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FoxO is required for optimal fitness of the migratory brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae)

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Insect Science 2023年第5期30卷 1352-1362页

作者： Jin-Li Zhang ke-liang liu Xin-Yu Cai Xin-Yang liu Hai-Jun Xu State key Laboratory of Rice Biology Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang ProvinceInstitute of Insect SciencesCollege of Agriculture and BiotechnologyZhejiang UniversityHangzhouChina

The forkhead box O(FoxO)protein is the main transcriptional effector downstream of the insulin/insulin-like signaling pathway and regulates many developmental and physiological *** insects with loss-of-function mutations in FoxO exhibit phenotypes distinct from those of hemimetabolous insects in which RNA interference was *** the functional importance of FoxO,whether hemimetabolous insects share an evolutionally conserved function of FoxO with holometabolous insects remains to be *** used the clustered regularly interspaced short palindromic repeats/CRISPR-associated 9(CRISPR/Cas9)genome editing-system to establish a homozygous FoxO-null mutant(NlFoxO^(4E))of the wing-dimorphic brown planthopper(BPH)Nilaparvata lugens,an economically important insect pest of rice *** phenotypes of NlFoxO^(4E) mutants included extended nymphal duration,shortened lifespan,reduced reproduction,and decreased stress *** addition,depletion of NlFoxO promoted cell proliferation in wing buds and led to 100%long-winged morphs,in stark contrast to short-winged wild-type *** findings indicate that NlFoxO is highly functionally conserved with its counterpart in holometabolous insects,and is required for optimal fitness of *** insights from FoxO studies may facilitate the identification of potential target genes for BPH control applications.

关键词： cell proliferation CRISPR/Cas9 FoxO longevity planthopper reproduction

Ureido-modification of the resin-bound LHRH analogue with N,N'-carbonyldiimidazole

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Chinese Chemical Letters 2009年第6期20卷 668-671页

作者： Yong Qing Gao Ning Zhou Yu Jian Lv Mao Sheng Cheng ke liang liu School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China Beijing Institute of Pharmacology and Toxicology Beijing 100850 China

The ureido-modification of the resin-bound a luteinizing hormone releasing hormone （LHRH） analogue was investigated by CDI-activating method. The amino group at the side chain of LHRH analogue could be transformed into various substituted urea moieties in high yields. However, its terminal amino group was partially converted to a hydantoin structure due to the attack of the N atom of the adjacent amide bond.

关键词： Urea moiety N,N'-carbonyldiirnidazole (CDI) Solid-phase Peptide

Generating Microstructures with Highly Variable Mechanical Performance using Two-Photon Lithography and Thiol-ene Photopolymerization

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Chinese Journal of Polymer Science 2023年第1期41卷 67-74页

作者： Xiao Yang Yan-Fang Niu Meng-Xiao Wei Jun-Ning Zhang ke-liang liu Xin Du Zhong-Ze Gu State key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China

In this study,we investigate the effect of the exposure dose on the mechanical property of the photoresins generated with acrylate self-polymerization and thiol-ene *** results indicate that the mechanical performance of the thiol-ene photoresin is highly depended on the exposure dose during the solidification *** 350-fold exposure dose change,the stiffness of the thiol-ene photoresin reached more that 700-fold change compare to 14-fold of the acrylate *** developed a TPL photoresist based on our results and show the capability to fabricate microstrucutres with high resolution and variable mechanical performances using this method.

关键词： Thiol-ene Two photo lithography 3D printing Photoresist

Comparative study on pharmacological effects of DM-phencynonate hydrochloride and its optical isomers

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Acta Pharmacologica Sinica 2005年第10期26卷 1187-1192页

作者： Li-yun WANG, Jian-quan ZHENG~2, Yun WANG, Bo-hua ZHONG, Jin-xiu RUAN, ke-liang liu Beijing Institute of Pharmacology and Toxicology, Beijing 100850. China Beijing Institute of Pharmacology and Toxicology Beijing China

Aim: The 3-azabicyclo(3,3,1)nonanyl-9-α-yl-α-cyclopentyl-α-phenyl-α-glycolate (DM-phencynonate hydrochloride, DMCPG) is a demethylated metabolite of 3-methyl-3-azabicyclo(3,3,1)nonanyl-9-α-yl-α-cyclopentyl-α-phenyl-α-glycolate (phencynonate hydrochloride, CPG). (±)DMCPG had one chiral center and two enantiomers [R(-) and S(+)DMCPG]. Here we carried out a comparative study of the pharmacological profiles of these optical isomers. Methods: Affinity and relative efficacy were tested using a radioligand-binding assay with muscarinic acetylcholine receptors from the rat cerebral cortex. Pharmacological activity was assessed in three individual experiments: (1) potentiating the effect of a subthreshold hypnotic dose of sodium pentobarbital; (2) inhibiting oxotremorineinduced salivation; and (3) inhibiting the contractile response to carbachol. Results: In the competitive binding assay, R(-)DMCPG (Ki=763.75 nmol/L) was 4-and 2-fold more potent than (±)DMCPG (Ki=3186nmol/L) and S(+)DMCPG (Ki=1699 nmol/L) in inhibiting the binding of [3~H]QNB. The R(-) and S (+) configurations showed positive cooperation (nH>1) with the muscarinic receptor, whereas (±)DMCPG had a negative cooperation (nH0.05). (±)DMCPG and its optical isomers suppressed the guinea pig ileum contractile response to carbachol. The IC50values were 7.78x 10-9, 1.88x 10-7, and 1.03x10-7nmol/L, respectively. In the anti-salivation study, (±)DMCPG and its enantiomers depressed oxotremorine-induced salivation in a dose-dependent manner, and the order of potency was R(-)DMCPG (ED50=0.44 mg/kg>(±)DMCPG (ED50=2.88 mg/kg)>S(+)DMCPG (ED50=5.05 mg/

关键词： optical isomers muscarinic acetylcholinic receptors pharmacological profiles radio-ligand binding assay

空气中不同温度下环氧树脂绝缘子表面电荷消散过程的实验研究

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高电压技术 2018年第5期44卷 1723-1728页

作者：陈可梁曦东刘杉清华大学电机工程与应用电子技术系

表面电荷的消散与绝缘材料的表面电阻率和体积电阻率有关,而温度的变化会影响绝缘材料的表面电阻率和体积电阻率。为了研究环氧树脂绝缘子在不同温度下的表面电荷消散规律,建立了一套测量系统,采用有源静电探头法,对空气中在针板电极下... 详细信息

表面电荷的消散与绝缘材料的表面电阻率和体积电阻率有关,而温度的变化会影响绝缘材料的表面电阻率和体积电阻率。为了研究环氧树脂绝缘子在不同温度下的表面电荷消散规律,建立了一套测量系统,采用有源静电探头法,对空气中在针板电极下的环氧树脂圆板绝缘子施加直流电压后进行了表面电位的测量。研究结果表明：各种配方的环氧树脂圆板绝缘子在不同温度下的消散过程都近似呈指数衰减规律;环氧树脂圆板绝缘子的表面电荷消散主要通过沿表面消散的方式进行;表面电阻率越高,表面电荷消散速率就越小;套管在实际运行过程中温度会高于常温,在选用环氧树脂材料时,应考虑其在工作温度范围内的电阻率变化,在保证绝缘强度的同时,尽量选择表面电阻率小的环氧树脂材料,以减少绝缘子表面电荷积聚。该研究结果对超大型直流穿墙套管中的环氧树脂绝缘支撑件的工程设计有借鉴意义。

关键词：表面电荷环氧树脂表面电阻率体积电阻率温度电荷消散

Domain generalization with semi-supervised learning for people-centric activity recognition

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Science China(Information Sciences) 2025年第1期68卷 171-188页

作者： Jing liu Wei ZHU Di LI Xing HU liang SONG Academy for Engineering & Technology Fudan University Shanghai East-bund Research Institute on Networking Systems of AI School of Optoelectronic Information and Computer Engineering University of Shanghai for Science & Technology

People-centric activity recognition is one of the most critical technologies in a wide range of real-world applications,including intelligent transportation systems, healthcare services, and brain-computer interfaces. Large-scale data collection and annotation make the application of machine learning algorithms prohibitively expensive when adapting to new tasks. One way of circumventing this limitation is to train the model in a semi-supervised learning manner that utilizes a percentage of unlabeled data to reduce the labeling burden in prediction tasks. Despite their appeal, these models often assume that labeled and unlabeled data come from similar distributions, which leads to the domain shift problem caused by the presence of distribution gaps. To address these limitations, we propose herein a novel method for people-centric activity recognition,called domain generalization with semi-supervised learning(DGSSL), that effectively enhances the representation learning and domain alignment capabilities of a model. We first design a new autoregressive discriminator for adversarial training between unlabeled and labeled source domains, extracting domain-specific features to reduce the distribution gaps. Second, we introduce two reconstruction tasks to capture the task-specific features to avoid losing information related to representation learning while maintaining task-specific consistency. Finally, benefiting from the collaborative optimization of these two tasks, the model can accurately predict both the domain and category labels of the source domains for the classification task. We conduct extensive experiments on three real-world sensing datasets. The experimental results show that DGSSL surpasses the three state-of-the-art methods with better performance and generalization.

关键词： activity recognition deep learning domain generalization semi-supervised learning adversarial training

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Experimental Study on Diesel Spray and Flame Asymmetry Characteristics of Dual-Orifice Nozzles for a Medium-Speed Engine

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Journal of Thermal Science 2025年第1期34卷 303-322页

作者： JU Dehao liu Rui ZHENG liang DENG Jiahui ZHANG Wenzheng HUO Jinlu HUANG Li Shanghai Marine Diesel Engine Research Institute National key Laboratory of Marine Engine Science and Technology key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong University

The asymmetry of the multi-orifice spray will cause uneven heat load of the marine diesel engine,thereby affecting its working performance and service ***,an in-depth understanding of the spray and flame characteristics of multi-orifice nozzles will guide the optimization of the nozzle structure,needle design and diesel atomization and combustion *** this reason,four groups of dual-orifice nozzles with different hole diameters(0.1-0.55 mm) and mass flow rates covering the typical marine medium-speed diesel injections are designed and customized,and the constant volume chamber(CVC) with high temperature and pressure is used to simulate the actual in-cylinder working conditions of the diesel engine for the spray visualization *** study the asymmetry of the fuel sprays discharged from a diesel injector,the multi-orifice nozzle is simplified as a dual-orifice nozzle in this *** with X-ray Computed Tomography(CT) imaging technology,the influences of the nozzle internal structure on the spray and flame asymmetry are studied in the constructed supercritical *** is found that the asymmetry of the inlet angle and the equivalent length-diameter ratio is positively correlated with the inconsistency of the dual *** an increase in the injection pressure and nozzle diameter,the asymmetry of the dual spray becomes more pronounced,resulting in greater disparities in the ignition delay times and ignition positions of the two ***,the increase in nozzle diameter also leads to combustion instability,resulting in a flame with a serrated *** the increase of ambient temperature,the proportion of liquid phase in the jet decreases and the relative density of spray front decreases.

关键词： atomization dual-orifice nozzle nozzle structure spray flame asymmetry

Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI ke XIE Meng XIA Huarong CHENG Anyu liu Yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei Li Qianqian liang Li Xu Changsheng Ding Yu liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies