检索结果-南通市图书馆

Design,synthesis and biological evaluation of new rhodacyanine analogues as potential antitumor agents

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2012年第4期23卷 415-418页

作者： Yang Xiong Li Xin Zhai Wei ke Liao Wu fu zhu Ying He Ping Gong key Laboratory of Structure-based Drug Design and Discovery of Ministry of Education School of Pharmaceutical EngineeringShenyang Pharmaceutieal UniversityShenyang 110016China

In an attempt to develop potent antitumor agents,new rhodacyanine analogues containing the pyridinium ring（5a-5h）,the isoquinolinium ring（6a-6c） and the quinolinium ring（7a-7e） linked to the rhodanine ring via N-N covalent bond were designed, synthesized and evaluated for antitumor activity against human lung cancer cell line（H460） by MTT assay in *** of the tested compounds showed enhanced antitumor activity with IC_（50） values ranging from 0.006 to 9.2 u,mol/L as compared to the lead compound *** them,the most promising compound 7d（IC_（50） = 0.006μmol/L） was 216.7 times more active than MKT-077（IC_（50） = 1.3μmol/L）.The preliminary structure-activity relationship of the target compounds was discussed.

关键词： Rhodacyanine analogues Antitumor Synthesis

Digital Twin for Integration of Design-Manufacturing-Maintenance:An Overview

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2022年第4期35卷 1-20页

作者： Yang fu Gang zhu Mingliang zhu fuzhen Xuan key Laboratory of Pressure Systems and Safety Ministry of EducationSchool of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237China

Traditional design,manufacturing and maintenance are run and managed independently under their own rules and regulations in an increasingly time-and-cost inefective manner.A unifed platform for efcient and intelligent designmanufacturing-maintenance of mechanical equipment and systems is highly needed in this rapidly digitized *** this work,the defnition of digital twin and its research progress and associated challenges in the design,manufacturing and maintenance of engineering components and equipment were thoroughly *** is indicated that digital twin concept and associated technology provide a feasible solution for the integration of design-manufacturingmaintenance as it has behaved in the entire lifecycle of *** this aim,a framework for information-physical combination,in which a more accurate design,a defect-free manufacturing,a more intelligent maintenance,and a more advanced sensing technology,is prospected.

关键词： Digital twin Design-manufacturing-maintenance integration Artifcial intelligence Deep learning Information fusion Cyber-physical systems

Numerical simulation study on penetration performance of depleted Uranium(DU)alloy fragments

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2021年第1期17卷 50-55页

作者： fu-lin zhu Yang Chen Gui-li zhu Sichuan Aerospace System Engineering Institute Chengdu610100SichuanChina

Due to its high strength,high density,high hardness and good penetration capabilities,Depleted uranium alloys have already shined in armor-piercing *** should also be a lot of room for improvement in the application of fragment killing ***,regarding the performance of the depleted uranium alloy to penetrate the target plate,further investigation is needed to analyze its advantages and disadvantages compared to tungsten *** study the difference in penetration performance between depleted uranium alloy and tungsten alloy fragments,firstly,a theoretical analysis of the adiabatic shear sensitivity of DU and tungsten alloys was given from the perspective of material constitutive ***,taking the cylindrical fragment penetration target as the research object,the penetration process and velocity characteristics of the steel target plates penetrated by DU alloy fragment and tungsten alloy fragment were compared and analyzed,by using finite element software ANSYS/LS-DYNA and Lagrange ***,the influence of different postures when impacting target and different fragment shapes on the penetration results is carried out in the *** results show that in the penetration process of the DU and tungsten alloy fragments,the self-sharpening properties of the DU alloy can make the fragment head sharper and the penetrating ability *** the same conditions,the penetration capability of cylindrical fragment impacting target in vertical posture is better than that in horizontal posture,and the penetration capability of the spherical fragment is slightly better than that of cylindrical fragment.

关键词： Depleted uranium alloy Constitutive model Adiabatic shear Penetration performance Numerical simulation

Analysis of the dominant frequency in a subsonic compressor stator at near stall condition

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2014年第1期59卷 23-28页

作者： ke Shi Song fu School of Aerospace Tsinghua University

IDDES method was applied to investigate the highly unsteady flow in a subsonic compressor stator with very large hub clearance and high incidence *** blade loading variation frequency was found close to the rotating instability(RI)frequency f RI&333 Hz observed in the *** analysis of the flow physics shows that the loading variation is caused by the periodic swing of the large scale separated flow on the blade suction side *** breakdown of the leakage vortex has no significant dominant frequencies,thus cannot be the cause of RI in this compressor stator as normally ***,the vortex shedding and vortex breakdown due to shear layer instability at the outer edge of the blade suction surface separation region excite high frequency unsteadiness that can form the sources of noise.

关键词：压气机亚音速静子非定常流动频分状态失速优势频率

Ionic Charge State Distribution of Au Plasma for 7-Ion System

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2006年第2期45卷 353-356页

作者： CHENG ke zhu Zheng-He TANG Chang-Hua TANG Yong-Jian fu Yi-Bei Institute of Atomic and Molecular Physics Sichuan University Chengdu 610065 China School of Physics Science and Technology Yangtze University Jingzhou 434100 China China Academy of Engineering Physics Mianyang 621900 China

The present work extends the previous work^[2] on 5-ion system to consider 7-ion system （i.e., Au^47＋ -Au^53＋）. It is found that more highly charged ions, e.g., Au^53＋, Au^54＋ etc., could be able to be neglected, however, less highly charged ions, e.g., Au^47＋, Au^46＋ etc., are rather important. Therefore, a new idea to consider 8-ion system, i.e., Au^46＋ - Au^53＋, is under way. As a supplement, we discuss the simultaneous reaction, which would be important in this sort of works.

关键词： Au plasma 7-ion system simultaneous reaction process

A fault locating method for multi-branch hybrid transmission lines in wind farm based on redundancy parameter estimation

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2019年第5期7卷 1033-1043页

作者： ke ZHANG Yongli zhu Xuechun LIU State key Laboratory of Alternate Electrical Power System with Renewable Energy Sources(North China Electric Power University) Baoding 071003China State Grid Wuxi Power Supply Company Wuxi 214000China

In order to solve the problem of‘‘abandoned’’wind caused by short circuit faults in a wind farm,a wind farm fault locating method based on redundancy parameter estimation is *** the characteristics of the traveling wave,transmission equations containing the position of the fault point are *** estimation from statistical theory is used to solve the redundant transmission equations formed by multiple measuring points to locate the *** addition,the bad data error detection capability of the parameter estimation is used to determine bad data and remove *** improves locating accuracy.A length coefficient is introduced to solve the error enlargement problem caused by a transmission line *** proposed fault locating method can solve the fault branch misjudgment problem caused by the short-circuit faults near the data measuring nodes of thewind farm based on the proposed fault interval *** also avoids the requirements to the traveling wave speed of traditional methods,thus its fault location is more *** effectiveness is verified through simulations in PSCAD/EMTDC,and the results show that it can be used in thefault locating of hybrid transmission lines.

关键词： Transmission line Fault location method Parameter estimation Wind power Least squares

A user requirements-oriented privacy policy self-adaption scheme in cloud computing

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2023年第2期17卷 33-44页

作者： Changbo ke fu XIAO Zhiqiu HUANG Fangxiong XIAO School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing 210003China College of computer science and technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Software Engineering Jinling Institute of TechnologyNanjing 210000China

In an ever-changing environment,Software as a Service(SaaS)can rarely protect users'*** able to manage and control the privacy is therefore an important goal for *** the participant of composite service is substituted,it is unclear whether the composite service satisfy user privacy requirement or *** this paper,we propose a privacy policies automatic update method to enhance user privacy when a service participant change in the composite ***,we model the privacy policies and service variation ***,according to the service variation rules,the privacy policies are automatically generated through the negotiation between user and service ***,we prove the feasibility and applicability of our method with the *** the service quantity is 50,ratio that the services variations are successfully checked by monitor is 81%.Moreover,ratio that the privacy policies are correctly updated is 93.6%.

关键词： cloud computing SaaS service privacy protec-tion privacy policies update

RECONSTRUCTION OF SYMMETRIC B-SPLINE CURVES AND SURFACES

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2007年第4期20卷 112-116页

作者： zhu Weidong ke Yinglin College of MechanicaTand Energy Engineering Zhejiang UniversityHangzhou 310027 China

A method to reconstruct symmetric B-spline curves and surfaces is presented. The symmetry property is realized by using symmetric knot vector and symmetric control points. Firstly, data points are divided into two parts based on the symmetry axis or symmetry plane extracted from data points. Then the divided data points are parameterized and a symmetric knot vector is selected in order to get symmetric B-spline basis functions. Constraint equations regarding the control points are deduced to keep the control points of the B-spline curve or surface to be symmetric with respect to the extracted symmetry axis or symmetry plane. Lastly, the constrained least squares fitting problem is solved with the Lagrange multiplier method. Two examples from industry are given to show that the proposed method is efficient, robust and able to meet the general engineering requirements.

关键词： Reconstruction Symmetry Freeform curve Freeform surface B-spline

锐钛矿相TiO_(2)吸附柴油中典型碱性氮化物的模拟计算

在线全文

学校读者我要写书评

暂无评论

石油炼制与化工 2025年第1期56卷 66-75页

作者：王聚财唐克孙潇镝富添洪新辽宁工业大学化学与环境工程学院辽宁锦州121001

为了探究锐钛矿相TiO_(2)(a-TiO_(2))对柴油中典型氮化物(吡啶、苯胺、喹啉)及非氮化物的吸附行为和选择性,利用模拟计算方法研究了吡啶、苯胺、喹啉及非氮化物在a-TiO_(2)(101)晶面吸附过程中的吸附构型、吸附能、Mulliken电荷、电荷... 详细信息

为了探究锐钛矿相TiO_(2)(a-TiO_(2))对柴油中典型氮化物(吡啶、苯胺、喹啉)及非氮化物的吸附行为和选择性,利用模拟计算方法研究了吡啶、苯胺、喹啉及非氮化物在a-TiO_(2)(101)晶面吸附过程中的吸附构型、吸附能、Mulliken电荷、电荷密度、差分电荷密度和态密度等。结果表明:吡啶、苯胺、喹啉吸附于a-TiO_(2)(101)晶面的吸附能分别为-188.59,-100.99,-201.63 kJ mol,3种氮化物均能稳定吸附于a-TiO_(2)(101)晶面,其吸附稳定性由大到小的顺序为喹啉>吡啶>苯胺;在吸附过程中,氮化物将自身一定量的电荷转移到a-TiO_(2)(101)晶面,形成氮化物→a-TiO_(2)(101)晶面的电荷转移通道;吡啶和喹啉在a-TiO_(2)(101)晶面吸附时形成N—Ti化学键,苯胺的氨基H和a-TiO_(2)(101)晶面的O形成氢键。芳烃、烷烃、环烷烃等非氮化物在a-TiO_(2)(101)晶面的吸附强度相近,均弱于氮化物。a-TiO_(2)对氮化物有较好的吸附脱除效果,能选择性去除柴油中的碱性氮化物。

关键词： TiO_(2) 吸附氮化物柴油模拟计算