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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang jiali Wu Yu Wang Hanlin Huang jun ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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深度学习赋能波束管理:现状、挑战与机遇

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中山大学学报（自然科学版）（中英文） 2025年第1期64卷 40-50页

作者：王昭诚马可清华大学电子工程系北京100084

随着载波频率的不断提高和大规模天线阵列的广泛部署,基于模拟移相器的波束赋形成为下一代无线通信的标志性技术之一。此时,波束管理被用于获取和维护基站和用户端具有最大接收功率的最优波束对,以保障可靠的无线通信服务。传统波束管... 详细信息

随着载波频率的不断提高和大规模天线阵列的广泛部署,基于模拟移相器的波束赋形成为下一代无线通信的标志性技术之一。此时,波束管理被用于获取和维护基站和用户端具有最大接收功率的最优波束对,以保障可靠的无线通信服务。传统波束管理方法往往依赖于海量搜索。同时,传统数学模型无法全面的、准确刻画非线性的波束的内在关联和高维无线环境特征,因而难以取得令人满意的波束增益性能。近年来,得益于深度学习强大的自适应拟合能力,深度学习赋能波束管理得到了国内外广泛关注。本文总结了深度学习赋能波束管理的研究进展,并展望了未来的研究方向。首先,阐述了深度学习应用于波束管理的典型场景和潜在优势;随后,从空/时/频域切入,讨论当前深度学习赋能波束管理的主要研究路线和代表性工作;最后,面向更大规模的无线网络、更多元的波束管理功能和更鲁棒的深度学习模型,阐述未来的研究挑战与机遇。

关键词：深度学习波束管理空域时域频域

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Softening of phonon spectra in metallic glasses

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npj Computational Materials 2016年第1期2卷 31-35页

作者： Reza Mahjoub Nicholas E Hamilton ke.in j laws Michael Ferry School of Materials Science and Engineering The University of New South WalesSydneyNSWAustralia

The vibrational spectra of a series of MgZnCa amorphous alloys were computed using density functional theory and implementing the small displacement *** atomic structures of the alloys were obtained by ab initio molecular dynamics *** vibrational thermodynamic properties were calculated as a function of temperature and,in particular,the specific heat at low temperature was approximated by temperature cubed based on the Debye *** computed the contribution of Mg vibrations to the specific heat and investigated the softening of Mg phonon spectra,where the maximum allowed vibrational frequency is lowered and highly collective diffusion processes are *** statistical correlation between the reported critical casting thickness of the alloys and softening of Mg phonons was *** calculations were performed for two distinctively different amorphous ZrTiCuAl alloys with large and small reported critical casting thickness,*** findings were consistent with those of the MgZnCa alloys.

关键词： alloys softening casting

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渗透氢对BCC金属裂纹扩展行为的影响

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原子与分子物理学报 2025年第4期42卷 45-52页

作者：朱云蝶赵可可张吉鼎江晓禹西南交通大学力学与航空航天学院成都611756

在氢环境下,氢原子会吸附在金属材料表面.随着时间推移,氢原子会渗透进入金属内部占据空隙位置.氢原子的聚集会导致应力集中,最终进一步影响材料的力学行为.本文通过分子动力学方法研究氢在裂纹尖端行为的力学响应.研究结果表明,裂纹尖... 详细信息

在氢环境下,氢原子会吸附在金属材料表面.随着时间推移,氢原子会渗透进入金属内部占据空隙位置.氢原子的聚集会导致应力集中,最终进一步影响材料的力学行为.本文通过分子动力学方法研究氢在裂纹尖端行为的力学响应.研究结果表明,裂纹尖端吸附的氢降低了原子间的键合力,导致局部应力集中所需的临界外加载荷减小;使得材料在较低的断裂强度条件下发生破坏,并在很大程度上促进了裂纹的扩展.模拟观察到在外加载荷下吸附氢在裂纹尖端的渗透过程,氢原子会聚集在高应力区域,造成材料塑性降低.另外,渗透进材料的氢原子数目会随着计算时间的增加达到一个最大临界值.当施加应变增大,裂纹尖端渗透氢原子数最大临界值和达到临界值的时间会增加.

关键词：分子动力学裂纹扩展氢渗透塑性损失

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Effect of Austenite Ageing on Martensitic Transformation

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journal of Materials Science & Technology 1997年第6期13卷 508-514页

作者： Chen, QZ Wu, XF Wei, LY ke, j Univ Sci & Technol Beijing Dept Mat Phys Beijing 100083 Peoples R China

The effect of austenite ageing on martensite transformation in an iron and nickel alloy was studied. Attention was paid to the variation of dislocation configurations in austenite before martensite transformation, The clusters or precipitates produced during austenite ageing and the alteration of dislocation configurations affect together the consequent martensite transformation. Dispersed fine clusters and precipitates cripple nucleus role of special dislocation configurations and drop M-s. Coarse precipitates make M-g rise again. Densely piled up dislocations in nuclei lead to rise of M-s. All the changes in austenite are of benefit to small martensite plates.

关键词： Iron alloys

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Iodoacetic acid exposure alters the transcriptome in mouse ovarian antral follicles

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journal of Environmental Sciences 2022年第7期34卷 46-57页

作者： Andressa Gonsioroski Mary laws Vasiliki E.Mourikes Alison Neff jenny Drnevich Michael j.Plewa jodi A.Flaws Department of Comparative Biosciences University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Roy j.Carver Biotechnology Center University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Department of Crop Sciences and the Safe Global Water Institute University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA

Iodoacetic acid(IAA) is an unregulated water disinfection byproduct that is an ovarian toxicant. However, the mechanisms of action underlying IAA toxicity in ovarian follicles remain unclear. Thus, we determined whether IAA alters gene expression in ovarian follicles in mice. Adult female mice were dosed with water or IAA(10 or 500 mg/L) in the water for 35-40 days. Antral follicles were collected for RNA-sequencing analysis and sera were collected to measure estradiol. RNA-sequencing analysis identified 1063 differentially expressed genes(DEGs) in the 10 and 500 mg/L IAA groups(false discovery rate FDR key candidate genes and pathways involved in IAA toxicity and can help to further understand the molecular mechanisms of IAA toxicity in ovarian follicles.

关键词： Disinfection byproducts Iodoacetic acid Ovary Ovarian follicles Steroidogenesis Endocrine disruptors

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第一性原理对M@B_(12)N_(12)(M=Sc-Zn)团簇结构和性质的研究

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原子与分子物理学报 2025年第4期42卷 93-99页

作者：张颂程露吴学科凯里学院理学院凯里556011

利用基于密度泛函理论的第一性原理对M@B_(12)N_(12)(M=Sc-Zn)团簇的几何、电子结构,电偶极性和红外吸收光谱进行详细的研究.结果显示:当B_(12)N_(12)团簇内嵌过渡金属原子后,虽然结构稳定性稍稍降低,但其化学活性得到提高,摩尔体积明... 详细信息

利用基于密度泛函理论的第一性原理对M@B_(12)N_(12)(M=Sc-Zn)团簇的几何、电子结构,电偶极性和红外吸收光谱进行详细的研究.结果显示:当B_(12)N_(12)团簇内嵌过渡金属原子后,虽然结构稳定性稍稍降低,但其化学活性得到提高,摩尔体积明显增大.过渡金属原子与B_(12)N_(12)结合的过程中,除Cu和B原子外,剩余金属与N原子的Mulliken电荷出现负值.另外,金属原子的加入,不仅增加电偶极矩和极化率的值,还促使其红外吸收光谱发生红移.

关键词：团簇结构性质第一性原理

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碳排放权交易制度的权利逻辑与规范进路

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河北大学学报（哲学社会科学版） 2025年第1期50卷 123-134页

作者：柯坚曹辰武汉大学环境法研究所湖北武汉430072

当下我国碳排放权交易制度体系正在经历着由政策引领向法治构建的转变。目前碳排放权交易制度行政立法中简单将“权利”与“配额”等同的做法,既无法体现碳排放权所兼具的公法、私法双重特征,也难以有效回应碳排放权交易市场的发展需求... 详细信息

当下我国碳排放权交易制度体系正在经历着由政策引领向法治构建的转变。目前碳排放权交易制度行政立法中简单将“权利”与“配额”等同的做法,既无法体现碳排放权所兼具的公法、私法双重特征,也难以有效回应碳排放权交易市场的发展需求以及完善碳排放权交易制度的规范构建。为此,需要构建以碳排放权交易市场为语境、以碳排放“权利”为逻辑主线的碳排放权交易制度,夯实其法治基础并明确其规范进路。从语境与语义出发,“碳排放权”的表述本身就意味着其私法的权利属性。在碳排放权交易制度的理论逻辑层面,双阶理论可以为碳排放权交易制度中“配额”到“权利”的过渡提供理论支撑;在其实践逻辑层面,碳排放权交易制度需要借助“权利”的确立为其交易市场的展开提供法治的基础。最后,考虑到碳排放权权利属性共识不足、碳排放权交易制度结构尚待稳定、权利基础呈现多元特征以及权利来源并非稳固不变等因素,策略上可以考虑暂时搁置碳排放权权属争议,以权益为抓手、以“权益表现—适用规范领域—法律保护方式”为主线,分步骤、分阶段推进碳排放权交易制度的规范构建。

关键词：碳排放权权益配额权利逻辑规范进路

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Unraveling transition-metal-mediated stability of spinel oxide via in situ neutron scattering

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journal of Energy Chemistry 2022年第5期31卷 60-70页

作者： Yan Chen ke An Neutron Scattering Division Oak Ridge National LaboratoryOak RidgeTN 37831USA

The energy materials performance is intrinsically determined by structures from the average lattice structure to the atom arrangement, valence, and distribution of the containing transition metal(TM) elements. Understanding the mechanism of the structure transition and atom rearrangement via synthesis or processing is key to expediting the exploration of excellent energy materials. In this work, in situ neutron scattering is employed to reveal the real-time structure evolution, including the TM-O bonds, lattice,TM valence and the migration of the high-voltage spinel cathode LiNi_(0.5)Mn_(1.5)O_(4). The transition-metalmediated spinel destabilization under the annealing at the oxygen-deficient atmosphere is *** formation of Mn^(3+) is correlated to the TM migration activation, TM disordered rearrangement in the spinel, and the transition to a layered-rocksalt phase. The further TM interdiffusion and Mn^(3+) reduction are also revealed with multi-stage thermodynamics and kinetics. The mechanisms of phase transition and atom migrations as functions of temperature, time and atmosphere present important guidance on the synthesis in various-valence element containing oxides.

关键词： In situ neutron diffraction Pair distribution function Energy storage material Material synthesis High-temperature phase transition Disordering Atomic interdiffusion

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