检索结果-南通市图书馆

Chinese Medical Sciences Journal 2013年第1期28卷 16-19页

作者： Ye jin Li Zhou ke-min jin Bao-cai Xing Clinical Research Laboratory Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College key Laboratory of Carcinogenesis and Translational Research(ministry of Education) Department of Hepatobiliary Surgery IPeking University Cancer Hospital

Objective To investigate the association between plasminogen activator inhibitor(PAI)-2 expression and invasive potential in hepatocellular carcinoma(HCC) *** The HCC cell lines with high,low,and non-metastatic potentials,namely MHCC97-H,MHCC97-L,and SMMC-7721 respectively,were cultured in *** invasion assay and Western blot of PAI-2 protein expression were *** The number of invaded cells in MHCC97-L was significantly higher than that in SMMC-7721(P=0.005),whereas that in MHCC97-H was higher than in MHCC97-L(P=0.017) and SMMC-7721(P=0.001).Contrarily,PAI-2 protein expression was gradually reducing from SMMC-7721,MHCC97-L,to MHCC97-H(MHCC97-H ***97-L,P<0.001;MHCC97-H ***-7721,P=0.001;MHCC97-L ***-7721,P=0.001).The Pearson's correlation analysis revealed a significant negative association between invaded cell number and PAI-2 expression(r= 0.892,P=0.001).Conclusion PAI-2 expression may be negatively associated with the invasive potential of HCC.

关键词： hepatocellular carcinoma plasminogen activator inhibitor-2 invasive potential

Cortactin Overexpression Correlates with Poor Prognosis in Hepatocellular Carcinoma

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2010年第2期22卷 112-118页

作者： ke-min jin min Lu Fang-fang Liu jin Gu Xiao-juan Du Bao-cai Xing key laboratory of Carcinogenesis and Translational Research （ministry of Education） Department of Hepatic Biliary ＆ Pancreatic Surgery Unit I Department of Genetics Department of Gastrointestinal Surgery Unit II Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China Department of Pathology Department of Cell Biology Cancer Research Center Peking University Health Science Center Beijing 100191 China

Objective： To investigate cortactin expression in hepatocellular carcinoma （HCC） and explore its significance in the prognosis of HCC patients. Methods： Immunohistochemistry was performed for paraffin samples of 119 pairs of HCC tissues （HCCs） and paratumorous liver tissues （PTLTs） to evaluate cortactin expression. The cortactin expression difference in HCCs and PTLTs were analyzed by the McNemar＇s test. The relationship of cortactin expressions in HCCs and clinicopathologic factors was analyzed with Mann-Whitney U test. The Kaplan-Meier method and log-rank test were employed to compare the overall survival between Cortactin negative expression group, weak expression group and strong expression group. Expression of cortactin was further determined in 19 pairs of fresh HCCs and PTLTs specimens with Western blotting. Results： Cortactin expression rate was significantly higher in HCCs （53/119, 44.5%） than that in PTLTs （2/119, 1.7%）（P〈0.001）. The upregulated cortactin expression in HCCs was significantly correlated to absence of capsule formation （P=0.012）, vascular invasion （P=0.037） and high Edmondson-Steiner grade （P=0.020）, and predicted shorter overall survival. Western blotting demonstrated that cortactin expression was upregulated in 9 out of 19 HCCs （47.4%） compared to corresponding PTLTs. Conclusion： Cortactin expression is upregulated in HCC and is related to shorter overall survival of patients, suggesting that cortactin might play roles in the metastasis of HCC and predict a poor prognosis of HCC patients.

关键词： Hepatoeellular carcinoma (HCC) Carcinogenesis Prognosis Cortactin

Irinotecan-vs oxaliplatin-based regimens for neoadjuvant chemotherapy in colorectal liver metastasis patients:A retrospective study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2022年第9期14卷 904-917页

作者： Wei Liu Feng-Lin Chen Kun Wang Quan Bao Hong-Wei Wang ke-min jin Bao-Cai Xing Department of Hepatopancreatobiliary Surgery Peking University School of OncologyBeijing Cancer HospitalBeijing 100142China Department of Hepatopancreatobiliary Surgery Key Laboratory of Carcinogenesis and Translational ResearchMinistry of EducationPeking University School of OncologyBeijing Cancer Hospital and InstituteBeijing 100142China

BACKGROUND Neoadjuvant chemotherapy(NC)improves the survival outcomes of selected patients with colorectal liver metastasis(CRLM).The benefits of irinotecan-based regimens in these patients are still under *** To compare the benefits of irinotecan-and oxaliplatin-based regimens in patients with resectable *** From September 2003 to August 2020,554 patients received NC and underwent hepatectomy for *** on a 1:1 propensity score matching(PSM)model,175 patients who received irinotecan were matched to 175 patients who received oxaliplatin to obtain two balanced groups regarding demographic,therapeutic,and prognostic *** Chemotherapy was based on oxaliplatin in 353(63.7%)patients and irinotecan in 201(36.3%).After PSM,the 5-year progression-free survival(PFS)and overall survival(OS)rates with irinotecan were 18.0%and 49.7%,respectively,while the 5-year PFS and OS rates with oxaliplatin were 26.0%and 46.8%,*** blood loss,operating time,and postoperative complications differed significantly between the two *** the multivariable analysis,carbohydrate antigen 19-9,RAS mutation,response to NC,tumor size>5 cm,and tumor number>1 were inde-pendently associated with *** In NC in patients with CRLM,irinotecan is similar to oxaliplatin in survival outcomes,but irinotecan is superior regarding operating time,intraoperative blood loss,and postoperative complications.

关键词： Colorectal cancer Liver metastasis Liver resection Neoadjuvant chemotherapy

Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou ke Yajing Zhao Xin min Yanghong Li Ruiyu Mi Yangai Liu Xiaowen Wu minghao Fang Zhaohui Huang Engineering Research Center of ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

Extramedullary plasmacytoma with the uvula as first affected site:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： jing Yang Hui Peng Sheng-ke Tu min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

大直径行波型超声电机的优化

微电机 2005年第3期38卷 16-19页

作者：徐志科胡敏强金龙顾菊平东南大学电气工程系南京210096

大直径行波型超声电机在压电陶瓷制作、定子和转子设计及驱动器设计等方面都比较困验。本文以定子直径为100mm的行波型超声电机为例,通过有限元分析方法,利用ANSYS计算,对电机的定子和转子的结构进行优化设计。在优化的基础下,制作了样... 详细信息

大直径行波型超声电机在压电陶瓷制作、定子和转子设计及驱动器设计等方面都比较困验。本文以定子直径为100mm的行波型超声电机为例,通过有限元分析方法,利用ANSYS计算,对电机的定子和转子的结构进行优化设计。在优化的基础下,制作了样机,并进行了初步的测试。改进后的超声电机的性能有了很大的提高,堵转转矩由原来的2.5N·m增大到现的3.5N·m,输出功率也有了显著提高。

关键词：超声电机行波型大直径有限元分析方法 ANSYS计算压电陶瓷转子设计优化设计输出功率堵转转矩驱动器定子制作

Primary parenchymal squamous cell carcinoma of the kidney:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-min Xu ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Inhibited aptazyme-based catalytic molecular beacon for amplified detection of adenosine

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2014年第9期25卷 1211-1214页

作者： jin Huang Yong He Xiao-Hai Yang ke Quan ke-min Wang State key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringKey Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceHunan University

Combining the inhibited aptazyme and molecular beacon （MB）, we developed a versatile sensing strategy for amplified detection of adenosine. In this strategy, the adenosine aptamer links to the 8-17 DNAzyme to form an aptazyme. A short sequence, denoted as inhibitor, is designed to form a duplex spanning the aptamer-DNAzyme junction, which blocks the catalytic function of the DNAzyme. Only in the presence of target adenosine, the aptamer binds to adenosine, thus the inhibitor dissociates from the aptamer portion of the aptazyme and can no longer form the stable duplex required to inhibit the catalytic activity of the aptazyme. The released DNAzyme domain will hybridize to the MB and catalyze the cleavage in the presence of Zn2＋, making the fluorophore separate from the quencher and resulting in fluorescence signal. The results showed that the detection method has a dynamic range from 10 nmol/L to 1nmol/L, with a detection limit of 10 nmol/L.

关键词： Aptazyme DNAzyme Catalytic molecular beacon Adenosine

Equivalent input disturbance-based load frequency control for smart grid with air conditioning loads

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2022年第2期65卷 106-123页

作者： Li jin Yong HE Chuan-ke ZHANG Xing-Chen SHANGGUAN Lin JIANG min WU School of Automation China University of Geosciences Hubei key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Department of Electrical Engineering and Electronics University of Liverpool Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education

Integrating intermittent wind power into power systems results in low or zero inertia, threatening their frequency stability. To accommodate intermittent generations, the demand response(DR) is introduced, and air conditioning loads(ACs) account for an increasing proportion of all loads. The replacement of traditional generators with wind turbines and the ACs user uncertainties produce parameter uncertainties. This paper aims to construct an equivalent input disturbance(EID)-based load frequency control(LFC) strategy for the power system by considering wind power and ACs. First, an open-loop model is constructed for the LFC scheme with parameter uncertainties. Then, the parameter uncertainties and external disturbance are lumped into a fictitious disturbance, which is estimated using an EID *** incorporating the estimation of disturbance into the control input, the disturbance-rejection performance is achieved. Next, the Lyapunov theory is used to derive the two linear-matrix-inequality-based asymptotic stability criteria. A design algorithm is developed for the EID-based LFC scheme by exploiting an overall performance evaluation index. Finally, simulation results for the single-area and two-area LFC schemes show that, compared with the existing approaches, the method presented realizes the better disturbance rejection and higher robustness against parameter uncertainties, wind power fluctuation, and tie-line power ***, its robustness to time delays is verified.

关键词： equivalent input disturbance load frequency control parameter uncertainties wind power air conditioning loads

同方期刊数据库

A matrix grammar approach for automatic distributed network resource management

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2013年第4期7卷 583-594页

作者： Weidong min ke CHEN Yongzhenke School of Computer Science and Software Engineering Tianjin Polytechnic University Tianjin 300387 China

Network resource management is critical to ensure the security and optimal performance of distributed networks and information systems. Existing technologies are not capable of managing large-scale network resources because of a lack of reusability and scalability. This paper presents a matrix grammar approach for automatic distributed network resource management to alleviate these problems. A matrix grammar is proposed using WMI, CIM, and SNMP to manage network resources, and provides a generic mechanism to describe what needs to be managed and how to manage it. A scalable distributed multi-agent architecture for automatic network resource management is proposed, at its core lies a management automation engine consisting of a matrix analyzer and a recipe processor. The proposed solution has been implemented in software and applied in industrial products that achieve good technical and industrial results. It has good extensibility, scalability, ment automation and software and enables network managereusability.

关键词： network management multi-agent matrixgrammar WMI CIM SNMP distributed networks