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Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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Neural Regeneration Research 2025年第4期20卷 960-972页

作者： kedong zhu Hualong Wang keqiang Ye Guiqin Chen Zhaohui Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurology The First Hospital of Hebei Medical UniversityBrain Aging and Cognitive Neuroscience Laboratory of Heibei ProvinceShijiazhuangHebei ProvinceChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal *** profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic *** amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of *** findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative *** a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关键词： Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways Netrin-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C

Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang zhu Chenxi Ding Zhe Sui Hong Su Xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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不同木麻黄无性系对木毒蛾抗性评价

福建林学院学报 2013年第1期33卷 67-72页

作者：黄金水曾丽琼蔡守平柯玉铸何学友福建省林业科学研究院国家林业局南方山地用材林培育重点实验室福建福州350012

通过2010-2011年连续2 a木毒蛾取食选择性试验和不同木麻黄无性系饲养幼虫的发育和排粪量的调查,选育抗木毒蛾的木麻黄优良种质材料。结果表明,湛江3、惠76、惠83、广东A8-2为抗木毒蛾的木麻黄无性系,木毒蛾幼虫对这4个无性系的取食相... 详细信息

通过2010-2011年连续2 a木毒蛾取食选择性试验和不同木麻黄无性系饲养幼虫的发育和排粪量的调查,选育抗木毒蛾的木麻黄优良种质材料。结果表明,湛江3、惠76、惠83、广东A8-2为抗木毒蛾的木麻黄无性系,木毒蛾幼虫对这4个无性系的取食相对频数小于0.03,其饲养的木毒蛾幼虫平均化蛹率在55%以内,最低的仅有20%,平均蛹重在0.6 g以下,排粪量少;东山2号、广东501、抗风属于感虫无性系,木毒蛾幼虫对这3个无性系的取食相对频数超过0.08,其饲养的木毒蛾平均化蛹率在70%以上,平均蛹重大于0.66 g。

关键词：木麻黄木毒蛾幼虫无性系抗虫性

Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu ke Wang Jia-zhu Wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Stabilities of delay stochastic Mckean-Vlasov equations in the G-framework

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Science China(Information Sciences) 2025年第1期68卷 255-277页

作者： Haiyan yuAN Quanxin zhu Department of Mathematics Heilongjiang Institute of Technology key Laboratory of Computing and Stochastic Mathematics (Ministry of Education) School of Mathematics and Statistics Hunan Normal University

This article focuses on a type of stochastic Mc kean-Vlasov equation in the G-framework(G-SMVE) and addresses the stability issue for delay stochastic Mc kean-Vlasov equations in the G-framework(G-SMVDEs). Distribution dependence and uncertainty prevent us from directly applying the stochastic analysis method for stochastic Mc kean-Vlasov equations(SMVEs)to G-SMVEs directly. To overcome this difficulty, we introduce definitions, including the derivative of a function with a law under the G-expectation and the Lions derivatives. Then we construct a new G-It? formula for G-SMVEs according to the G-It? formula for stochastic differential equations in the G-framework(G-SDEs) and the It? formula for SMVEs. Using the new G-It? formula and the Lyapunov functional method, we investigate the moment exponential stability and almost sure asymptotic stability of G-SMVDEs. To overcome the difficulty in obtaining the distribution dependence of the exact solution to the G-SMVDE, we introduce the empirical measure and the corresponding interacting particle system, and then prove the stability equivalence between the underlying G-SMVDE and the corresponding interacting particle system. Two examples are used to confirm our theoretical results.

关键词： delay stochastic Mckean-Vlasov equations Wasserstein distance G-Brownian motion Lions derivative stability

Software-defined process-near-memory architecture using 3D hybrid bonding integration

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Science China(Information Sciences) 2025年第1期68卷 366-378页

作者： Anlin XU Chenchen DENG Jianfeng zhu Yao WANG Shaojun WEI Leibo LIU School of Integrated Circuits Tsinghua University Beijing Institution of Tracking and Communication Technology Beijing National Research Center for Information Science and Technology Tsinghua University

With the unprecedented explosive growing amount of global data, the development of computing chips, which encounter bottlenecks such as power wall and memory wall, cannot satisfy the demanding requirement. This work proposes a software-defined process-near-memory(SDPNM) computing architecture implemented using 3D hybrid bonding *** software-defined chip architecture, featuring spatial computations and dynamic reconfiguration, innovates in a top-down manner to achieve high energy efficiency while maintaining flexibility after fabrication. The process-near-memory integration further advances the SDNPM chip in a bottom-up way to reduce the energy consumption of data movement while improving the bandwidth. Utilizing a relatively mature fabrication and bonding process can result in feasible solutions for both data-intensive and compute-intensive applications including digital signal processing and artificial intelligence. The logic die is fabricated in the SMIC 40 nm process and the DRAM die is fabricated in the PSMC 25 nm process. The hybrid bonding is implemented by XMC. The experimental results show that the energy efficiency of the proposed SDPNM chip is 33.1× better than the state-of-the-art FPGA ranging from 8.2× to 104.1×.

关键词： software-defined chips process near memory energy efficiency dynamic reconfiguration domain specific

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Secure beamforming and deployment design for rate-splitting multiple access-based UAV communications

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Science China(Information Sciences) 2025年第1期68卷 342-356页

作者： Bing WANG Xiaofeng TAO Shujun HAN Huici WU Kai YANG zhu HAN National Engineering Research Center of Mobile Network Technologies Beijing University of Posts and Telecommunications Peng Cheng Laboratory Department of Electrical and Computer Engineering University of Houston

Rate-splitting multiple access(RSMA) has recently gained attention as a potential robust multiple access(MA)scheme for upcoming wireless networks. Given its ability to efficiently utilize wireless resources and design interference management strategies, it can be applied to unmanned aerial vehicle(UAV) networks to provide convenient services for large-scale access ground users. However, due to the line-of-sight(LoS) broadcast nature of UAV transmission, information is susceptible to eavesdropping in RSMA-based UAV networks. Moreover, the superposition of signals at the receiver in such networks becomes complicated. To cope with the challenge, we propose a two-user multi-input single-output(MISO) RSMA-based UAV secure transmission framework in downlink communication networks. In a passive eavesdropping scenario, our goal is to maximize the sum secrecy rate by optimizing the transmit beamforming and deployment location of the UAV-base station(UAV-BS),while considering quality-of-service(QoS) constraints, maximum transmit power, and flight space limitations. To address the non-convexity of the proposed problem, the optimization problem is first decoupled into two subproblems. Then, the successive convex approximation(SCA) method is employed to solve each subproblem using different propositions. In addition, an alternating optimization(AO)-based location RSMA(L-RSMA) beamforming algorithm is developed to implement joint optimization to obtain the suboptimal solution. Numerical results demonstrate that(1) the proposed L-RSMA scheme yields a28.97% higher sum secrecy rate than the baseline L-space division multiple access(SDMA) scheme;(2) the proposed L-RSMA scheme improves the security performance by 42.61% compared to the L-non-orthogonal multiple access(NOMA) scheme.

关键词： rate-splitting multiple access UAV communication precoding optimization deployment location physical layer security

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Wafer‑Scale Ag_(2)S‑Based Memristive Crossbar Arrays with Ultra‑Low Switching‑Energies Reaching Biological Synapses

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Nano-Micro Letters 2025年第3期17卷 328-339页

作者： yuan zhu Tomas Nyberg Leif Nyholm Daniel Primetzhofer Xun Shi Zhen Zhang Division of Solid‑State Electronics Department of Electrical EngineeringUppsala University75121 UppsalaSweden Department of Chemistry Uppsala UniversityUppsalaSweden Department of Physics and Astronomy Uppsala UniversityUppsalaSweden State key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China

Memristive crossbar arrays(MCAs)offer parallel data storage and processing for energy-efficient neuromorphic ***,most wafer-scale MCAs that are compatible with complementary metal-oxide-semiconductor(CMOS)technology still suffer from substantially larger energy consumption than biological synapses,due to the slow kinetics of forming conductive paths inside the memristive *** we report wafer-scale Ag_(2)S-based MCAs realized using CMOS-compatible processes at temperatures below 160℃.Ag_(2)S electrolytes supply highly mobile Ag+ions,and provide the Ag/Ag_(2)S interface with low silver nucleation barrier to form silver filaments at low energy *** further enhancing Ag+migration in Ag_(2)S electrolytes via microstructure modulation,the integrated memristors exhibit a record low threshold of approximately−0.1 V,and demonstrate ultra-low switching-energies reaching femtojoule values as observed in biological *** low-temperature process also enables MCA integration on polyimide substrates for applications in flexible ***,the intrinsic nonidealities of the memristive units for deep learning can be compensated by employing an advanced training *** impressive accuracy of 92.6%in image recognition simulations is demonstrated with the MCAs after the *** demonstrated MCAs provide a promising device option for neuromorphic computing with ultra-high energy-efficiency.

关键词： Wafer-scale Ag_(2)S films Reactive sputter Silver nucleation Ag^(+)migration Energy-efficient neuromorphic computing

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凝胶注模法制备复杂形状钨铜复合材料

稀有金属与硬质合金 2017年第4期45卷 28-33页

作者：陶庆良魏瑶瑶李邦怿谢海林吴坷朱玉斌上海大学材料科学和工程学院上海200444

利用非水基体系凝胶注模法制备了复杂形状钨铜复合材料坯体。研究了分散剂含量以及固相含量对钨铜浆料黏度的影响,绘制了坯体的室温干燥曲线并制订了干燥制度,同时对坯体微观形貌、抗弯强度等进行了表征和测试。结果表明:分散剂添加量为... 详细信息

利用非水基体系凝胶注模法制备了复杂形状钨铜复合材料坯体。研究了分散剂含量以及固相含量对钨铜浆料黏度的影响,绘制了坯体的室温干燥曲线并制订了干燥制度,同时对坯体微观形貌、抗弯强度等进行了表征和测试。结果表明:分散剂添加量为0.15%(质量分数,基于金属粉末质量)时浆料黏度达到最低,在此基础上浆料的固相含量可达到45%(体积分数),满足凝胶注模的要求;坯体先在室温下干燥10h后放入100℃的恒温干燥箱中干燥8h,可得到表面无变形、无开裂的钨铜坯体;随着固相含量的增大,坯体致密性和均匀性均随之提高;坯体表面质量较好,抗弯强度可达到26.9 MPa。

关键词：钨铜复合材料坯体复杂形状凝胶注模成形浆料黏度分散剂