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Femtosecond laser corneal refractive surgery for the correction of high myopic anisometropic amblyopia in juveniles

International Journal of Ophthalmology(English edition) 2017年第11期10卷 1678-1685页

作者： Jing Zhang ke-ming yu State key Laboratory of Ophthalmology Zhongshan OphthalmicCenter Sun Yat-sen University Guangzhou 510060 GuangdongProvince China

AIM： To evaluate the effects of femtosecond laser-assisted in situ keratomileusis（FS-LASIK） and small-incision lenticule extraction（SMILE） to correct high myopic anisometropic amblyopia in juvenile patients. METHODS： From November 2013 to January 2015, 33 amblyopic patients with high myopic anisometropic amblyopia were studied. FS-LASIK（30 eyes） or SMILE（3 eyes） was performed in the amblyopic eyes. Visual acuity, refraction, contrast sensitivity, stereoacuity and complications were evaluated. Patients completed followup examinations at 3 d, 1 mo, 3 mo and the last follow-up time（mean 8.17±3.23 mo） after surgery. RESULTS： The mean age at surgery was 9.04±3.04 y（range 6-16 y）. The mean spherical equivalent in the amblyopic eyes was significantly decreased from-10.00±2.39 D preoperatively to-0.06±1.06 D at 1 mo,-0.19±1.33 D at 3 mo and-0.60±1.43 D at approximately 8 mo postoperatively（P〈0.05 for all）. The mean myopic anisometropia was significantly decreased from-9.45±2.33 D preoperatively to ＋0.37±1.48 D at 1 mo,-0.46±1.47 D at 3 mo and-0.09±1.83 D at approximately 8 mo（P〈0.05 for all）. The logarithm of the minimum angle of resolution（log MAR） for uncorrected and corrected distance visual acuity（UDVA and CDVA, respectively） of the amblyopic eye improved from 1.74±0.35 and 0.98±0.63 preoperatively to 0.45±0.31 and 0.41±0.33 at approximately 8 mo after surgery, respectively. The logM AR CDVA at 3 d, 1, 3 and 8 mo postoperatively improved by means of 1.42, 2.22, 2.96, and 4.39 lines, and a gain of more than two lines accounted for 45%, 50%, 74% and 86% of all patients, respectively. The contrast sensitivity of both amblyopic eyes and dominant eyes at 0.5, 2, 8 cycles perdegree was significantly improved postoperatively（P〈0.05 for all）. Of the 33 pediatric patients, no patients had near stereopsis preoperatively and seven patients（21.2%） recovered near stereopsis（400″ to 60″） at approximately 8 mo after surgery. No intraoperative or postoperative complications occurred in

关键词： refractive surgery myopic anisometropic amblyopia pediatric patients small-incision lenticule extraction femtosecond laser-assisted in situ keratomileusis

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Posterior chamber phakic intraocular lens for the correction of high myopic anisometropic amblyopia in adults

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1870-1874页

作者： Jing Zhang Jing Zhuang ke-ming yu Shenzhen Eye Hospital Shenzhen Key Laboratory of Ophthalmology Affiliated Shenzhen Eye Hospital of Jinan University State key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University

This study aims to evaluate the clinical results of posterior chamber implantable collamer lens（ICL） implantation in adults with high myopic anisometropic amblyopia. Thirteen patients aged 27.04±7.24 y（range 19.2 to 42.5） were studied. ICL implantation was performed in 13 amblyopic eyes. The mean myopic anisometropia was significantly dropped from-10.70±3.02 D preoperatively to ＋0.09±1.67 D at 1 mo postoperatively. The logMAR CDVA at 3 d, 1, 3 and mean 9 mo postoperatively improved by a mean of 1.69, 2.50, 3.01 and 3.00 lines and gained more than 2 lines accounted for 23.08%（3 eyes）, 41.67%（5 eyes）, 63.63%（7 eyes） and 55.56%（5 eyes）, respectively. The contrast sensitivity of amblyopic eyes was significantly increased after surgery. Four patients partially recovered near stereopsis（400＂ to 100＂）. There was no severe complications were observed. ICL implantation alone can improve vision, contrast sensitivity, and partial restoration of binocular vision in adult patients with high myopic anisometropia.

关键词： phakic intraocular lens myopic anisometropic amblyopia refractive surgery

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Composite Hierachical Linear Quantile Regression

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Acta Mathematicae Applicatae Sinica 2014年第1期30卷 49-64页

作者： Yan-liang CHEN Mao-zai TIAN ke-ming yu Jian-xin PAN Center for Applied Statistics School of StatisticsRenmin University of China School of Business Shihezi University Mathematical Sciences John Crank 209Brunel University School of Mathematics The University of Manchester School of Statistics and Mathematics Yunnan University of Finance and Economics

Multilevel （hierarchical） modeling is a generalization of linear and generalized linear modeling in which regression coefficients are modeled through a model, whose parameters are also estimated from data. Multilevel model fails to fit well typically by the use of the EM algorithm once one of level error variance （like Cauchy distribution） tends to infinity. This paper proposes a composite multilevel to combine the nested structure of multilevel data and the robustness of the composite quantile regression, which greatly improves the efficiency and precision of the estimation. The new approach, which is based on the Gauss-Seidel iteration and takes a full advantage of the composite quantile regression and multilevel models, still works well when the error variance tends to infinity, We show that even the error distribution is normal, the MSE of the estimation of composite multilevel quantile regression models nearly equals to mean regression. When the error distribution is not normal, our method still enjoys great advantages in terms of estimation efficiency.

关键词： multilevel model composite quantile regression E-CQ algorithm, fixed effects, random effects

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Comparison of anterior section parameters using anterior segment optical coherence tomography and ultrasound biomicroscopy in myopic patients after ICL implantation

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 58-62页

作者： Jing Zhang Hui-Hui Luo Jing Zhuang ke-ming yu State key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University

AIM：To compare the agreement of anterior chamber depth（ACD）and central vault measurements obtained by anterior segment optical coherence tomography（AS-OCT）and ultrasound biomicroscopy（UBM）of post surgical high myopic eyes with posterior chamber phakic intraocular lens（Visian ICL;STAAR Surgical）implantation.·METHODS：Fifty-two phakic eyes of 28 high myopic patients who underwent implantable Collamer lens（ICL）surgery for the correction of high myopia were *** postoperative ACD,the distance between the corneal endothelium and the anterior surface of ICL（cornea-ICL）and the central vault were measured with the AS-OCT system and the UBM *** correlation coefficient（ICC）and the Bland-Altman plot were used to evaluate the repeatability and agreement of two devices.·R ESULTS：The mean ACD,cornea-ICL and central vault in the 52 phakic eyes after ICL surgery was 3.19±0.28 mm,2.47±0.28 mm,0.50±0.19 mm by AS-OCT and3.13±0.25 mm,2.49±0.25 mm,0.44±0.19 mm by UBM,*** comparison of ACD and central vault measurements showed significant differences between AS-OCT and UBM（〈0.05）.However,no statistically significant difference was found between these imaging techniques in cornea-ICL（〉0.05）.The Pearson correlation coefficient（）between AS-OCT and UBM measurements for ACD,cornea-ICL and vault was0.88,0.80 and 0.89,respectively（〈0.001）.The ICC was0.89-0.94 for the measurements of AS-OCT and ***-Altman analysis showed the 95%limits of agreement of ACD,cornea-ICL,central vault measurements between these two devices were-0.20 to 0.32 mm,-0.36to 0.32 mm and-0.12 to 0.24 mm,respectively.58·CONCLUSION：Central ACD and vault measurements using AS-OCT demonstrated a slight significantly higher value than using UBM in phakic eyes after ICL *** two devices should not be used interchangeably for measurements of central ACD and vault in patients after phakic intraocular lens implantation.

关键词： anterior chamber depth vault phakicintraocular lens anterior segment imaging optical coherencetomography ultrasound biomicroscopy

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Phakic posterior chamber intraocular lens for unilateral high myopic amblyopia in Chinese pediatric patients

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1790-1797页

作者： Jing Zhang Jin-Rong Li Zi-Dong Chen Min-Bin yu ke-ming yu State key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 Guangdong Province China Depertment of Ophthalmology the East Area of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Chengdu 610110 Sichuan Province China

AIM： To assess the outcomes of posterior chamber implantable collamer lens （ICL） implantation in Chinese pediatric patients with unilateral high myopic ***： Eleven eyes of 11 amblyopic patients aged 11.02±3.34y underwent ICL （model V4, Staar Surgical Inc.） implantation to treat unilateral anisometropia were studied. Visual acuity, cycloplegic refraction, contrast sensitivity, stereopsis, intraocular pressure （IOP）, vaulting, corneal endothelial cell count and complications were evaluated. Patients completed follow-up at 3d, 1, 3mo and the last follow-up time （mean 8.18±2.82mo） after ***： The mean myopic anisometropia was -13.70±3.25 D preoperatively and ＋0.69±2.63 D at 8mo postoperatively. The logMAR corrected distance visual acuity （CDVA） of the amblyopic eye was 1.51±0.72 preoperatively and 0.75±0.40 at 8mo postoperatively. The logMAR CDVA at 3d, 1, 3 and 8mo postoperatively improved by a mean of 0.64, 1.55, 1.82 and 2.64 lines and gained more than 2 lines accounted for 18%, 45%, 45%, 64%, respectively. The contrast sensitivity of 0.5, 1 and 2 cpd in amblyopic eyes was significantly increased after surgery. No patient had near stereopsis recovery. The vaulting at 3 and 8mo was significantly lower than that at 1mo postoperatively. No other intraoperative or postoperative complications were observed, except an acute pupillary block glaucoma happened in a patient at two weeks ***： This short-term results indicate that ICL implantation can be a promising alternative therapy for high myopic anisometropic amblyopia in pediatric patients who have failed with conventional treatments and not suitable to corneal refraction surgery.

关键词： phakic intraocular lens myopic anisometropic amblyopia pediatric patients refractive surgery

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Investigation of children’s habits of smartphone usage and parental awareness of myopia control in underdeveloped areas of China

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1691-1698页

作者： An-Qi He Si-An Liu Sheng-yu He Huan Yao Pei Chen Yan Li Jin Qiu ke-ming yu Jing Zhuang State key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina

AIM: To investigate the behaviors of smartphone usage and parental knowledge of vision health among primary students in the rural areas of China. METHODS: In this school-based, cross-sectional study, a total of 52 606 parents of students from 30 primary schools in the Xingguo County were investigated through an online questionnaire from July 2020 to August 2020. The self-designed questionnaire contained three parts: the demographic factors of both children and parents, parental knowledge and attitude toward myopia, and the preventive treatment of ***: A total of 52 485 appropriately answered questionnaires were received, showing an effective response rate of 95.1%. The average age of the primary students was 10.1±0.98 y and the prevalence of myopia among the primary students was 40.3%. The age of myopia occurrence in elementary students was significantly correlated with the parents’ educational level(95%CI: 0.82-0.98, P=0.013), children’s gender(95%CI: 1.08-1.20, P<0.001), school location(county or countryside)(95%CI: 0.59-0.66, P<0.001), children’s smartphone ownership(95%CI: 1.09-1.26, P<0.001), and the average time spent on smartphone per day(95%CI: 0.78-0.88, P<0.001). School location in the county town, high family income, and high parents’educational level significantly affected both parents’ myopia awareness and children’s vision-threatening behaviors(P<0.01). Left-behind children showed a higher incidence of vision-threatening habits than those who lived with their parents(P<0.01).CONCLUSION: The results reveal the current situation of myopia development among rural primary school students and their parents. This survey will serve as a guidance for designing myopic prevention policies in the rural areas of China.

关键词： myopia prevalence rural China smartphone use left-behind children

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Corneal flap morphological analysis using anterior segment optical coherence tomography in laser in situ keratomileusis with femtosecond lasers versus mechanical microkeratome

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 69-73页

作者： Xiao-Xiao Zhang Xing-Wu Zhong Jun-Shu Wu Zheng Wang ke-ming yu Quan Liu and Bin Yang Zhongshan Ophthalmic Center and State key Laboratory of Ophthalmology Sun Yat-sen University Guangzhou 510060 Guangdong Province China

AIM: To assess and compare the flap morphology using anterior segment optical coherence tomography (AS-OCT) in laser in situ keratomileusis (LASIK) with Femto LDV femtosecond lasers versus Hansatome mechanical Microkeratome. METHODS: AS-OCT (Visante) was used to compare 1 month postoperatively the morphology of the flaps created with Femto LDV femtosecond lasers or Hansatome Microkeratome. The intendedfiap thickness was 110 mu m and 160 mu m respectively. The thickness of twenty-five points across each flap, which were 0mm, 1.5mm, 2.5mm, and 3.5mm to the corneal vertex on the horizontal, vertical, 45 degrees and 135 degrees meridian respectively, was evaluated. RESULTS: One month postoperative, the central flap thickness in the Femto LDV group was 107.43 +/- 4.70 mu m, while 125.90 +/- 17.50 mu m in the Hansatome group. The difference between the actual and the expectedfiap thickness was 5.61 +/- 3.84 mu m and 31.52 +/- 12.27 mu m, respectively. The Hansatome group had presented a statistically significant result (Pkeratome.

关键词： AS-OCT laser in situ keratomileusis flap femtosecond laser

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Glycogen synthase kinase-3β inhibitor SB216763 promotes DNA repair in ischemic retinal neurons

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Neural Regeneration Research 2021年第2期16卷 394-400页

作者： Zhang Jing Lai Zhipeng Chen Pei Ying Yang Zhuang Jing yu keming Zhongshan Ophthalmic Center Sun Yat-sen University State Key Laboratory of Ophthalmology Guangdong Guangzhou

Glycogen synthase kinase-3β(GSK-3β) has been shown to attenuate DNA damage in nerve cells, thereby enhancing neuronal survival under pathological conditions;however, the underlying mechanism remains unclear. An in vitro serum-starvation retinal neuron model and in vivo ischemia/reperfusion retina injury rat model were established and treated with SB216763, a GSK-3β inhibitor. SB21673 decreased the formation of γ-H2 A histone family member X foci and enhanced the viability of ischemic retinal neurons. In addition, SB216763 upregulated expression of phosphorylated-CREB1, a ligase IV transcription factor, and significantly increased the transcriptional activity of ligase IV in ischemic retinal neurons. These results were confirmed in rat retinas following ischemia/reperfusion injury. Furthermore, we found that unlike lithium chlorine(a well-known direct inhibitor of GSK-3β), SB216763 inhibited GSK-3β activity by suppressing its phosphorylation. Taken together, our results suggest that GSK-3β inhibition enhances repair of DNA double-strand breaks by upregulating ligase IV expression in ischemic retinal neurons. This study was approved by the Institutional Animal Care and Use Committee of Zhongshan Ophthalmic Center on February 18, 2018.

关键词： factor GSK-3β in vitro injury ligase IV neuroprotection optic nerve pathways protein repair

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： ke Jiang Zhi Chen Ji yu Chen Zheng Shan Huang ming Wang Chongqing key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

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具有广义正则化与遗忘机制的在线贯序超限学习机

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控制与决策 2017年第2期32卷 247-254页

作者：郭威徐涛汤克明于建江南京航空航天大学计算机科学与技术学院南京210016 盐城师范学院信息工程学院江苏盐城224002 中国民航大学计算机科学与技术学院天津300300

针对非平稳时间序列预测问题,提出一种具有广义正则化与遗忘机制的在线贯序超限学习机算法.该算法以增量学习新样本的方式实现在线学习,以遗忘旧的失效样本的方式增强对非平稳系统的动态跟踪能力,并通过引入一种广义的l2正则化使其具有... 详细信息

针对非平稳时间序列预测问题,提出一种具有广义正则化与遗忘机制的在线贯序超限学习机算法.该算法以增量学习新样本的方式实现在线学习,以遗忘旧的失效样本的方式增强对非平稳系统的动态跟踪能力,并通过引入一种广义的l2正则化使其具有持续的正则化功能,从而保证算法的持续稳定性.仿真实例表明,所提出算法具有较同类算法更好的稳定性和更小的预测误差,适用于具有动态变化特性的非平稳时间序列在线建模与预测.

关键词：在线贯序超限学习机广义正则化遗忘因子时间序列预测

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