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In vitro degradation and cytocompatibility of a low temperature in-situ grown self-healing Mg-Al LDH coating on MAO-coated magnesium alloy AZ31

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Bioactive Materials 2020年第2期5卷 364-376页

作者： Chang-Yang Li Ling Gao Xiao-Li Fan Rong-Chang Zeng Dong-Chu Chen ke-qian zhi Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao266590China Department of Oral and Maxillofacial Surgery The Affiliated Hospital of Qingdao UniversityQingdaoShandong266555China key Lab of Oral Clinical Medicine The Affiliated Hospital of Qingdao UniversityQingdaoShandong266555China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China School of Materials Science and Energy Engineering Foshan UniversityFoshan528000China

Basically,Mg–Al layered double hydroxide(LDH)coatings are prepared on the surface of micro-arc oxidation(MAO)coated magnesium(Mg)alloys at a high temperature or a low pH *** scenario leads to the growth rate of LDH coating inferior to the dissolution rate of the MAO *** in turn results in limited corrosion resistance of the composite *** this study,a Mg–Al LDH coating on MAO-coated Mg alloy AZ31 is prepared through a water bath with a higher pH(13.76)at a lower temperature(60℃).FE-SEM,EDS,XRD,XPS,and FT-IR are applied to analyze the surface morphology,chemical compositions,and growth *** polarization,electrochemical impedance spectroscopy(EIS)and hydrogen evolution tests are employed to evaluate the corrosion resistance of the *** results disclose that the MAO coating is completely covered by the nanosheet-structured LDH coating with a thickness of approximately 3.8μ*** corrosion current density of the MAO-LDH composite coating is decreased four orders of magnitude in comparison to its substrate;the presence of a wide passivation region in anodic polarization branch demonstrates its strong self-healing ability,indicating the hybrid coating possesses excellent corrosion *** formation mechanism of the LDH coating on the MAO-coated Mg alloy is ***,the cytocompatibility is assessed via an indirect extraction test for MC3T3-E1 pre-osteoblasts,which indicates an acceptable cytocompatibility of osteoblasts for the composite coating.

关键词： Magnesium alloy Micro-arc oxidation Layered double hydroxide Corrosion resistance Cytocompatibility

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In vitro corrosion resistance,antibacterial activity and cytocompatibility of a layer-by-layer assembled DNA coating on magnesium alloy

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Journal of Magnesium and Alloys 2021年第1期9卷 266-280页

作者： Lan-Yue Cui Ling Gao Jing-Chao Zhang Zhe Tang Xiao-Li Fan Jia-Cheng Liu Dong-Chu Chen Rong-Chang Zeng Shuo-Qi Li ke-qian zhi College of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Department of Oral and Maxillofacial Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266555China key Lab of Oral Clinical Medicine The Affiliated Hospital of Qingdao UniversityQingdao 266555China School of Materials Science and Energy Engineering Foshan UniversityFoshan 528000China

A chitosan/deoxyribonucleic acid(CHI/DNA)_(5)coating was constructed by layer-by-layer(LbL)assembly dip coating method with Mg(OH)_(2)coating as an inner protective layer on AZ31 alloy.X-ray diffractometry,X-ray photoelectron spectrometry,Fourier transform infrared spectroscopy and field-emission scanning electron microscopy were utilized to represent the chemical compositions and surface morphologies of the *** tests and hydrogen evolution measurements were implemented to confirm the good corrosion resistance of the composite coating in artificial body *** activity of the composite coatings was tested via the plate-counting method,and the cytotoxicity of the samples was appraised by MTT assay and Live/dead staining.A double action was put into effect for the composite coating,which the inner Mg(OH)2 coating plays the part of physical barrier,and the outer(CHI/DNA)5 coating is employed as an inducer to fabricate a biocompatible Ca-P corrosion product coating during immersion,making up for its thin ***,the composite coating is also beneficial for the growth of bone,resulting from the biomineralization effect of the outer polyelectrolyte *** good antibacterial property of the(CHI/DNA)5/Mg(OH)2 coating is ascribed to the contact-killing strength of ***,the obtained(CHI/DNA)5/Mg(OH)2 coating has a wide application prospect in the field of Mg-based bone implantation.

关键词： Magnesium alloys Coatings Layer-by-layer assembly Biomaterials Antibacterial properties Corrosion

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Co-expression and Immunity of Legionella pneumophila mip Gene and Immunoadjuvant ctxB Gene

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Acta Biochimica et Biophysica Sinica 2005年第3期37卷 199-204页

作者： Tao WANG Jian-Ping CHEN Hong LI ke-qian zhi Lei ZHANG Chun-Lei YANG Da-Chang TAO School of Precliaical and Forensic Medicine of West China,Sichuan University,Chengdu 610041,China School of Stomatolngy,Xi'an Jiaotong University,Xi'an 710004,China School of Life Science,Sichuan University,Chengdu 610041,China School of Preclinical and Forensic Medicine of West China Sichuan UniversityChengdu 610041 China School of Stomatology Xi'an Jiaotong UniversityXi'an 710004 China School of Life Science Sichuan UniversityChengdu 610041 China

The mip gene of Legionella pneumophila and the ctxB gene of Vibrio cholerae were amplifiedby PCR *** amplified cDNA was ligated to the pcDNA3.1(+)*** recombinant plasmidspcDNA3,1-mip and pcDNA3.1-ctxB were identified by restriction analysis and PCR,and further confirmedby sequencing ***3T3 cells were transfected with pcDNA3.1-mip and pcDNA3.1-ctxB accordingto the Lipofection *** and stable products of the co-expression of the mip gene and ctxB genewere detected by immunofluorescence and Western *** results showed that NIH3T3 cells weresuccessfully transfected,and that the transiently and stably co-expressed products can be detected in thetransfected *** detect the humoral and cellular immune response in immunized mice induced by the co-immunization of the mip and ctxB genes,female BALB/c mice were immunized intramuscularly with pcDNA3.1-mip and *** results showed that the specific antibody titer and the cytotoxic T-lymphocyteresponse for pcDNA3,1-mip immunization and co-immunization were increased compared with that ofpcDNA3.1(+) ***,the specific antibody titer and cytotoxic T-lymphocyte responsefor co-immunization were increased compared with that of pcDNA3.1-mip *** analysisusing one-way analysis of variance(ANOVA)showed that there was a significant difference between thegroups(P<0.01).The results indicated that the ctxB gene enhanced the humoral and cellular immune responseto the mip gene *** findings provide experimental evidence to support the development ofthe *** DNA vaccine.

关键词： Legionella pneumophila co-expression humoral immunity cellular immunity

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Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu Sheng Pang Liangwei Cong Guoyu qian Dong Wang Laishi Li Yusheng Wu zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： ke Jiang zhi Chen Ji Yu Chen Zheng Shan Huang Ming Wang Chongqing key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-zhi Wu qian-qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： zhi-Hui Zheng Bo Shao Chao-Min Xu ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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Conversion of cadherin isoforms in cultured human gastriccarcinoma cells

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World Journal of Gastroenterology 2006年第6期12卷 966-970页

作者： Bing-Jing Wang zhi-qian Zhang Yang ke Beijing Institutefor Cancer Research and School of Oncology Peking UniversityBeijing 100034 China

AIM： To explore the expression of cadherin isoforms in cultured human gastric carcinoma cells and its regulation. METHODS： The expressions of cell adhesion molecules （including E-cadherin, N-cadherin, α-catenin, β-catenin） and cadherin transcription factors including snail, slug and twist were determined by reverse transcriptasepolymerase chain reaction（RT-PCR）, immunoblotting and immunofluorescence in SV40-immortalized human gastric cell line Ges-1 and human gastric cancer cell lines MGC-803, BGC-823 and SGC-7901. RESULTS： All cell lines expressed N-cadherin, but not E-cadherin. N-cadherin immunofluorescence was detected at cell membranous adherents junctions where co-localization with immunofluorescent staining of inner surface adhesion proteins α- and β-catenins was observed. The transformed Ges-1 and gastric cancer cell lines all expressed transcription factors （snail, slug and twist） which inhibited the expression of E-cadherin and triggered epithelial-mesenchymal transformation. CONCLUSION： Cadherin isoforms can change from E-cadherin to N-cadherin in transformed human gastric cancer cells, which is associated with intracellular events of stomach carcinogenesis and high expression of corresponding transcription factors.

关键词： E-cadherin N-cadherin Transcription factor Gastric cancer

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Interface strengthening for thermal sprayed WC-10Co4Cr coating subjected to pulsed magnetic treatment

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Rare Metals 2024年第2期43卷 780-795页

作者： Cheng-Kai qian Qu Liu Heng Wang ke-Jian Li zhi-Peng Cai Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Tianjin Research Institute for Advanced Equipment Tsinghua UniversityTianjin300304China State key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing100084China

The reliability of the coated industry components demands ideal fatigue properties of the coating,and it is mainly determined by the performance of the *** this study,pulsed magnetic treatment(PMT)was applied to the thermal sprayed WC-10Co4Cr coating,and the fatigue lifetime of the coated bolt increased by 219.82%under an imitation of the operating mode *** tests further proved that both the adhesion and cohesion strength were improved after PMT,and they benefit from the interface strengthening *** formation of coherent WC/Co interfaces was characterized by in-situ transmission electron microscopy(TEM),and the molecular dynamic simulations indicate that the work of separation of these interfaces is much higher than the original disordered *** stress was relaxed and distributed more homogeneously after PMT,and it mainly contributes to the coating/substrate *** work provides a new post-treatment method focusing on the interfaces in the WC-based coating and gives insight into its mechanism so that it is hopeful to be applied to other kinds of coatings.

关键词： Cemented carbide coating Pulsed magnetic treatment Interface strengthening Fatigue properties Adhesion strength

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Simultaneous approach for simulation of a high-temperature gas-cooled reactor

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第7期12卷 567-574页

作者： Yang CHEN Jiang-hong YOU zhi-jiang SHAO ke-xin WANG Ji-xin qian State key Laboratory of Industrial Control Technology Zhejiang University Hangzhou 310027 China

The simulation of a high-temperature gas-cooled reactor pebble-bed module(HTR-PM) plant is *** lumped parameter model has the form of a set differential algebraic equations(DAEs) that include stiff equations to model point neutron *** nested approach is the most common method to solve DAE,but this approach is very expensive and time-consuming due to inner *** paper deals with an alternative approach in which a simultaneous solution method is *** DAEs are discretized over a time horizon using collocation on finite elements,and Radau collocation points are *** resulting nonlinear algebraic equations can be solved by existing *** discrete algorithm is discussed in detail;both accuracy and stability issues are ***,the simulation results are presented to validate the efficiency and accuracy of the simultaneous approach that takes much less time than the nested one.

关键词： Differential algebraic equations(DAEs) High-temperature gas-cooled reactor(HTR) Simulation Simultaneous approach

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