检索结果-南通市图书馆

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 18-45页

作者： ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong li Yuewei Chen Nian liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

贵州省基层疾控机构职业卫生应急处置能力的现状调查

在线全文

学校读者我要写书评

暂无评论

中国冶金工业医学杂志 2017年第5期34卷 507-508页

作者：陈燕陈可风李玲汪思顺吴玛莉贵州省疾病预防控制中心贵州贵阳550004

目的研究贵州省基层疾控职业卫生应急处置能力现状,为卫生行政部门及各级政府进一步加强职业病防治工作提供科学依据。方法通过问卷调查,采用描述性分析、卡方检验等流行病学研究方法,对贵州省基层疾控职业卫生应急处置能力现状进行分... 详细信息

目的研究贵州省基层疾控职业卫生应急处置能力现状,为卫生行政部门及各级政府进一步加强职业病防治工作提供科学依据。方法通过问卷调查,采用描述性分析、卡方检验等流行病学研究方法,对贵州省基层疾控职业卫生应急处置能力现状进行分析。结果贵州省基层疾控职业卫生应急处置机构(专兼职)严重匮乏,应急体系不健全,多缺乏常规的应急计划及规范化、标准化管理。缺乏训练有素的专业应急人员,专项经费及应急物资储备不充分。结论提升应急处置能力具有重大的现实意义,加快建设和完善我省职业病应急体系迫在眉睫。

关键词：基层疾控职业卫生应急处置现状调查

Cell polarization in ischemic stroke: molecular mechanisms and advances

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

在线全文

学校读者我要写书评

暂无评论

人离体牙深低温保存的实验研究

上海铁道大学学报 2000年第9期21卷 18-21页

作者：王丽潘可风殷立行上海铁道大学医学院附属口腔医院上海200072

目的　探索一种较佳的离体牙延期再植的保存方法。方法　 10 0颗正常上下第一双尖牙 ,随机分成 5组 ,即对照组 ;微机控制降温 ,液氮 (- 196℃ )保存 1周、2周的离体牙 ;普通冰箱自然降温 ,液氮保存 1周、2周的离体牙。行活力检测 ,结果... 详细信息

目的　探索一种较佳的离体牙延期再植的保存方法。方法　 10 0颗正常上下第一双尖牙 ,随机分成 5组 ,即对照组 ;微机控制降温 ,液氮 (- 196℃ )保存 1周、2周的离体牙 ;普通冰箱自然降温 ,液氮保存 1周、2周的离体牙。行活力检测 ,结果行 t检验。结果　离体牙在深低温保存后仍可观察到一定数量的有活性的正常形态的牙周膜细胞。各实验组分别与对照组比较 ,实验组组间比较 ,差别都无统计学意义。结论　人类离体牙在经过不同方法冻存一段时间后 ,其根面一定量的牙周膜细胞仍可保持活性。

关键词：低温保存牙周膜细胞牙再植人离体牙

在线全文

学校读者我要写书评

暂无评论

氨氯地平联合美托洛尔治疗冠心病的临床研究

现代药物与临床 2020年第11期35卷 2158-2162页

作者：潘建军孟平平冯克丽商丘市第四人民医院内二科河南商丘476100

目的探讨氨氯地平联合美托洛尔治疗冠心病患者的临床疗效。方法选取2019年1月—2020年6月在商丘市第四人民医院就诊的冠心病患者142例为研究对象,随机分为对照组和治疗组,每组各71例。对照组患者口服酒石酸美托洛尔片,1片/次,2次/d。治... 详细信息

目的探讨氨氯地平联合美托洛尔治疗冠心病患者的临床疗效。方法选取2019年1月—2020年6月在商丘市第四人民医院就诊的冠心病患者142例为研究对象,随机分为对照组和治疗组,每组各71例。对照组患者口服酒石酸美托洛尔片,1片/次,2次/d。治疗组在对照组的基础上口服苯磺酸氨氯地平片,1片/次,1次/d。两组患者连续治疗5周。观察两组患者临床疗效,同时比较治疗前后两组患者低密度脂蛋白胆固醇(LDL-C)和单核细胞趋化蛋白-1(MCP-1)水平,心率(HR)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)和左心室射血分数(LVEF)心功能水平,及炎症因子白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α)水平。结果治疗后,对照组临床总有效率为76.06%,显著低于治疗组的94.37%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者LDL-C、MCP-1水平均明显低于治疗前(P<0.05),且治疗组LDL-C、MCP-1水平均低于对照组(P<0.05)。治疗后,两组患者HR、LVESD、LVEDD水平均低于治疗前(P<0.05),但是LVEF水平均高于治疗前(P<0.05),且治疗组HR、LVESD、LVEDD和LVEF水平均好于对照组(P<0.05)。治疗后,两组患者IL-6、hs-CRP、TNF-α水平均显著低于治疗前(P<0.05),且治疗组IL-6、hs-CRP、TNF-α水平明显低于对照组(P<0.05)。结论氨氯地平联合美托洛尔可有效提高冠心病的治疗效果,降低患者的LDL-C、MCP-1、IL-6、hs-CRP、TNF-α水平,改善患者心功能,抑制机体炎症反应。

关键词：苯磺酸氨氯地平片酒石酸美托洛尔片冠心病低密度脂蛋白胆固醇单核细胞趋化蛋白-1 左心室射血分数

在线全文

学校读者我要写书评

暂无评论

数学模型与河流管理

山东建筑工程学院学报 2002年第4期17卷 54-58页

作者：张克峰邢丽贞西安建筑科技大学市政与环境工程学院陕西西安710055

数学模型是定量解决环境污染控制问题的基础。在河流的管理中,通过建立环境系统工程数学模型,可确定污染物的允许或限制排放量,制定各污染源的最优控制处理方案。本文对河段上一个和多个污染源的情况分别进行了分析。通过对济南小清河... 详细信息

数学模型是定量解决环境污染控制问题的基础。在河流的管理中,通过建立环境系统工程数学模型,可确定污染物的允许或限制排放量,制定各污染源的最优控制处理方案。本文对河段上一个和多个污染源的情况分别进行了分析。通过对济南小清河的研究,确定小清河的主要污染类型为耗氧型有机污染,据此建立了小清河上游水质的BOD—DO模型,为小清河的水质管理打下了良好的基础。

关键词：数学模型河流管理污染物环境影响评价水质

Pressure-sensitive plasticity of lithiated silicon in li-ion batteries

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2013年第3期29卷 379-387页

作者： ke-Jie Zhao Yong-Gang li Laurence Brassart Department of Nuclear Science and Engineering and Materials Science and Engineering Massachusetts Institute of Technology key Laboratory for Materials Physics Institute of Solid State Physics Chinese Academy of Sciences Institute of Mechanics Materials and Civil Engineering Université catholique de Louvain

lithiation-induced plasticity is a key factor that enables Si electrodes to maintain long cycle life in li-ion batteries. We study the plasticity of various lithiated sili-con phases based on first-principles calculations and iden-tify the linear dependence of the equivalent yield stress on the hydrostatic pressure. Such dependence may cause the compression-tension asymmetry in an amorphous Si thin film electrode from a lithiation to delithiation cycle, and leads to subsequent ratcheting of the electrode after cyclic lithiation. We propose a yield criterion of amorphous lithi-ated silicon that includes the effects of the hydrostatic stress and the lithiation reaction. We further examine the micro-scopic mechanism of deformation in lithiated silicon under mechanical load, which is attributed to the flow-defects mediated local bond switching and cavitation. Hydrostatic compression confines the flow defects thus effectively strength-ens the amorphous structure, and vice versa.

关键词： li-ion batteries · Si · Pressure-sensitive plasticity · Ratcheting.

Primary parenchymal squamous cell carcinoma of the kidney:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu ke Wang Jia-Zhu Wen li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Efficient polysulfide blocker from conductive niobium nitride@graphene for li-S batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2020年第6期29卷 135-141,I0006页

作者： Huifa Shi Zhenhua Sun Wei Lv Shujie Xiao Huicong Yang Ying Shi ke Chen Shaogang Wang Bingsen Zhang Quan-Hong Yang feng li Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055GuangdongChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina Laboratory of Advanced Materials School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Nanoyang Group State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

lithium sulfur batteries are one of the most promising alternative electrochemical systems,but their practical applications are largely hindered by the serious shuttling problems and sluggish redox ***,the conductive and polar niobium nitride(NbN)is in-situ introduced onto graphene with ultrasmall size and high dispersion,and their composite is used to construct an efficient lithium polysulfide blocking *** graphene helps to construct highly conductive pathways,and niobium nitride serves as the sulfiphilic sites to chemically adsorb the migrating lithium polysulfides and catalyze their redox ***,the cells with the Nb N/G interlayers exhibit a long cycle life with a lower capacity decay of 0.096%/cycle at 1 C for 300 cycles and high rate capability of 937 m Ah g^-1 at 2 *** coupling with a sulfur/carbon nanofiber electrode,the cell with an ultra-high sulfur loading of 10.8 mg cm^-2 delivers an areal capacity of 12.5 m Ah cm^-2 at 0.1 C.

关键词： lithium-sulfur batteries Niobium nitride Chemical adsorption Catalytic effect High loading