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Black holes as the source of dark energy:A stringent test with high-redshift JWST AGNs

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 181-188页

作者： Lei Lei Lei Zu Guan-Wen Yuan zhao-Qiang Shen Yi-Ying Wang Yuan-Zhu Wang Zhen-Bo Su Wen-ke Ren Shao-Peng Tang Hao Zhou Chi Zhang Zhi-Ping Jin Lei Feng Yi-Zhong Fan Da-Ming Wei key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China CAS key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China

Studies have proposed that there is evidence for cosmological coupling of black holes(BHs)with an index of k≈3;hence,BHs serve as the astrophysical source of dark ***,the data sample is limited for the redshifts of≤*** recent years,the James Webb Space Telescope(JWST)has detected many high-redshift active galactic nuclei(AGNs)and *** the JWST NIRSpec-/NIRCam-resolved AGNs,three are determined to be in early-type host galaxies with a redshift of z~***,their M_(*)and MBH are in tension with the predicted cosmological coupling of black holes with k=3 at a confidence level of~2σ,which challenges the hypothesis that BHs serve as the origin of dark *** work on high-redshift AGNs using the JWST will further assess such a hypothesis by identifying more early-type host galaxies in the higher mass range.

关键词： dark energy supermassive black hole active galactic nuclei James Webb Space Telescope

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma ke Ye Xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Ultrafast sodium storage of alkylamine molecule tailored MnPSenabled by quasi-topological intercalation mechanism

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Science China Chemistry 2024年

作者： Xueyang Tu ke Fan Baixin Peng Zhuoran Lv Yiran Hao Wujie Dong Wei zhao Zuocheng Wang Haitao Huang Yuqiang Fang Fuqiang Huang State key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Research Institute for Smart Energy The Hong Kong Polytechnic University State key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University Jiangxi Far East Battery Co. Ltd.

Two-dimensional transition metal trithiophosphates （TMPS3,TM=Mn,Fe,Co,etc.） are competitive anode materials for sodium-ion batteries （SIBs） due to their high theoretical capacity (>1,300 mAh g-1) but suffer from limited practical capacity(～300 mAh g-1) and inferior rate capability caused by sluggish Na+intercalation/deintercalation kinetics and severe structural ***,alkylamine molecules are first proposed as intercalation guests to significantly boost the electrochemical activity and stability of *** to MnPS3,C3H9N-MnPS3enlarges the interlayer spacing from 6.48 to 10.23?and shows a 10～5times higher electrical conductivity,which provides fast ion/electron transport and high strain adaptability,realizing a quasi-topological Na+intercalation ***,C3H9N-MnPS3exhibits an ultrahigh reversible capacity of 775m Ah g-1at 0.5 A g-1and superior high-rate cycling stability with～100%capacity retention after 2,500 cycles at 15 A g-1,ranking it among the top metal trithiophosphate-based anode materials *** calculations indicate that the improved sodium storage performance of C3H9N-MnPS3results from the reduced bonding energy of P–S bonds and increased adsorption energy of Na+.This work is expected to provide an efficient strategy for the design of high-performance layered anode materials for SIBs.

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欧盟对华认知变化及其影响

现代国际关系 2024年第9期 41-60,142页

作者：赵柯唐耀卓中共中央党校(国家行政学院)国际战略研究院俄罗斯与欧洲研究所中共中央党校(国家行政学院)研究生院

当前,欧盟对华认知出现偏差,认为中国的经济模式损害了欧盟的经济竞争力,其发展挑战了西方主导的国际秩序,削弱了欧盟的战略地位。在此基础上,欧盟积极推进“印太战略”,加强跨大西洋对华政策协调,以更具“对抗性”的姿态对中欧经济关... 详细信息

当前,欧盟对华认知出现偏差,认为中国的经济模式损害了欧盟的经济竞争力,其发展挑战了西方主导的国际秩序,削弱了欧盟的战略地位。在此基础上,欧盟积极推进“印太战略”,加强跨大西洋对华政策协调,以更具“对抗性”的姿态对中欧经济关系进行“再平衡”。在欧盟对华政策地缘政治色彩越来越浓的情况下,中欧关系出现“安全转向”,经贸关系的紧密程度下降,务实合作受意识形态分歧的冲击加大。但中欧关系有着强大内生动力和广阔发展前景,双方都是多边主义的坚定维护者,欧盟需要与中国合作来共同解决全球问题,欧盟的对华政策调整存在约束。

关键词：中欧关系欧盟对华政策国际秩序

Impacts of monsoon break events in the western North Pacific on the cross-equatorial flows over the Maritime Continent

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Atmospheric and Oceanic Science Letters 2024年第2期17卷 33-38页

作者： Xiaoxuan zhao Minghao Bi ke Xu Jianqi Sun Riyu Lu Nansen-Zhu International Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina State key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

本文利用ERA5逐日再分析资料,探讨了1979-2020年间西北太平洋季风中断事件对海洋性大陆越赤道气流的影响.合成结果表明,西北太平洋季风中断事件会造成高,低空越赤道气流减弱,即高层南风异常,低层北风异常,与此相关的环流异常表现为西北... 详细信息

本文利用ERA5逐日再分析资料,探讨了1979-2020年间西北太平洋季风中断事件对海洋性大陆越赤道气流的影响.合成结果表明,西北太平洋季风中断事件会造成高,低空越赤道气流减弱,即高层南风异常,低层北风异常,与此相关的环流异常表现为西北太平洋高层气旋,低层反气旋的斜压结构。特别的是,西北太平洋季风中断对高空越赤道气流的影响更为显著,92%的季风中断事件都导致高空越赤道气流减弱,而只有70%的事件造成低空越赤道气流减弱,这是由于低空越赤道气流同时还受到赤道中东太平洋海温异常的调控.

关键词：西北太平洋夏季风季风中断越赤道气流海洋性大陆

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盾构掘进姿态控制技术研究现状与未来展望

隧道建设（中英文） 2024年第6期44卷 1154-1164页

作者：陈珂刘天瑞杨钊华中科技大学国家数字建造技术创新中心湖北武汉430074 华中科技大学土木与水利工程学院湖北武汉430074 中交第二航务工程局有限公司湖北武汉430040

为系统地分析我国盾构掘进姿态控制技术的研究进展,基于知网检索到的32篇相关文献,总结盾构掘进姿态的主要表征参数和影响因素,并以盾构液压推进系统为例论述其控制原理。同时,结合盾构姿态智能控制的部分案例,总结PID控制、自适应控制... 详细信息

为系统地分析我国盾构掘进姿态控制技术的研究进展,基于知网检索到的32篇相关文献,总结盾构掘进姿态的主要表征参数和影响因素,并以盾构液压推进系统为例论述其控制原理。同时,结合盾构姿态智能控制的部分案例,总结PID控制、自适应控制、模糊控制、基于神经网络的控制和基于智能算法的控制等技术的优劣势及应用场景。基于以上分析,对盾构姿态控制技术的发展方向进行展望。研究发现:1)盾构掘进姿态的影响因素主要包括几何参数、地层参数和盾构掘进参数。2)由于盾构推进系统需要同时完成盾构向前推进和姿态调整等复杂任务,因此该系统的参数对盾构姿态有着很大的影响,是姿态控制的关键因素之一。3)相较于传统PID控制方法,智能控制方法与PID控制的结合可以提高系统的响应速度、精度、适应能力和鲁棒性。4)未来研究可以围绕基于多源数据融合的控制算法、构建数据-机制混合驱动的控制技术以及加强控制技术在实际工程中的实用性等方面展开,实现更精准、更高效的盾构掘进姿态控制。

关键词：盾构掘进姿态控制 PID控制自适应控制模糊控制神经网络智能算法

数字鸿沟与中国式现代化:理论分析与实证检验

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管理现代化 2024年第2期44卷 190-200页

作者：赵若男克甝新疆财经大学统计与数据科学学院新疆乌鲁木齐830012

选取2014-2022年30个省市区的面板数据,从理论分析与实证检验的角度探讨了数字鸿沟对中国式现代化的影响。结论:数字鸿沟是阻碍中国式现代化发展的显著因素;数字鸿沟对中国式现代化发展的影响主要集中于使用鸿沟,但有向结果鸿沟转移的趋... 详细信息

选取2014-2022年30个省市区的面板数据,从理论分析与实证检验的角度探讨了数字鸿沟对中国式现代化的影响。结论:数字鸿沟是阻碍中国式现代化发展的显著因素;数字鸿沟对中国式现代化发展的影响主要集中于使用鸿沟,但有向结果鸿沟转移的趋势;数字鸿沟对中国式现代化发展的影响呈边际递增趋势;数字鸿沟对中国式现代化发展的影响具有北部地区大于南部地区、西部地区大于东中部地区的特征;数字鸿沟通过降低市场主体活力、扩大城乡居民收入差距和减缓产业结构升级速度,阻滞中国式现代化发展。

关键词：使用鸿沟中国式现代化梅特卡夫定律边际递增

Growth hormone improves insulin resistance in visceral adipose tissue after duodenal-jejunal bypass by regulating adiponectin secretion

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World Journal of Diabetes 2024年第6期15卷 1340-1352页

作者： Zi-Tian Liu Guang-Wei Yang Xiang zhao Shuo-Hui Dong Yang Jiao Zheng Ge Ao Yu Xi-Qiang Zhang Xin-Zhen Xu Zhi-Qiang Cheng Xiang Zhang ke-Xin Wang Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of General Surgery Shandong University of Qilu Hospital(Qingdao)Qingdao 266000Shandong ProvinceChina

BACKGROUND The mechanism of improvement of type 2 diabetes after duodenal-jejunal bypass(DJB)surgery is not *** To study the morphological and functional changes in adipose tissue after DJB and explore the potential mechanisms contributing to postoperative insulin sensitivity improvement of adipose tissue in a diabetic male rat *** DJB and sham surgery was performed in a-high-fat-diet/streptozotocin-induced diabetic rat *** adipose tissue was weighed and observed under *** inguinal fat to represent subcutaneous adipose tissue(SAT)and mesangial fat to represent visceral adipose ***-sequencing was utilized to evaluate gene expression alterations *** hematoxylin and eosin staining,reverse transcription-quantitative polymerase chain reaction,western blot,and enzyme-linked immunosorbent assay were used to study the *** resistance was evaluated by *** After DJB,whole body blood glucose metabolism and insulin sensitivity in adipose tissue *** cell volume in both visceral adipose tissue(VAT)and SAT *** to SAT,VAT showed more significantly functional alterations after DJB and keGG analysis indicated growth hormone(GH)pathway and downstream adiponectin secretion were involved in metabolic *** circulating GH and adiponectin levels and GH receptor and adiponectin levels in VAT *** experiment showed that GH stimulated adiponectin secretion and improve insulin *** GH improves insulin resistance in VAT in male diabetic rats after receiving DJB,possibly by increasing adiponectin secretion.

关键词： Growth hormone Insulin resistance Bariatric surgery Adipose tissue Adiponectin

Genomic investigation and nationwide tracking of pediatric invasive nontyphoidal Salmonella in China

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mLife 2024年第1期3卷 156-160页

作者： Yefang ke Lin Teng Zhe Zhu Wenbo Lu Wenyuan Liu Haiyang Zhou Qi Yu Lina Ye Pan Zhu Guoping zhao Min Yue Deparment of Clinical Laboratory Ningbo Women and Children's HospitalNingboChina Department of Veterinary Medicine Zhejiang University Cllege of Animal SciencesHangzhouChina Department of Blood Transfusion Ningbo No.2 HospitalNingboChina Office of Screening Ningbo Women and Children's HospitalNingboChina Neonatal Intensive Care Unit Ningbo Women and Children's HospitalNingboChina School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouChina CAS key Laboratory of Synthetic Biology Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina Department of Microbiology and Microbial Engineering School of Life SciencesFudan UniversityShanghaiChina State key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouChina Hainan Institute of Zhejiang University SanyaChina

Impact Statement。Invasive nontyphoidal Salmonella(iNTS)causes significant concern with~15%morbidity,affecting populations mainly in African countries.

关键词： pediatric nationwide morbidity