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Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma

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Signal Transduction and Targeted Therapy 2020年第1期5卷 382-401页

作者： Yuanbo kang Weihan He Caiping Ren Jincheng Qiao Qiuyong Guo Jingyu Hu Hongjuan Xu Xingjun Jiang Lei Wang Department of Neurosurgery Cancer Research InstituteXiangya HospitalCentral South University410008 ChangshaHunanChina Cancer Research Institute Collaborative Innovation Center for Cancer MedicineSchool of Basic Medical ScienceCentral South University410008 ChangshaHunanChina The NHC key Laboratory of Carcinogenesis and The key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Xiangya HospitalCentral South University410008 ChangshaHunanChina

Nasopharyngeal carcinoma(NPC)is a malignant epithelial carcinoma of the head and neck region which mainly distributes in southern China and Southeast Asia and has a crucial association with the Epstein–Barr *** on epidemiological data,both incidence and mortality of NPC have significantly declined in recent decades grounded on the improvement of living standard and medical level in an endemic region,in particular,with the clinical use of individualized chemotherapy and intensity-modulated radiotherapy(IMRT)which profoundly contributes to the cure rate of NPC *** tackle the challenges including local recurrence and distant metastasis in the current NPC treatment,we discussed the implication of using targeted therapy against critical molecules in various signal pathways,and how they synergize with chemoradiotherapy in the NPC *** treatment including targeted therapy and IMRT or concurrent chemoradiotherapy is presumably to be future options,which may reduce radiation or chemotherapy toxicities and open new avenues for the improvement of the expected functional outcome for patients with advanced NPC.

关键词： chemotherapy targeted treatment

Changes in neurological and pathological outcomes in a modified rat spinal cord injury model with closed canal

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Neural Regeneration Research 2020年第4期15卷 697-704页

作者： Xin Sun Xing-Zhen Liu Jia Wang Hai-Rong Tao Tong Zhu Wen-Jie Jin kang-Ping Shen Shanghai key Laboratory of Orthopedic Implants Department of Orthopedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pathology Shanghai Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Most animal spinal cord injury models involve a laminectomy,such as the weight drop model or the transection ***,in clinical practice,many patients undergo spinal cord injury while maintaining a relatively complete spinal ***,open spinal cord injury models often do not simulate real injuries,and few previous studies have investigated whether having a closed spinal canal after a primary spinal cord injury may influence secondary ***,we aimed to assess the differences in neurological dysfunction and pathological changes between rat spinal cord injury models with closed and open spinal ***-Dawley rats were randomly divided into three *** the sham group,the tunnel was expanded only,without inserting a screw into the spinal *** the spinal cord injury with open canal group,a screw was inserted into the spinal canal to cause spinal cord injury for 5 minutes,and then the screw was pulled out,leaving a hole in the vertebral *** the spinal cord injury with closed canal group,after inserting a screw into the spinal canal for 5 minutes,the screw was pulled out by approximately 1.5 mm and the flat end of the screw remained in the hole in the vertebral plate so that the spinal canal remained closed;this group was the modified model,which used a screw both to compress the spinal cord and to seal the spinal *** 7 days post-operation,the Basso-Beattie-Bresnahan scale was used to measure changes in neurological ***-eosin staining was used to assess *** evaluate the degree of local secondary hypoxia,immunohistochemical staining and western blot assays were applied to detect the expression of hypoxia-inducible factor 1α(HIF-1α)and vascular endothelial growth factor(VEGF).Compared with the spinal cord injury with open canal group,in the closed canal group the Basso-Beattie-Bresnahan scores were lower,cell morphology was more irregular,the percentage of morphologically normal neurons was lower

关键词： Basso-Beattie-Bresnahan scores closed spinal canal HIF-1α hypoxia model nerve regeneration open spinal canal rat secondary injury spinal cord injury VEGF

Chemically Modified Ordered Mesoporous Carbon/Polyaniline Composites for Electrochemical Capacitors

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Chemical Research in Chinese Universities 2011年第2期27卷 295-299页

作者： KONG Llng-bin ZHANG Jing CAI Jlan-jun YANG Zhen-sheng LUO Yong-chun kang Long State key Laboratory of Gansu Advanced Non-ferrous Metal Materials School of Materials Science and Engineering Lanzhou University of Technology Lanzhou 730050 P. R. China

Chemically modified ordered mesoporous carbon CMK-3 materials were prepared by means of an easy wet-oxidative method in 2 mol/L nitric acid aqueous solution. A large amount of oxygen-containing functional groups were introduced onto the CMK-3 surface. Modified CMK-3（m-CMK-3） and aniline monomer were polymerized via an in situ chemical oxidative polymerization method. Morphological characterizations of m-CMK-3/PANI （polyaniline） composites were carried out via field emission scanning electron microscopy（SEM）. Their electrochemical properties were investigated with cyclic voltammetry, galvanostatic charge-discharge, and electrochemical impedance spectroscopy. The m-CMK-3/PANI composites have excellent properties in capacitance, and the highest specific capacitance（SC） value was up to 489 F/g, suggesting their potential application in the electrode material for electrochemical capacitors.

关键词： Ordered mesoporous carbon Polyaniline Chemical modification In situ chemical polymerization Electrochemical capacitor

A Novel Self-Penetrated Framework with New Topology Based on Rigid Ligands

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Chinese Journal of Chemistry 2014年第10期32卷 1029-1032页

作者： Guangxun Lyu Qihui Chen Feilong Jiang kang Zhou Kongzhao Su Lian Chen Daqiang Yuan Maochun Hong key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China University of the Chinese Academy of Sciences Beijing 100049China

A novel coordination polymer,formulated as Zn_(6)(TIB)_(4)(BPTC)_(3)(DMA)_(4)(H_(2)O)_(10)[TIB=1,3,5-tris(1-imidazolyl)-benzene,H_(4)BPTC=3,3',5,5'-biphenyltetracarboxylate],has been synthesized and structurally *** investigations reveal that it presents a new topology(topological symbol{6^(2).8^(4)}{6^(3)}4{6^(5).8}6{6^(6)}2)based on self-penetration,and shows interesting fluorescent properties.

关键词： coordination polymer self-penetration new topology interpenetration fluorescent

利用近场、远场激光后向散射反演能见度的新算法

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激光与红外 2008年第4期38卷 315-319页

作者：沈科宇康圣王江安海军装备研究院航空装备论证研究所上海200436 海军工程大学电子工程学院湖北武汉430033

报道了一种综合激光近场回波修正信号与远场信号计算大气均值消光系数并反演大气能见度的新算法。该算法与传统的仅利用远场信息计算大气能见度的方法相比,利用了更多高信噪比信息并提供了传统算法所不能提供的近场信息。利用此算法,自... 详细信息

报道了一种综合激光近场回波修正信号与远场信号计算大气均值消光系数并反演大气能见度的新算法。该算法与传统的仅利用远场信息计算大气能见度的方法相比,利用了更多高信噪比信息并提供了传统算法所不能提供的近场信息。利用此算法,自行研制便携式激光后向散射大气能见度测量仪样机一套,通过大量外场试验证明了该算法的有效性及可靠性。

关键词：后向散射近场回波修正消光系数能见度

Superconductivity in LaPd2Bi2 with CaBe2Ge2-type structure

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Science China(Physics,Mechanics & Astronomy) 2018年第12期61卷 63-66页

作者： QingGe Mu BoJin Pan BinBin Ruan Tong Liu kang Zhao Lei Shan GenFu Chen ZhiAn Ren Institute of Physics and Beijing National Laboratory for Condensed Matter Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Collaborative Innovation Center of Quantum Matter Beijing 100190China

Since the discovery of superconductivity in LaFeAsO1-xFx, the high-Tc iron-based superconductors have been extensively studied from both experimental and theoretical viewpoints [1-8].However,the mechanism of the unconventional superconductivity is still to be *** address such issues,numerous 3d,4d,5d transition metal pnietide,silicide,germanide,chalcogenide materials crystalizing in the similar crystal structure with iron pnictide/ selenide suoerconductors were studied [9-24].

关键词： Superconductivity LaPd2Bi2 CaBe2Ge2-type structure

Isolated rectal diverticulum complicating with rectal prolapse and outlet obstruction: Case report

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World Journal of Gastroenterology 2005年第48期11卷 7697-7699页

作者： Chuang-Wei Chen, Shu-Wen Jao, Huang-Jen lai, Ying-Chun Chill, Jung-Cheng kang, Division of Colon and Rectal Surgery, Department of Surgery Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan, China Division of Colon and Rectal Surgery Department of Surgery Tri-Service General Hospital No. 325 Cheng-Gong Road Section 2 Taipei Taiwan China

The occurrence of rectal diverticula is very rare, with only sporadic reports in the literature since 1911. Symptomatic rectal diverticula are encountered even less *** of these complicated events range from conservative treatments to major surgical *** present a hitherto unreported occurrence of isolated rectal diverticulum complicated with rectal prolapse and outlet obstruction. Delorme's procedure resulted in subsidence of symptoms and resolution of the diverticulum. It provides a minimal invasive surgical technique to successfully address the reported malady.

关键词： Rectal diverticula Rectal prolapse Delorme'sprocedure

颈椎保留椎体后壁椎体次全切除减压结合钛笼植骨AO钢板内固定的有限元分析

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中国组织工程研究 2017年第11期21卷 1723-1729页

作者：康正阳王可刘百峰哈尔滨医科大学附属第五医院骨科黑龙江省大庆市163000

背景:颈椎椎体次全切除减压标准术式是临床常用颈椎前路减压方法之一。近年来在颈椎前路手术治疗原则的指导下有学者提出了颈椎前路保留椎体后壁次全切除减压术,其保留了椎体后壁,不仅增加了颈椎的稳定性,还增加了植骨面积,有利于远期融... 详细信息

背景:颈椎椎体次全切除减压标准术式是临床常用颈椎前路减压方法之一。近年来在颈椎前路手术治疗原则的指导下有学者提出了颈椎前路保留椎体后壁次全切除减压术,其保留了椎体后壁,不仅增加了颈椎的稳定性,还增加了植骨面积,有利于远期融合;同时椎体后壁的保留,可有效防止骨块及植入物误伤脊髓。目的:通过羊颈椎CT数据建立有限元模型,评估行颈椎前路保留椎体后壁椎体次全切除减压加钛笼植骨AO钢板内固定的力学稳定性。方法:选取实验用成年羊颈椎标本进行CT平扫,运用有限元软件将CT数据构建有限元模型(未行手术组)。保留椎体后壁组行C_4保留后壁椎体次全切除及钛笼植骨、AO钢板内固定术;不保留椎体后壁组进行传统术式,即不保留后壁的椎体次全切除及钛笼植骨加AO钢板内固定术。通过有限元软件测试分析颈椎标本各状态下的应力、位移变化。结果与结论:(1)虽然保留后壁组颈椎模型较未行手术组以及不保留后壁组位移略小,术后即刻稳定性较好;但保留后壁组与不保留后壁组位移及应力相比差异并无显著性意义;(2)综上,与传统椎体次全切除减压术相比,保留椎体后壁椎体次全切除减压加钛笼植骨AO钢板内固定具有较好的术后即刻稳定性。

关键词：骨科植入物脊柱植入物颈椎手术保留椎体后壁稳定性有限元分析黑龙江省自然科学基金

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纤维增强复合材料在汽车覆盖件中的应用

吉林大学学报（工学版） 2020年第2期50卷 417-425页

作者：叶辉刘畅闫康康吉林大学汽车仿真与控制国家重点实验室长春130022 陕西汽车控股集团有限公司技术中心西安710200

采用碳纤维和玻璃纤维两种增强材料与环氧树脂基体材料,对汽车发动机罩进行了铺层结构设计、样件制造和性能对比分析。研究表明:纤维增强发动机罩在满足刚度、模态要求的同时能有效减轻质量,实现发动机罩减重51.2%。在不同工况下,将发... 详细信息

采用碳纤维和玻璃纤维两种增强材料与环氧树脂基体材料,对汽车发动机罩进行了铺层结构设计、样件制造和性能对比分析。研究表明:纤维增强发动机罩在满足刚度、模态要求的同时能有效减轻质量,实现发动机罩减重51.2%。在不同工况下,将发动机罩自由模态、横向弯曲刚度、扭转刚度的仿真结果与试验结果和原钢制件发动机罩性能进行了对比,验证了设计的有效性。对复合材料发动机罩铺层优化设计进行了研究,通过优化发动机罩质量相对于初始设计减重9.7%,充分发挥了纤维复合材料在汽车轻量化方面的优势。

关键词：车辆工程纤维复合材料轻量化发动机罩优化设计