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Disruption of PABPN1 phase separation by SNRPD2.drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1

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Science China(Life Sciences) 2024年第6期67卷 1212-1225页

作者： Zhijie Hu Mengxia Li Yufeng Chen liutao Chen Yuting Han Chengyong Chen Xin Lu Nan You Yawen Lou Yingye Huang Zhanfeng Huo Chao liu Cheng Liang Susu liu ke Deng Liangfu Chen Shangwu Chen Guohui Wan Xiaojian Wu Yonggui Fu Anlong Xu State key Laboratory of Biocontrol Guangdong Province Key Laboratory of Pharmaceutical Functional GenesDepartment of BiochemistrySchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Department of General Surgery(Colorectal Surgery)&Guangdong Provincial key Laboratory of Colorectal and Pelvic Floor Diseases&Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation National Engineering Research Center for New Drug and Druggability(cultivation)Guangdong Province Key Laboratory of New Drug Design and EvaluationSchool of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China

Generally shortened 3′UTR due to alternative polyadenylation(APA)is widely observed in cancer,but its regulation mechanisms for cancer are not well ***,with profiling of APA in colorectal cancer tissues and poly(A)signal editing,we firstly identified that the shortened 3′UTR of CTNNIBP1 in colorectal cancer promotes cell proliferation and *** found that liquid-liquid phase separation(LLPS)of PABPN1 is reduced albeit with higher expression in cancer,and the reduction of LLPS leads to the shortened 3′UTR of CTNNBIP1and promotes cell proliferation and ***,the splicing factor SNRPD2.upregulated in colorectal cancer,can interact with glutamic-proline(EP)domain of PABPN1,and then disrupt LLPS of PABPN1,which attenuates the repression effect of PABPN1 on the proximal poly(A)*** results firstly reveal a new regulation mechanism of APA by disruption of LLPS of PABPN1,suggesting that regulation of APA by interfering LLPS of 3′end processing factor may have the potential as a new way for the treatment of cancer.

关键词： alternative polyadenylation colorectal cancer CTNNBIP1 PABPN1 liquid-liquid phase separation SNRPD2

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WT-FCTGN:A wavelet-enhanced fully connected time-gated neural network for complex noisy traffic flow modeling

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Chinese Physics B 2024年第7期33卷 652-664页

作者：廖志芳孙轲刘文龙余志武刘承光宋禹成 School of Computer Science and Engineering Central South UniversityChangsha 410083China National Engineering Research Center of High-speed Railway Construction Technology Changsha 410075China School of Civil Engineering Central South UniversityChangsha 410075China School of Traffic&Transportation Engineering Central South UniversityChangsha 410083China

Accurate forecasting of traffic flow provides a powerful traffic decision-making basis for an intelligent transportation system. However, the traffic data's complexity and fluctuation, as well as the noise produced during collecting information and summarizing original data of traffic flow, cause large errors in the traffic flow forecasting results. This article suggests a solution to the above mentioned issues and proposes a fully connected time-gated neural network based on wavelet reconstruction(WT-FCTGN). To eliminate the potential noise and strengthen the potential traffic trend in the data, we adopt the methods of wavelet reconstruction and periodic data introduction to preprocess the data. The model introduces fully connected time-series blocks to model all the information including time sequence information and fluctuation information in the flow of traffic, and establishes the time gate block to comprehend the periodic characteristics of the flow of traffic and predict its flow. The performance of the WT-FCTGN model is validated on the public Pe MS data set. The experimental results show that the WT-FCTGN model has higher accuracy, and its mean absolute error(MAE), mean absolute percentage error(MAPE) and root mean square error(RMSE) are obviously lower than those of the other algorithms. The robust experimental results prove that the WT-FCTGN model has good anti-noise ability.

关键词： traffic flow modeling time-series wavelet reconstruction

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“电子科学与技术”领域2.2.年度国家自然科学基金项目申请与资助情况综述

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电子与信息学报 2024年第1期46卷 373-382页

作者：孙玲刘晶文珺何杰刘克国家自然科学基金委员会信息科学部北京100085 天津大学精密仪器与光电子工程学院天津300072

国家自然科学基金委员会信息科学部一处“电子科学与技术”领域涉及电路与系统、电磁场与波、电子学及应用等相关研究。本文介绍了2.2.年度该领域“人才”和“研究”两大项目系列中部分项目的申请与资助情况,并从申请代码、申请人年龄... 详细信息

国家自然科学基金委员会信息科学部一处“电子科学与技术”领域涉及电路与系统、电磁场与波、电子学及应用等相关研究。本文介绍了2.2.年度该领域“人才”和“研究”两大项目系列中部分项目的申请与资助情况,并从申请代码、申请人年龄、依托单位分布及其近五年的变化趋势等角度进行了分析,旨在为广大科研人员了解该领域的研究热点和未来发展方向提供参考。

关键词：国家自然科学基金电子科学与技术申请与资助

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Rh/CeO_(2.催化剂中Rh的负载量对其CO_(2.加氢生成甲醇和乙醇产物选择性的影响

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燃料化学学报（中英文） 2024年第9期52卷 1214-1223页

作者：郑珂刘冰胥月兵刘小浩江南大学化学与材料工程学院江苏无锡214122

将CO_(2.捕获并通过加氢转化为醇类等高值化学品是实现CO_(2.减排和碳资源循环利用的重要途径之一。本文对Rh/CeO_(2.催化剂在CO_(2.加氢反应中的性能进行了研究,并结合XRD、Raman、H2.TPR、CO_(2.-TPD、CO-DRIFTS和XPS等表征方法,揭示... 详细信息

将CO_(2.捕获并通过加氢转化为醇类等高值化学品是实现CO_(2.减排和碳资源循环利用的重要途径之一。本文对Rh/CeO_(2.催化剂在CO_(2.加氢反应中的性能进行了研究,并结合XRD、Raman、H2.TPR、CO_(2.-TPD、CO-DRIFTS和XPS等表征方法,揭示了Rh负载量(0.1%–2.0%)对其CO_(2.加氢活性和产物选择性的影响。结果表明,在3.0 MPa、2.0℃的反应条件下,Rh负载量为0.1%时Rh/CeO_(2.催化剂上CO_(2.加氢产物以乙醇为主。随着Rh含量的增加,CO_(2.转化率增加,但乙醇选择性降低;当Rh负载量为2.0%时,产物以甲醇为主。对于Rh负载量不同的催化剂上的CO_(2.加氢反应,其产物选择性的差异与催化剂中Rh的存在形式和电子性质有关;原子分散的Rh^(+)有利于稳定CO^(*),CO^(*)与CH_(3)^(*)进行C–C偶联形成乙醇,而金属态的Rh团簇则容易促成CO^(*)加氢生成甲醇。

关键词： CO_(2.加氢甲醇乙醇氧空位 Rh单原子 Rh团簇

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A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance

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Acta Pharmaceutica Sinica B 2024年第1期14卷 223-240页

作者： Lei Sun Arabella H.Wan Shijia Yan Ruonian liu Jiarui Li Zhuolong Zhou Ruirui Wu Dongshi Chen Xianzhang Bu Jingxing Ou Kai Li Xiongbin Lu Guohui Wan Zunfu ke Department of Pathology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation National Engineering Research Center for New Drug and Druggability(Cultivation)Guangdong Province Key Laboratory of New Drug Design and EvaluationSchool of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA Department of Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Department of Hepatic Surgery and Liver Transplantation Center Third Affiliated HospitalOrgan Transplantation InstituteSun Yat-sen UniversityOrgan Transplantation Research Center of Guangdong ProvinceGuangdong Province Engineering Laboratory for Transplantation MedicineGuangzhou 510630China Guangdong Provincial key Laboratory of Liver Disease Research Guangzhou 510630China Department of Ultrasound Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Melvin and Bren Simon Comprehensive Cancer Center Indiana UniversityIndianapolisIN 46202USA

Lenvatinib,a second-generation multi-receptor tyrosine kinase inhibitor approved by the FDA for first-line treatment of advanced liver cancer,facing limitations due to drug ***,we applied a multidimensional,high-throughput screening platform comprising patient-derived resistant liver tumor cells(PDCs),organoids(PDOs),and xenografts(PDXs)to identify drug susceptibilities for conquering lenvatinib resistance in clinically relevant *** and passaging of PDCs and PDOs from resistant patient liver tumors retained functional fidelity to lenvatinib treatment,expediting drug repurposing *** screening identified romidepsin,YM155,apitolisib,NVP-TAE684 and dasatinib as potential antitumor agents in lenvatinib-resistant PDC and PDO ***,romidepsin treatment enhanced antitumor response in syngeneic mouse models by triggering immunogenic tumor cell death and blocking the EGFR signaling pathway.A combination of romidepsin and immunotherapy achieved robust and synergistic antitumor effects against lenvatinib resistance in humanized immunocompetent PDX ***,our findings suggest that patient-derived liver cancer models effectively recapitulate lenvatinib resistance observed in clinical settings and expedite drug discovery for advanced liver cancer,providing a feasible multidimensional platform for personalized medicine.

关键词： Lenvatinib Drug resistance High-throughput screening Drug discovery Patient-derived model Romidepsin EGFR Liver cancer

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State Estimator for Linear High-Dimensional Systems With State Partition and Block-Dependent Compensation

State Estimator for Linear High-Dimensional Systems With Sta...

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第35届中国过程控制会议

作者： ke Li Shunyi Zhao Fei liu key Laboratory of Advanced Process Control for Light Industry (Ministry of Education) Institute of Automation Jiangnan University

This paper proposes a Bayesian estimation scheme with block-dependent compensation for linear high-dimensional systems. The state vector is divided into blocks by considering the relationship of state variables in time series and physical interpretation to reduce the underlying computational cost. However, blocking states damages the original system and introduces systematic errors. Consequently, the divided state blocks are compensated by introducing distinct compensation coefficients to improve state estimation accuracy. Considering the difference and uniqueness of state blocks, the distinct compensation coefficients are adaptively adjusted and updated over time to ensure higher accuracy of state estimation. Simulation results of numerical example are used to evaluate the performance of the proposed algorithm. It shows that the proposed algorithm possesses moderate computational cost and higher estimation accuracy compared with the existing methods.

关键词： State estimation Bayesian inference Block-dependent compensation Linear high-dimensional systems

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Recess-free enhancement-mode AlGaN/GaN RF HEMTs on Si substrate

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Journal of Semiconductors 2024年第6期45卷 81-86页

作者： Tiantian Luan Sen Huang Guanjun Jing Jie Fan Haibo Yin Xinguo Gao Sheng Zhang ke Wei Yankui Li Qimeng Jiang Xinhua Wang Bin Hou Ling Yang Xiaohua Ma Xinyu liu High-Frequency High-Voltage Device and Integrated Circuits R&D Center Institute of Microelectronics of Chinese Academy of SciencesBe i-jing 100029China School of integrated Circuits University of Chinese Academy of SciencesBeijing 100049China Faculty of integrated Circuits Xidian UniversityXi’an 710071China

Enhancement-mode(E-mode)GaN-on-Si radio-frequency(RF)high-electron-mobility transistors(HEMTs)were fabri-cated on an ultrathin-barrier(UTB)AlGaN(<6 nm)/GaN heterostructure featuring a naturally depleted 2.D electron g... 详细信息

Enhancement-mode(E-mode)GaN-on-Si radio-frequency(RF)high-electron-mobility transistors(HEMTs)were fabri-cated on an ultrathin-barrier(UTB)AlGaN(2.D electron gas(2.EG)*** fabricated E-mode HEMTs exhibit a relatively high threshold voltage(VTH)of+1.1 V with good uniformity.A maxi-mum current/power gain cut-off frequency(fT/fMAX)of 31.3/99.6 GHz with a power added efficiency(PAE)of 52.47%and an out-put power density(Pout)of 1.0 W/mm at 3.5 GHz were achieved on the fabricated E-mode HEMTs with 1-μm gate and Au-free ohmic contact.

关键词： AlGaN/GaN heterostructure ultrathin-barrier enhancement-mode radio-frequency power added efficiency silicon substrate

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The energy response of LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals for GECAM

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Nuclear Science and Techniques 2024年第2期35卷 110-122页

作者： Pei-Yi Feng Xi-Lei Sun Zheng-Hua An Yong Deng Cheng-Er Wang Huang Jiang Jun-Jie Li Da-Li Zhang Xin-Qiao Li Shao-Lin Xiong Chao Zheng ke Gong Sheng Yang Xiao-Jing liu Min Gao Xiang-Yang Wen Ya-Qing liu Yan-Bing Xu Xiao-Yun Zhao Jia-Cong liu Fan Zhang Hong Lu Particle and Astrophysics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Experimental Physics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of South ChinaHengyang 421001China National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.and General Research Institute for Nonferrous MetalsBeijing 100088China

The GECAM series of satellites utilizes LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals as sensitive materials for gamma-ray detectors(GRDs).To investigate the nonlinearity in the detection of low-energy gamma rays and address the errors in the calibration of the E-C relationship,comprehensive tests and comparative studies of the three aforementioned crystals were conducted using Compton electrons,radioactive sources,and mono-energetic *** nonlinearity test results of the Compton electrons and X-rays demonstrated substantial differences,with all three crystals presenting a higher nonlinearity for X/-rays than for Compton *** the LaBr_(3)(Ce)and LaBr_(3)(Ce,Sr)crystals having higher absolute light yields,they exhibited a noticeable nonlinear decrease in the light yield,especially at energies below 400 *** NaI(Tl)crystal demonstrated an"excess"light output in the 6-2.0 keV range,reaching a maximum"excess"of 9.2.at 30 keV in the X-ray testing and up to 15.5%at 14 keV during Compton electron testing,indicating a significant advantage in the detection of low-energy gamma ***,we explored the underlying causes of the observed nonlinearity in these *** study not only elucidates the detector responses of GECAM,but also initiates a comprehensive investigation of the nonlinearity of domestically produced lanthanum bromide and sodium iodide crystals.

关键词： LaBr_(3)(Ce)detector LaBr_(3)(Ce,Sr)detector NaI(Tl)detector GECAM Energy response Light yield nonlinearity

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NiCoFeCu medium-entropy alloy nanoparticles encapsulated in carbon nanotubes as catalysts for enhancing the hydrogen desorption of MgH2

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Rare Metals 2024年第11期 5868-5879页

作者： Ya-Fei liu Yi-ke Huang Yu-Sang Guo Meng-Yuan Yue Hua-Xu Shao Yi-Jing Wang key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Renewable Energy Conversion and Storage CenterCollaborative Innovation Center of Chemical Science and Engineering (Tianjin)College of Chemistry Nankai University

Recently,high/medium-entropy alloys（HEAs/MEA s） have been considered attractive catalysts due to their unique physicochemical ***,the synthesis of nano-sized HEAs/MEAs catalysts with desirable morphology presents significant ***,we report the synthesis of NiCoFeCu MEA nanoparticles encapsulated in nitrogen-doped carbon nanotubes（NCTs）via a straightforward one-step pyrolysis *** unique structure of NiCoFeCu/NCTs and the nano-sized MEA catalysts contributes to the improved hydrogen desorption kinetics of *** onset dehydrogenation temperature of the MgH2.NiCoFeCu/NCTs composite decreased to 173.4℃,a reduction of 117.4℃ compared to pure *** MgH2.NiCoFeCu/NCTs composite could release 6.50 wt% H2.ithin 30 min at 32.℃.Furthermore,an activation energy of 116.3 kJ·mol-1for the MgH2.NiCoFeCu/NCTs composite has been obtained,much lower than pure milled MgH2.demonstrating an enhanced hydrogen desorption ***,the exceptional dispersion capability of the carbon material contributes to outstanding cyclic stability without any loss of capacity even after 10 cycles of de/hydrogenation at300℃.

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裂缝作用下CO_(2.吞吐动用基质页岩油特征

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大庆石油地质与开发 2024年第2期43卷 152-159页

作者：刘客张驰中国石油吉林油田公司二氧化碳捕集埋存与提高采收率开发公司吉林松原138000

为明确裂缝作用下CO_(2.吞吐过程中基质页岩油的动用特征,通过采用实时在线称质量方法和核磁共振成像技术,研究了裂缝作用下不同混相压力、基质长度以及基质渗透率对CO_(2.吞吐效果的影响,并建立了注CO_(2.提高基质页岩油动用程度的吞... 详细信息

为明确裂缝作用下CO_(2.吞吐过程中基质页岩油的动用特征,通过采用实时在线称质量方法和核磁共振成像技术,研究了裂缝作用下不同混相压力、基质长度以及基质渗透率对CO_(2.吞吐效果的影响,并建立了注CO_(2.提高基质页岩油动用程度的吞吐方法。结果表明:CO_(2.在非混相、多次接触混相和一次接触混相压力下首轮吞吐动用基质深度分别为12.0、2..5、36.5 mm,累计吞吐采收率逐渐升高;但当压力大于多次接触混相压力后,累计吞吐采收率提高幅度减小;采用逐级增大衰竭压差的吞吐方式,能够弥补基质长度增加对吞吐采收率造成的不利影响,提高大尺寸基质原油的动用深度和动用程度;当裂缝密度保持不变时,基质渗透率的降低会导致累计吞吐采收率减小,且裂缝对吞吐采收率的影响程度降低;虽然增加吞吐次数和闷井时间可以提高低渗透率基质的动用程度,但提高裂缝密度、减小基质原油尺寸才是最有效的提高低渗透基质动用程度的开发方式。研究成果可为提高裂缝作用下页岩油CO_(2.吞吐采收率提供借鉴。

关键词：裂缝基质磁悬浮天平核磁共振成像 CO_(2.吞吐页岩油

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