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A new look at anti-Helicobacter pylori therapy

World Journal of Gastroenterology 2011年第35期17卷 3971-3975页

作者： Seng-kee Chuah Feng-Woei Tsay Ping-I Hsu Deng-Chyang Wu Division of Gastroenterology Kaohsiung Chang Gung Memorial HospitalCollege of MedicineChang Gung University833 KaohsiungTaiwan Division of Gastroenterology Department of Internal MedicineKaohsiung Veterans General HospitalNational Yang-Ming University813 KaohsiungTaiwan Department of General Medicine School of MedicineCollege of MedicineTaipei Medical University110 TaipeiTaiwan Department of Internal Medicine Kaohsiung Medical University Hospital807 KaohsiungTaiwan

With the rising prevalence of antimicrobial resistance,the treatment success of standard triple therapy has recently declined to unacceptable levels (i.e.,80% or less) in most ***,several treatment regimens have emerged to cure Helicobacter pylori (***) *** first-line *** therapies in 2011 include sequential therapy,concomitant quadruple therapy,hybrid (dual-concomitant) therapy and bismuth-containing quadruple *** the failure of standard triple therapy,a bismuth-containing quadruple therapy comprising a proton pump inhibitor (PPI),bismuth,tetracycline and metronidazole can be employed as rescue ***,triple therapy combining a PPI,levofloxacin and amoxicillin has been proposed as an alternative to the standard rescue *** salvage regimen can achieve a higher eradication rate than bismuth-containing quadruple therapy in some regions and has less adverse *** best second-line therapy for patients who fail to eradicate *** with first-line therapies containing clarithromycin,amoxicillin and metronidazole is ***,a levofloxacin-based triple therapy is an accepted rescue *** guidelines suggest that patients requiring third-line therapy should be referred to a medical center and treated according to the antibiotic susceptibility ***,an empirical therapy (such as levofloxacin-based or furazolidone-based therapies) can be employed to terminate *** infection if antimicrobial sensitivity data are unavailable.

关键词： Bismuth-containing quadruple therapy Concomitant quadruple therapy Hybrid (dual-concomitant) therapy Rescue anti-Helicobacter pylori treatment Sequential therapy

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Prediction of Perineural Invasion and Its Prognostic Value in Patients with Prostate Cancer

Prediction of Perineural Invasion and Its Prognostic Value i...

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第十七届全国泌尿外科学术会议

作者： Jeong Zoo Lee Hong Koo Ha Wan Lee moon kee Chung Department of Urology Pusan National University School of MedicineBusanKorea

Purpose The prognostic significance ofperineural invasion by prostate cancer is *** investigated the association between perineural invasion and clinico-pathological factors and the effect of perineural invasion on su...

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Metal organic framework modulated nanozymes tailored with their biomedical approaches

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Chinese Chemical Letters 2024年第11期35卷 155-171页

作者： Manoj Kumar Sarangi L.D Patel Goutam Rath Sitansu Sekhar Nanda Dong kee Yi Department of Pharmaceutics Amity Institute of PharmacyAmity UniversityLucknow 201313India Department of Pharmaceutics Parul Institute of PharmacyParul UniversityVadodara 391760India Department of Pharmaceutics School of Pharmaceutical SciencesSiksha'O'Anusandhan UniversityBhubaneswar 751030India Department of Chemistry Myongji UniversityYongin 03674Republic of Korea

Nanozymes are the paradigm for bridging inorganic nanomaterials with biology and environment for taking the spontaneous responsibilities to outplay natural ***-organic frameworks(MOFs) are mesoporous materials of inorganic-organic coordination,bearing ampoules of active/target sites and having the tendency to mimic natural *** MOF-based nanozymes(NZs) could be recognized for their tremendous potential for ***,MOFs are of four types namely: modified MOFs,pristine MOFs,MOF-derived materials and MOFs comprised of natural *** MOFs-based NZ modulated via ultrasound,light,and heat revealed diversified *** article is concentrated on different methods for the preparation of MOF-based NZ for mimicking the responses of catalases,multifunctional enzymes,oxidases,superoxide dismutase,hydrolases,and peroxidases,progress and challenges of MOFs/MOF-based materials for exploiting their recent and futuristic approaches in biomedical sector.

关键词： MOF Nanozyme Catalysis Biomedicine Theranostics

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Efficient page layout analysis on small devices

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第6期10卷 800-804页

作者： Eun-jung HAN Chee-onn WONG kee-chul JUNG Kyung-ho LEE Eun-yi KIM Department of Naval Architecture and Ocean Engineering Inha University Human-Centered Interfaces Lab Department of Digital MediaSoongsil University Internet and Media Engineering Konkuk University

Previously we have designed and implemented new image browsing facilities to support effective offiine image contents on mobile devices with limited capabilities： low bandwidth, small display, and slow processing. In this letter, we fulfill the automatic production of cartoon contents fitting small-screen display, and introduce a clustering method useful for various types of cartoon images as a prerequisite stage for preserving semantic meaning. The usage of neural networks is to properly cut the various forms of pages. Texture information that is useful for grayscale image segmentation gives us a good clue for page layout analysis using the multilayer perceptron （MLP） based x-y recursive algorithm. We also automatically frame the segment MLP using agglomerative segmentation. Our experimental results show that the combined approaches yield good results of segmentation for several cartoons.

关键词： Efficient page layout analysis MLP-based segmentation Mobile devices Image segmentation Neural network

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Effect of metal catalyst on the mechanism of hydrogen spillover in three-dimensional covalent-organic frameworks

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Chinese Physics B 2017年第2期26卷 412-419页

作者： Xiu-Ying Liu Jing-Xin Yu Xiao-Dong Li Gui-Cheng Liu Xiao-Feng Li Joong-kee Lee College of Science Henan University of Technology Zhengzhou 450000 China Center for Energy Convergence Research Green City Research Institute Korea Institute of Science and Technology (KIST) Seou102792 Republic of Korea College of Physical and Electronic Information Luoyang Normal University Luoyang 471022 China

Hydrogen spillover mechanism of metal-supported covalent-organic frameworks COF-105 is investigated by means of the density functional theory, and the effects of metal catalysts M_4（Pt_4, Pd_4, and Ni_4） on the whole spillover process are systematically analyzed. These three metal catalysts exhibit several similar phenomena：（i） they prefer to deposit on the tetra（_4-dihydroxyborylphenyl） silane（TBPS） cluster with surface-contacted configuration;（ii） only the H atoms at the bridge site can migrate to 2,3,6,7,10,11-hexahydroxy triphenylene（HHTP） and TBPS surfaces, and the migration process is an endothermic reaction and not stable;（iii） the introduction of M_4 catalyst can greatly reduce the diffusion energy barrier of H atoms, which makes it easier for the H atoms to diffuse on the substrate surface. Differently, all of the H2 molecules spontaneously dissociate into H atoms onto Pt_4 and Pd_4clusters. However, the adsorbed H2 molecules on Ni_4 cluster show two types of adsorption states： one activated state with stretched H–H bond length of 0.88 ？A via the Kubas interaction and five dissociated states with separated hydrogen atoms. Among all the M_4 catalysts, the orders of the binding energy of M_4 deposited on the substrate and average chemisorption energy per H2 molecule are Pt_4〉Ni_4〉Pd_4. On the contrary, the orders of the migration and diffusion barriers of H atoms are Pt_4

关键词： covalent-organic frameworks hydrogen spillover hydrogen storage density functional theory

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Real-world comparison of non-vitamin K antagonist oral anticoagulants and warfarin in Asian octogenarian patients with atrial fibrillation

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Journal of Geriatric Cardiology 2016年第7期13卷 566-572页

作者： chang Hee Kwon Minsu Kim Gi-Byoung Nam kee-Joon Choi You-Ho Kim Division of Cardiology Konkuk University Medical Center Konkuk University School of Medicine Seoul South Korea Division of Cardiology Asan Medical Center University of Ulsan College of Medicine Seoul South Korea

Background The efficacy and safety of non-vitamin K antagonist oral anticoagulants （NOACs） and warfarin in Asian octogenarian atrial fibrillation （AF） patients have not been established in a real-world setting. We aimed to evaluate the efficacy and safety of NOACs and warfarin in Korean octogenarian patients. Methods A total of 293 consecutive patients aged 〉 80 years with non-valvular AF who had taken either NOACs 048 cases, 50.5%） or warfarin （145 cases, 49.5%） were retrospectively reviewed. The efficacy outcome was the com- posite of stroke or systemic embolism. The safety outcome was major bleeding. Results The follow-up duration was 375 patient-years （ 172 patient-years with NOACs and 203 patient-years with warfarin）. Patients on NOACs were slightly older （P = 0.006） and had slightly higher HAS-BLED scores （P = 0.034）. The efficacy of both anticoagulants was high （1.16% for NOACs vs. 2.98% for warfarin per 100 pa- tient-years, P = 0.46）. The safety outcome was relatively high in both NOACs and warfarin groups （8.96% vs. 12.46%, P = 0.29）. The effi- cacy and safety outcomes tended to decrease non-significantly in low dose NOACs than in common dose NOACs or warfarin （0.85% vs. 1.84% vs. 2.98% in efficacy outcome, P = 0.69; and 6.97% vs. 13.29% vs. 12.46% in safety outcome, P = 0.34）. Conclusions NOACs were highly effective for prevention of stroke or systemic embolism in Asian octogenarian AF patients. However, major bleeding occurred excessively high in both anticoagulant groups. Further study is required on the optimal anticoagulant regimen in octogenarian population.

关键词： Anticoagulants Atrial fibrillation Efficacy Octogenarian Safety

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Synthesized flavanoid-derived ligand reduced dengue virus type-2 replication in vitro

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Asian Pacific Journal of Tropical Biomedicine 2017年第2期7卷 91-95页

作者： Mudiana Muhamad Yean kee Lee Noorsaadah Abd. Rahman Rohana Yusof Faculty of Medicine Universiti Teknologi MARASungai Buloh47000SelangorMalaysia Drug Design and Development Research Group University MalayaKuala Lumpur50603Malaysia Department of Chemistry Faculty of ScienceUniversity MalayaKuala Lumpur50603Malaysia Department of Molecular Medicine Faculty of MedicineUniversity MalayaKuala Lumpur50603Malaysia

Objective: To investigate the antiviral property of a lead ligand, YK51 that was synthesized based on the flavanoid of a natural product toward dengue virus type-2(DENV2)***: c RNA was isolated from HepG2 cells inoculated with 1 000 median tissue culture infective dose of DENV2 and treated with different doses of the ligand followed by RT-PCR to quantify the virus gene copies. Confocal microscopy of actin and tubulin redistribution was also ***: The quantitative RT-PCR result showed reduction of the DENV2 gene copies as the ligand concentration was increased. The confocal microscopy result showed increase in the tubulin intensity(79.6%) of infected BHK21 cells treated with the ligand,compared with the non-treated cells(54.8%). The 1.5-fold increase in the intensity of tubulin suggested that the ligand inhibitory effect stabilized the cellular microtubule ***: The synthesized ligand YK51 reduced DENV2 viral load by inhibiting virus replication thus is highly potential to be developed as antiviral agent.

关键词： Synthesized derived ligand Dengue replication Inhibition assay Quantitative RT-PCR Cytoskeletal actin tubulin distribution

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Cultivation of microalgae for biodiesel production:A review on upstream and downstream processing

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Chinese Journal of Chemical Engineering 2018年第1期26卷 17-30页

作者： Xin Bei Tan Man kee Lam Yoshimitsu Uemura Jun Wei Lim Chung Yiin Wong Keat Teong Lee Chemical Engineering Department Universiti Teknologi PETRONAS Centre for Biofuel and Biochemical Research Universiti Teknologi PETRONAS Fundamental and Applied Science Department Universiti Teknologi PETRONAS School of Chemical Engineering Universiti Sains MalaysiaEngineering Campus

Fluctuating market price of fossil fuel and overwhelming emission of greenhouse gases to the atmosphere have resulted in climate change and have been a global concern in this decade. Hence, biodiesel has become an alternative option to fossil diesel as it is renewable and environmentally friendly. Nevertheless, this alternative fuel that is usually derived from terrestrial oil crops will cause shortage in food supply and deforestation if mass production is realized. In recent years, cultivation of aquatic microorganism(particularly microalgae) to produce biodiesel is considered as a practical solution due to their high growth rate and ability to synthesize large quantity of lipid within their cell. However, the development of energy and cost-efficiency of microalgae cultivation system are the main issues in producing renewable microalgae biodiesel. Of late, wastewater or organic compost has been used as the cultivation medium as it can provide sufficient nutrients to sustain microalgae *** cultivation method and system are vitally important as these factors undoubtedly affect the final microalgae biomass and lipid yield. In this review, the cultivation system of microalgae, nutrients demanded for microalgae production, cell harvesting and drying, microalgae oil extraction, and utilization of microalgae biomass for biodiesel production are introduced and discussed. It is anticipated to convey clearer perspectives in upstream and downstream processes in microalgae-derived biodiesel production.

关键词： Microalgae Cultivation Lipid Biodiesel Harvesting

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Soy, soil and beyond

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Soil Ecology Letters 2023年第4期5卷 1-3页

作者： Wee kee Tan Jingling Zhu Jun Li Choon Nam Ong NUS Environmental Research Institute National University of Singapore5A Engineering Drive 1T-Lab#02-01Singapore 117411Singapore Department of Biomedical Engineering National University of Singapore7 Engineering Drive 1Singapore 117574Singapore Saw Swee Hock School of Public Health National University of Singapore12 Science Drive 2Singapore 117549Singapore

Summary Soy and its quest for future food ***,or soybean(Glycine max),is a leguminous plant that has played a significant role in various civilizations throughout human *** are native to East Asia and have been cultivated in China for thousands of *** a food source,soy has a wide range of uses,they include tofu,tempeh,soy milk,soy sauce,miso,soy-based meat alternatives,desserts and *** products serve as alternatives to animal-based proteins and dairy products for vegetarians,vegans,and individuals with dietary *** addition,soybean oil is one of the most widely consumed cooking oils *** is used for frying,baking,sautéing,and salad dressings due to its mild flavour and high smoke *** oil is also used as an ingredient in margarine,mayonnaise,and other food products.

关键词： soybean smoke soil

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Noninvasive Parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2012年第13期18卷 1525-1530页

作者： Hye Ran Yang Hae Ryoung Kim Myung Jin Kim Jae Sung Ko Jeong kee Seo Department of Pediatrics Seoul National University College of MedicineSeoul 110-744South Korea Department of Pediatrics Seoul National University Bundang HospitalSeongnam-siGyonggi-do 463-707South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam-siGyonggi-do 464-894 South Korea

AIM:To evaluate the noninvasive parameters and hepatic fibrosis scores in obese children with nonalcoholic fatty liver disease(NAFLD).METHODS:A total of 77 children diagnosed with NAFLD via liver biopsy were included and divided into 2 subgroups according to the histopathologic staging of hepatic fibrosis:mild(stage 0-1)vs significant fibrosis(stage 2-4).Clinical and laboratory parameters were evaluated in each *** aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST/platelet ratio index(APRI),PGA index,Forns index,FIB-4,NAFLD fibrosis score,and pediatric NAFLD fibrosis index(PNFI)were ***:No clinical or biochemical parameter exhibited a significant difference between patients with mild and significant *** noninvasive hepatic fibrosis scores,only APRI and FIB4 revealed a significant difference between patients with mild and significant fibrosis(APRI:0.67±0.54 vs 0.78±0.38,P=0.032 and FIB4:0.24±0.12 vs 0.31±0.21,P=0.010).The area under the receiving operating characteristic curve of FIB4 was 0.81,followed by Forns index(0.73),APRI(0.70),NAFLD fibrosis score(0.58),AST/ALT ratio(0.53),PGA score(0.45),and PNFI(0.41).CONCLUSION:APRI and FIB4 might be useful noninvasive hepatic fibrosis scores for predicting hepatic fibrosis in children with NAFLD.

关键词： Fatty liver Hepatic fibrosis Noninvasive Obesity Child

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