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RNA Structural Dynamics Modulate EGFR-TKI Resistance Through Controlling YRDC Translation in NSCLC Cells

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Genomics, Proteomics & Bioinformatics 2023年第4期21卷 850-865页

作者： Boyang shi ke An Yueqin Wang Yuhan Fei Caixia Guo Qiangfeng Cliff Zhang Yun-Gui Yang xin Tian Quancheng Kan Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan key Laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou 450052China key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China MOE key Laboratory of Bioinformatics Center for Synthetic and Systems BiologyBeijing Advanced Innovation Center for Structural BiologyTsinghua-Peking Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China

Epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs)positively affect the initial control of non-small cell lung cancer(NSCLC).Rapidly acquired resistance to EGFR-TKIs is a major hurdle in successful ***,the mechanisms that control the resistance of EGFR-TKIs remain largely *** structures have widespread and crucial functions in many biological regulations;however,the functions of RNA structures in regulating cancer drug resistance remain ***,the psoralen analysis of RNA interactions and structures(PARIS)method is used to establish the higher-order RNA structure maps of EGFRTKIs-resistant and-sensitive cells of *** results show that RNA structural regions are enriched in untranslated regions(UTRs)and correlate with translation efficiency(TE).Moreover,yrdC N6-threonylcarbamoyltransferase domain containing(YRDC)promotes resistance to *** structure formation in YRDC 30 UTR suppresses embryonic lethal abnormal vision-like 1(ELAVL1)binding,leading to EGFR-TKI sensitivity by impairing YRDC translation.A potential therapeutic strategy for cancer treatment is provided using antisense oligonucleotide(ASO)to perturb the interaction between RNA and *** study reveals an unprecedented mechanism through which the RNA structure switch modulates EGFR-TKI resistance by controlling YRDC mRNA translation in an ELAVL1-dependent manner.

关键词： RNA structure EGFR-TKI resistance Non-small cell lung cancer YRDC ELAVL1

Research Status and Strategies for Cognitive Function in Schizophrenia

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上海精神医学 2018年第3期30卷 199-201页

作者： ke MA Chuan shi Peking University Sixth Hospital Beijing China

Cognition is divided into neurocognition and social cognition,both of which are interconnected with each other and yet are mutually ***,which is based on neuroanatomical structures,function connections,neuroelectrophy... 详细信息

关键词：精神分裂症认知功能神经解剖学神经功能认知过程生物学社会大脑

Effect of cerium on microstructure,eutectic carbides and Laves phase in electroslag remelted 15Cr-22Ni-1Nb austenitic heat-resistant steel

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Journal of Iron and Steel Research International 2023年第2期30卷 338-349页

作者： xin Zhu Cheng-bin shi shi-jun Wang Peng Lan Jing Li State key Laboratory of Advanced Metallurgy University of Science and Technology Beijing(USTB)Beijing100083China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China

The dendrites,eutectic carbides,Laves phase and microsegregation of alloying element in electroslag remelted 15Cr-22Ni-1Nb austenitic heat-resistant steel with varying cerium contents were *** liquidus and solidus temperatures of the steel were determined to reveal the effect of cerium on solidification temperature interval and local solidification time of the *** secondary dendrite arm spacing decreases from 57.10 to 40.18μm with increasing the cerium content from 0 to 0.0630 wt.%.The eutectic NbC and Laves phase in as-cast ingots exhibit blocky and honeycomb morphology,*** area fractions and sizes of eutectic NbC and Laves phase in as-cast ingots decrease with the increase in cerium *** atomic percentage of Laves phase-forming element(Ni,Nb,Cr,Mo and Si)decreases with the increase in cerium content of the *** microsegregation of Mo,Ni,Si,Cr and Nb decreases with increasing the cerium content,which is favorable to reducing both the amount and sizes of eutectic NbC and Laves phase in as-cast *** solidification temperature interval and local solidification time of the steel decrease as the cerium content is increased from 0 to 0.0630 wt.%,which inhibits the growth of dendrites,eutectic NbC and Laves phase.

关键词： Heat-resistant steel Rare earth cerium Eutectic NbC Laves phase Microsegregation Solidification characteristics

Preparation of Macroporous Poly (vinyl alcohol-co-triallyl isocyanurate) Beads Bearing Aminocarboxylic Acid as Functional Groups by Suspension Polymerization

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Chinese Chemical Letters 2003年第3期14卷 267-269页

作者： Hai Tao LI ke Yu shi 等 DepartmentofChemistry HunanNormalUniversityChangsha410081 TheStatekeyLaboratoryofFunctionalPolymerMaterialsforAdsorptionandSeparation InstituteofPolymerChemistrynankaiUniversity

Macroporous poly (vinyl acetate-co-triallyl isocyanurate) beads were prepared with suspension polymerization method. The copolymer beads were then transformed into poly (vinyl alcohol-co-triallyl isocyanurate) by ester exchange reaction. Aminocarboxylic acids were immobilized on the copolymer beads by the esterification of hydroxyl groups with diethyl-lenetriaminepentaacetic bisanhydride. The weak acid exchange capacities, specific surface areas and mean pore diameters of the resultant resin beads were measured.

关键词： Macroporous adsorption resin suspension polymerization poly (vinyl alcohol-co-triallyl isocyanurate) aminocarboxylic acid.

Prophylactic stenting for esophageal stricture prevention after endoscopic submucosal dissection

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World Journal of Gastroenterology 2017年第6期23卷 931-934页

作者： ke-Da shi Feng Ji Department of Gastroenterology First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

Endoscopic submucosal dissection (ESD) of superficial esophageal cancer has been increasingly used as an alternative to surgery because it is minimally invasiveand has a high rate of en bloc resection. However, a high rate of esophageal stricture is observed after ESD for large lesions, which can dramatically decrease the patient's quality of life. Stricture prevention is necessary to allow for endoscopic therapy to expand. We, herein, review the most recent evidence and discuss the role of the metallic self-expandable stent and the biodegradable stent in esophageal stricture prevention. Limited studies suggested that prophylactic stenting could reduce the stricture rate without increasing the number of complications. In addition, the number of bougie dilation procedures was significantly lower with stent placement. Esophageal stenting is a promising option for post-ESD stricture prevention. However, current evidence is too preliminary to formulate practice standards. Future studies are needed to further validate the efficacy and safety of prophylactic stenting and determine the best strategy for stricture prevention. Stent migration is the most common complication. A new stent that has advantages of a low migration rate and minimal tissue reaction will need to be developed. Therefore, randomized controlled trials with long-term follow-up periods are required before prophylactic stenting could be considered a valid option to prevent post-ESD stricture.

关键词： Biodegradable stent Stricture prevention Esophageal stricture Metallic self-expandable stent Endoscopic submucosal dissection

Thermally-triggered grain boundary relaxation in a nanograined Ni-Mo-W alloy

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Nano Research 2023年第11期16卷 12800-12808页

作者： Dongsong Zeng Jiongxian Li Yinong shi Xiuyan Li ke Lu Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Conventionally,nanograined metals and alloys can be stabilized through segregating foreign elements at grain boundaries(GBs).Yet such an effect may be offset by formation of second phase at elevated *** this paper,by introducing minor W into a binary Ni-Mo alloy,we found precipitation of intermetallic phases was suppressed,enhancing thermal stability of the nanograined *** faceted GBs and a high-fraction ofΣ3 coincidence site lattice(CSL)boundaries illustrate that GB structures are relaxed by formation of copious annealing *** W reduces stacking fault energy of the solid solution and facilitates the thermally-triggered GB *** precipitation of the intermetallic phases may be attributed to depletion of solutes at relaxed GBs.

关键词： grain boundary relaxation nanograined ternary alloy thermal stability stacking fault energy

A dilute fluorine-free electrolyte design for high-voltage hybrid aqueous batteries

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Journal of Energy Chemistry 2023年第2期77卷 180-190,I0005页

作者： Rui Lin Jiahao Chen Changming ke shi Liu Jianhui Wang School of Materials Science&Engineering Zhejiang UniversityHangzhou 310024ZhejiangChina key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024ZhejiangChina Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhou 310024ZhejiangChina key Laboratory for Quantum Materials of Zhejiang Province Department of PhysicsSchool of ScienceWestlake UniversityHangzhou 310030ZhejiangChina Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024ZhejiangChina

Fluorinated salts and/or high salt concentrations are usually necessary to produce protective films on the electrodes for high-voltage aqueous batteries,yet these approaches increase the cost,toxicity and reaction resistances of ***,we report a dilute fluorine-free electrolyte design to overcome this *** using the LiClO_(4) salt and polyethylene glycol dimethyl ether(PED)solvent and optimizing the LiClO_(4)/PED/H_(2)O molar ratio,we formulate a 1 mol kg^(-1)3 V-class hybrid aqueous electrolyte that enables reversible charge/discharge of 2.5 V LiMn_(2)O_(4)|Li_(4)Ti_(5)O_(12) full cell at both low(0.5C,92.4%capacity retention in 300 cycles)and high(5C,80.4%capacity retention in 2000 cycles)*** excellent performance is reached even without the generation of protective film on either anode or cathode as identified by in/ex situ *** selection of appropriate ingredients that have both high stability and strong interactions with water is critical to widen the potential window of electrolyte while suppressing parasitic reactions on the *** work suggests that expensive and toxic fluorinate salts are no longer necessary for 3 V-class aqueous electrolytes,boosting the development of low-cost,environmentally-friendly,high-power and high-energy-density aqueous batteries.

关键词： High-voltage hybrid aqueous batteries Fluorine-free electrolyte design Interphase chemistry Polyethylene glycol dimethyl ether

On the Random Conjugate Spaces of a Random Locally Convex Module

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Acta Mathematica Sinica,English Series 2012年第4期28卷 687-696页

作者： Tie xin GUO shi En ZHAO LMIB and School of Mathematics and Systems Science Beihang University

Theoretically speaking, there are four kinds of possibilities to define the random conjugate space of a random locally convex module. The purpose of this paper is to prove that among the four kinds there are only two which are universally suitable for the current development of the theory of random conjugate spaces. In this process, we also obtain a somewhat surprising and crucial result： if the base （Ω,F, P） of a random normed module is nonatomic then the random normed module is a totally disconnected topological space when it is endowed with the locally L0-convex topology.

关键词： Random locally convex module (ε λ)-topology locally L0-convex topology random con-jugate space

Computing the k-error joint linear complexity of binary periodic multisequences

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The Journal of China Universities of Posts and Telecommunications 2013年第6期20卷 96-101页

作者： LI Fu-lin ZHU shi-xin School of Mathematics Hefei University of Technology

Complexity measures for multisequences over finite fields, such as the joint linear complexity and the k-error joint linear complexity, play an important role in cryptology. In this paper we study a fast algorithm, presented by Venkateswarlu A, to computer the k-error joint linear complexity of a binary periodic multisequence. In this paper, the aim is mainly to complement the theoretical derivation and proof of the existing algorithm. Moreover, our algorithm reduces computation.

关键词： cryptology multisequence algorithm joint linear complexity k-error joint linear complexity