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Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization

Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 25-34页

作者： Hai-Li Bao Chuan-Zhi Chen Chang-Zhen Ren ke-yan Sun Hao Liu Shao-Hua song Zhi-Ren Fu Department of Organ Transplantation Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China Department of Surgical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Cardiology Shanghai Changzheng HospitalNaval Military Medical UniversityShanghai 200003China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Background:Polydatin,a glucoside of resveratrol,has shown protective effects against various diseases.However,little is known about its effect on hepatic ischemia-reperfusion(I/R)injury.This study aimed to elucidate whether polydatin protects liver against I/R-induced injury and to explore the underlying mechanism.Methods:After gavage feeding polydatin once daily for a week,mice underwent a partial hepatic I/R procedure.Serum alanine aminotransferase(ALT)/aspartate aminotransferase(AST),hematoxylin-eosin(H&E)and TdT-mediated dUTP nick-end labeling(TUNEL)staining were used to evaluate liver injury.The severity related to the inflammatory response and reactive oxygen species(ROS)production was also investigated.Furthermore,immunofluorescence and Western blotting were used to detect macrophage polarization and the NF-κB signaling pathway in macrophages.Results:Compared with the I/R group,polydatin pretreatment significantly attenuated I/R-induced liver damage and apoptosis.The oxidative stress marker(dihydroethidium fluorescence,malondialdehyde,superoxide dismutase and glutathione peroxidase)and I/R related inflammatory cytokines(interleukin1β,interleukin-10 and tumor necrosis factor-α)were significantly suppressed after polydatin treatment.In addition,the result of immunofluorescence indicated that polydatin reduced the polarization of macrophages toward M1 macrophages both in vivo and in vitro.Western blotting showed that polydatin inhibited the pro-inflammatory function of RAW264.7 via down-regulating the NF-κB signaling pathway.Conclusions:Polydatin protects the liver from I/R injury by remodeling macrophage polarization via NFκB signaling.

关键词： Hepatic ischemia-reperfusion injury Polydatin Macrophage Polarization Inflammation

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Topological Stability and Pseudo-orbit Tracing Property for Homeomorphisms on Uniform Spaces

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Acta Mathematica Sinica,English Series 2022年第2期38卷 431-442页

作者： ke song yan Fan Ping ZENG School of Information and Statistics Guangxi University of Finance and EconomicsNanning 530003P.R.China

In this paper,we investigate the topological stability and pseudo-orbit tracing property for homeomorphisms on uniform spaces.We introduce the concept of topological stability for homeomorphisms on compact uniform spaces and prove that if a homeomorphism on a compact uniform space is expansive and has pseudo-orbit tracing property,then it is topologically stable.Moreover,we discuss the topological stability for homeomorphisms on uniform spaces from the view of localization.We introduce definitions of topologically stable point and shadowable point for homeomorphisms on uniform spaces and show that every shadowable point of an expansive homeomorphism on a compact uniform space is topologically stable.

关键词： Topological stability pseudo-orbit tracing property expansiveness uniform space

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Design,fabrication,and characterization of hierarchical mechanical metamaterials

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Frontiers of Mechanical Engineering 2024年第1期19卷 73-83页

作者： Jian song Junfei yan Bengang YI Automotive Engineering Research Institute BYD Auto Industry Co.Ltd.Shenzhen 518000China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China

Natural mechanical materials,such as bamboo and bone,often exhibit superior specific mechanical properties due to their hierarchical porous architectures.Using the principle of hierarchy as inspiration can facilitate the development of hierarchical mechanical metamaterials(HMMs)across multiple length scales via 3D printing.In this work,we propose self-similar HMMs that combine octet-truss(OCT)architecture as the first and second orders,with cubic architecture as the third or more orders.These HMMs were fabricated using stereolithography 3D printing,with the length sizes ranging from approximately 200µm to the centimeter scale.The compressive stress–strain behaviors of HMMs exhibit a zigzag characteristic,and the toughness and energy absorption can be significantly enhanced by the hierarchical architecture.The compressive moduli are comparable to that of natural materials,and the strengths are superior to that of most polymer/metal foams,alumina hollow/carbon lattices,and other natural materials.Furthermore,the flexural stress–strain curves exhibit a nonlinear behavior,which can be attributed to the hierarchical architecture and local damage propagation.The relatively high mechanical properties can be attributed to the synergistic effect of the stretch-dominated OCT architecture and the bending-dominated cube architecture.Lastly,an ultralight HMM-integrated unmanned aerial vehicle(HMM-UAV)was successfully designed and printed.The HMM-UAV is~85%lighter than its bulk counterpart,remarkably extending the flight duration time(~53%).This work not only provides an effective design strategy for HMMs but also further expands the application benchmark of HMMs.

关键词： 3D printing mechanical metamaterials hierarchical architecture mechanical behavior unmanned aerial vehicle(UAV)

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The impact of water quality on the formation of halogenated benzoquinones and the adsorption efficiency by activated carbon

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Journal of Environmental Sciences 2024年第1期135卷 693-702页

作者： Yongjing Wang song Gao Xinyu yan songtao Wang Ruolin Zhang yan Zhou Lianhai Ren Cheng Li State Environmental Protection key Laboratory of Food Chain Pollution Control Beijing Technology and Business UniversityBeijing 100048China Institute of Scientific and Technical Information of China Beijing 100038China Institute of Quality Standard and Testing Technology Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China key Laboratory of Cleaner Production and Integrated Resource Utilization of China National Light Industry Beijing Technology and Business UniversityBeijing 100048China

Halogenated benzoquinones(HBQs)could cause bladder cancer,but there were few related studies on the generation and control.In this study,the impact of different precursors,pH,bromide concentration,and algae-derived organic matters on the formation of HBQs and the removal efficiency by activated carbon were investigated.It was found that the chlorination of bisphenol A produced the most 2,6-dichloro-1,4-benzoquinone(2,6-DCBQ),reaching 14.86μg/L at 1 hr,followed by tyrosine,2-chlorophenol,P-hydroxybenzoic acid,trichlorophenol,and N-methylaniline.The production of 2,6-DCBQ increased first and then decreased from 0 to 36 hr(chlorination doses 0-20 mg/L),indicating that HBQs were unstable in water.Trihalomethanes(THMs)were detected during chlorination,and the concentration increased with prolongation of reaction time.2,6-DCBQ production decreased and 2,6-dibromo-1,4-benzoquinone(2,6-DBBQ)production increased with increment bromide concentration and the bromide promoted the formation of tribromomethane.The production of 2,6-DCBQ decreased with increase of pH,and the maximum production was 141.38μg/L at pH of 5.Microcystis aeruginosa,Chlorella algae cells,and intracellular organic matters(IOM)could be chlorinated as potential precursors for HBQs.The most amount of 2,6-DCBQ was generated from algae cells of Microcystis aeruginosa,followed by Chlorella algae cells,Microcystis aeruginosa IOM,and Chlorella IOM.This study compared the removal efficiency of HBQs by granular activated carbon(GAC)and columnar activated carbon(CAC)under different carbon doses and initial concentrations of HBQs.It was found that the removal efficiency by GAC(80.1%)was higher than that by CAC(51.8%),indicating that GAC has better control for HBQs.

关键词： HBQS DBPS Drinking water Algae derived organic matters Activated carbon

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Genome-wide SNP markers provided insights into the reproductive strategy and genetic diversity of the green tide causative species Ulva prolifera in China

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Journal of Oceanology and Limnology 2024年第2期42卷 533-543页

作者： song SUN Weiwei MA Nan WANG song FENG yan SUN CAS key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Ecology and Environmental Science Laoshan LaboratoryQingdao 266237China Jiaozhou Bay Marine Ecosystem Research Station Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

Ulva prolifera is the causative species of the annually occurring large-scale green tides in China since 2007.Its specific biological features on reproductivity strategies,as well as intra-species genetic diversity,are still largely unknown,especially at the genome level,despite their importance in understanding the formation and outbreak of massive green tides.In the present study,the restriction site-associated DNA genotyping approach(2b-RAD)was adopted to identify the genome-wide single-nucleotide polymorphisms(SNPs)of 54 individual thalli including samples collected from Subei Shoal in 2019 and Qingdao coast from 2019 to 2021.SNPs genotype results revealed that most of the thalli in 2019 and 2020 were haploid gametophytes,while only half of the thalli were gametophytes in 2021,indicating flexibility in the reproductive strategies for the formation of the green tides among different years and the dominance of asexual and vegetative reproductive mode for the floating period.Besides,population analysis was conducted,and it revealed a very low genetic diversity among samples from Subei Shoal and the Qingdao coast in the same year and a higher divergence among samples in different years.The results showed the efficiency of 2b-RAD in the exploration of SNPs in U.prolifera and provided the first genome-wide scale evidence for the origin of the large-scale green tides on the Qingdao coast.This study improved our understanding of the reproductive strategy and genetic diversity of the green tide causative species and will help further reveal the biological causes of the green tide in China.

关键词： green tide Ulva prolifera 2b-RAD single-nucleotide polymorphism(SNP) reproductive strategy genetic diversity

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High-responsivity on-chip waveguide coupled germanium photodetector for 2 μm waveband

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Photonics Research 2024年第1期12卷 115-122页

作者： JIANING WANG XI WANG YIHANG LI yanFU yanG QINGHAI song ke XU Guangdong Provincial key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic Systems Harbin Institute of TechnologyShenzhen 518055China Department of Electronic&Information Engineering Harbin Institute of TechnologyShenzhen 518055China Department of Science Harbin Institute of TechnologyShenzhen 518055China

Recently,the emerging 2μm waveband has gained increasing interest due to its great potential for a wide scope of applications.Compared with the existing optical communication windows at shorter wavelengths,it also offers distinct advantages of lower nonlinear absorption,better fabrication tolerance,and larger free carrier plasma effects for silicon photonics,which has been a proven device technology.While much progress has been witnessed for silicon photonics at the 2μm waveband,the primary challenge still exists for on-chip detectors.Despite the maturity and compatibility of the waveguide coupled photodetectors made of germanium,the 2μm regime is far beyond its cutoff wavelength.In this work,we demonstrate an efficient and high-speed on-chip waveguidecoupled germanium photodetector operating at the 2μm waveband.The weak sub-bandgap absorption of epitaxial germanium is greatly enhanced by a lateral separation absorption charge multiplication structure.The detector is fabricated by the standard process offered by a commercial foundry.The device has a benchmark performance with responsivity of 1.05 A/W and 3 dB bandwidth of 7.12 GHz,which is able to receive high-speed signals with up to 20 Gbit/s data rate.The availability of such an efficient and fast on-chip detector circumvents the barriers between silicon photonic integrated circuits and the potential applications at the 2μm waveband.

关键词： waveguide responsivity wave

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Chinese Medicine Combined with Adjuvant Chemotherapy for Improving Myelosuppression in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis

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Chinese Journal of Integrative Medicine 2024年第7期30卷 643-652页

作者： LI Rui ZHANG Tong yan Shao-hua yan Yun-zi DING Ya-cong WANG yan-song yanG Yu-fei Department of Oncology China Academy of Chinese Medical Sciences Xiyuan Hospital Department of Oncology Dongfang Hospital Beijing University of Chinese Medicine Graduate School Beijing University of Chinese Medicine

Objective: To assess the effectiveness of Chinese herbal medicine(CHM) combined with adjuvant chemotherapy on myelosuppression for colorectal cancer(CRC) patients using network meta-analysis(NMA). Methods: Literature searches in both international(PubMed, Embase, Web of Science, and Cochrane Library) and Chinese(China Science and Technology Journal Database, Wanfang Data, China National Knowledge Infrastructure) databases for relevant randomized controlled trials(RCTs) were conducted from inception until October 10, 2022. We included RCTs of patients who received CHM combined with chemotherapy, including FOLFOX, XELOX, FOLFIRI, and other relevant regimens in the CHM treatment group. The outcomes included the incidence of myelosuppression, leukopenia, hemoglobin reduction, and thrombocytopenia. Two reviewers independently screened the databases, extracted the data, and assessed the risk of bias and credibility of evidence. RevMan 5.4.1 software and STATA 14.0 were used to perform the NMA. Results: A total of 31 RCTs were included, published from 2008 to 2021 in Chinese. Among these, 2,314 participants comparing the following 9 CHMs were identified: Shengbai Recipe(SBR), Bazhen Decoction(BZD), Jianpi Jiedu Recipe(JJR), Jianpi Recipe(JR), Compound Cantharis Capsule(CCC), Zaofan Pill(ZFP), Guilu Erxian Gel(GL), Buzhong Tiaogan Decoction(BZ), and Qiamagu Capsule(QM). The results of NMA found an indirect comparison. Based on the surface under the cumulative ranking curve(SUCRA), the ZFP+ chemotherapy group had the lowest incidence of myelosuppression, with an odds ratio(OR) of 0.08 [95% confidence interval(CI): 0.01, 0.76], whereas the GL+ chemotherapy group had the lowest incidence of leukopenia, hemoglobin reduction, and thrombocytopenia, with an OR of 5.25(95% CI: 2.41, 11.43), 4.66(95% CI: 2.23, 9.72), and 0.27(95% CI: 0.13, 0.54), respectively. Moreover, BZD + chemotherapy could alleviate leukopenia, hemoglobin reduction, and thrombocytopenia(P<0.01). Pairwise comparison showed that there was no difference in the

关键词： Chinese herbal medicine colorectal cancer network meta-analysis systematic review myelosuppression chemotherapy

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Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease

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Neural Regeneration Research 2024年第8期19卷 1759-1767页

作者： Zihang Zhou Yalong yan Heng Gu Ruiao Sun Zihan Liao ke Xue Chuanxi Tang Department of Neurobiology Xuzhou Key Laboratory of NeurobiologyXuzhou Medical UniversityXuzhouJiangsu ProvinceChina

Parkinson’s disease can affect not only motor functions but also cognitive abilities,leading to cognitive impairment.One common issue in Parkinson’s disease with cognitive dysfunction is the difficulty in executive functioning.Executive functions help us plan,organize,and control our actions based on our goals.The brain area responsible for executive functions is called the prefrontal co rtex.It acts as the command center for the brain,especially when it comes to regulating executive functions.The role of the prefrontal cortex in cognitive processes is influenced by a chemical messenger called dopamine.However,little is known about how dopamine affects the cognitive functions of patients with Parkinson’s disease.In this article,the authors review the latest research on this topic.They start by looking at how the dopaminergic syste m,is alte red in Parkinson’s disease with executive dysfunction.Then,they explore how these changes in dopamine impact the synaptic structure,electrical activity,and connection components of the prefrontal cortex.The authors also summarize the relationship between Parkinson’s disease and dopamine-related cognitive issues.This information may offer valuable insights and directions for further research and improvement in the clinical treatment of cognitive impairment in Parkinson’s disease.

关键词： dopamine dopamine receptor dopamine transporter executive dysfunction neural network neural oscillation prefrontal cortex synaptic plasticity

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On the Quantum Cohomology of Blow-ups of Four-dimensional Quadrics

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Acta Mathematica Sinica,English Series 2024年第1期40卷 313-328页

作者： Jian Xun HU Hua Zhong ke Chang Zheng LI Lei song School of Mathematics Sun Yat-sen UniversityGuangzhou 510275P.R.China

We propose a conjecture relevant to Galkin’s lower bound conjecture,and verify it for the blow-ups of a four-dimensional quadric at a point or along a projective plane.We also show that Conjecture O holds in these tw... 详细信息

关键词： Quantum cohomology blow-up quadric hypersurface

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Empirical likelihood for spatial cross-sectional data models with matrix exponential spatial specification

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 125-139页

作者： LIU yan RONG Jian-rong QIN Yong-song Nanning University Nanning 530200China Center for Applied Mathematics of Guangxi and College of Mathematics and Statistics Guangxi Normal UniversityGuilin 541004China

In this paper,we study spatial cross-sectional data models in the form of matrix exponential spatial specification(MESS),where MESS appears in both dependent and error terms.The empirical likelihood(EL)ratio statistics are established for the parameters of the MESS model.It is shown that the limiting distributions of EL ratio statistics follow chi-square distributions,which are used to construct the confidence regions of model parameters.Simulation experiments are conducted to compare the performances of confidence regions based on EL method and normal approximation method.

关键词： MESS empirical likelihood con dence region

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