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Neutrophil extracellular traps in gastrointestinal cancer

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World Journal of Gastroenterology 2021年第33期27卷 5474-5487页

作者： Zi-Qiang Chu ke-cheng zhang Lin Chen Graduate School Chinese PLA General HospitalBeijing 100853China Institute of Basic Medical Sciences Chinese PLA General HospitalBeijing 100853China Department of General Surgery Chinese PLA General Hospital First Medical CenterBeijing 100853China

Gastrointestinal(GI)cancer is a high-risk malignancy and is characterized by high mortality and morbidity *** extracellular traps(NETs),a weblike structure consisting of chromatin DNA with interspersed cytoplasmic and granule proteins,are extruded by activated neutrophils to entrap and kill bacteria and ***,accumulating evidence shows that NETs are related to the progression and metastasis of *** clinical studies,NETs infiltrate primary GI cancer tissues and are even more abundant in metastatic *** quantity of NETs in peripheral blood is revealed to be associated with ascending clinical tumour stages,indicating the role of NETs as a prognostic markers in GI ***,several inhibitors of NETs or NET-related proteins have been discovered and used to exert anti-tumour effects in vitro or in vivo,suggesting that NETs can be regarded as targets in the treatment of GI *** this review,we will focus on the role of NETs in gastric cancer and colorectal cancer,generalizing their effects on tumour-related thrombosis,invasion and *** reports are also listed to show the latest evidences of how NETs affect GI ***,notwithstanding the scarcity of systematic studies elucidating the underlying mechanisms of the interaction between NETs and cancer cells,we highlight the potential importance of NETs as biomarkers and anti-tumour therapeutic targets.

关键词： Neutrophil extracellular traps Gastric cancer Colorectal cancer Biomarkers Therapeutic targets

Stochastic Nash Games for Markov Jump Linear Systems with State-and Control-Dependent Noise

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Journal of the Operations Research Society of China 2014年第4期2卷 481-498页

作者： Huai-Nian Zhu cheng-ke zhang Ning Bin School of Economics&Commerce Guangdong University of TechnologyGuangzhou 510520China School of management Guangdong University of TechnologyGuangzhou 510520China

This paper investigates Nash games for a class of linear stochastic systems governed by Itô’s differential equation with Markovian jump parameters both in finite-time horizon and infinite-time ***,stochastic Nash games are formulated by applying the results of indefinite stochastic linear quadratic(LQ)control ***,in order to obtain Nash equilibrium strategies,crosscoupled stochastic Riccati differential(algebraic)equations(CSRDEs and CSRAEs)are ***,in order to demonstrate the validity of the obtained results,stochastic H2/H∞control with state-and control-dependent noise is discussed as an immediate ***,a numerical example is provided.

关键词： Stochastic differential games Markov jump linear systems indefinite stochastic LQ control problem

Status quo and future prospects of artificial neural network from the perspective of gastroenterologists

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World Journal of Gastroenterology 2021年第21期27卷 2681-2709页

作者： Bo Cao ke-cheng zhang Bo Wei Lin Chen Department of General Surgery&Institute of General Surgery Chinese People’s Liberation Army General HospitalBeijing 100853China

Artificial neural networks(ANNs)are one of the primary types of artificial intelligence and have been rapidly developed and used in many *** recent years,there has been a sharp increase in research concerning ANNs in gastrointestinal(GI)*** state-of-the-art technique exhibits excellent performance in diagnosis,prognostic prediction,and *** between ANNs and GI experts suggest that efficiency and accuracy might be compatible in virtue of technique ***,the shortcomings of ANNs are not negligible and may induce alterations in many aspects of medical *** this review,we introduce basic knowledge about ANNs and summarize the current achievements of ANNs in GI diseases from the perspective of *** limitations and future directions are also proposed to optimize ANN’s clinical *** consideration of barriers to interdisciplinary knowledge,sophisticated concepts are discussed using plain words and metaphors to make this review more easily understood by medical practitioners and the general public.

关键词： Artificial neural network Gastrointestinal disease Diagnosis Treatment Prognosis Endoscopy

Solvothermal synthesis of CdS nanorods and photovoltaic characteristics of CdS/PVK composite system

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Chinese Science Bulletin 2008年第1期53卷 46-52页

作者： JI YanLing cheng ke zhang HongMei zhang XingTang LI YunCai DU ZuLiang key Lab for Special Functional Materials of Ministry of Education Henan University Kaifeng 475004 China

Large quantities of CdS nanorods are successfully synthesized through Cd(CH3COO)2·2H2O reacting with Na2S·9H2O and EDA in aqueous solution. XRD result shows that the sample is of hexagonal structure. And TEM result shows that the morphologies of the resulting CdS are mainly in three-armed rod-like structure with a diameter of 10―15 nm and a length of 100 nm. The nanocomposites of CdS/PVK with different molar ratios are prepared by spin coating method on tin-doped indium oxide (ITO) substrate. A notable decrease of photoluminescence (PL) efficiency and a significant enhance-ment of surface photovoltage signal have been observed in CdS/PVK composites when the molar frac-tion of CdS increases. We interpret these results as the energy level matching between CdS and PVK in nanocomposites. This energy level matching facilitates fast interfacial charge transfer then increases the separation efficiency of electron-hole pairs and the carrier generation efficiency. The detailed charge transfer process has also been demonstrated.

关键词：复合材料光电特性纳米杆载荷传输

Investigations on Nitrate Pollution of Soil, Groundwater and Vegetable from Three Typical Farmlands in Beijing Region, China

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Agricultural Sciences in China 2011年第3期10卷 423-430页

作者： DU Lian-feng ZHAO Tong-ke zhang cheng-jun AN Zhi-zhuang WU Qiong LIU Bao-cun LI Peng MA Mao-ting Institute of Plant Nutrition and Resources Beijing Academy of Agricultural and Forestry Sciences Beijing 100097 P.R.China

The aim of this study was to determine the nitrate pollution status of soil, groundwater, and vegetable from three typical farmlands （croplands, vegetable fields, and orchards） in Beijing region. During the investigation, hundreds of the soil, groundwater, and vegetable samples from three typical farmlands were collected and analyzed. In addition, attributes of all samples were recorded for data analysis. The results showed that nitrate was substantially accumulated in soil profiles, while the soil nitrate concentrations of vegetable fields and orchards were higher than those of croplands. Nitrate concentration in 0-30 cm soil of vegetable field and orchard were 3.8 and 1.2 times of that of cropland, respectively. Nitrate content of groundwater in vegetable field was 13.8 mg L-1 （with the over-standard ratio 44.8%）, which was 2.8 folds of that in cropland. Nitrate concentration of groundwater under orchard was 9.3 mg L-1 （with the over-standard ratio 23.5%）, which was 1.9 folds of that in cropland. High concentrations of the nitrate in vegetables were detected, particularly green leafy vegetables ranked first with 2 685.5 mg kg-1, followed by rhizome vegetables, cabbages, and fruit vegetables. The nitrate over-standard ratios of rhizome vegetables, green leafy vegetables, fruit vegetables, and cabbages were 80.9, 37.9, 29.7, and 2.2%, respectively. The results revealed that the high nitrate concentrations of soil, vegetable, and groundwater might result from the high fertilization dose.

关键词： farmland vegetables groundwater soil nitrate

Can a single-port robot be safely used for robotic total gastrectomy for advanced gastric cancer?First experience using the da Vinci SP platform

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Gastroenterology Report 2022年第1期10卷 363-369页

作者： Hao Cui Jian-Xin Cui ke-cheng zhang Wen-Quan Liang Shu-Yan Li Jun Huang Lin Chen Bo Wei Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijingP.R.China School of Medicine Nankai UniversityTianjinP.R.China Foreign Languages College Shandong University of Traditional Chinese MedicineJinanShandongP.R.China

Background Many studies have shown the operative feasibility and safety of robotic *** are pursuing single-port(SP)surgery to leverage the advantages of minimally invasive *** purpose of this study was to describe technical considerations and short-term outcomes from the first reported SP robotic total gastrectomy(RTG)using the da Vinci SP *** A 75-year-old patient with a body-mass index of 19.8 kg/m^(2) and clinical stage III cancer(cT3NtM0)underwent SP RTG on 22 January 2022 at the Department of General Surgery,the Chinese PLA General *** procedures were performed successfully using the da Vinci SP robotic *** The SP RTG was successfully performed with D2 lymphadenectomy including No.10 lymph-nodes dissection and extracorporeal Roux-en-Y *** for subcutaneous emphysema,no severe adverse events occurred during the *** to a visual analogue scale(VAS),the subjective feeling of post-operative pain was given a VAS score of 3 of 10 on Post-Operative Day 1(POD 1),1 of 10 on POD 3,and 1 of 10 on POD *** removed the gastric tube on POD 2 and advised sipping water,a liquid diet,and a soft diet on PODs 2,4,and 6,*** patient was discharged without any complications on POD *** RTG is technically feasible and safe using the da Vinci SP robotic *** our knowledge,this is the first study using the da Vinci SP platform in RTG for advanced gastric cancer in elderly *** verify its superior operative outcomes,further clinical trials are needed.

关键词： gastric cancer single port robot gastrectomy da Vinci SP platform

Comparison of short-term efficacy between totally laparoscopic gastrectomy and laparoscopic assisted gastrectomy for elderly patients with gastric cancer

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 950-962页

作者： Rui-Yang Zhao Hang-Hang Li ke-cheng zhang Hao Cui Huan Deng Jing-Wang Gao Bo Wei Department of General Surgery First Medical CenterChinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Chinese PLA General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China

BACKGROUND Totally laparoscopic gastrectomy(TLG)entails both gastrectomy and gastrointestinal reconstruction under *** with laparoscopic assisted gastrectomy(LAG),TLG has been demonstrated in many studies to require a smaller surgical incision,result in a faster postoperative recovery and less pain and have comparable long-term efficacy,which has been a research hotspot in recent *** TLG is equally safe and feasible for elderly patients remains *** To compare the short-term efficacy of and quality of life(QOL)associated with TLG and LAG in elderly gastric cancer(GC)*** The clinicopathological data of 462 elderly patients aged≥70 years who underwent LAG or TLG(including distal gastrectomy and total gastrectomy)between January 2017 and January 2022 at the Department of General Surgery,First Medical Center,Chinese PLA General Hospital were retrospectively collected.A total of 232 patients were in the LAG group,and 230 patients were in the TLG *** patient information,clinicopathological characteristics,operation information and QOL data were collected to compare *** with those in the LAG group,intraoperative blood loss in the TLG group was significantly lower(P220 min were independent risk factors for postoperative complications in elderly patients with GC(P0.05).Compared with the laparoscopic-assisted total gastrectomy group,patients who received totally laparoscopic total gastrectomy had lower nausea and vomiting scores and higher sat

关键词： Totally laparoscopic gastrectomy Laparoscopic assisted gastrectomy Gastric cancer Elderly patients Efficacy comparison Quality of life

Preoperative albumin levels predict prolonged postoperative ileus in gastrointestinal surgery

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World Journal of Gastroenterology 2020年第11期26卷 1185-1196页

作者： Wen-Quan Liang ke-cheng zhang Hua Li Jian-Xin Cui Hong-Qing Xi Ji-Yang Li Ai-Zhen Cai Yu-Hua Liu Wang zhang Lan zhang Bo Wei Lin Chen Department of General Surgery&Institute of General Surgery Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Surgical Oncology Xing Tai People's HospitalXingtai 054001Hebei Province China Institute of Army Hospital Management Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Prolonged postoperative ileus(PPOI) is a prolonged state of "pathological"gastrointestinal(GI) tract dysmotility. There are relatively few studies examining the influence of preoperative nutritional status on the development of PPOI in patients who underwent GI surgery. The association between preoperative albumin and PPOI has not been fully studied. We hypothesized that preoperative albumin may be an independent indicator of *** To analyze the role of preoperative albumin in predicting PPOI and to establish a nomogram for clinical risk *** Patients were drawn from a prospective hospital registry database of GI surgery.A total of 311 patients diagnosed with gastric or colorectal cancer between June 2016 and March 2017 were included. Potential predictors of PPOI were analyzed by univariate and multivariable logistic regression analyses, and a nomogram for quantifying the presence of PPOI was developed and internally *** The overall PPOI rate was 21.54%. Advanced tumor stage and postoperative opioid analgesic administration were associated with PPOI. Preoperative albumin was an independent predictor of PPOI, and an optimal cutoff value of 39.15 was statistically calculated. After adjusting multiple variables, per unit or per SD increase in albumin resulted in a significant decrease in the incidence of PPOI of 8%(OR = 0.92, 95%CI: 0.85-1.00, P = 0.046) or 27%(OR = 0.73, 95%CI:0.54-0.99, P = 0.046), respectively. Patients with a high level of preoperative albumin(≥ 39.15) tended to experience PPOI compared to those with low levels(< 39.15)(OR = 0.43, 95%CI: 0.24-0.78, P = 0.006). A nomogram for predicting PPOI was developed [area under the curve(AUC) = 0.741] and internally validated by bootstrap resampling(AUC = 0.725, 95%CI: 0.663-0.799).CONCLUSION Preoperative albumin is an independent predictive factor of PPOI in patients who underwent GI surgery. The nomogram provided a model to screen for early indications in the clinic

关键词： Albumin Prolonged postoperative ileus Gastrointestinal surgery Nomogram Complications

Timing of surgery after neoadjuvant chemotherapy for gastric cancer: Impact on outcomes

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World Journal of Gastroenterology 2018年第2期24卷 257-265页

作者： Yi Liu ke-cheng zhang Xiao-hui huang hong-qing Xi Yun-he Gao Wen-quan Liang Xin-Xin Wang Lin chen Department of General Surgery & Institute of General Surgery Chinese People's Liberation Army General Hospital

AIM To evaluate whether the neoadjuvant chemotherapy(NAc T)-surgery interval time significantly impacts the pathological complete response(pc R) rate and longterm *** One hundred and seventy-six patients with gastric cancer undergoing NAc T and a planned gastrectomy at the chinese p LA General hospital were selected from January 2011 to January 2017. Univariate and multivariable analyses were used to investigate the impact of NAc T-surgery interval time( 6 wk) on pc R rate and overall survival(OS).RESULTS The NAc T-surgery interval time and clinician T stage were independent predictors of pc R. The interval time > 6 wk was associated with a 74% higher odds of pc R as compared with an interval time of 4-6 wk(p = 0.044), while the odds ratio(OR) of clinical T3 vs clinical T4 stage for pc R was 2.90(95%c I: 1.04-8.01, p = 0.041). In cox regression analysis of long-term survival, postneoadjuvant therapy pathological N(yp N) stage significantly impacted OS(N0 vs N3: h R = 0.16, 95%c I: 0.37-0.70, p = 0.015; N1 vs N3: h R = 0.14, 95%c I: 0.02-0.81, p = 0.029) and disease-free survival(DFS)(N0 vs N3: h R = 0.11, 95%c I: 0.24-0.52, p = 0.005; N1 vs N3: h R = 0.17, 95%c I: 0.02-0.71, p = 0.020). The surgical procedure also had a positive impact on OS and DFS. The hazard ratio of distal gastrectomy vs total gastrectomy was 0.12(95%c I: 0.33-0.42, p = 0.001) for OS, and 0.13(95%c I: 0.36-0.44, p = 0.001) for *** The NAc T-surgery interval time is associated with pc R but has no impact on survival, and an interval time > 6 wk has a relatively high odds of pc R.

关键词： Gastric cancer Timing of surgery Neoadjuvant chemotherapy