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An Efficient Synthesis of Dicyclohexylmethyl Diazoacetate

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Chinese Chemical Letters 1999年第6期10卷 435-436页

作者： Zheng ning li Zhuo ZHENG Hut lin CHEN(Dalian Institute of Chemical Physies. the Chinese Aeademy of Sciences. Dalian 116023) Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

Dicyclohexylmethyl diazoacetate was synthesized in excellent yield from the corresponding glycinate. which was derived in high yield from dicyclohexylmethyl chloroacetate via azide substitutuion, and reduction.

关键词： synthesis alkyl diazoacetate alkyl azidoacetate

Study on the Roles of FWUA in Construction, Management and Maintenance of Small-Scale Irrigation and Water Conservancy

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Asian Agricultural Research 2013年第4期5卷 139-144页

作者： Shaoshu li ke YUAN School of Public Administration South China University of Technology

In recent years, China has been frequented by floods and droughts which has greatly evoked much concern from the Central Government about rural water conservancy construction. Irrigation is closely related to the "three rural" issues and concerns about the vital interests of farmers. To achieve a virtuous circle of agricultural water supply, it is necessary and urgent to establish Farmer Water User Association (FWUA) to participate in the construction, management and maintenance of small-scale irrigation system. Based on the survey on nationwide "Small-scale irrigation conditions", the roles of FWUA in the construction, management and maintenance of small-scale water conservancy have studied in this study.

关键词： Small-scale irrigation FWUA Construction Managemen

Synchronized lineage tracing of cell membranes and nuclei by dual recombinases and dual fluorescent

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Journal of Genetics and Genomics 2024年第12期51卷 1474-1484页

作者： Xueying Yang Shun He Xufeng li Zhihou Guo Haichang Wang Zhuonan Zhang Xin Song ke Jia lingjuan He Bin Zhou School of life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences School of life Sciences Westlake University New Cornerstone Science Laboratory State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences University of Chinese Academy of Sciences School of life Science and Technology Shanghai Tech University

Genetic lineage tracing has been widely employed to investigate cell lineages and fate. However, conventional reporting systems often label the entire cytoplasm, making it challenging to discern cell boundaries. Additionally, single Cre-lox P recombination systems have limitations in tracing specific cell populations. This study proposes three reporting systems utilizing Cre, Dre, and Dre+Cre mediated recombination. These systems incorporate td Tomato expression on the cell membrane and Phi YFP expression within the nucleus, allowing for clear observation of the nucleus and membrane. The efficacy of these systems is successfully demonstrated by labeling cardiomyocytes and hepatocytes. The potential for dynamic visualization of the cell membrane is showcased using intravital imaging microscopy or threedimensional imaging. Furthermore, by combining this dual recombinase system with the Pro Tracer system, hepatocyte proliferation is traced with enhanced precision. This reporting system holds significant importance for advancing the understanding of cell fate studies in development, homeostasis, and diseases.

关键词： lineage tracing Dual recombinases system Cre-loxP Dre-rox Cell membrane and nucleus labeling ProTracer system

Influence of As_2O_3 combined with ginsenosides Rg3 on inhibition of lung cancer NCI-H1299 cells and on subsistence of nude mice bearing hepatoma

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Asian Pacific Journal of Tropical Medicine 2014年第10期7卷 772-775页

作者： Jian-Bo Che Zhong-Hua liu Hong-Bing Ma Yong li Hui Zhao Xiao-Hui li Wei-Chao liu Gong-ning Shi Huaihe River Hospital Henan University

Objective:To study the effect of arsenic trioxide（As2O3）combined with ginsenosides Rg3 on inhibiting the NCI-H1299 lung cancer cells and subsistence in nude mice bearing ***:MTT method was used to measure the inhibition effect of（As2O3）combined Rg3 on NC1-H1299 cells,and the proliferation inhibiting effect was observed via establishing the transplanted tumor model in vitro.A total of 40 tumor-bearing nude mice were randomly divided into normal saline group,（As2O3）,Rg3 and As2O3+Rg3 *** tumor model of lung cancer in nude mice was constructed,followed by injection of certain concentrations of normal saline,As2O3,ginseng saponin Rg3 and As2O3+Rg3 every *** survival duration and the tumors size of the mice were recorded and the Kaplan-Meier curve was made;microscopic observation of apoptosis of tumor cells in vivo was done using TUNEL ***:After 72 h of *** rate of tumor cell in normal saline group,As2O3 ***3 group and As2O3+Rg3 group was（5.66±0.31）%,（65.58±4.75）%,（44.69±3.32）%and（82.67±5.43）%,*** rate of tumor cell in As2O3 ***3 groap and As2O3+Rg3 group was significantly higher than that of normal saline group（Pline group was 1.21 times of the original size（Pline group,Rg3 group,As2O3 group were significantly shorter than that of As2O3+Rg3 group（Plity of As2O3+Rg3 on NCI-H1299 cell was significantly higher than that of As2O3 or Rg3,***:As2O3 combined with Rg3 can significantly inhibit prolifaration of NCI-H1299 cells in lung cancer,prolong survival fo tumor-bearing nude mice,and promote tumor cell

关键词： As_2O_3 Rg3 Lung cancer Combination therapy

A Fiber Tractography Study of Social-Emotional Related Fiber Tracts in Children and Adolescents with Autism Spectrum Disorder

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Neuroscience Bulletin 2017年第6期33卷 722-730页

作者： Yun li Hui Fang Wenming Zheng Lu Qian Yunhua Xiao Qiaorong Wu Chen Chang Chaoyong Xiao Kangkang Chu Xiaoyan ke Nanjing Brain Hospital Affiliated to Nanjing Medical University Child Mental Health Research Center key Laboratory of Child Development and Learning Science of the Ministry of Education Research Center for Learning Science Southeast University

The symptoms of autism spectrum disorder（ASD） have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the‘‘disconnectivity＇＇ hypothesis has been used to explain characteristic impairments in ‘‘socio-emotional＇＇ ***, in this study we compared the facial emotional recognition（FER） feature and the integrity of socialemotional-related white-matter tracts between children and adolescents with high-functioning ASD（HFA） and their typically developing（TD） counterparts. The correlation between the two factors was explored to find out if impairment of the white-matter tracts is the neural basis of social-emotional disorders. Compared with the TD group,FER was significantly impaired and the fractional anisotropy value of the right cingulate fasciculus was increased in the HFA group（P ／ 0.01）. In conclusion, the FER function of children and adolescents with HFA was impaired and the microstructure of the cingulate fasciculus had abnormalities.

关键词： Autism spectrum disorder Facial emotional recognition Social-emotional related white matter fiber tracts Diffusion tensor imaging Tractography

Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model

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Regenerative Biomaterials 2021年第2期8卷 74-84页

作者： Bei Qian Jialun li ke Guo Nengqiang Guo Aimei Zhong Jie Yang Jiecong Wang Peng Xiao Jiaming Sun lingyun Xiong Department of Plastic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology1277 Jiefang AvenueWuhan 430022China Wuhan Clinical Research Center for Superficial Organ Reconstruction Wuhan 430022China

Associated with persistent oxidative stress,altered inflammatory responses,poor angiogenesis and epithelization,wound healing in diabetic patients is impaired.N-acetylcysteine(NAC)is reported to resist excess reactive oxygen species(ROS)production,prompt angiogenesis and maturation of the *** have revealed that graphene oxide(GO)can regulate cellular behavior and form cross-links with naturally biodegradable polymers such as collagen(COL)to construct composite ***,we reported a COL-based implantable scaffold containing a mixture of GO capable of the sustained delivery of NAC to evaluate the wound healing in diabetic *** morphological,physical characteristics,biocompatibility and NAC release profile of the GO-COL-NAC(GCN)scaffold were evaluated in *** healing studies were performed on a 20mm dorsal full-skin defect of streptozotocin(STZ)-induced diabetic *** injured skin tissue was removed at the 18th day post-surgery for histological analysis and determination of glutathione peroxidase(GPx),catalase(CAT)and superoxide dismutase(SOD)*** diabetic rats,we confirmed that the GCN scaffold presented a beneficial effect in enhancing the wound healing ***,due to the sustained release of NAC,the scaffold may potentially induce the antioxidant defense system,upregulating the expression levels of the antioxidant enzymes in the wound *** findings revealed that the antioxidant biocompatible composite collagen dressing could not only deliver NAC in situ for ROS inhibition but also promote the wound healing *** scaffold with valuable therapy potential might enrich the approaches for surgeon in diabetic wound treatment in the future.

关键词： collagen graphene oxide N-acetylcysteine sustained release diabetic wound healing

linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study

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World Journal of Gastroenterology 2023年第12期29卷 1899-1910页

作者： Zi-Xin Wang Long-Song li Song Su Jin-Ping li Bo Zhang Nan-Jun Wang Sheng-Zhen liu Sha-Sha Wang Shuai Zhang Ya-Wei Bi Fei Gao Qun Shao ning Xu Bo-Zong Shao Yi Yao Fang liu En-Qiang linghu ning-li Chai Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND Lugol chromoendoscopy(LCE)has served as a standard screening technique in high-risk patients with esophageal ***,LCE is not suitable for general population screening given its side *** color imaging(LCI)is a novel image-enhanced endoscopic technique that can distinguish subtle differences in mucosal *** To compare the diagnostic performance of LCI with LCE in detecting esophageal squamous cell cancer and precancerous lesions and to evaluate whether LCE can be replaced by LCI in detecting esophageal neoplastic *** In this prospective study,we enrolled 543 patients who underwent white light imaging(Wli),LCI and LCE *** compared the sensitivity and specificity of LCI and LCE in the detection of esophageal neoplastic *** features and color analysis of lesions were *** In total,43 patients(45 neoplastic lesions)were *** them,36 patients(38 neoplastic lesions)were diagnosed with LCI,and 39 patients(41 neoplastic lesions)were diagnosed with *** sensitivity of LCI was similar to that of LCE(83.7%vs 90.7%,P=0.520),whereas the specificity of LCI was greater than that of LCE(92.4%vs 87.0%,P=0.007).The LCI procedure time in the esophageal examination was significantly shorter than that of LCE[42(34,50)s vs 160(130,189)s,Pning strategy for general populations.

关键词： linked color imaging Lugol chromoendoscopy Esophageal squamous cell cancer Precancerous lesions Color difference

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隧道内脉冲激励下地层振动传递特性研究

振动与冲击 2013年第8期32卷 162-165,198页

作者：王文斌刘维宁孙宁李克飞聂志理中国铁道科学研究院工程咨询有限公司北京100081 北京交通大学土木建筑工程学院北京100044

目前,对于地铁运营引起的振动在地层中的传递特性一直未有系统深入的研究。利用自动落锤激励装置锤击轨道减振与控制实验室10 m埋深隧道内轨道,研究了0～200 Hz频段振动加速度在地层中的传播衰减特性。试验结果表明:①隧道结构-地面振... 详细信息

目前,对于地铁运营引起的振动在地层中的传递特性一直未有系统深入的研究。利用自动落锤激励装置锤击轨道减振与控制实验室10 m埋深隧道内轨道,研究了0～200 Hz频段振动加速度在地层中的传播衰减特性。试验结果表明:①隧道结构-地面振动加速度峰值衰减率达到81.25%,地层对振动有很强的衰减作用。②除了30 Hz附近频段传递函数幅值大于1,隧道结构到地面振动响应传递函数幅值普遍小于0.4。③隧道结构-地面1/3倍频程加速度级传递损失曲线呈V形分布,传递损失在30 Hz附近最小,且为负值,此频段振动加速度能量从隧道传递到地面有放大现象。

关键词：脉冲试验自动落锤激励装置传递损失振动响应传递函数相干系数

电脉冲处理对预变形Fe13Mn6Si13Cr4Ni0.1C合金形状记忆效应及显微组织的影响（英文）

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稀有金属材料与工程 2016年第1期45卷 51-55页

作者：杨世洲李宁李辉四川大学四川成都610065 四川建筑职业技术学院博士后创新实践基地四川德阳618000

研究了电脉冲处理对预变形Fe13Mn6Si13Cr4Ni0.1C合金形状记忆效应及其显微组织的影响。结果表明:电脉冲处理能加速Cr和C原子的迁移及Cr_(23)C_6碳化物的析出,降低时效温度,缩短时效时间,并能诱发Cr_(23)C_6碳化物的形核。因此,与10%拉... 详细信息

研究了电脉冲处理对预变形Fe13Mn6Si13Cr4Ni0.1C合金形状记忆效应及其显微组织的影响。结果表明:电脉冲处理能加速Cr和C原子的迁移及Cr_(23)C_6碳化物的析出,降低时效温度,缩短时效时间,并能诱发Cr_(23)C_6碳化物的形核。因此,与10%拉伸预变形后再经973,1073 K时效的合金相比,10%拉伸预变形后经300 V,1100μF,1 Hz电脉冲处理的Fe13Mn6Si13Cr4Ni0.1C合金,其形状回复率能在300 s时间内从固溶态合金的32%提高到87.2%。

关键词：形状记忆效应预变形电脉冲处理时效 Cr23C6碳化物形核率