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Outcomes of patients with pelvic leiomyosarcoma treated by surgery and relevant auxiliary diagnosis

World Journal of Clinical Cases 2020年第10期8卷 1887-1896页

作者： Qian Sun Xin Yang zhen Zeng Xiao Wei ke-zhen li Xiao-Yan Xu Department of Obstetrics and Gynaecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Leiomyosarcoma is a subtype of soft tissue sarcoma with adverse *** accounts for nearly 70%of all uterine sarcomas and is responsible for a considerable proportion of deaths because of uterine *** characteristics and relevant diagnosis of pelvic leiomyosarcoma should be further *** To identify the outcome and relevant perioperative evaluation of patients with pelvic *** The Kaplan-Meier method was used to determine progression-free survival and overall survival *** predictive of outcomes were identified using univariate and multivariate Cox proportional hazards *** Fifty-one patients with pelvic leiomyosarcoma were enrolled and divided into two groups including uterine leiomyosarcoma and non-uterine ***,28.6%and 45.5%of uterine leiomyosarcoma and non-uterine leiomyosarcoma patients,respectively,had elevated carbohydrate antigen 125 levels,whereas 45.7%and 68.8%,respectively,underwent *** 68.8%of uterine leiomyosarcoma patients were initially diagnosed with hysteromyoma,72.7%of non-uterine leiomyosarcoma patients had pelvic and abdominal ***,93.3%of the recurrent lesions were detected using *** with International Federation of Gynaecology and Obstetrics(FIGO)stages III–IV disease had poorer progression-free survival values than those with FIGO stages I–II(P=0.027)*** stage was significantly associated with poor progression-free survival in the univariate(hazard ratio=2.64,P=0.03)and multivariate(hazard ratio=2.49,P=0.048)*** Serum tumour biomarkers cannot be used for pelvic leiomyosarcoma *** stage is critical to predict the outcome of uterine *** is more reliable for postoperative follow-up than preoperative diagnosis.

关键词： Uterine leiomyosarcoma Non-uterine leiomyosarcoma Serum biomarker Prognosis Ultrasonography

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Clinical characteristics and survival of patients with normal-sized ovarian carcinoma syndrome: Retrospective analysis of a single institution 10-year experiment

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World Journal of Clinical Cases 2020年第21期8卷 5116-5127页

作者： Nan Yu Xi li Bin Yang Jing Chen Ming-Fu Wu Jun-Cheng Wei ke-zhen li Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Normal size ovarian cancer syndrome(NOCS)is a challenge for clinicians regarding timely diagnosis and management due to atypical clinical and imaging *** is extremely rare with only a few cases reported in the *** data are needed to clarify its biological behavior and compare the differences with abnormal size ovarian *** To assess the clinical and pathological features of NOCS patients treated in our institution in the last 10 years and to explore risk factors for relapse and *** Patients who were pathologically diagnosed with NOCS between 2008 and 2018 were *** serous ovarian carcinoma(PSOC)patients were initially randomly recruited as the control ***,tumor characteristics,treatment procedures,and clinical follow-up were retrospectively *** factors for progression-free survival and overall survival were *** A total of 110 NOCS patients were included;80(72.7%)had primary adnexal carcinoma,two(1.8%)had mesotheliomas,18(16.4%)had extraovarian peritoneal serous papillary carcinoma,and eight(7.3%)had metastatic *** antigen(CA)125 and ascites quantity were lower in the NOCS cohort than in the PSOC *** only statistically significant risk factors for worse overall survival(Plinical symptoms of the NOCS group are atypical,and the misdiagnosis rate is *** cytology and laparoscopic exploration are valuable in the early diagnosis to avoid a *** level of CA199 is the most important predictor of overall survival,and more than six cycles of chemotherapy contributes to the increased survival rates of NOCS patients.

关键词： Normal-sized ovarian carcinoma syndrome Ovarian cancer Survival Prognostic factors Epithelial ovarian carcinomas Carbohydrate antigen 125

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Influence of Different Quality Sperm on Early Embryo Morphokinetic Parameters and Cleavage Patterns:A Retrospective Time-lapse Study

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Current Medical Science 2020年第5期40卷 960-967页

作者： Qiu-yue liAO Bo HUANG Si-jia ZHANG Jing CHEN Ge CHEN ke-zhen li Ji-hui AI Reproductive Medicine Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

To investigate whether sperm with low concentration and motility can impact preimplantation embryos and to analyze how the effects present under a time-lapse incubation system,2905 oocytes were collected from 219 couples between January 2014 and December *** were divided into three groups according to sperm *** parameters and six cleavage patterns in the initial three cleavages were evaluated using the Primo Vision *** quality and clinic outcomes such as implantation rate,pregnancy rate and live birth rate were *** results showed that the concentration and motility of sperm correlated strongly with the rate of 2PN embryos,good-quality embryos on D3,blastocysts on D5/6 and good quality embryos on D5/*** time-lapse system recordings showed that compromised sperm quality could result in a significant delay in cc l and a decrease in cc2,and impact embryo developmental potential mainly through large fragments or/and blastomere fragmentation in the initial three *** conclusion,sperm with low concentration and motility can have paternal effects on preimplantation *** paternal effects present both as changes in morphokinetic parameters and cleavage patterns,which occur as early as fertilization and may cause severe damage to the preimplantation embryos.

关键词： embryo development patermal effect time-lapse morphokinetic parameters cleavage patterns

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Oncological and Reproductive Outcomes of Fertility-sparing Surgery in Women with Early-stage Epithelial Ovarian Carcinoma:A Multicenter Retrospective Study

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Current Medical Science 2020年第4期40卷 745-752页

作者： Jing CHEN Fen-fen WANG Yan ZHANG Bin YANG Ji-hui AI Xin-yu WANG Xiao-dong CHENG ke-zhen li Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gynecologic Oncology Women's HospitalZhejiang UniversityHangzhou 310006China Reproductive Medicine Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Summary:With delayed childbearing in women,preservation of fertility is an important issue for reproductive-age patients with epithelial ovarian carcinoma(EOC).Fertility-sparing surgery(FSS)can be considered in patients with early-stage disease in order to preserve fertility and improve quality of *** order to evaluate oncological safety,attitudes toward childbearing and reproductive outcomes in women with EOC who underwent FSS,this multicenter retrospective study was *** January 2005 and December 2014,total of 87 young women with FIGO stage I EOC were included,with their clinicopathologic parameters in relation to disease-free survival(DFS)and overall survival(OS)*** toward childbearing,ovarian function and fertility were studied in women undergoing FSS(n=36).As a result,in contrast to radical sur ery,FSS did not affect prognosis by Kaplan-Meier curves(log-rank test;DFS:P=0.484;OS:P=0.125).However,two of the three recurrence cases and both death cases were in FSS group stage *** women undergoing FSS resumed regular menstrual periods after *** 16(44.44%)had tried to conceive,and 17 pregnancies occurred in 15(93.75%)*** 20 women who did not attempt conception,the most common reason was not being married(70%),followed by already having children(15%).In summary,FSS is considered safe in young women with stage IA *** menstruation and good obstetric outcomes can be *** study also provides some insight into the attitudes and social factors regarding fertility in EOC patients.

关键词： epithelial ovarian cancer fertility outcome fertility preservation fertility sparing surgery ovarian function

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Adjuvant Chemotherapy May Not Be Necessary for Women with Stage IC1 Epithelial Ovarian Cancer

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Current Medical Science 2022年第1期42卷 192-200页

作者： Dong-mei DENG Qiu-yue liAO Jie YANG Jing CHEN Ge CHEN Hua-lin BAI Bo ZHANG ke-zhen li Department of Gynecology and Obstetrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:To determine whether adjuvant chemotherapy improves the prognoses in women with stage IC1 epithelial ovarian cancer(EOC).Methods:All eligible women diagnosed with stage IC1 EOC from 2003 to 2019 in Tongji Hospital were *** characteristics,tumor features,surgical types,and chemotherapeutic treatments were ***-Meier analysis and Cox regression analysis were performed to evaluate progression-free survival(PFS)and overall survival(OS).

关键词： adjuvant chemotherapy epithelial ovarian cancer intraoperative rupture overall survival progression-free survival

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Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai li zhen Ma Jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

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Ni-Mn杂化对Mn_(50)Ni_(41-x)Sn_9Cu_x合金中马氏体相变温度和马氏体相磁性的影响

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物理学报 2016年第24期65卷 170-176页

作者：申建雷李萌萌赵瑞斌李国科马丽甄聪棉候登录河北师范大学物理科学与信息工程学院石家庄050024

研究了Ni-Mn杂化对Mn_(50)Ni_(41-x)Sn_9Cu_x合金马氏体相变温度和马氏体相磁性的影响.研究表明:在Mn_(50)Ni_(41-x)Sn_9Cu_x(x=0,1,3,5)合金中,随着Cu含量增加,马氏体相变温度和居里温度均降低;自发交换偏置场也随着Cu含量的增加从1182... 详细信息

研究了Ni-Mn杂化对Mn_(50)Ni_(41-x)Sn_9Cu_x合金马氏体相变温度和马氏体相磁性的影响.研究表明:在Mn_(50)Ni_(41-x)Sn_9Cu_x(x=0,1,3,5)合金中,随着Cu含量增加,马氏体相变温度和居里温度均降低;自发交换偏置场也随着Cu含量的增加从1182 Oe(1 Oe=79.5775 A/m)降低到0 Oe.马氏体相变温度和马氏体相磁性的变化归因于掺杂Cu削弱了体系中Ni 3d eg与Mn 3d之间的杂化.

关键词： Mn50Ni41-xSn9Cux合金 Ni-Mn杂化马氏体相变交换偏置

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Coronavirus disease 2019 in pregnant and non-pregnant women:a retrospective study

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Chinese Medical Journal 2021年第10期134卷 1218-1220页

作者： Ying Zha Ge Chen Xun Gong Yuan-Yuan Wu Xing-Guang lin Jian-li Wu Ya-Fei Huang Yu-Qi li Ying Zhang Dong-Rui Deng Su-Hua Chen Fu-Yuan Qiao ling Feng Wan-Jiang Zeng ke-zhen li Hai-Yi liu Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Pathogen Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Coronavirus disease 2019(COVID-19)arises from infection with the new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).[1]The susceptible population can be of any age and gender;thus,the disease threatens the health and life of everyone,including pregnant *** can influence the physiological function of various organs,and thus may affect the prognosis of many infectious *** example,higher mortality rates and more complications were reported in pregnant patients infected with SARS-CoV than those in non-pregnant patients.

关键词： organs mortality acute

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liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing liu Hongli li Lemei Zhu lingfeng Zeng zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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From blocker to booster:Harnessing garnet surface chemistry for advanced solid-state electrolytes

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Nano Research 2025年第1期18卷 323-331页

作者： Jun Cheng Xuan Zhou Hongqiang Zhang zhen Zeng Yuanyuan li Yulong Zhu Yingsheng liao lijie Ci Deping li State key Laboratory of Precision Welding and Joining of Materials and Structures School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China

Garnet electrolytes with high ionic conductivity and electrochemical stability are widely used as fillers to fabricate composite solid electrolytes(CPEs)within polymer ***,the performance of CPEs is significantly influenced by the surface characteristics of the garnet ***,the impact of garnet surface characteristics on CPEs was systematically investigated and a conversion from a typically unstable and Lewis basic surface to a more stable Lewis acidic surface was realized,which is shown to be more conductive to the improved performance of *** simultaneously removing the li_(2)CO_(3)layer and applying a li-Al-O coating,the influence of surface characteristics on CPEs was *** Lewis acid li-Al-O surface coating not only promotes lithium salt dissociation,improving the ionic conductivity and ionic transfer number,but also prevents the reformation of the passive Lewis basic li_(2)CO_(3)*** to garnet with a Lewis basic li_(2)CO_(3)surface,the garnet modified with a Lewis acid li-Al-O coating enhances CPEs,which exhibit an improved critical current density of 1.0 mA·cm^(-2)and highly stable lithium symmetric cell cycling for 400 h at 0.2 mA·cm^(-2).This research highlights the importance of surface chemistry in the design of high-performance solid-state batteries and presents a strategic modification approach for garnetbased CPEs.

关键词： garnet electrolyte composite solid electrolyte surface chemistry all-solid-state batteries

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