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Parallelized volumetric fluorescence microscopy with a reconfigurable coded incoherent light-sheet array

Light(Science & Applications) 2020年第1期9卷 1914-1924页

作者： Yu-Xuan Ren Jianglai Wu Queenie T.k.Lai Hei Ming Lai Dickson M.D.Siu Wutian Wu kenneth k.Y.Wong ke.in k.tsia Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong KongSAR 999077China Department of Physics University of CaliforniaBerkeleyCA 94720USA School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongSAR 999077China Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongHong KongSAR 999077China GHM Institute of CNS Regeneration Jinan University601 Huangpu Avenue WestGuangzhou 510632China Re-Stem Biotechnology Suzhou 215007China

Parallelized fluorescence imaging has been a long-standing pursuit that can address the unmet need for a comprehensive three-dimensional(3D)visualization of dynamical biological processes with minimal ***,the available approaches are limited to incomplete parallelization in only two dimensions or sparse sampling in three *** hereby develop a novel fluorescence imaging approach,called coded light-sheet array microscopy(CLAM),which allows complete parallelized 3D imaging without mechanical *** the concept of an“infinity mirror”,CLAM generates a light-sheet array with controllable sheet density and degree of ***,CLAM circumvents the common complications of multiple coherent light-sheet generation in terms of dedicated wavefront engineering and mechanical dithering/***,the encoding of multiplexed optical sections in CLAM allows the synchronous capture of all sectioned images within the imaged *** demonstrate the utility of CLAM in different imaging scenarios,including a light-scattering medium,an optically cleared tissue,and microparticles in fluidic *** can maximize the signal-to-noise ratio and the spatial duty cycle,and also provides a further reduction in photobleaching compared to the major scanning-based 3D imaging *** flexible implementation of CLAM regarding both hardware and software ensures compatibility with any light-sheet imaging modality and could thus be instrumental in a multitude of areas in biological research.

关键词： scattering light mirror

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High-contrast,fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser

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Light(Science & Applications) 2020年第1期9卷 1775-1786页

作者： Cihang kong Christian Pilger Henning Hachmeister Xiaoming Wei Tom H.Cheung Cora S.W.Lai Nikki P.Lee ke.in k.tsia kenneth k.Y.Wong Thomas Huser Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong KongChina Biomolecular Photonics Department of PhysicsUniversity of BielefeldUniversitatsstr2533615 BielefeldGermany Division of Life Science The Hong Kong University of Science and TechnologyHong KongChina Department of Physiology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong KongChina Department of Surgery The University of Hong KongPokfulam RoadHong KongChina Division of Engineering and Applied Science California Institute of Technology1200 East California BoulevardPasadenaCA 91125USA

Coherent Raman scattering(CRS)microscopy is widely recognized as a powerful tool for tackling biomedical problems based on its chemically specific label-free contrast,high spatial and spectral resolution,and high ***,the clinical translation of CRS imaging technologies has long been hindered by traditional solid-state lasers with environmentally sensitive operations and large *** fibre lasers can potentially overcome these shortcomings but have not yet been fully exploited for CRS imaging,as previous implementations have suffered from high intensity noise,a narrow tuning range and low power,resulting in low image qualities and slow imaging ***,we present a novel high-power self-synchronized two-colour pulsed fibre laser that achieves excellent performance in terms of intensity stability(improved by 50 dB),timing jitter(24.3 fs),average power fluctuation(20 dB)and pulse width variation(k by imaging a wide range of species such as living human cells and mouse arterial tissues and performing multimodal nonlinear imaging of mouse tail,kidney and brain tissue sections by utilizing second-harmonic generation and twophoton excited fluorescence,which provides multiple optical contrast mechanisms simultaneously and maximizes the gathered information content for biological visualization and medical *** work also establishes a general scenario for remodelling existing lasers into synchronized two-colour lasers and thus promotes a wider popularization and application of CRS imaging technologies.

关键词： scattering tuning fibre

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Potassium ions and cyano group modified g-C3N4 for effective generation of H2O2 through two-electron oxygen reduction

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Science China Chemistry 2025年第1期 192-200页

作者： Dongying Wang Shulan Pu Yongmin Chen ke Lei Yujie Duan Linjiao Mao Xuhui Zeng Xi Luo Yuntao Zhang Yuqin Dong Jin Zhong Zhang Yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （k+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （kOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing k+.Under simulated sunlight irradiation,the sample with a k+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.k+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

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Hepatoid carcinoma of the pancreas:A case report and review of the literature

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World Journal of Clinical Cases 2020年第6期8卷 1116-1128页

作者： Shao-Xiong Zeng Si-Wei Tan Christ-Jonathan tsia Hin Fong Qiong Liang Bin-Liang Zhao ke Liu Jia-Xiang Guo Jin Tao Department of Gastroenterology the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Pathology the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Radiology the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACkGROUND Hepatoid carcinoma(HC)is an extremely rare neoplasm that is morphologicallysimilar to hepatocellular *** has been described in various organs;however,HC of the pancreas is extremely *** our knowledge,only 38 caseshave been *** present a case of HC of the pancreas in a 36-year-oldmale *** SUMMARY A 36-year-old cachexic man with no significant past medical history wastransferred to our hospital with a history of painless jaundice,elevated bloodglucose and significant weight *** tests showed elevated serumtransaminases,bilirubin and alpha-fetoprotein *** resonanceimaging of the upper abdomen showed a diffusely enlarged pancreas,appearing“sausage-shaped”.Magnetic resonance cholangiopancreatography showedupstream ductal dilation secondary to stricture of the main pancreatic duct andthe common bile duct,which were not *** ofbiopsied tissue from a percutaneous pancreatic biopsy showed tumor cellpositivity for HepPar1,polyclonal carcinoembryonic antigen and Ck19,suggestive of HC of the *** characteristics of 39 patients with HC ofthe pancreas were *** HC of the pancreas is more prevalent in males,and patients have a median age of57 *** is most commonly asymptomatic or presents as abdominal back pain,and the pancreatic tail is the most common *** the time of diagnosis,liver metastasis is often present.

关键词： Hepatoid carcinoma Pancreas Case report Review

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Phosphatase and tensin homologue:a therapeutic target for SMA

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Signal Transduction and Targeted Therapy 2017年第1期2卷 108-114页

作者： Vinay k Godena ke Ning Department of Neuroscience Sheffield Institute of Translational Neuroscience(SITraN)University of SheffieldSheffieldUK

Spinal muscular atrophy(SMA)is one of the most common juvenile neurodegenerative diseases,which can be associated with child *** is caused by a mutation of ubiquitously expressed gene,Survival Motor Neuron1(SMN1),leading to reduced SMN protein and the motor neuron *** disease is incurable and the only therapeutic strategy to follow is to improve the expression of SMN protein levels in motor *** numbers of motor neurons in SMA mice and SMA cultures are caspase positive with condensed nuclei,suggesting that these cells are prone to a process of cell death called *** for other potential molecules or signaling pathways that are neuroprotective for central nervous system(CNS)insults is essential for widening the scope of developmental ***,a Phosphatase and Tensin homologue,is a tumor suppressor,which is widely expressed in *** depletion activates anti-apoptotic factors and it is evident that the pathway plays an important protective role in many neurodegenerative *** functions as a negative regulator of PIP3/AkT pathway and thereby modulates its downstream cellular functions through lipid phosphatase ***,previous reports from our group demonstrated that,PTEN depletion using viral vector delivery system in SMN delta7 mice reduces disease pathology,with significant rescue on survival rate and the body weight of the SMA *** knockdown/depletion/mutation of PTEN and manipulation of PTEN medicated Akt/PkB signaling pathway may represent an important therapeutic strategy to promote motor neuron survival in SMA.

关键词： protective therapeutic mortality

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Formation mechanism of titanium and niobium carbides in hardfacing alloy

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Rare Metals 2017年第8期36卷 640-644页

作者： ke Yang kèYang Ye-Feng Bao Yong-Feng Jiang College of Mechanical and Electrical Engineering Hohai UniversityChangzhou 213022China

The most effective carbide-forming elements titanium and niobium were added into hardfacing *** and composition of carbides in the hardfacing alloy were investigated by means of optical microscope（OM）,scanning electron microscope（SEM）,X-ray diffraction（XRD）and energy-dispersive spectrometer（EDS）.Hardness and impact toughness of the hardfacing alloy were *** thermodynamics and formation mechanism of carbides were also *** is found that the carbides consist of TiC and NbC which are able to form directly from welding pool during the welding *** formation mechanism of carbides involves nucleation of TiC followed by epitaxial precipitation of NbC on the surface of *** formation of titanium and niobium carbides can obviously refine the microstructure and deplete the carbon in the *** micros tructure transforms to well-distributed carbides and a tough martensite matrix,contributing to a good combination of high hardness and high toughness in the hardfacing alloy.

关键词： Titanium Niobium Hardfacing alloy Carbides Microstructure

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Effect of corrosion product films on the in vitro degradation behavior of Mg-3%Al-1%Zn(in wt%) alloy in Hank's solution

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Journal of Materials Science & Technology 2018年第10期34卷 1756-1764页

作者： B.J.Wang D.k.Xu J.H.Dong W.ke School of Environmental and Chemical Engineering Shenyang Ligong University CAS key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal Research Chinese Academy of Sciences Environmental Corrosion Center Institute of Metal Research Chinese Academy of Sciences

Through investigating the corrosion behavior of an as-extruded Mg-3wt%gAl-lwt%Zn （AZ31） alloy in a simulated physiological fluid of Hank＇s solution, it demonstrates that the corrosion process was depen- dent on the immersion time. Further analyses revealed that the highest corrosion resistance could be obtained at 24 h due to the formation of a compact layer of corrosion products on the sample surface. With increasing the immersion time to up to 48 h, the thickness of surface films increased gradually but obvious de-bonding of such film from the substrate could take place, resulting in a certain resilience of the overall corrosion resistance.

关键词： Magnesium Surface layer Corrosion product Interface

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A novel weighting scheme for random k-SAT

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Science China(Information Sciences) 2016年第9期59卷 5-10页

作者： Jun LIU ke XU State key Laboratory of Software Development Environment Beihang University

Consider a random k-conjunctive normal form F;（n, rn） with n variables and rn clauses. We prove that if the probability that the formula Fk（n, rn） is satisfiable tends to 0 as n →∞, then r≥2.83, 8.09, 18.91,40.... 详细信息

关键词： computational complexity satisfiability phase transition second moment method weighting scheme

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Predefined-Time Sliding Mode Control with Prescribed Convergent Region

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IEEE/CAA Journal of Automatica Sinica 2022年第5期9卷 934-936页

作者： ke Shao Jinchuan Zheng Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyHawthornVIC 3122Australia IEEE

Dear editor,k1 In recent years,the finite-time and fixed-time control techniques have drawn much *** letter will present a new method for designing a predefined-time adaptive sliding mode controller with prescribed convergent *** specifically,class function is used to construct the sliding function,and to achieve a real sliding mode,the function is also adopted in designing the adaptive gain without knowing the disturbance’s upper bound(DUB).Compared to the existing finite-time and fixed-time controllers,the key superiority of the proposed method is that the system can converge to a prescribed arbitrarily small region in predefined time irrespective of the initial *** addition,the control signal is bounded along the settling period,where the settling time instance can be estimated without conservation.

关键词： prescribed designing letter

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Activation and counteraction of antiviral innate immunity by kSHV: an update

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Science Bulletin 2018年第18期63卷 1223-1234页

作者： Xiaoqin Wei ke Lan State key Laboratory of Virology College of Life Sciences Medical Research Institute Wuhan University

The innate immune responses triggering production of type 1 interferons and inflammatory cytokines constitute a nonspecific innate resistance that eliminates invading pathogens including viruses. The acti- vation of innate immune signaling through pattern recognition receptors （PRRs） is by sensing pathogen- associated molecular patterns derived from viruses. According to their distribution within cells, PRRs are classified into three types of receptors： membrane, cytoplasmic, and nuclear. kaposi＇s sarcoma- associated herpesvirus （I（SHV）, a large DNA virus, replicates in the nucleus. Its genome is protected by capsid proteins during transport in the cytosol. Multiple PRRs are involved in kSHV recognition. To suc- cessfully establish latent infection, kSHV has evolved to manipulate different aspects of the host antiviral innate immune responses. This review presents recent advances in our understanding about the activation of the innate immune signaling in response to infection of kSHV. It also reviews the evasion strate- gies used by kSHV to subvert host innate immune detection for establishing a persistent infection.

关键词： kSHV PRRs Innate immune response Evasion strategies

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