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Degradable magnesium alloy suture promotes fibrocartilaginous interface regeneration in a rat rotator cuff transosseous repair model

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Journal of Magnesium and Alloys 2024年第1期12卷 384-393页

作者： Baoxiang zh.ng Wen zh.ng Fei zh.ng Chao Ning Mingyang An ke Yang Lili Tan Qiang zh.ng Department of Sports Medicine Chinese PLA General HospitalBeijing 100853China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Medical School of PLA Beijing 100853China Institute of Orthopedics Chinese PLA General HospitalBeijing Key Lab of Regenerative Medicine in OrthopedicsKey Lab of Musculoskeletal Trauma&War Injuries of Chinese PLABeijing 100853China

Despite transosseous rotator cuff tear repair using sutures is widely accepted for tendon-bone fixation,the fibrocartilaginous enthesis regeneration is still hardly achieved with the traditional *** the present work,degradable magnesium(Mg)alloy wire was applied to suture supraspinatus tendon in a rat acute rotator cuff tear model with Vicryl Plus 4±0 absorbable suture as *** shoulder joint humerus-supraspinatus tendon complex specimens were retrieved at 4,8,and 12 weeks after *** Mg alloy suture groups showed better biomechanical properties in terms of ultimate load to *** observation showed that hyperplastic response of the scar tissue at the tendon-bone interface is progressively alleviated over time in the both Mg alloy suture and Vicryl suture *** the histological analysis,for Mg alloy suture groups,chondrocytes appear to proliferate at 4 weeks postoperatively,and the tendon-bone interface showed an orderly structural transition zone at 8 weeks *** collagenous fiber tended to be aligned and the tendon-bone interlocking structures apparently formed,where transitional structure from unmineralized fibrocartilage to mineralized fibrocartilage was closer to the native fibrocartilaginous *** vivo degradation of the magnesium alloy wire was completed within 12 *** results indicated that Mg alloy wire was promising as degradable suture with the potential to promotes fibrocartilaginous interface regeneration in rotator cuff repair.

关键词： Rotator cuff repair Mg alloy wire Tendon-bone healing Fibrocartilaginous interface

Fabrication and Characterization of Ca-Mg-P Containing Coating on Pure Magnesium

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Journal of Materials Science & Technology 2012年第7期28卷 636-641页

作者： Yanjin Lu Lili Tan Honglia. ng Xiang Bingchun zh.ng ke Yang Yangde Li Institute of Metal Researchl Chinese Academy of Sciences -Shenyang 110016 China School of Mechanical Engineering and Automation Fuzhou University ~zhou 350108 China Dongguan EONTEC Co. Ltd. Dongguan 523662 China

A biodegradable Ca-P coating mainly consisting of β-tricalcium phosphate （β-TCP） was fabricated on pure magnesium via the chemical deposition in a simulated Hank’s solution. The method significantly accelerated the coating formation on magnesium. Moreover, the morphology, phase/chemical composition, the coating formation mechanism as well as degradation behavior in phosphate buffered saline （PBS） solution were in- vestigated. Scanning electron microscopy （SEM） images showed that the coating had three layers and X-ray diffraction （XRD） patterns showed that the coating mainly contained Ca3（PO4）2 and （Ca,Mg）3（PO4）2. Elec- trochemical test showed that the corrosion current density （Icorr） of the coated Mg was decreased by about one order of magnitude as compared to that of pure magnesium. The immersion test indicated that the coating could obviously reduce the degradation rate.

关键词： Magnesium β-tricalcium phosphate (β-TCP) Biodegradation Chemicaldeposition

Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min LIU Hao SU Meng-qing LI Lan YU Ai-ling CHEN ken HUAng Yun-ke zhAO Qiu-long HUAng Wen-ya HUAng Xi Institute of Traditional Chinese Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,Pkedly abolished by ng-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3K/AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

Efficacy and safety of Xileisan combined with mesalazine for ulcerative colitis:A meta-analysis and trial sequential analysis

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World Journal of Clinical Cases 2024年第21期12卷 4703-4716页

作者： Xin-Yu Yang Yun-Feng Yu ke-ke Tong Gang Hu Rong Yu Lian-Jun Su School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND The benefits and risks of Xileisan(XLS)in the treatment of ulcerative colitis(UC)remain *** The present study aimed to evaluate the efficacy and safety of the combination of XLS and mesalazine when treating *** We searched eight databases for clinical trials evaluating the combination of XLS and mesalazine in the treatment of UC,up to January ***-analysis and trial sequential analysis(TSA)were performed using Revman 5.3 and TSA 0.***.5.10 beta,*** The present study included 13 clinical studies involving 990 patients,of which 501 patients received XLS combined with mesalazine while 489 patients received mesalazine *** meta-analysis showed that,in terms of efficacy,the combination of XLS and mesalazine significantly improved the clinical efficacy rate by 22%[risk ratio(RR)=1.22;95%CI:1.15–1.28;Png the duration of abdominal pain by 2.25 days[mean difference(MD)=-2.25;95%CI:-3.35 to-1.14;Png/mL(MD=-16.25;95%CI:-20.48 to-12.01;Png/mL(MD=-14.14;95%CI:-24.89 to-3.39;P=0.01).The TSA indicated conclusiveness in the meta-analysis of the efficacy *** terms of safety,the meta-analysis revealed that the combination of XLS and mesalazine did not increase the occurrence of total and gastrointestinal adverse events,abdominal distension,and erythema(P>0.05).The TSA showed non conclusive findings in the meta-analysis of the safety ***’s test showed no publication bias(P=0.734).CONCLUSION Treatment with XLS alleviated the clinical symptoms,intestinal mucosal injury,and inflammatory response in patients with UC,while demonstrating good safety.

关键词： Xileisan Mesalazine Ulcerative colitis Meta-analysis Trial sequential analysis

定向凝固条件下Ti_(3)Al合金中梯度纳米结构的形成机制与力学行为——原子尺度研究

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Transactions of Nonferrous Metals Society of China 2024年第5期34卷 1507-1519页

作者：邹鹏飞李昌侯兆阳 Jia-yi SUN 高全华李克凡王真 ke-jun DOng 长安大学理学院西安710064 Faculty of Natural Mathematics&Engineering SciencesKing’s College LondonLondonWC2R 2LSUnited Kingdom School of Engineering Design and Built EnvironmentWestern Sydney UniversityPenrithNSW 2751Australia

通过分子动力学(MD)模拟方法对Ti_(3)Al合金在定向凝固条件下的生长机理进行系统研究,并通过对比纳米晶(ng)、粗晶(CG)和梯度纳米晶(Gng)合金,研究Ti_(3)Al合金的结构力学性能。结果表明,在凝固过程中Ti_(3)Al相优先生长为等轴晶组织,... 详细信息

通过分子动力学(MD)模拟方法对Ti_(3)Al合金在定向凝固条件下的生长机理进行系统研究,并通过对比纳米晶(ng)、粗晶(CG)和梯度纳米晶(Gng)合金,研究Ti_(3)Al合金的结构力学性能。结果表明,在凝固过程中Ti_(3)Al相优先生长为等轴晶组织,随后逐渐演变为柱状粒,并最终形成梯度纳米晶结构。此时,晶粒在与凝固方向平行的方向优先生长。此外,研究还发现,相较于ng和CG结构,Gng结构定向凝固合金具有更高的抗拉强度和更好的延展性。Gng结构不仅有效抑制了小晶粒区域的应变局域化和晶粒生长,而且促进了较大晶粒区域的位错形成,从而获得更好的力学性能。

关键词：定向凝固 Ti_(3)Al合金分子动力学模拟梯度纳米结构

Effects of Medicines and Supplements on Spontaneous Pregnancy and Semen Parameters in Male Infertility:A Systematic Review Update and Network Meta-Analysis

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Engineering 2022年第9期16卷 198-209页

作者： Jian Li Qi Wu Ernest Hung Yu ng Ben Willem J.Mol Xiao ke Wu Chi Chiu Wang Department of Obstetrics and Gynecology First Affiliated HospitalHeilongjiang University of Chinese MedicineHarbin 150040China Department of Obstetrics and Gynecology The Affiliated Hospital of Gui Zhou Medical UniversityGuiyang 550004China Department of Obstetrics and Gynaecology Prince of Wales HospitalThe Chinese University of Hong KongHong Kong 999077China Department of Obstetrics and Gynecology Obstetrics and Gynecology HospitalFudan UniversityShanghai 30009China Department of Obstetrics and Gynaecology Queen Mary HospitalThe University of Hong KongHong Kong 999077China Department of Obstetrics and Gynaecology Monash UniversityClaytonVIC 3168Australia Heilongjiang Provincial Hospital Harbin Institute of TechnologyHarbin 150036China Reproduction and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077China i School of Biomedical SciencesThe Chinese University of Hong KongHong Kong 999077China The Chinese University of Hong Kong–Sichuan University Joint Laboratory of Reproductive Medicine Hong Kong 999077China

In this study,we used a network meta-analysis(NMA)to compare the effectiveness of medicines and supplements for idiopathic male infertility and to identify the best ***,Excerpta Medica Database(EMBASE),Ovid,and China National Knowledge Infrastructure(CNKI),were searched for the period from January 1990 to June 2021 using the keywords"male infertility,""medical therapy,""supplement/nutrient therapy,"and related *** controlled trials(RCTs)investigating medicines(mainly follicle-stimulating hormone(FSH),androgen,and clomiphene/tamoxifen)or supplements(mainly zinc,selenium,vitamin C or E,carnitine,coenzyme Q10(CoQ10),or combined treatment)for idiopathic infertile men were selected for *** reporting items for systematic reviews and meta-analysis(PRISMA)was used for data extraction,and a risk-of-bias tool and grades of recommendation,assessment,development,and evaluation(GRADE)system adapted to the NMA were employed to assess the quality of the *** primary outcomes were live birth and spontaneous pregnancy rate(SPR).The secondary outcomes were sperm parameters(including concentration,progressive motility,and morphology)and side *** total,65 RCTs involving 7541 men with sperm abnormalities but normal hormone levels were included.A total of 36 studies reported SPR but only three reported live birth *** quality of the included studies was found to be moderate to *** with a placebo or being untreated,carnitine plus vitamins significantly improved SPR(relative risk(RR)=3.7,95%confidence interval(95%CI),1.6-8.5);fatty acids significantly increased sperm concentrations(mean difference(MD)=12.5×10^(6)mL-1,95%CI,3.1×10^(6)-22.0×10^(6));and selective estrogen receptor modulator(SERM)plus CoQ10 significantly improved sperm progressive motility(MD=11.0%,95%CI,0.1%-21.9%)and normal sperm morphology(MD=11.0%,95%CI,4.6%-17.4%).The most optimal intervention was carnitine plus vitamins and fatty acids for SPR a

关键词： Male infertility Medicine Supplement Spontaneous pregnancy rate Sperm parameters

Modeling the high-energy emission from the gamma-ray binary 1FGL J1018.6–5856

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Research in Astronomy and Astrophysics 2021年第8期21卷 46-58页

作者： A-Ming Chen Chowing ng Jumpei Takata Yun-Wei Yu School of physics Huazhong University of Science and TechnologyWuhan 430074China Department of Physics The University of Hong KongPokfulam RoadHong KongChina College of Physical Science and Technology Central China Normal UniversityWuhan 430079China

1FGL J1018.6–5856 is a high mass gamma-ray binary containing a compact object orbiting around a massive star with a period of 16.544 *** the compact object is a pulsar,non-thermal emissions are likely produced by electrons accelerated at the termination shock,and may also originate from the magnetosphere and the un-shocked wind of the *** this paper,we investigate the non-thermal emissions from the wind and the shock with different viewing geometries and study the multi-wavelength emissions from 1FGL J1018.6–*** present the analysis results of the Fermi/LAT using nearly 10 years of *** phase-resolved spectra indicate that the Ge V emissions comprise a rather steady component that does not vary with orbital motion and a modulated component that shows flux maximum around inferior *** ke V/Te V light curves of 1FGL J1018.6–5856 also exhibit a sharp peak around inferior conjunction,which are attributed to the boosted emission from the shock,while the broad sinusoidal modulations could be originating from the deflected shock tail at a larger *** modulations of Ge V flux are likely caused by the boosted synchrotron emission from the shock and the IC emission from the unshocked pulsar wind,while the steady component comes from the outer gap of the pulsar ***,we discuss the similarities and differences of 1FGL J1018.6–5856 with other binaries,like LS 5039.

关键词： binaries:close gamma rays:stars X-rays:binaries radiation mechanisms:non-thermal

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社区老年人自然干预措施范围综述

风景园林 2024年第5期31卷 39-53页

作者：赖锦玉李玉丽李同予伍尚美王克芳杨文嘉(译) 羿可(译) 美国护理科学院中国香港护理专科学院中国香港山东大学护理与康复学院哈尔滨工业大学建筑与设计学院哈尔滨工业大学寒地城乡人居环境科学与技术工业和信息化部重点实验室香港理工大学康复治疗科学系中国香港香港理工大学中医药创新研究中心中国香港

【目的】健康老龄化是世界卫生组织(World Health Organization,WHO)提倡的一项优先政策,旨在创造能够支持老年人健康积极生活的环境,提高老年人的健康水平。目前,学界对自然干预措施(nature-based interventions,NBIs)的研究方兴未艾,N... 详细信息

【目的】健康老龄化是世界卫生组织(World Health Organization,WHO)提倡的一项优先政策,旨在创造能够支持老年人健康积极生活的环境,提高老年人的健康水平。目前,学界对自然干预措施(nature-based interventions,NBIs)的研究方兴未艾,NBIs日益受到科学家和学者的关注。【方法】采用范围综述的方法探讨针对社区老年人的NBIs类型及其理论框架。运用史蒂芬斯数据库(EBSCOhost)对Academic Search Premier、Art&Architecture Complete、CINAHL Complete、Education Resources Information Center(ERIC)、GreenFILE、MEDLINE 6个数据库进行检索。检索文献的语种涵盖中、英文,但仅检索到英文文献,最终共纳入22篇文献进行分析。【结果】关于老年人NBIs类型的研究成果较为多样化,但仅有3篇文献探讨了理论框架。尽管健康老龄化已被WHO列入全球国家政策议程的关键优先事项,但是检索到的文献都聚焦于个体健康,没有一篇侧重于老年群体的健康促进。【结论】老年人是一个特殊群体,随着年龄的增长,身体机能会逐渐下降,然而他们有着个性化的需求,因此在为老年人制订健康促进计划时需要特别注意。研究人员和从业人员需要把握当前形势,以宏观、系统的视角来审视健康问题。

关键词：自然干预措施园艺疗法社区老年人健康促进范围综述

Evidence-based interventions of threatened miscarriage

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World Journal of Traditional Chinese Medicine 2017年第1期3卷 32-34页

作者： Juan Li Jing-shu Gao Chi Chiu Wang Ernest HY ng Xiao-ke Wu Department of Traditional Chinese Medicine The First Affiliated Hospital of Guangzhou Medical University Department of Obstetrics & Gynaecology National Key Discipline and Clinical Base Heilongjiang University of Chinese Medicine Department of Obstetrics & Gynaecology The Chinese University of Hong Kong Hong Kong Special Administrative Region Department of Obstetrics & Gynaecology The University of Hong Kong Hong Kong Special Administrative Region

Threatened miscarriage is the commonest complication of early pregnancy and affects about 20% of pregnancies. It presents with vaginal bleeding with or without abdominal cramps. Increasing age of women, smoking, obesity or polycystic ovary syndrome(PCOS) and a previous history of miscarriage are risk factors for threatened miscarriage. The pathophysiology has been associated with changes in levels of cytokines or maternal immune dysfunction. Clinical history and examination, maternal serum biochemistry and ultrasound findings are important to determine the treatment options and provide valuable information for the prognosis. Bed rest is the commonest advice, but there is little evidence of its value. Other options include progesterone, human chorionic gonadotropin(HCG) and muscle relaxants. The complementary and alternative medicine(CAM) therapies such as acupuncture and Chinese herbs have also been tried. There is some evidence from clinical studies indicating that CAM therapies may reduce the rate of miscarriage, but the quality of studies is poor. Thus, further double-blind,randomized-controlled trials are necessary to confirm its effectiveness, especially acupuncture and Chinese herbs.

关键词： Threatened miscarriage Evidence-based Intervention Complementary and alternative medicine