field of SRNF.

关键词： Nanofiltration Solvent-resistant Polymeric membranes Nanomaterials Crosslinking Industrial applications

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Void defect detection in ball grid array X-ray images using a new blob filter

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第11期13卷 840-849页

作者： Shao-hu PENG hyun Do nam Department of Electronics and Electrical Engineering Dankook University

Ball grid arrays (BGAs) have been used in the production of electronic devices/assemblies because of their advantages of small size, high I/O port density, etc. However, BGA voids can degrade the performance of the board and cause failure. In this paper, a novel blob filter is proposed to automatically detect BGA voids presented in X-ray images. The proposed blob filter uses the local image gradient magnitude and thus is not influenced by image brightness, void position, or component interference. Different sized average box filters are employed to analyze the image in multi-scale, and as a result, the proposed blob filter is robust to void size. Experimental results show that the proposed method obtains void detection accuracy of up to 93.47% while maintaining a low false ratio. It outperforms another recent algorithm based on edge detection by 40.69% with respect to the average detection accuracy, and by 16.91% with respect to the average false ratio.

关键词： Ball grid array (BGA) X-ray Defect detection Blob detection Void detection

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Electrochemical characteristics of phosphorus doped Si-C composite for anode active material of lithium secondary batteries

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中国有色金属学会会刊：英文版 2009年第4期19卷 1018-1022页

作者： Jae-hyun NOH Kwan-Yo ung LEE Joong-kee LEE Battery Research Center Korea Institute of Science and Technology Department of Chemical and Biological Engineering Korea University

Phosphorus doped silicon-carbon composite particles were synthesized through a DC arc plasma ***(SiH4) and methane(CH4) were introduced into the reaction chamber as the precursor of silicon and carbon,***(PH3) was used as a phosphorus dopant *** of synthesized particles were carried out by scanning electron microscopy(SEM),X-ray diffractometry(XRD),X-ray photoelectron spectroscopy(XPS) and bulk resistivity *** properties were investigated by cyclic test and electrochemical voltage spectroscopy(EVS).In the experimental range,phosphorus doped silicon-carbon composite electrode exhibits enhanced cycle performance than intrinsic silicon and phosphorus doped *** can be explained that incorporation of carbon into silicon acts as a buffer matrix and phosphorus doping plays an important role to enhance the conductivity of the electrode,which leads to the improvement of the cycle performance of the cell.

关键词：电化学特性磷掺杂负极活性材料磷硅电池材料锂离子 X射线光电子能谱扫描电子显微镜

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Landscape pattern and its effect on ecosystem functions in Seoul Metropolitan area:Urban ecology on distribution of the naturalized plant species

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Journal of Environmental Sciences 2003年第2期15卷 199-204页

作者： Sun-kee Hong In-Ju Song hyun-Ok Kim Eung-Kyong Lee Environmental Planning Institute Seoul National UniversitySeoul Development InstituteTechnical University BerlinEnvironmental Planning Institute Seoul National University Seoul 151-742 Korea Seoul 100-250 KoreaGermanySeoul 151-742 Korea

During land transformation process in the human history, naturalized plants were introduced to several land use patterns by the different ways of plant itself. Including some naturalized plants that had been contribute to land restoration, many naturalized plants have been invaded to original habitat or landscape for native plants. Once the plants were colonized, they extend their area and population size. Urban developed areas often give an important role of source habitat for naturalized plants and expanding their population size. In recent, this situation is appearing as one of environmental problems about the urban landscape management controlling the naturalized plants that invaded in the developed area and conserving the native vegetation. This paper is focusing on relationships between distribution of habitat of naturalized plants and landscape patch in urban area in Seoul. Gangdong-Gu, one of the administrative areas in Seoul was selected for this study. We examined the recent land use change using LANDSAT TM data and spreading of the representative naturalized plants (Robinia pseudoacacia and Eupatorium rugosum) by Seoul Biotope Mapping Project and field survey in 1999. As a result, these two species were often occurred in the same habitat and distributed in forest edge disturbed by man. Their distribution patterns were related to landscape indices (patch size and shape) in the forest edge.

关键词： biotope mapping ecosystem management human impact landscape pattern naturalized plants urban ecology

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Circadian fluctuations in three types of sensory modules in healthy subjects

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Neural Regeneration Research 2014年第4期9卷 436-439页

作者： Yong hyun Kwon Ki Seok nam Department of Physical Therapy Yeungnam University College of Science and TechnologyHyunchung-roNam-guDaeguRepublic of Korea

This study was designed to observe and compare the circadian fluctuations in tactile sense, joint reposition sense and two-point discrimination in healthy subjects. Twenty-one healthy adult subjects received perceptual ability tests through these three different sensory modules at approximately 9：00, 13：00 and 18：00 in a day. The distribution of ranking for perceptual ability was significantly different among the three different time points in each individual, with highest perceptual ability in the evening compared with noon and morning, in terms of tactile sense and two-point discrimination. These findings suggest that the perceptual ability of healthy subjects fluctuates according to the time points in a day.

关键词： nerve regeneration circadian pattern biological rhythm circadian fluctuations perceptual ability tactile sensory joint reposition sense two-point discrimination Basic Science ResearchProgram through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology neural regeneration

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UBP12/UBP13-mediated deubiquitination of salicylic acid receptor NPR3 suppresses plant immunity

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Molecular Plant 2023年第1期16卷 232-244页

作者： Yu Zhou Su-hyun Park nam-Hai Chua Temasek Life Sciences Laboratory National University of Singapore1 Research LinkSingapore 117604Singapore Disruptive&Sustainable Technologies for Agricultural Precision Singapore-MIT Alliance for Research and Technology1 CREATE WaySingapore 138602Singapore

Salicylic acid(SA),a defense hormone produced after pathogen challenge,is critical for plant *** NONEXPRESSER OF PR GENES 1(NPR1)and its paralogs NPR3 and NPR4 can bind SA and mediate SA signal ***1 functions as a transcriptional co-activator to promote defense gene expression,whereas NPR3 and NPR4 have been shown to function as negative regulators in the SA signaling *** the mechanism about NPR1 regulation has been well studied,how NPR3/NPR4 proteins are regulated in immune responses remains largely ***,we show that the stability of NPR3/NPR4 is enhanced by *** the absence of pathogen challenge,NPR3/NPR4 are unstable and degraded by the 26S proteasome,whereas the increase in cellular SA levels upon pathogen infection suppresses NPR3/NPR4 *** found that UBP12 and UBP13,two homologous deubiquitinases from a ubiquitin-specific protease subfamily,negatively regulate plant immunity by promoting NPR3/NPR4 *** genetic results further showed that UBP12/UBP13-mediated immunity suppression is partially dependent on NPR3/NPR4 *** interacting with NPR3 in the nucleus in an SA-dependent manner,UBP12 and UBP13 remove ubiquitin from polyubiquitinated NPR3 to protect it from being *** stabilization of NPR3/NPR4 promoted by UBP12/UBP13 is essential for negative regulation of basal and SA-induced immunity.

关键词： plant immunity salicylic acid NPR3 UBP12/UBP13

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Silver-palladium alloy deposited by DC magnetron sputtering method as lubricant for high temperature application

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中国有色金属学会会刊：英文版 2009年第4期19卷 1001-1004页

作者： Jung-Dae KWON Sung-Hun LEE Koo-hyun LEE Jong-Joo RHA kee-Seok nam Sang-Hoon CHOI Dong-Min LEE Dong-Il KIM Materials Processing Division Korea Institute of Materials Science Technology Research & Development Institute Korea Plant Service and Engineering

The silver-palladium(Ag-Pd) alloy coating as a solid lubricant was investigated for its application to the high temperature stud bolts used in nuclear power plants.A hex bolt sample was prepared in the following steps:1) bolt surface treatment using alumina grit blasting for cleaning and increasing the surface area;2) nickel(Ni) film coating as a glue layer on the surface of the bolt;and 3) Ag-Pd alloy coating on the Ni *** films were deposited by using a direct current(DC) magnetron sputtering *** thickness and composition of the Ag-Pd alloy film have effect on the friction coefficient,which was determined using axial force measurement.A 500 nm-thick Ag-Pd(80-20,molar ratio) alloy film has the lowest friction coefficient of 0.109.A cyclic test was conducted to evaluate the durability of bolts coated with either the Ag-Pd(80-20) alloy film or N-5000 *** a cycle,the bolts were inserted into a block using a torque wrench,which was followed by heating and *** only one cycle,it was not possible to remove the bolts coated with the N-5000 oil from the ***,the bolts coated with the Ag-Pd(80-20) alloy could be easily removed up until 15 cycles.

关键词：银钯合金直流电高温润滑剂沉积磁控溅射法固体润滑涂层高温螺栓

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