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Positive reverse transcription-polymerase chain reaction assay results in patients recovered from COVID-19: Report of two cases

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World Journal of Clinical Cases 2021年第12期9卷 2816-2822页

作者： ke-xin huang Cheng He Yan-Li Yang Di huang Zhi-Xia Jiang Bang-Guo Li Heng Liu Department of Radiology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Nursing Guizhou Jiangjunshan HospitalGuiyang 563000Guizhou ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)has spread around the *** February 28,2020,the World Health Organization adjusted the risk of spread and impact of COVID-19 to“very high”at the global *** have mainly focused on the etiology,epidemiology,and treatment of COVID-19 to limit further spread and the negative impact of the disease,while less attention has been devoted to the follow-up and reexamination of patients who recovered from COVID-19 or were released from *** SUMMARY This study reports two cases where patients who had negative reverse transcription-polymerase chain reaction(RT-PCR)test results and met the criteria for discharge subsequently had positive RT-PCR test *** clinical manifestations and computed tomography(CT)findings of these patients were *** conversion of RT-PCR test results in these two patients may be related to false-negative and false-positive outcomes of the *** images helped track improvement of pulmonary *** The timing of discharge of COVID-19 patients should be determined by comprehensive analysis of CT images and RT-PCR test results.

关键词： COVID-19 False negative Recovery Reverse transcription-polymerase chain reaction SARS-CoV-2 Case report

Three new diarylheptanoids and their antioxidant property

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Chinese Chemical Letters 2007年第10期18卷 1243-1246页

作者： Chang xin Zhou Xiang Yi Zhang Xiao Wu Dong Qiao Feng Tao Hui Dou Rong Ping Zhang ke xin huang Xiao Kun Li Chang Xiang Chen Su Zeng Yu Zhao College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China College of Pharmacy Kunming College of Medicine Kunming 650031 China Pharmacy School of Wenzhou Medical College Wenzhou 325035 China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

Three new diarylheptanoids, i.e., sodium（5S,2E）- 1,7-bis（4-hydroxyphenyl）- 1-hydroxy-2-hepten-5 -sulfonate （1）, sodium（5R,2E）-1,7-bis（4-hydroxyphenyl）-1-hydroxy-2-hepten-5-sulfonate （2） and 3,5-diacetoxy-1-（3-methoxy-4,5-dihydroxyphenyl）-7-（4-hydroxy-3-methoxyphenyl）heptane （3） were isolated from the rhizomes of Zingiber officinale. The structures of the new compounds were elucidated on the basis of spectroscopic methods. The antioxidant activities of 3 were assayed by in vitro models involving DPPH free radicals and superoxide anion radicals.

关键词： Diarylhcptanoid Zingiber officinale Antioxidant

Two new compounds from Zingiber officinale

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Chinese Chemical Letters 2007年第10期18卷 1247-1249页

作者： Yu Zhao Qiao Feng Tao Rong Ping Zhang Chang xin Zhou Hui Dou Shu Yun Shi Ye Cheng Xiao Lian Li Sun Su Zeng ke xin huang Xiao Dong Zhang Xiao Kun Li Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China College of Pharmacy Kunming College of Medicine Kunming 650031 China Pharmacy School of Wenzhou Medical College Wenzhou 325035 China

A new cyclic diarylheptanoid, 1,5-epoxy-3-hydroxy-1-（3-methoxy-4,5-dihydroxyphenyl）-7-（4-hydroxyphenyl）-heptane （1）, as well as a new monoterpene, 10-O-β-n-glucopyranosyl-hydroxy cineole （2） were isolated from the rhizomes of Zingiber officinale. The structures of compounds 1 and 2 were established based on their spectral data. In addition, the antioxidant activities of these compounds were also measured.

关键词： Diarylheptanoid Monoterpene Zingiber officinale Antioxidant

Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties

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Chinese Chemical Letters 2009年第9期20卷 1030-1033页

作者： ke xin huang Jing Xu Gong Wei Xiong Lei Xiang Yang Feng Wang Qiao Feng Tao Yi Hang Wu Xiao Kun Li Joachim Stockigt Yu Zhao Jia Qu key Laboratory of Southern Zhejiang TCM R&D Pharmacy School of Wenzhou Medical College Wenzhou 325035 China Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

Twelve 23-esterified silybin derivatives with different patterns of substituents such as aromatic and aliphatic groups （1-12） were designed and synthesized. The antioxidative properties of these compounds were evaluated. The modifed silybin analogues exhibited improved inhibitory effects against rat liver homogenate lipid peroxidation compared to silybin, with exception of the trimethoxylated ester （5） and the aliphatic one （9）. Compounds 3, 5, 7, 8 and 11 displayed their protective properties on DNA cleavage in a dose-dependent manner. 2009 Xiao Kun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Silybin derivatives Antioxidant Lipid peroxidation DNA cleavage

Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou ke Yajing Zhao xin Min Yanghong Li Ruiyu Mi Yangai Liu Xiaowen Wu Minghao Fang Zhaohui huang Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang Yu-Wen Alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

One chloro-furoeremophilanoid and two new natural dimers from Ligularia atroviolacea

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Chinese Chemical Letters 2008年第11期19卷 1319-1322页

作者： Jun Zhao Hao Wu ke xin huang Shu Yun Shi Hua Peng Xian Feng Sun Liu Rong Chen Qun Xiong Zheng Qi Jun zhang Xiao Jiang Hao Joachim Stockigt Xiao Kun Li Yu Zhao Jia Qu Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China key Laboratory of Southern Zhejiang TCM R＆D Pharmacy School of Wenzhou Medical College Wenzhou 325035 China School of Chemical Engineering Central South University Changsha 410083 China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

Three new compounds, including one chloro-furoeremophilanoid （1）, one eremophiladiolide （2）, a rare dimer of nor- furoeremophilanoid, ligulatrovine A （3）, and a known furoeremophilanolide （4）, were isolated from Ligularia atroviolacea. The structures of compounds 1-4 were elucidated by spectroscopic methods including 1D and 2D NMR experiments as well as X- ray diffraction study.

关键词： Natural scsquilcrpene Eremophiladiolidc Dimcr Chloro-furanocrcmophilanc X-ray Ligularia atroviolacea

A High-Randomness and High-Stability Electronic Quantum Random Number Generator without Post Processing

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Chinese Physics Letters 2023年第7期40卷 13-17页

作者：刘宇轩黄可馨白玉明杨哲李俊林 State key Laboratory of Low-Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China

Random numbers are one of the key foundations of *** work implements a discrete quantum random number generator(QRNG)based on the tunneling effect of electrons in an avalanche photo *** any post-processing and conditioning,this QRNG can output raw sequences at a rate of 100 ***,the statistical min-entropy of the 8,000,000 bits sequence reaches 0.9944 bits/bit,and the min-entropy validated by NIST SP 800-90B reaches 0.9872 bits/*** metric is currently the highest value we have investigated for QRNG raw ***,this QRNG can continuously and stably output raw sequences with high randomness over extended *** system produced a continuous output of 1,174 Gbits raw sequence for a duration of 11,744 s,with every 8 Mbits forming a unit to obtain a statistical min-entropy distribution with an average value of 0.9892 bits/*** statistical min-entropy of all data(1,174 Gbits)achieves the value of0.9951 bits/*** QRNG can produce high-quality raw sequences with good randomness and *** has the potential to meet the high demand in cryptography for random numbers with high quality.

关键词： Random entropy value

Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG Jian NIE Wei huang Jin ZHU ke LIU Ruxia ZHANG Ruizhi LUO Guoqiang SHEN Qiang State key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys