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Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder

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General Psychiatry 2024年第2期37卷 265-273页

作者： Jie Wang Wenfeng zhao Huang Wang Haixia Leng Qing Xue Mao Peng Baoquan Min Xiukun Jin Liucen Tan keming Gao Hongxing Wang Songjiang Hospital and Songjiang Research Institute Shanghai Key Laboratory of Emotions and Affective DisordersShanghai Jiao Tong University School of MedicineShanghaiChina Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyangHubeiChina Division of Neuropsychiatry and Psychosomatics Department of NeurologyXuanwu Hospital of Capital Medical UniversityBeijingChina Electroconvulsive Therapy University Hospitals Cleveland Medical CenterClevelandOhioUSA Department of Psychiatry Case Western Reserve University School of MedicineClevelandOhioUSA Institute of Sleep and Consciousness Disorders Center of EpilepsyBeijing Institute for Brain DisordersCapital Medical UniversityBeijingChina Institute of Special Medical Sciences School of Forensic MedicineShanxi Medical UniversityTaiyuanShanxiChina

Background Although 15 mA transcranial alternating current stimulation(tACS)has a therapeutic effect on depression,the activations of brain structures in humans accounting for this tACS configuration remain largely *** To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA,delivered via the forehead and the mastoid electrodes in the human *** Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve,first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS *** The electric field distributions of the sagittal,coronal and axial planes showed that the bilateral frontal lobes,bilateral temporal lobes,hippocampus,cingulate,hypothalamus,thalamus,amygdala,cerebellum and brainstem were visibly stimulated by the 15 mA tACS *** Brain-wide activation,including the cortex,subcortical structures,cerebellum and brainstem,is involved in the 15 mA tACS intervention for first-episode major depressive *** results indicate that the simultaneous involvement of multiple brain regions is a possible mechanism for its effectiveness in reducing depressive symptoms.

关键词： stimulation involvement activation

Investigation on vehicle occupant dummy applicability for under-foot impactloading conditions

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Chinese Journal of Traumatology 2024年第4期27卷 235-241页

作者： Teng-Fei Tian Fu-Hao Mo Hao-Yang Su Can Huang Hui zhao Jun Liu Bo Shang Kui Li Jin-Long Qiu State key Laboratory of Advanced Design and Manufacture for Vehicle Body Hunan UniversityChangsha410082China Institute for Traffic Medicine Daping HospitalArmy Medical UniversityChongqing400042China Chongqing Zhongzheng Judicial Expert Center Chongqing400020China NIO Limited Liability Company Shanghai200050China College of Medical Informatics Chongqing Medical UniversityChongqing400016China Chongqing key Laboratory of Traffic Injury and Vehicle Ergonomics Chongqing400042China

Purpose:Under-foot impact loadings can cause serious lower limb injuries in many activities,such asautomobile collisions and underbody explosions to military *** present study aims to comparethe biomechanical responses of the mainstream vehicle occupant dummies with the human body lowerlimb model and analyze their robustness and applicability for assessing lower limb injury risk in underfoot impact loading ***:The Hybrid III model,the test device for human occupant restraint(THOR)model,and a hybridhuman body model with the human active lower limb model were adopted for under-foot impactanalysis regarding different impact velocities and initial lower limb ***:The results show that the 2 dummy models have larger peak tibial axial force and highersensitivity to the impact velocities and initial postures than the human lower limb *** particular,the Hybrid III dummy model presented extremely larger peak tibial axial forces than the human lowerlimb *** the case of minimal difference in tibial axial force,Hybrid III's tibial axial force(7.5 KN)isstill 312.5%that of human active lower limb's(2.4 KN).Even with closer peak tibial axial force values,thebiomechanical response curve shapes of the THOR model show significant differences from the humanlower limb ***:Based on the present results,the Hybrid III dummy cannot be used to evaluate the lowerlimb injury risk in under-foot loading *** contrast,potential improvement in ankle biofidelity and related soft tissues of the THOR dummy can be implemented in the future for betterapplicability.

关键词： Lower limb Under-foot impact Human body model Dummy Finite element model

Ultraclean transfer of graphene by mechanically exfoliating polymer with modified crosslink density

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Nano Research 2024年第8期17卷 6795-6802页

作者： Qi Lu Jiawei Yang Chaofan Zhou zhaoning Hu Saiyu Bu Bingbing Guo Yixuan zhao Junhao Liao Mingpeng Shang Ge Chen Kaicheng Jia Jianbo Yin Qiang Zeng Li Lin Zhongfan Liu College of Science China University of Petroleum(Beijing)Beijing 102249China School of Materials Science and Engineering Peking UniversityBeijing 100871China Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular ScienceCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene Institute Beijing 100095China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Department of Electronics Peking UniversityBeijing 100871China Second Clinical Division National Engineering Laboratory for Digital and Material Technology of StomatologyPeking University School and Hospital of StomatologyBeijing 100081China

The transfer of graphene from metallic substrates onto application-specific substrates is usually inevitable for the applications of high-quality graphene films derived from chemical vapour deposition(CVD)*** used to support the graphene films during the transfer,the coating of the polymer would produce the surface contaminations and hinder the industrially compatible *** this work,through the thermal imidization of polyamide acid(PAA)to polyimide(PI)and tuning of the concentration of dangling chains,we achieved the ultraclean and crack-free transfer of graphene wafers with high electronic *** resulting contamination-free and hydrophilic surface also enabled the observed improved cell viability in a biomedical *** avoiding aqueous etching or the usage of strong bases,our proposed transfer method is industrially compatible for batch transfer of graphene films towards the real applications.

关键词： chemical vapour deposition(CVD)graphene films graphene transfer ultraclean transfer transfer medium crosslink density cell viability assay

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有砟与无砟轨道系统隧底上拱变形传递规律

中国铁道科学 2024年第2期45卷 123-133页

作者：宋慧来赵一馨刘钰赵国堂西南交通大学土木工程学院四川成都610031 中国铁道科学研究院集团有限公司铁路基础设施检测所北京100081 中国国家铁路集团有限公司北京100844

在分析不同成因上拱变形隧道力学环境基础上,构建隧底荷载作用下有砟与无砟轨道的隧底上拱变形传递模型,获得这种变形向轨面的传递规律,并建立隧底荷载与变形传递比的函数关系。结果表明:上拱变形在初支底面—填充层表面传递时,幅值减小... 详细信息

在分析不同成因上拱变形隧道力学环境基础上,构建隧底荷载作用下有砟与无砟轨道的隧底上拱变形传递模型,获得这种变形向轨面的传递规律,并建立隧底荷载与变形传递比的函数关系。结果表明:上拱变形在初支底面—填充层表面传递时,幅值减小,波长增大;在道床表面—轨面传递时,幅值和波长均减小;上拱变形在道床内传递时,有砟道床的波长和幅值均减小,无砟道床则波长增大,幅值基本不变;隧底荷载的大小及纵向分布长度变化会使幅值传递曲线整体平移,且荷载大小主要改变波长变化速度,而荷载纵向长度则主要改变初始波长;在大小低于250 kPa、长度超过27.8 m的隧底荷载作用下,选用有砟轨道更易控制轨面幅值和轨面波长;当荷载大小超过250 kPa或长度小于27.8 m时,选用无砟轨道更易控制轨面幅值和波长。

关键词：高速铁路隧道无砟轨道有砟轨道上拱变形变形传递

Amelioration of dextran sodium sulphate-induced colitis in mice by treatment with Lactobacillus rhamnosus and Lactobacillus reuteri:intraspecific and interspecific patterns

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Food Science and Human Wellness 2024年第5期13卷 2799-2812页

作者： Chunxiu Lin Yuxing Zheng Bo Zhang Guopeng Lin kexin Shang Jianxin zhao Gang Wang Wei Chen State key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China

Lactobacillus rhamnosus(Rh)and Lactobacillus reuteri(Re)are well-known probiotic species in inflammatory bowel disease(IBD)*** variations between these species’efficacy against colitis,and their model of action in this regard,are intriguing and enable treatment to be individually tailored to *** this study,four strains each of Rh and Re were isolated from fecal samples and their draft genomes were *** anti-colitis activities of both strains involved various aspects of intestinal immune,physical,chemical,and biological barrier ***,the tested strains exhibited considerable interspecies and intraspecies specificity in colitis *** strains significantly outperformed Re strains in terms of short-chain fatty acid ***,Re strains were more effective than Rh strains in inhibiting production of inflammatory factors;promoting production of intestinal mucus,antimicrobial peptides,and tight junction proteins;and supporting the stem cell *** accounts for the anti-colitis outcomes of Re strains being superior to those of Rh *** addition,the effective Rh and Re strains were found to express high concentrations of specific carbohydrate metabolism-and prophage-related genes,*** together,the results of this study could assist researchers in developing effective therapies for IBD.

关键词： Inflammatory bowel disease Anti-colitis Lactobacillus rhamnosus Lactobacillus reuteri Intestinal barrier function Short-chain fatty acids

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多簧片结构的磁保持继电器多物理场刚柔耦合仿真模型建立和实验分析

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电工技术学报 2024年第10期39卷 3192-3205页

作者：赵靖英李宁张雪辉赵正元河北工业大学电气工程学院天津300401 河北工业大学省部共建电工装备可靠性与智能化国家重点实验室天津300401 西安铁路信号有限责任公司西安710010

多簧片结构的磁保持继电器衔铁转动引起的触点碰撞、弹跳现象使运动过程复杂,静、动态特性理论分析和仿真模型建立困难。以某型号多簧片结构的磁保持继电器为研究对象,理论分析结构拓扑及工作机理,考虑触点间切入深度,引入狄拉克函数和... 详细信息

多簧片结构的磁保持继电器衔铁转动引起的触点碰撞、弹跳现象使运动过程复杂,静、动态特性理论分析和仿真模型建立困难。以某型号多簧片结构的磁保持继电器为研究对象,理论分析结构拓扑及工作机理,考虑触点间切入深度,引入狄拉克函数和赫维赛德函数,解决簧片受力分散及触点由于碰撞、弹跳引起的作用力不连续问题;将簧片等效为悬臂梁,基于欧拉-伯努利梁理论建立触簧系统三簧片分段耦合动力学模型。利用Ansys Maxwell引入基于误差的自适应网格划分方法求解电磁机构静态特性;考虑触簧系统簧片运动变形效应,通过ADAMS基于模态理论,构建刚柔耦合动力学仿真模型。基于分段动力学思想,搭建电-磁-机械运动多物理场刚柔耦合仿真模型。利用高速摄像机、电流探头等设计磁保持继电器实验方案,搭建实验平台,测试并分析磁保持继电器触点吸合运动时间、触点压力、弹跳时间、线圈电流,并分析人工装配簧片引起触点压力不同使继电器动作过程存在的不一致性问题,验证该文所提多簧片结构的磁保持继电器特性分段耦合分析方法和多物理场刚柔耦合仿真模型的有效性。

关键词：磁保持继电器多簧片结构碰撞弹跳分段耦合动力学模型多物理场刚柔耦合

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横向磁通永磁直线电机电磁振动特性分析

电工技术学报 2024年第1期39卷 168-181页

作者：赵玫赵君左思承禹国栋张华强哈尔滨工业大学电气工程及自动化学院哈尔滨150001 特种电机与高压电器教育部重点实验室(沈阳工业大学) 沈阳110023 国网江西省电力有限公司超高压分公司南昌330096

横向磁通永磁直线电机的电负荷与磁负荷相互解耦,且各相之间相互解耦,易于实现模块化和多相化,因此在石油开采领域有着良好的应用前景。首先,该文基于磁场调制原理,对横向磁通永磁直线电机的径向电磁力波进行了推导计算,得出对径向电磁... 详细信息

横向磁通永磁直线电机的电负荷与磁负荷相互解耦,且各相之间相互解耦,易于实现模块化和多相化,因此在石油开采领域有着良好的应用前景。首先,该文基于磁场调制原理,对横向磁通永磁直线电机的径向电磁力波进行了推导计算,得出对径向电磁力波影响最大的因素为轴向气隙磁通密度分量与径向气隙磁通密度分量,在此基础上对径向电磁力波的时空特性与频谱特性进行仿真计算,得出电枢磁通密度对电机径向电磁力波的频谱特性的影响;然后,考虑到电机实际运行中可能出现的次级偏心问题,揭示偏心度的大小对径向电磁力波幅值的影响,并对比不同偏心度下的电机径向磁拉力与轴向磁拉力,定量分析偏心度对不平衡磁拉力的影响;最后,为避免共振,利用有限元软件对电机的初级进行了模态分析与谐响应分析,结果表明低速状态下横向磁通永磁直线电机的额定运行频率较低,不会引起初级的共振,适合用作往复式潜油电泵的驱动电机。

关键词：横向磁通永磁直线电机径向电磁力波电磁振动偏心度

Treatment outcomes and cognitive function following electroconvulsive therapy in patients with severe depression

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World Journal of Psychiatry 2023年第11期13卷 949-957页

作者： ke-Yan Han Chao-Min Wang Chong-Bo Du Jun Qiao Yong-Liang Wang Li-zhao Lv Department of Neurology The First Hospital of Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina

BACKGROUND Traditional treatments for major depressive disorder(MDD),including medication and therapy,often fail and have undesirable side *** therapy(ECT)uses electrical currents to induce brief seizures in the brain,resulting in rapid and potent antidepressant ***,owing to misconceptions and controversies,ECT is not as widely used as it could and often faces *** To evaluate the efficacy and safety of ECT compared to those of medication and/or therapy in patients with severe *** This prospective cohort study included 220 individuals with severe MDD who were divided into the ECT and non-ECT *** patients in the ECT group underwent bilateral ECT three times a wk until they either achieved remission or reached a maximum of 12 *** non-ECT group received medication and/or therapy according to clinical guidelines for *** primary outcome was the variation in the hamilton depression rating scale(HDRS)score from treatment/ECT initiation to week *** addition,patients’quality of life,cognitive abilities,and biomarkers were measured throughout the *** Although both groups showed significant improvements in their HDRS scores over time,the improvement was more pronounced in the ECT group than in the non-ECT ***,the ECT group exhibited a more substantial improvement in the quality of life and cognitive function than those of the non-ECT *** with the non-ECT group,the ECT group exhibited evidently lower variations in the brain-derived neurotrophic factor(BDNF)and cytokine interleukin-6(IL-6)*** side effects were generally mild and comparable between the two *** is safer and more potent than medication and/or therapy in mitigating depressive symptoms,enhancing wellbeing,and bolstering cognitive capabilities in individuals with severe *** may also affect the levels of BDNF and IL-6,which are indicators of neuroplasticity and inflammation,***

关键词： Alternative therapies Biomarkers Cognitive function Electroconvulsive therapy Major depressive disorder Medication therapy

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轮式收获机变速箱总成磨合试验台研发设计

拖拉机与农用运输车 2024年第3期51卷 75-79页

作者：李艳波潘华磊何向辉步雨辰赵亚燊刘克洛阳西苑车辆与动力检验所有限公司河南洛阳471039 中国一拖集团有限公司收获机具公司河南洛阳471041

针对现有轮式收获机变速箱总成磨合试验台的缺点,基于变频驱动技术、液压控制技术和自动换挡技术,设计了一种全新的、可实现多功能测试的轮式收获机变速箱总成磨合试验台。试验台采用LabVIEW软件设计数据采集系统,可以很好地采集到轮式... 详细信息

针对现有轮式收获机变速箱总成磨合试验台的缺点,基于变频驱动技术、液压控制技术和自动换挡技术,设计了一种全新的、可实现多功能测试的轮式收获机变速箱总成磨合试验台。试验台采用LabVIEW软件设计数据采集系统,可以很好地采集到轮式收获机变速箱总成在试验过程中的数据及数据曲线,根据所得数据自动判断变速箱总成的装配是否满足要求,并依此判断变速箱总成的安全性能,更早地发现产品的缺陷。

关键词：轮式收获机变速箱磨合 LabVIEW