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A high-precision multi-dimensional microspectroscopic technique for morphological and properties analysis of cancer cell

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Light(Science & Applications) 2023年第6期12卷 1117-1126页

作者： Lirong Qiu Yunhao Su ke-mi Xu Han Cui Dezhi Zheng Yuanmin Zhu Lin Li Fang Li Weiqian Zhao miIT key Laboratory of Complex-field Intelligent Exploration School of Optics and PhotonicsBeijing Institute of Technology100081 BeijingChina Department of Gastroenterology Aerospace Central HospitalPeking University Aerospace School of Clinical Medicine100081 BeijingChina Department of Pathology Aerospace Central HospitalPeking University Aerospace School of Clinical Medicine100081 BeijingChina

Raman and Brillouin scattering are sensitive approaches to detect chemical composition and mechanical elasticity pathology of cells in cancer development and their medical treatment *** application is,however,suffering from the lack of ability to synchronously acquire the scattering signals following three-dimensional(3D)cell morphology with reasonable spatial resolution and signal-to-noise ***,we propose a divided-aperture laser differential confocal 3D Geometry-Raman-Brillouin microscopic detection technology,by which reflection,Raman,and Brillouin scattering signals are simultaneously in situ collected in real time with an axial focusing accuracy up to 1 nm,in the height range of 200μ*** divided aperture improves the anti-noise capability of the system,and the noise influence depth of Raman detection reduces by 35.4%,and the Brillouin extinction ratio increases by 22 dB.A high-precision multichannel microspectroscopic system containing these functions is developed,which is utilized to study gastric cancer *** a result,a 25%reduction of collagen concentration,42%increase of DNA substances,17%and 9%decrease in viscosity and elasticity are finely resolved from the 3D *** findings indicate that our system can be a powerful tool to study cancer development new therapies at the sub-cell level.

关键词： elasticity dimensional spectroscopic

A comparison of in vitro anticancerous activity and mechanism of ethanolic extracts from different Ganoderma genus

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Frontiers in Biology 2006年第3期1卷 275-279页

作者： ZHOU Yueqin YANG Xiaotong LI Xuquan FENG Huiqin mi ke YANG Qingyao Institute of microbiology and Immunology Life and Environment Science CollegeShanghai Normal UniversityShanghai 200234China 8^(th) floor Building No.14th100 Guilin RoadShanghai 200234China

Five ethanolic extracts from the mycelia of Ganoderma lucidum,***,***,***,and *** were respectively studied on their anticancerous activities against leukemic HL-60 cell line in *** showed that all five extracts potently inhibited HL-60 *** extract from *** mycelia exerted the highest *** V/PI bivariate flow cytometric analysis further revealed that the five extracts significantly induced early apoptosis in HL-60 *** results illustrate that not only *** but also other Ganoderma species can inhibit cancer cells,and their mechanisms are related to induction of apoptosis.

关键词： Ganoderma anti-proliferation apoptosis HL-60

Inner limiting membrane peeling prevents secondary epiretinal membrane after vitrectomy for proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1496-1501页

作者： Rong-Han Wu ming-Na Xu ke Lin ming-Xue Ren Han Wen ke-mi Feng Hong-Jia Zhou Nived Moonasar Zhong Lin Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Wenzhou 325027Zhejiang ProvinceChina Caribbean Eye Institute ValsaynTrinidad and Tobago

·AIM:To evaluate the role of internal limiting membrane(ILM)peeling in preventing secondary epiretinal membrane(ERM)formation in pars plana vitrectomy(PPV)for proliferative diabetic retinopathy(PDR).·METHODS:This retrospective study analyzed the medical records of patients who underwent PPV for PDR and were followed up for minimum 3 *** peeling was performed based on the intraoperative surgeons’*** was assessed by optical coherence tomography *** relationship between ILM peeling and postoperative ERM was analyzed.·RESULTS:In total,212 eyes from 197 patients were included in this *** incidence of secondary ERM in the ILM non-peeling group was significantly higher than that in the ILM peeling group(37.0%vs 14.0%;P<0.001).Multivariate logistical regression revealed that ILM peeling was highly associated with the prevention of secondary ERM development[odds ratio 0.38;95%confidence interval0.17-0.86;P<0.05].·CONCLUSION:ILM peeling during PPV for PDRs can effectively reduce the incidence of secondary ERM development and is worth consideration by vitreoretinal surgeons.

关键词： internal limiting membrane secondary epiretinal membrane proliferative diabetic retinopathy

Incidence of rhegmatogenous retinal detachments is increasing in Wenzhou,China

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 260-266页

作者： ming-Na Xu Jia-Yu Zhang Hui Yang Ben-Hao Song Rong-Han Wu Zi-Pei Jiang ke-mi Feng ming-Xue Ren ke Lin Zhong Lin National Clinical Research Center for Ocular Diseases Eye HospitalWenzhouMedicalUniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology the Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325200Zhejiang ProvinceChina Department of Ophthalmology the Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

AIM:To estimate and compare the incidence and characteristics of rhegmatogenous retinal detachments(RRDs)in the Wenzhou area in 2015 to ***:All newly developed RRD cases among residents of the Wenzhou area,from January 2015 to December 2019,were retrospectively retrieved from hospital *** population data were extracted from the Wenzhou Statistical ***:There were 3629 eligible *** average incidence of RRD was 7.79 cases per 100000 population(95%confidence interval,7.24-8.34),and the incidences were 7.99 and 7.56 for males and females,*** annual incidence increased gradually from 7.26 cases per 100000 in 2015 to 10.00 cases per 100000 in 2019,with an overall increase of 37.74%.The highest rate of increase occurred in the age group from 60 to 69 *** 2750 eyes with axial length(AL)data,1675(60.91%)had an AL greater than 24 ***:A trend to increasing RRD incidence is observed in the Wenzhou area over the past 5-year period.

关键词： rhegmatogenous retinal detachments retina incidence Chinese

THE PARALLEL NUMERICAL METHOD OF PROVING THE CONSTRUCTIVE GEOMETRIC THEOREM

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Chinese Science Bulletin 1989年第13期34卷 1066-1070页

作者：邓米克 Department of Mathematics University of Science and Technology of China Hefei

J. W. Hong shows in [1,2] that: in order to justify some geometric proposition, one needs only to justify a special instance. This work opens up a new field for mechanical theorem proving in elementary geometries. But... 详细信息

关键词： parallel numerical method significant digit length of parameters the highest degree in variables of these polynomials

Association between Mean Ocular Perfusion Pressure and Diabetic Retinopathy in a Northeastern Chinese Population

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Biomedical and Environmental Sciences 2020年第9期33卷 701-707页

作者： ZHAI Gang LIN Zhong WANG Feng Hua WANG Yu LI Dong WEN Liang DING Xiao Xia JIANG Jing FENG ke mi LIANG Yuan Bo XIE Cong Fushun Eye Hospital Fushun 113006LiaoningChina School of Ophthalmology&Optometry Wenzhou Medical UniversityEye Hospital of Wenzhou Medical UniversityWenzhou 325035ZhejiangChina Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Science Key LabBeijing 100730China

Objective To evaluate the association between diabetic retinopathy(DR) and mean ocular perfusion pressure(MOPP) in patients with type 2 diabetes mellitus(T2 DM).Methods Patients from the Fushun Diabetic Retinopathy Cohort Study(FS-DIRECT), a communitybased prospective cohort study conducted in northeast China, were included in this study. The presence and severity of DR were determined by grading fundus photographs according to the Early Treatment Diabetic Retinopathy Study(ETDRS) retinopathy scale. Systolic and diastolic blood pressure(SBP and DBP) were recorded using an electronic sphygmomanometer. Intraocular pressure(IOP) was measured using an iCare rebound tonometer. MOPP was calculated using the formula MOPP = 2/3 [DBP + 1/3(SBP-DBP)]-*** In total, 1,857 patients who had gradable fundus photography and MOPP data were enrolled in this study. Male patients had a higher MOPP than female patients(52.25 ± 8.75 vs. 50.96 ± 8.74 mmHg, P = 0.002). Overall, both male and female patients with any type of DR, non-proliferative DR(NPDR), or non-sight-threatening DR(non-STDR) had significantly higher MOPP relative to patients without DR. Increased MOPP(per 1 mmHg) was in turn associated with the presence of any type of DR[odds ratio(OR) = 1.03, 95% confidence interval(CI) : 1.02–1.04], NPDR(OR = 1.03 95% CI: 1.02–1.04),and non-STDR(OR = 1.03, 95% CI: 1.01–1.04) after adjusting for confounders. Increased MOPP(per 1 mmHg) was also associated with an increased likelihood of macular edema(OR = 1.02, 95% CI:1.01–1.04).Conclusions The results suggest that increased MOPP was associated with DR and macular edema in northeastern Chinese patients with T2 DM.

关键词： Diabetic retinopathy Ocular perfusion pressure Systolic blood pressure Diastolic blood pressure

Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou ke Yajing Zhao Xin min Yanghong Li Ruiyu mi Yangai Liu Xiaowen Wu minghao Fang Zhaohui Huang Engineering Research Center of ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

Ultrafast laser-induced decomposition for selective activation of GaAs

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Light(Advanced Manufacturing) 2024年第2期5卷 87-94页

作者： ke-mi Xu Chao Liu Lei Wang Feng-Chun Pang Xin-Jing Zhao Xian-Bin Li Qi-Dai Chen Wei-Qian Zhao miIT key Laboratory of Complex-field Intelligent Exploration School of Optics and PhotonicsBeijing Institute of TechnologyBeijing100081China State key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012China

The manipulation of micro/nanostructures to customise their inherent material characteristics has garnered considerable *** this study,we present the selective activation of gallium arsenide(GaAs)via ultrafast laser-induced decomposition,which correlates with the emergence of ripples on the *** instigated a pronounced enrichment in the arsenic(As)concentration around the surface while inducing a depletion of gallium(Ga)at the structural *** simulations based on first principles exhibited a robust inclination towards the phase separation of GaAs,with the gasification of As-As pairs proving more facile than that of Ga-Ga pairs,particularly above the melting point of *** an illustrative application,a metal-semiconductor hybrid surface was confirmed,showing surface chemical bonding and surface-enhanced Raman scattering(SERS)through the reduction of silver ions on the laser-activated *** laser-induced selective activation holds promise for broader applications,including the controlled growth of Pd and the development of Au/Ag alloy-based platforms,and thereby opens innovative avenues for advancements in semiconductors,solar cell technologies,precision sensing,and detection methodologies.

关键词： Laser-induced activation Decomposition Laser-induced ripples Reduction SERS

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我国体育产业的发展及其可行性分析

北京体育大学学报 2000年第3期23卷 308-310页

作者：田克敉山东省体育科研中心济南250002

论述了当前我国国民经济的发展态势和国外体育产业发展的启示 ,阐述了体育产业在我国当前国民经济发展中的作用 ,并对在我国大力发展体育产业的可行性进行了分析。

关键词：体育产业中国发展国民经济可行性