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Elucidating regulatory processes of intense physical activity by multi-omics analysis

Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim jennifer E.Kyle kelly G.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus ke.t j.bloodsworth kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark Grant tietje justin teeguarden Kristin E.Burnum-johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:to study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:this study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

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Partial Collapsing Degeneration of Floer trajectories and Adiabatic Gluing

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Acta Mathematica Sinica,English Series 2024年第1期40卷 161-249页

作者： Yong-Geun OH ke ZHU Center for Geometry and Physics Institute for Basic Science(IBS)79 Jigok-ro 127beon-gilNam-guPohang-siGyeongsangbuk-doKorea 37673&POSTECHGyeongsangbuk doKorea Department of Mathematics and Statistics Minnesota State UniversityMankatoMN 56001USA

In the present paper,we study partial collapsing degeneration of Hamiltonian-perturbed Floer trajectories for an adiabatic ε-family and its reversal adiabatic gluing,as the prototype of the partial collapsing degeneration of 2-dimensional(perturbed)j-holomorphic maps to 1-dimensional gradient *** consider the case when the Floer equations are S^(1)-invariant on parts of their domains whose adiabatic limit has positive length as ε→0,which we call thimble-flow-thimble *** main gluing theorem we prove also applies to the case with Lagrangian boundaries such as in the problem of recovering holomorphic disks out of pearly *** particular,our gluing theorem gives rise to a new direct proof of the chain isomorphism property between the Morse-Bott version of Lagrangian intersection Floer complex of L by Fukaya-Oh-Ohta-Ono and the pearly complex of L Lalonde and *** also provides another proof of the present authors’earlier proof of the isomorphism property of the PSS map without involving the target rescaling and the scale-dependent gluing.

关键词： Floer trajectory equation partial collapsing degeneration thimble-flow-thimble moduli space adiabatic gluing exponential decay estimates three-interval method

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Universal silicon ring resonator for error-free transmission links

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Photonics Research 2024年第4期12卷 701-711页

作者： jUNBO ZHU WEIWEI ZHANG ke LI BHARAt PANt MARtIN EBERt XINGZHAO YAN MEHDI BANAKAR DEHN t.tRAN CALLUM G.LIttLEjOHNS FUWAN GAN GRAHAM REED DAVID j.tHOMSON Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK National key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China Peng Cheng Laboratory ShenzhenChina

We report the design, fabrication, and characterization of a universal silicon PN junction ring resonator for C band error-free communication links operated up to 50 Gb/s with co-designed optical modulation and detection performance. the universal p-n junction ring device shows co-designed detection responsivity up to 0.84 A/W, in conjunction with a modulation efficiency of -4 V·mm and>8 d B optical modulation extinction ratio, enabling C band 50 Gb/s NRZ communication link with a bit error rate≤3×10^(-12).

关键词： Gb/s resonator communication

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Analyzing topics in social media for improving digital twinning based product development

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Digital Communications and Networks 2024年第2期10卷 273-281页

作者： Wenyi tang Ling tian Xu Zheng ke Yan School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

Digital twinning enables manufacturers to create digital representations of physical entities,thus implementing virtual simulations for product *** efforts of digital twinning neglect the decisive consumer feedback in product development stages,failing to cover the gap between physical and digital *** work mines real-world consumer feedbacks through social media topics,which is significant to product *** specifically analyze the prevalent time of a product topic,giving an insight into both consumer attention and the widely-discussed time of a *** primary body of current studies regards the prevalent time prediction as an accompanying task or assumes the existence of a preset ***,these proposed solutions are either biased in focused objectives and underlying patterns or weak in the capability of generalization towards diverse *** this end,this work combines deep learning and survival analysis to predict the prevalent time of *** propose a specialized deep survival model which consists of two *** first module enriches input covariates by incorporating latent features of the time-varying text,and the second module fully captures the temporal pattern of a rumor by a recurrent network ***,a specific loss function different from regular survival models is proposed to achieve a more reasonable *** experiments on real-world datasets demonstrate that our model significantly outperforms the state-of-the-art methods.

关键词： Digital twinning Product development topic analysis Social media

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Relative Impacts of Sea Ice Loss and Atmospheric Internal Variability on the Winter Arctic to East Asian Surface Air temperature Based on Large-Ensemble Simulations with NorESM2

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Advances in Atmospheric Sciences 2024年第8期41卷 1511-1526页

作者： Shengping HE Helge DRANGE tore FUREVIK Huijun WANG ke FAN Lise Seland GRAFF Yvan j.ORSOLINI Geophysical Institute University of Bergen and Bjerknes Centre for Climate ResearchBergen 5020Norway Nansen Environmental and Remote Sensing Center Bergen 5007Norway key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 211544China Nansen-Zhu International Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 511458China School of Atmospheric Science Sun Yat-Sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Norwegian Meteorological Institute Oslo 0313Norway Norwegian Institute for Air Research Kjeller 2007Norway

to quantify the relative contributions of Arctic sea ice and unforced atmospheric internal variability to the “warm Arctic, cold East Asia”(WACE) teleconnection, this study analyses three sets of large-ensemble simulations carried out by the Norwegian Earth System Model with a coupled atmosphere–land surface model, forced by seasonal sea ice conditions from preindustrial, present-day, and future periods. Each ensemble member within the same set uses the same forcing but with small perturbations to the atmospheric initial state. Hence, the difference between the present-day(or future) ensemble mean and the preindustrial ensemble mean provides the ice-loss-induced response, while the difference of the individual members within the present-day(or future) set is the effect of atmospheric internal variability. Results indicate that both present-day and future sea ice loss can force a negative phase of the Arctic Oscillation with a WACE pattern in winter. the magnitude of ice-induced Arctic warming is over four(ten) times larger than the ice-induced East Asian cooling in the present-day(future) experiment;the latter having a magnitude that is about 30% of the observed cooling. Sea ice loss contributes about 60%(80%) to the Arctic winter warming in the present-day(future) experiment. Atmospheric internal variability can also induce a WACE pattern with comparable magnitudes between the Arctic and East Asia. Ice-lossinduced East Asian cooling can easily be masked by atmospheric internal variability effects because random atmospheric internal variability may induce a larger magnitude warming. the observed WACE pattern occurs as a result of both Arctic sea ice loss and atmospheric internal variability, with the former dominating Arctic warming and the latter dominating East Asian cooling.

关键词： Arctic sea ice loss warm Arctic–cold East Asia atmospheric internal variability large-ensemble simulation NorESM2 PAMIP

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In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

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Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan Yao tang tianwen Huang Lining ke En Huang key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PtB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PtB to knockdown PtB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PtB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PtB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. these findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke.treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

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Behaviour recognition based on the integration of multigranular motion features in the Internet of things

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Digital Communications and Networks 2024年第3期10卷 666-675页

作者： Lizong Zhang Yiming Wang ke Yan Yi Su Nawaf Alharbe Shuxin Feng School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China Beijing Institute of Remote Sensing Equipment Beijing100039China Applied College Taibah UniversityMedina42353Saudi Arabia

With the adoption of cutting-edge communication technologies such as 5G/6G systems and the extensive development of devices,crowdsensing systems in the Internet of things(Iot)are now conducting complicated video analysis tasks such as behaviour *** applications have dramatically increased the diversity of Iot ***,behaviour recognition in videos usually requires a combinatorial analysis of the spatial information about objects and information about their dynamic actions in the temporal *** recognition may even rely more on the modeling of temporal information containing short-range and long-range motions,in contrast to computer vision tasks involving images that focus on understanding spatial ***,current solutions fail to jointly and comprehensively analyse short-range motions between adjacent frames and long-range temporal aggregations at large scales in *** this paper,we propose a novel behaviour recognition method based on the integration of multigranular(IMG)motion features,which can provide support for deploying video analysis in multimedia Iot crowdsensing *** particular,we achieve reliable motion information modeling by integrating a channel attention-based short-term motion feature enhancement module(CSEM)and a cascaded long-term motion feature integration module(CLIM).We evaluate our model on several action recognition benchmarks,such as HMDB51,Something-Something and *** experimental results demonstrate that our approach outperforms the previous state-of-the-art methods,which confirms its effective-ness and efficiency.

关键词： Behaviour recognition Motion features Attention mechanism Internet of things Crowdsensing

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Optimization on magnetic properties of Nd-doped Fe_(3)O_(4) nanoparticles for magnetic shielding fabrics

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journal of Rare Earths 2024年第4期42卷 683-689页

作者： Xiaolei Song Congzhu Xu Yuyan Wang Huizhen ke Yonggui Li Qufu Wei Xinqun Feng Faculty of Clothing and Design Minjiang UniversityFuzhou350108China Fujian key Laboratory of Novel Functional textile Fibers and Materials Minjiang UniversityFuzhou350108China College of textile and Clothing Jiangnan UniversityWuxi214122China College of Fashion and Design Donghua UniversityShanghai201620China

High magnetic protective fabrics with rare earth Nd doped Fe_(3)O_(4) nanoparticles were fabricated via a grafting *** structure,crystal form,and elemental composition of nanoparticles were investigated by transmission electron microscopy,energy dispersive X-ray,X-ray powder diffraction,and X-ray photoelectron *** obtained NdFe_(2)O_(4) nanoparticles show spherical shape with fine dispersion and reasonable element ***,they demonstrate fine superparamagnetic properties with a magnetic saturation value of 29.25 A·m^(2)/g and low coercivity of 1.902 mt through the vibrating sample magnetometry technique,which can be well developed in magnetic shielding protective ***,the cotton fabrics with plain weave were finished by a proofing rapier loom as a *** NdFe_(2)O_(4) nanoparticles underwent some appropriate surface modification and then were grafted onto the cotton fabrics by a bridge agent of N,N’-dissuccinimidyl *** morphology,structure,dispersion effect,and electromagnetic protective properties of the fabrics were observed through scanning electron microscopy,Fourier infrared spectroscopy,thermogravimetric analysisdifferential scanning calorimetry(tG-DSC),and a vector network *** reliable fabrics with grafting reaction on the interface are expected to have potential applications in the field of electromagnetic protection and biomedicine fields.

关键词： Magnetic property Nd Fe_(3)O_(4)nanoparticles Magnetic shielding Fabrics Rare earths

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Sub-Seasonal Predictability of the Northeast China Cold Vortex in BCC and ECMWF S2S Model Forecasts for 2006-2021

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journal of Meteorological Research 2024年第3期38卷 453-468页

作者： Yiqiu YU jie WU Yihe FANG Chunyu ZHAO Zongjian ke Yitong LIN Liaoning Provincial Climate Centre Liaoning Provincial Meteorological AdministrationShenyang110166China key Opening Laboratory for Northeast China Cold Vortex Research China Meteorological AdministrationShenyang110166China Panjin National Climate Observatory Panjin124000China China Meteorological Administration key Laboratory for Climate Prediction Studies National Climate CentreChina Meteorological AdministrationBeijing100081China jilin Provincial Climate Centre Jilin Provincial Meteorological AdministrationChangchun130062China

As an important atmospheric circulation system in the mid-high latitudes of East Asia,the Northeast China cold vortex(NCCV)substantially influences weather and climate in this *** far,systematic assessment on the performance of numerical prediction of the NCCVs has not been carried *** on the Beijing Climate Centre(BCC)and the ECMWF model hindcast and forecast data that participated in the Sub-seasonal to Seasonal(S2S)Prediction Project,this study systematically examines the performance of both models in simulating and forecasting the NCCVs at the sub-seasonal *** results demonstrate that the two models can effectively capture the seasonal variations in the intensity,active days,and spatial distribution of NCCVs;however,the duration of NCCVs is shorter and the intensity is weaker in the models than in the *** analysis shows that the differences in the intensity and location of the East Asian subtropical westerly jet and the wave train pattern from North Atlantic to East Asia may be responsible for the deficient simulation of NCCV events in the S2S ***,in the deterministic forecasts,BCC and ECMWF provide skillful prediction on the anomalous numbers of NCCV days and intensity at a lead time of 4-5(5-6)pentads,and the skill limit of the ensemble mean is 1-2 pentads longer than that of individual *** the probabilistic forecasts of daily NCCV activities,BCC and ECMWF exhibit a forecasting skill of approximately 7 and 11 days,respectively;both models show seasonal dependency in the simulation performance and forecast skills of NCCV events,with better performance in winter than in *** results from this study provide helpful references for further improvement of the S2S prediction of NCCVs.

关键词： Northeast China cold vortex(NCCV) predictability sub-seasonal to seasonal(S2S)prediction deterministic forecast probabilistic forecast

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Weak interaction-steered evolution of polyoxovanadate-based metal-organic polyhedra from transformation via interlock to packing

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Chinese Chemical Letters 2024年第2期35卷 527-533页

作者： Yan-Hu Wang ke-Wei tong Chao-Qin Chen jing Du Peng Yang College of Chemistry and Chemical Engineering Advanced Catalytic Engineering Research Center of the Ministry of EducationHunan UniversityChangsha 410082China College of Chemistry and Materials Science Testing and Analysis CenterHebei Normal UniversityShijiazhuang 050024China

A bottleneck in biomimetic synthesis consists in the full copy of,for example,the hierarchical structure of proteins directed by weak *** contrast with covalent bonds bearing definite orientation and high stability,weak intermolecular forces within a continuous dynamic equilibrium can be hardly tamed for molecular *** this endeavor,a ligand-dominated strategy that embodies tunable electrostatic repulsion andπ···πstacking was first employed to shape polyoxovanadate-based metal-organic polyhedra(VMOPs).Structural evolution involving transformation,interlock,and discovery of an unprecedented prototype of the Star of David was hence *** only as a handy tool for the primary structural control over VMOPs,these weak forces allow for an advanced management on the spatial distribution of such manmade macromolecules as well as the associated physicochemical behaviors,representing an ideal model for simulating and interpreting the conformation-function relationship of proteins.

关键词： Polyoxometalates Polyoxovanadates Metal-organic polyhedron Interlock Weak intermolecular forces

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