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Molecular engineering of antibodies for site-specific conjugation to lipid polydopamine hybrid nanoparticles

Acta Pharmaceutica Sinica B 2020年第11期10卷 2212-2226页

作者： Hobin Yang Quoc-Viet Le Gayong Shim Yu-Kyoung Oh Young kee Shin Laboratory of Molecular Pathology and Cancer Genomics College of Pharmacy and Research Institute of Pharmaceutical SciencesSeoul National UniversitySeoul 08826Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea Bio-MAX Seoul National UniversitySeoul 08826Republic of Korea

Conjugation of antibodies to nanoparticles allows specific cancer targeting,but conventional conjugation methods generate heterogeneous conjugations that cannot guarantee the optimal orientation and functionality of the conjugated ***,a molecular engineering technique was used for sitespecific conjugation of antibodies to *** designed an anti-claudin 3(CLDN3)antibody containing a single cysteine residue,h4 G3 cys,then linked it to the maleimide group of lipid polydopamine hybrid nanoparticles(LPNs).Because of their negatively charged lipid coating,LPNs showed high colloidal stability and provided a functional surface for site-specific conjugation of h4 G3 *** activity of h4 G3 cys was tested by measuring the binding of h4 G3 cys-conjugated LPNs(C-LPNs)to CLDN3-positive tumor cells and assessing its subsequent photothermal effects.C-LPNsspecifically recognized CLDN3-overexpressing T47 D breast cancer cells but not CLDN3-negative Hs578 T breast cancer *** binding of C-LPNs to CLDN3-overexpressing T47 D cells resulted in significantly higher temperature generation upon NIR irradiation and potent anticancer photothermal *** with this,intravenous injection of C-LPNsin a T47 D xenograft mouse model followed by NIR irradiation caused remarkable tumor ablation compared with other treatments through high temperature *** results establish an accurate antibody-linking method and demonstrate the possibility of developing therapeutics using antibody-guided nanoparticles.

关键词： Molecular engineering Site-specific conjugation Lipid polydopamine hybrid nanoparticles Claudin 3 Photothermal therapy

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Stress analysis model of strip winding system with a sleeve for a coil of thin stainless steel

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Journal of Iron and Steel Research International 2017年第1期24卷 1-7页

作者： Yong-hui Park Kyutae Park Sung-yeun Won Wan-kee Hong Hyun-chul Park Graduate School of Engineering Masterships Pohang University of Science and Technology(POSTECH)Kyungbuk 790 784PohangRepublic of Korea Mechanical Engineering Pohang University of Science and Technology(POSTECH)Kyungbuk 790-784PohangRepublic of Korea Mechanical Facility Research Group Engineering Solution CenterPOSCOKyungbuk 790-360PohangRepublic of Korea

In a strip winding process,the sleeve is a hollow cylinder that is mounted between a strip coil and a mandrel to maintain uniform coil shape when the strip coil is very thin,but its deformation behavior has not been investigated ***,a finite element（FE）model was presented to calculate the stress distribution in a sleeve and strip coil when 1-3mm-thick stainless steel was wound around the *** FE model was developed by extending aprevious model by adding a sleeve between the mandrel and strip,and by modifying the boundary and interaction *** strip winding process was divided into an initial process and a steady-state *** the initial process,the minimum and maximum pressure required on the belt wrapper to maintain coil shape by self-friction of the strip was calculated by the FE model when the belt wrapper is ejected at the end of the initial *** the initial process,an analytical model of the steady-state process was established to calculate the stress distribution and was compared with the FE model to validate *** suggested analytical model took 11 sto give the same stress distribution that the FE model took 30 dto produce.

关键词： Strip winding system Belt wrapper Grooved joint Radial stress Hoop stress Von-Mises stress Interference fit

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Advances of macroalgae biomass for the third generation of bioethanol production

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Chinese Journal of Chemical Engineering 2020年第2期28卷 502-517页

作者： Inn Shi Tan Man kee Lam Henry Chee Yew Foo Steven Lim Keat Teong Lee Department of Chemical Engineering Curtin UniversitySarawak Campus CDT 25098009 MiriSarawakMalaysia Chemical Engineering Department Universiti Teknologi PETRONAS32610 Seri IskandarPerakMalaysia Centre for Biofuel and Biochemical Research Institute of Self-Sustainable BuildingUniversiti Teknologi PETRONAS32610 Seri IskandarPerakMalaysia Department of Chemical Engineering Lee Kong Chian Faculty of Engineering and ScienceUniversiti Tunku Abdul Rahman43000SelangorMalaysia School of Chemical Engineering Universiti Sains MalaysiaEngineering CampusSeri Ampangan14300 Nibong TebalPulau PinangMalaysia

In recent years, utilization of renewable sources for biofuel production is gaining popularity due to growing greenhouse gas(GHG) emissions which causes global warming. There has been a great effort in exploring alternative feedstock for bioethanol production. In this context, the production of third-generation bioethanol from macroalgae has emerged as an alternative feedstock to food crop-based starch and lignocellulosic *** is mainly due to the fast growth rate of macroalgae, no competition with agricultural land, high carbohydrate content and relatively simple processing steps compared to lignocellulosic biomass. This review paper provides an insight of recent innovative approaches for macroalgae bioethanol production, including conventional and advanced hydrolysis process to produce fermentable sugar, various fermentation technologies, economic analysis and life cycle assessment. With the current technology maturity, efficient utilization of macroalgae as sustainable source for bioethanol and other value-added chemicals production could be achieved in the near future.

关键词： Macroalage Hydrolysis Biomass Fermentation Bioethanol

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Resveratrol as an epigenetic therapy for flavivirus infection:A narrative review

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Asian Pacific Journal of Tropical Medicine 2023年第12期16卷 546-557,I0001-I0013页

作者： Kim-Ling Chin Kim-kee Tan Sazaly Abu Bakar Nurhafiza Zainal Department of Medical Microbiology Faculty of MedicineUniversiti MalayaKuala LumpurMalaysia Institute for Advanced Studies Universiti MalayaKuala LumpurMalaysia Tropical Infectious Diseases Research and Education Centre(TIDREC) Universiti MalayaKuala LumpurMalaysia

Flaviviruses are a group of positive-stranded RNA viruses that cause a broad spectrum of severe illnesses in humans *** manifestations of flavivirus infections range from mild febrile illness to hemorrhage,shock,and neurological *** infections cause a substantial global health impact,with an estimated more than 400 million cases of infections ***,an understanding of flavivirus-host interaction is urgently needed for new antiviral therapeutic *** recent years,many aspects concerning epigenetic therapy for viral infections have been addressed,including methylation of the genome,acetylation/deacetylation of histone complex and microRNA *** this context,we surveyed and reviewed the literature and summarized the epigenetic effects of resveratrol,a natural polyphenol with potential anti-viral properties,on flavivirus infections.

关键词： Infectious diseases Epigenetic Resveratrol Flavivirus DNA methylation Histone Non-histone proteins Micro-RNA

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Complications of common bile duct stones: A risk factors analysis

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 361-365页

作者： Dong Jun Oh Ji Hyung Nam Dong kee Jang Jun Kyu Lee Department of Internal Medicine Dongguk University Ilsan HospitalGoyang 10326Korea

Background: The latest guidelines recommended that common bile duct stones(CBDSs) should be removed, preferably endoscopically, regardless of the presence of symptoms or complications. However, the removal of CBDSs may not be feasible in very old patients or those with co-morbidities. In these cases, it is important to understand the risk factors for the development of CBDSs-related complications to decide whether or not to treat high-risk patients. Herein, we aimed to identify the risk factors for the development of complications after the diagnosis of CBDSs. Methods: The medical records of patients with CBDSs between October 2005 and September 2019 were retrospectively analyzed. All patients with radiologically-diagnosed CBDSs, including those who received treatment and those who did not, were analyzed. Results: A total of 634 patients were included and 95(15.0%) patients had CBDS-related complications during the mean follow-up period of 32.6 months. Forty-four(6.9%) high-risk patients remained asymptomatic and did not receive treatment during the follow-up period. In multivariate analyses, size of CBDSs ≥ 5 mm and no treatment within 30 days were independent risk factors for the development of complications. The spontaneous passage of CBDSs was proved radiologically in 9 out of 81(11.1%) patients within 30 days. Conclusions: It is recommended treating CBDSs within 30 days from the diagnosis, even in high-risk patients, especially if the size is larger than 5 mm.

关键词： Common bile duct stone Risk factors Obstructive jaundice Pancreatitis Cholangitis

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Leaf phenology rather than mycorrhizal type regulates soil nematode abundance,but collectively affects nematode diversity in seven common subtropical tree species

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Forest Ecosystems 2023年第2期10卷 187-194页

作者： Jianqing Wang Jiaoyan Mao Yunyan Tan Shu kee Lam Qiling Guo Xiuzhen Shi Key Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education Institute of GeographyFujian Normal UniversityFuzhou350117China Fujian Provincial Key Laboratory for Subtropical Resources and Environment School of Geographical SciencesFujian Normal UniversityFuzhou350117China Faculty of Veterinary and Agricultural Sciences The University of MelbourneParkvilleMelbourneVIC3010Australia

The underlying mechanisms of the relationships between tree species and the soil micro-food web in forest ecosystems remain uncertain,primarily ascribed to an insufficient understanding on how tree functional traits drive soil nematode communities,including in subtropical *** investigated the impacts of seven subtropical tree species(evergreen:Pinus massoniana,Mytilaria laosensis,Ilex chinensis,Michelia macclurei;and deciduous:Liquidambar formosana,Quercus acutissima,and Betula luminifera)on the soil nematode *** found that the abundance of soil nematodes was not affected by mycorrhizal types,but it was around 83%higher under the deciduous trees than the evergreen trees,indicating the importance of leaf phenology to the abundance of soil ***,both the evergreen and the arbuscular mycorrhizal trees increased soil nematode diversity,resulting from changes in root traits and soil ***,root traits(root C,root N,and root C:N ratio),and soil properties(total C,total N,moisture content,and bulk density)were the best predictors of the community composition of soil nematodes,indicating a key role of resource quality and soil microhabitat in regulating soil *** contrast,the ectomycorrhizal trees had lower plant parasite and Wasilewska indices,and evenness,whereas the evergreen trees slightly improved the evenness of soil *** study suggests that tree species affect the soil food web through changes in soil conditions and plant functional traits in subtropical forests.

关键词： Tree species Soil food web Soil fauna Forest soil Biodiversity

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Development of a LDIE Prediction Theory in the Condition of Magnetite Formation on Secondary Side Piping in Nuclear Power Plants

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World Journal of Nuclear Science and Technology 2017年第1期7卷 1-14页

作者： Kyeongmo M. Hwang Hyeok kee Seo chan Kyu Lee Won chang Nam Power Engineering Research Institute Gimcheon South Korea Seoul National University Seoul South Korea

It has been thought that wall thinning on the secondary side piping in nu-clear power plants is mostly caused by Flow-Accelerated Corrosion (FAC). Recently, it has been seen that wall thinning on the secondary side piping carrying two-phase flow is caused by not only FAC but also Liquid Droplet Impingement Erosion (LDIE). Moreover, it turns out that LDIE in nuclear power plants does not result from a single degradation mechanism but also from the simultaneous happenings of LDIE and FAC. This paper presents a comparison of the mass loss rate of the tested materials between carbon steel (A106 B) and low alloy steel (A335 P22) resulting from degradation effect. An experimental facility was set up to develop a prediction model for clarifying multiple degradation mechanisms that occur together. The experimental facility allows examining liquid droplet impingement erosion in the same conditions as the secondary side piping in nuclear power plants by generating the magnetite on the surface of the test materials. The magnetite is formed by controlling the water chemistry and the temperature of fluid inside the facility. In the initial stage of the experiments, the mass loss rate of A106 B was greater than that of A335 P22. However, after a certain period of time, the mass loss rate of A335 P22 became greater than that of A106 B. It is presumed that the results are caused by the different yield strengths of the test materials and the different degrees of buffer action of the magnetite deposited on their surfaces. The layer of magnetite on the surface of A106 is thicker than that of A335 P22, due to the different amount of chrome content. In nuclear power plants, carbon steel piping having experienced wall thinning degradation is generally replaced with low-alloy steel piping. However, the materials of pipes carrying two-phase flow should be selected considering their susceptibility to LDIE.

关键词： Liquid Droplet Impingement (LDI) Flow-Accelerated Corrosion (FAC) Multiple Degradations Wall Thinning Magnetite

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Innovative technique of needlescopic grasper-assisted single-incision laparoscopic common bile duct exploration:A comparative study

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World Journal of Gastroenterology 2015年第45期21卷 12857-12864页

作者： Say-June Kim kee-Hwan Kim chang-Hyeok An Jeong-Soo Kim Daejeon St.Mary’s Hospital College of MedicineThe Catholic University of Korea Department of Surgery Uijeongbu St. Mary’s HospitalCollege of MedicineThe Catholic University of Korea

AIM: To investigate the safety and feasibility of needlescopic grasper-assisted single-incision laparoscopic common bile duct exploration(n SIL-CBDE) by comparing the surgical outcomes of this technique with those of conventional laparoscopic CBDE(CL-CBDE).METHODS: We retrospectively analyzed the clinical data of patients who underwent CL-CBDE or n SILCBDE for the treatment of common bile duct(CBD) stones between January 2000 and December 2014. For performing n SIL-CBDE, a needlescopic grasper was also inserted through a direct puncture below the right subcostal line after introducing a single-port through the umbilicus. The needlescopic grasper helped obtain the critical view of safety by retracting the gallbladder laterally and by preventing crossing or conflict between laparoscopic instruments. The gallbladder was then partially dissected from the liver bed and used for retraction. CBD stones were usually extracted through a longitudinal supraduodenal choledochotomy, mostly using flushing a copious amount of normal saline througha ureteral catheter. Afterward, for the certification of CBD clearance, CBDE was performed mostly using a flexible choledochoscope. The choledochotomy site was primarily closed without using a T-tube, and simultaneous cholecystectomies were ***: During the study period, 40 patients underwent laparoscopic CBDE. Of these patients, 20 underwent CL-CBDE and 20 underwent n SIL-CBDE. The operative time for n SIL-CBDE was significantly longer than that for CL-CBDE(238 ± 76 min vs 192 ± 39 min, P = 0.007). The stone clearance rate was 100%(40/40) in both groups. Postoperatively, the n SIL-CBDE group required less intravenous analgesic(pethidine)(46.5 ± 63.5 mg/kg vs 92.5 ± 120.1 mg/kg, P = 0.010) and had a shorter hospital stay than the CL-CBDE group(3.8 ± 2.0 d vs 5.1 ± 1.7 d, P = 0.010). There was no significant difference in the incidence of postoperative complications between the two ***: The results of this study

关键词： Choledocholithiasis Choledochotomy Common bile duc

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Stable Zn Metal Anodes with Limited Zn-Doping in MgF_(2) Interphase for Fast and Uniformly Ionic Flux

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Nano-Micro Letters 2022年第3期14卷 169-183页

作者： Ji Young Kim Guicheng Liu Ryanda Enggar Anugrah Ardhi Jihun Park Hansung Kim Joong kee Lee Energy Storage Research Center Korea Institute of Science and TechnologyHwarang‑ro 14‑gil 5Seongbuk‑guSeoul 02792Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei‑roSeodaemun‑guSeoul 03722Republic of Korea Department of Physics Dongguk UniversitySeoul 04620Republic of Korea APC Technology 10868 Gangbyeonyeok‑ro‑4‑gilGwangjin‑guSeoul 05116Republic of Korea Department of Energy and Environmental Engineering KIST SchoolKorea University of Science and TechnologyHwarang‑ro 14‑gil 5Seongbuk‑guSeoul 02792Republic of Korea

The practical applications of aqueous Zn metal batteries are currently restricted by the inherent drawbacks of Zn such as the hydrogen evolution reaction,sluggish kinetics,and dendrite *** address these problems,herein,a limitedly Zn-doped MgF_(2)interphase comprising an upper region of pure,porous MgF_(2)and a lower region of gradient Zn-doped MgF_(2)is achieved via radio frequency sputtering *** porous MgF_(2)region is a polar insulator whose high corrosion resistance facilitates the de-solvation of the solvated Zn ions and suppression of hydrogen evolution,resulting in Zn metal electrodes with a low interfacial *** Zn-doped MgF_(2)region facilitates fast transfer kinetics and homogeneous deposition of Zn ions owing to the interfacial polarization between the Zn dopant and MgF_(2)matrix,and the high concentration of the Zn dopant on the surface of the metal substrate as fine ***,a symmetric cell incorporating the proposed Zn metal exhibits low overpotentials of~27.2 and~99.7 mV without Zn dendrites over 250 to 8000 cycles at current densities of 1.0 and 10.0 mA cm−2,*** developed Zn/MnO2 full cell exhibits superior capacity retentions of 97.5%and 84.0%with average Coulombic efficiencies of 99.96%after 1000 and 3000 cycles,respectively.

关键词： Zinc metal battery MgF_(2)layer Limited zinc doping Ion-transfer kinetic Deposition guidance

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Spliceosomal repression:unleashing human cell totipotency

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4162-4164页

作者： Felipe F.Lüttmann kee-Pyo Kim Johnny Kim The Center for Cardiovascular Regeneration and Immunology at TRON-Translational Oncology at the University Medical Center of the Johannes Gutenberg-University Mainz gGmbH MainzGermany Department of Medical Life Sciences College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea Vascular Biology and Therapeutics Program and Department of Comparative Medicine Yale University School of MedicineNew HavenCTUSA

In a recent publication in Cell,Li et *** that inhibiting the spliceosome in human pluripotent stem cells(hPSCs)can induce a stable totipotent state.1 This study signifies the importance of post-transcriptional regulation in controlling developmental potential and provides a powerful model system for studying the process of human pre-implantation development in vitro.

关键词： al. inhibiting implantation

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