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Gauss Sum of Index 4:(2)Non-cyclic Case

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Acta Mathematica Sinica,English Series 2006年第3期22卷 833-844页

作者： jing yang shi xin luo ke qin feng Department of Mathematical Science Tsinghua University

Assume that m ≥ 2, p is a prime number, （m,p（p - 1）） = 1,-1 not belong to 〈p〉 belong to （Z/mZ）^＊ and [（Z/mZ）^＊：〈p〉]=*** this paper, we calculate the value of Gauss sum G（X）=∑x∈F^＊x（x）ζp^T（x） over Fq,where q=p^f,f=φ（m）/4,x is a multiplicative character of Fq and T is the trace map from Fq to *** our assumptions,G（x） belongs to the decomposition field K of p in Q（ζm） and K is an imaginary quartic abelian unmber *** the Galois group Gal（K/Q） is cyclic,we have studied this cyclic case in anotyer paper：＂Gauss sums of index four：（1）cyclic case＂（accepted by Acta Mathematica Sinica,2003）.In this paper we deal with the non-cyclic case.

关键词： Gauss sum Stickelberger Theorem Davenport-Hawse formula class number of imaginary quadratic field

基于网络药理学探讨“半枝莲-白花蛇舌草”抗乳腺癌的作用机制

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中国中药杂志 2020年第18期45卷 4448-4454页

作者：许晶石凤芹杜可心董佳李冬云北京中医药大学东直门医院北京100700

该研究基于网络药理学方法探讨"半枝莲-白花蛇舌草"抗乳腺癌的作用机制。通过中药系统药理学分析平台(TCMSP)筛选半枝莲、白花蛇舌草的有效成分及相应的靶蛋白,通过Genecards,OMIM数据库筛选出乳腺癌的靶点,利用Venn在线软件获取药物与... 详细信息

该研究基于网络药理学方法探讨"半枝莲-白花蛇舌草"抗乳腺癌的作用机制。通过中药系统药理学分析平台(TCMSP)筛选半枝莲、白花蛇舌草的有效成分及相应的靶蛋白,通过Genecards,OMIM数据库筛选出乳腺癌的靶点,利用Venn在线软件获取药物与疾病的共同靶点,运用Cytoscape 3.7.2软件构建"化合物-靶点-疾病"网络图。使用STRING数据库绘制蛋白互作(PPI)网络,利用David数据库对有效作用靶点进行GO功能、keGG通路富集分析。结果显示,共筛选出半枝莲化合物29个,白花蛇舌草化合物7个,有效作用靶点109个。通过Venn图获得59个药物疾病共同靶点,PPI网络发现MYC,CCND1,EGFR,ESR1,CASP3,VEGFA等可能是"半枝莲-白花蛇舌草"治疗乳腺癌的关键靶点。GO功能分析发现88个条目,涉及转录因子活性、受体活性、细胞因子活性、酶活性及生物合成过程的调控等方面。keGG通路分析发现37个条目,涉及到癌症、细胞周期、细胞凋亡、血管生成等通路,其中包括p53信号通路、ErbB信号通路、NOD样受体信号通路、MAPK信号通路、VEGF信号通路、Wnt信号通路、mTOR信号通路等。该研究初步揭示了"半枝莲-白花蛇舌草"抗乳腺癌的关键靶点和涉及的生物学过程及信号通路,发现其作用是多靶点、多通路的,为今后的分子生物学实验奠定了基础。

关键词：半枝莲-白花蛇舌草乳腺癌网络药理学作用机制

南宁地区儿童青少年肥胖与代谢综合征相关性的流行病学研究

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中华流行病学杂志 2011年第10期32卷 969-972页

作者：陈少科罗静思秦映芬范歆唐晴冯莹广西壮族自治区妇幼保健院南宁530003 广西医科大学第一附属医院

目的分析儿童青少年肥胖与代谢综合征（MS）相关性及危险因素。方法采用分层整群随机抽样方法从南宁市396所中小学抽取14所学校6—18岁中小学生7893人，进行体格检查及空腹血糖（FBG）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白... 详细信息

目的分析儿童青少年肥胖与代谢综合征（MS）相关性及危险因素。方法采用分层整群随机抽样方法从南宁市396所中小学抽取14所学校6—18岁中小学生7893人，进行体格检查及空腹血糖（FBG）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、丙氨酸氨基转移酶（hLT）、天门冬氨酸氨基转移酶（AST）、空腹胰岛素（FINS）的血液生化检测，并计算胰岛素抵抗指数（HOMA-IR）。结果（1）MS患病率为正常组0．57％、超重组4．53％、肥胖组26．80％。（2）除HDL-C均值随肥胖增加而降低外，其余各指标均值、异常率比较均为肥胖组〉超重组〉正常组，3组间差异有统计学意义（P〈0．05）。（3）对MS有影响的指标为腰围（OR=1．087，95％CI：1．033～1．143）、SBP（OR=1．073，95％CI：1．032～1．116）、FBG（OR=1．394，95％CI：1．568～3．423）、TG（OR=3．213，95％CI：1．410-7．319）、HDL．C（OR=0．001，95％CI：O．000-0．012）。结论儿童青少年MS与肥胖密切相关，其患病率和危险因素随着肥胖程度的加重而增加。

关键词：肥胖代谢综合征危险因素

Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi Yun Kai yang Yu Liang ke Xu Xue feng Zhang Yun Kang Yu qin Jin Jun Wei Hou jing Zhang Tian yang Salah Hussein Mohamed Saif ElDein Ze Hua Lei Hao Zhang Shuai Shao Zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen yang Xiangfeng Cong Yao Tan Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu jing Zhang Mengjie yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang shi Chen Zhi jing Ma Fan Zheng Ya Nan Hou xin Yu Li xin Li Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Liang Qu Yun Tao Zhang Xiao Ming yang Guizhen Wu Qi Ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Company Limited LanzhouChina Beijing key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages.

关键词： phase neutral spectrum

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蔓性千斤拔药材中重金属含量分析

湖北农业科学 2012年第16期51卷 3592-3593,3596页

作者：覃景庄何弘施力军冯世鑫柯芳河池市计量测试研究所广西河池547000 中国医学科学院药用植物研究所广西分所南宁530023

采用微波消解蔓性千斤拔(Flemingia philippinensis)药材样品,用原子吸收分光光度法测定铅、镉和铜,用原子荧光光度法测定砷、汞的含量。结果表明,样品中5种有害重金属元素均未超标,方法回收率为98.5%～102.6%,相对标准偏差为0.75%～3.... 详细信息

采用微波消解蔓性千斤拔(Flemingia philippinensis)药材样品,用原子吸收分光光度法测定铅、镉和铜,用原子荧光光度法测定砷、汞的含量。结果表明,样品中5种有害重金属元素均未超标,方法回收率为98.5%～102.6%,相对标准偏差为0.75%～3.26%。该法精密度和准确度较高,可用于蔓性千斤拔药材中的重金属元素含量快速分析。

关键词：蔓性千斤拔(Flemingia philippinensis) 重金属原子吸收分光光度法原子荧光光度法

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin Xiong Xiang-yang Wen xin-Qiao Li Ce Cai Shuo Xiao Qi luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An ke Gong Jin-Yuan Liao Yan-Qiu Zhang Yue Huang Lu Li xing Wen Fei Zhang jing Duan Chen-Wei Wang Dong-Li shi Peng Zhang Qi-Bin Yi Chao-yang Li Yan-Bing Xu Xiao-Hua Liang Ya-qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu Wang Sheng yang Xiao-jing Liu Min Gao Mao-Shun Li Jin-Zhou Wang xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng Jia-Cong Liu xing-Bo Han Jin-Ling Qi Jia Huang ke-ke Zhang Can Chen Xiong-Tao yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo Li Ping Wang xin-Ying Song Li-Ming Song shi-Jie Zheng Bing Li Hong-Mei Zhang Yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-Yu Wang Zong-Yuan yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng feng shi Hui Wang Hui-Zhen Wang Yu-Peng Xu Jia-Wei yang Xue-Juan yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

卵泡刺激素(FSH)对卵巢癌HEY细胞系Notch通路及转录因子Snail表达的影响

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复旦学报（医学版） 2013年第4期40卷 385-389页

作者：刘姝蓉姚晔俪贾罗琦陈奇丁景新华克勤丰有吉复旦大学附属妇产科医院妇科上海200011 浙江大学附属妇产科医院妇产科杭州310006 上海交通大学附属第一人民医院妇产科上海200080

目的研究卵泡刺激素(follicle stimulating hormone,FSH)体外对卵巢癌HEY细胞系Notch通路上Notch1胞内段蛋白(N1ICD)、转录因子CSL与靶基因表达以及对转录因子Snail家族的调节作用,以探讨FSH促进卵巢癌侵袭的可能机制。方法体外培养卵巢... 详细信息

目的研究卵泡刺激素(follicle stimulating hormone,FSH)体外对卵巢癌HEY细胞系Notch通路上Notch1胞内段蛋白(N1ICD)、转录因子CSL与靶基因表达以及对转录因子Snail家族的调节作用,以探讨FSH促进卵巢癌侵袭的可能机制。方法体外培养卵巢癌HEY细胞系,设PBS对照组和FSH 40mU/mL实验组,改良的Boyden小室检测两组细胞侵袭力,Western blot检测两组N1ICD、CSL、Snail、Slug蛋白表达,RT-PCR检测HEY-1、HEY-2、HES-1mRNA表达。结果 FSH 40mIU/mL可显著增强卵巢癌HEY细胞系的侵袭能力(P=0.001)。相比于对照组,实验组FSH 40mIU/mL作用24h后N1ICD和CSL蛋白表达显著上升(P=0.001,P=0.028)。FSH 40mIU/mL作用后18～24hHEY-1mRNA的表达增加,作用24h时HEY-2mRNA的表达增加。而FSH作用后HES-1mRNA水平无明显变化。FSH 40mIU/mL作用24h后,相比于对照组Snail蛋白表达显著上升(P=0.009),而Slug蛋白的表达无显著变化(P>0.05)。结论 FSH可能激活Notch1信号通路和Snail转录因子,进而促进卵巢癌细胞的侵袭能力。

关键词：卵泡刺激素(FSH) 卵巢癌 Notch1 CSL Snail

一株木霉菌(Trichoderma sp.)TY2纤维素酶最佳产酶条件及部分酶学特性研究

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新疆农业科学 2010年第7期47卷 1324-1331页

作者：冯蕾严琴徐晓立罗思施杨新平秦新政陈竞唐娴谢君华南农业大学应用生物化学研究所广州510642 广东省高校生物质能源重点实验室广州510642 新疆农业科学院微生物所乌鲁木齐830000

【目的】筛选高活力纤维素酶产生菌,高效利用纤维素资源。【方法】从朽木和和纸浆样品中分离筛选出一株产纤维素酶活较高的菌株TY2。对其形态和18SrDNA特征序列分析鉴定为木霉菌(Trichodermasp.)。对菌株发酵条件及酶学特性进行研究。... 详细信息

【目的】筛选高活力纤维素酶产生菌,高效利用纤维素资源。【方法】从朽木和和纸浆样品中分离筛选出一株产纤维素酶活较高的菌株TY2。对其形态和18SrDNA特征序列分析鉴定为木霉菌(Trichodermasp.)。对菌株发酵条件及酶学特性进行研究。【结果】TY2菌株的最佳产酶条件为:1%滤纸+2%麸皮+0.5%葡萄糖为碳源,0.5%蛋白胨为氮源,起始pH5.0,温度28℃,200r/min,5d,其CMCase和FPase活力分别达412.5和100.3U/mL。经分离纯化出TY2菌株内切β-葡聚糖苷酶。内切β-葡聚糖苷酶最适反应温度为60℃,最适反应pH为4.6,在50℃以下,pH3.0～5.0,酶活性稳定,且在80℃仍具有降解CMC-Na的效果。同时研究发现铜离子、锌离子、钾离子和钠离子对内切β-葡聚糖苷酶的酶活有促进作用,而汞离子有明显的抑制作用。【结论】所筛选的TY2菌株具有潜在的工业应用价值。

关键词：纤维素酶木霉发酵条件内切β-葡聚糖苷酶酶学特性

Expert consensus on the perioperative management of patients with sepsis

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World Journal of Emergency Medicine 2015年第4期6卷 245-260页

作者： Jun-ping Chen Xiang-ming Fang Xiao-ju Jin Rong-tian Kang ke-xuan Liu Jin-bao Li Yan luo Zhi-jie Lu Chang-hong Miao Han-xiang Ma Wei Mei yang-wen Ou Si-hua Qi Zai-sheng qin Guo-gang Tian An-shi Wu Dong-xin Wang Tian Yu Yong-hao Yu jing Zhao Ming-zhang Zuo shi-hai Zhang Department of Anesthesiology Ningbo Number 2 Hospital Department of Anesthesiology First Affiliated HospitalSchool of MedicineZhejiang University Department of Anesthesiology and Critical Care Medicine Yijishan HospitalWannan Medical College Department of Anesthesiology Second Hospital of Hebei Medical University Department of Anesthesiology First Affiliated HospitalSun Yat-sen University Department of Anesthesiology and Intensive Care Medicine Changhai HospitalSecond Military Medical University Department of Anesthesiology Ruijin HospitalSchool of MedicineShanghai Jiaotong University Department of Anesthesiology and Intensive Care Medicine Eastern Hepatobiliary Surgery HospitalSecond Military Medical University Department of Anesthesiology Fudan University Shanghai Cancer CenterShanghai Medical CollegeFudan University Department of Anesthesiology General Hospital of Ningxia Medical University Department of Anesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Anesthesiology Third Xiangya HospitalCentral South University Department of Anesthesiology Fourth Affiliated HospitalHarbin Medical University Department of Anesthesiology Nanfang HospitalSouthern Medical University Department of Anesthesiology People's Hospital of Sanya Department of Anesthesiology Beijing Chaoyang HospitalCapital Medical University Department of Anesthesiology and Surgical Intensive Care Peking University First Hospital Department of Anesthesiology Affiliated Hospital of Zunyi Medical College Department of Anesthesiology Tianjin Medical University General Hospitaland Tianjin Research Institute of Anesthesiology Department of Anesthesiology Peking Union Medical College HospitalChinese Academy of Medical Sciences Department of Anesthesiology Beijing Hospital Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

INTRODUCTION Sepsis is defined as an infection associated with systemic manifestations of inflammation, which has become the most common complication in the perioperative period caused by severe burn/trauma and major surgical operation.[1,2] The incidence of sepsis in adults is estimated to be 149–240/100 000 per year, and that of severe sepsis and septic shock is 56–91/100 000 per year. In the last decade, the short-term mortality of sepsis has declined to around 20% in developed countries partly due to the international Surviving Sepsis Campaign （SSC）, while the mortality remains very high （50%–80%） in 1–5 years after discharge from hospitals.[3–7] Thus, sepsis and its subsequent severe sepsis and septic shock are currently major issues in the field of medical and health care.

关键词： Expert consensus perioperative management patients with sepsis