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学前教育公共服务供给的需求逻辑和现实选择

湖南师范大学教育科学学报 2021年第2期20卷 114-122页

作者：柯亮西北大学公共管理学院陕西西安710127 陕西学前师范学院经济与管理学院陕西西安710100

从我国大众对学前教育资源的需求侧出发研判学前教育公共服务的供给现实,对于厘清当前学前教育资源的需求层次、提升学前教育公共服务供给质量具有关键意义。学前教育公共服务的目标应把握保基本和求发展的需求逻辑,从基本需求、差额需... 详细信息

从我国大众对学前教育资源的需求侧出发研判学前教育公共服务的供给现实,对于厘清当前学前教育资源的需求层次、提升学前教育公共服务供给质量具有关键意义。学前教育公共服务的目标应把握保基本和求发展的需求逻辑,从基本需求、差额需求和超额需求三个层次出发构建学前教育公共服务供给的差序格局。在明晰学前教育公共服务供给现实问题的基础上,提供公共性和共享性的普及化基本公共服务、公益性和分享性的普惠化补充性公共服务、私益性和独享性的个性化非公共服务,保证学前教育公共服务供给的可实现性和可获得性。对学前教育公共服务供给机制的设计探索,需积极构建责任共担与收益共享的供给制度,保证经费供给的可行性和可持续性,从参与主体、服务供给、成本分担、人员管理、监督管理五个维度设计供给路径。

关键词：学前教育公共治理供给模式需求层次多元供给

Mycobacterium tuberculosis and Escherichia coli Abscess of Prostate in Patient with Acquired Immunodeficiency Syndrome

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Mycobacterium tuberculosis and Escherichia coli Abscess of P...

Role of vacuolar invertase in regulation of stomatal behavior

中华医学会第十三次全国感染病学术会议

作者： ke liang Zhushan Peng Wei Guo Department of Infectious Diseases Zhongnan Hospital of Wuhan University Pathology department Wuhan University School of Basic Medical Sciences

Background Prostatic abscess is an unusual urologic disease,the diagnosis and management are not easy,especially for patient with acquired immunodeficiency syndrome(AIDS).Case presentation A 31-year-old man with AIDS presented with high fever and urinary retention,and his ultrasound and pelvic cavity CT showed abscess in *** antibiotic treatment was *** examination for pus collected by transrectal ultrasound(TRUS)guided needle aspiration showed Mycobacterium tuberculosis and Escherichia coli(***)infection.

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Role of vacuolar invertase in regulation of stomatal behavio...

Comparative study on pharmacological effects of DM-phencynonate hydrochloride and its optical isomers

2016年全国植物生物学大会

作者： Sufeng Chen ke liang DiAn Ni School of Ecological Technology and Engineering Shanghai Institute of Technology

There are several hypotheses that explain stomatal behavior. These include the concept of osmoregulation mediated by potassium and its counter-ions malate and chlorine and the more recent starch–sugar hypothesis. Here we report that the activity of the sucrose cleavage enzyme,vacuolar invertase(VIN),is significantly higher in guard cells than in other leaf epidermal cells and its activity is correlated with stomatal aperture. Changes in VIN activity was speculated to be affected by the p H within the vacuole through potential modulation of the activities of H+/sugar antiporters on the tonoplast or other transporters for potassium,chloride,and malate,across guard cell membrane. To this end,it has been reported that guard cell vacuolar p H increases during stomatal closing,but it decreases during stomatal opening. Further more,we examined whether VIN indeed controls stomatal movement under normal and drought conditions by transforming Arabidopsis with a tobacco vacuolar invertase inhibitor homolog(Nt-inhh) under the control of an abscisic acid-sensitive and guard cellspecific promoter(At Rab18). The data obtained showed that guard cells of transgenic Arabidopsis plants had lower VIN activity,stomatal aperture and conductance than that of wild-type plants. Moreover,the transgenic plants also displayed higher drought tolerance than wild-type plants. The data indicate that VIN is a promising target for manipulating stomatal function to increase drought tolerance.

关键词： vacuolar invertase stomatal behavior drought tolerance

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Acta Pharmacologica Sinica 2005年第10期26卷 1187-1192页

作者： Li-yun WANG, Jian-quan ZHENG~2, Yun WANG, Bo-hua ZHONG, Jin-xiu RUAN, ke-liang LIU Beijing Institute of Pharmacology and Toxicology, Beijing 100850. China Beijing Institute of Pharmacology and Toxicology Beijing China

Aim: The 3-azabicyclo(3,3,1)nonanyl-9-α-yl-α-cyclopentyl-α-phenyl-α-glycolate (DM-phencynonate hydrochloride, DMCPG) is a demethylated metabolite of 3-methyl-3-azabicyclo(3,3,1)nonanyl-9-α-yl-α-cyclopentyl-α-phenyl-α-glycolate (phencynonate hydrochloride, CPG). (±)DMCPG had one chiral center and two enantiomers [R(-) and S(+)DMCPG]. Here we carried out a comparative study of the pharmacological profiles of these optical isomers. Methods: Affinity and relative efficacy were tested using a radioligand-binding assay with muscarinic acetylcholine receptors from the rat cerebral cortex. Pharmacological activity was assessed in three individual experiments: (1) potentiating the effect of a subthreshold hypnotic dose of sodium pentobarbital; (2) inhibiting oxotremorineinduced salivation; and (3) inhibiting the contractile response to carbachol. Results: In the competitive binding assay, R(-)DMCPG (Ki=763.75 nmol/L) was 4-and 2-fold more potent than (±)DMCPG (Ki=3186nmol/L) and S(+)DMCPG (Ki=1699 nmol/L) in inhibiting the binding of [3~H]QNB. The R(-) and S (+) configurations showed positive cooperation (nH>1) with the muscarinic receptor, whereas (±)DMCPG had a negative cooperation (nH0.05). (±)DMCPG and its optical isomers suppressed the guinea pig ileum contractile response to carbachol. The IC50values were 7.78x 10-9, 1.88x 10-7, and 1.03x10-7nmol/L, respectively. In the anti-salivation study, (±)DMCPG and its enantiomers depressed oxotremorine-induced salivation in a dose-dependent manner, and the order of potency was R(-)DMCPG (ED50=0.44 mg/kg>(±)DMCPG (ED50=2.88 mg/kg)>S(+)DMCPG (ED50=5.05 mg/

关键词： optical isomers muscarinic acetylcholinic receptors pharmacological profiles radio-ligand binding assay

Study on Torrential Rain Disaster Index and Threshold in Zhangjiajie City

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Meteorological and Environmental Research 2022年第5期13卷 60-67,72页

作者： Yueyong LI Wei ZHOU Hao LI ke liang Hunan Provincial Meteorological Service Centre Changsha 410118China key Laboratory of Hunan Province for Meteorological Disaster Prevention and Mitigation Changsha 410118China Zhangjiajie Meteorological Office of Hunan Province Zhangjiajie 427000China

Based on the precipitation data and torrential rain disaster data in Zhangjiajie City of Hunan Province from 2016 to 2020,taking the claim cases of the property and cargo insurance(hereinafter referred to as"property and cargo insurance")from Hunan Branch of the People’s Insurance Company of China as the research sample,the Dominance Analysis Method was used to determine the influence weights of disaster-causing factors to establish a comprehensive disaster-causing index(I)model of torrential ***,an exponential function was used to fit the relationship between the number of town or street which filed claims of property and cargo insurance and I,then to determine the threshold of I corresponding to different accident *** claim cases caused by torrential rain disaster in Zhangjiajie in the flood season of 2021 were selected to verify the I and its *** results showed that the number of property and cargo insurance accidents caused by torrential rain in Zhangjiajie was generally low in east and west but high in middle *** the disaster-causing factors,the weight of the 96-h accumulated precipitation on the scope of accident was the largest,reaching 28.6%.The simulated grades of the scope of accident,the amount of claim and the number of accidents of property and cargo insurance had a high correlation with the grades of actual disasters,and all passed the test at the 0.01 significance *** threshold test results showed that the consistency rate or accuracy between the predicted level and the actual level of torrential rain disaster-causing cases was 71.4%,in which the predicted values of accuracy for the mild,moderate and severe disaster levels were 70%,70%and 100%,***,the threshold of I established in this study can be used for the industrial meteorological services related to the property and cargo insurance in Zhangjiajie.

关键词： Torrential rain Property and cargo insurance Disaster threshold

Pharmacological profiles of an anticholinergic agent,phencynonate hydrochloride,and its optical isomers

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Acta Pharmacologica Sinica 2005年第5期26卷 527-532页

作者： Li-yun WANG,Yun WANG,Jian-quan ZHENG~2,Bo-hua ZHONG,He LIU,Si-jian DONG,Jin-xiu RUAN,ke-liang LIUBeijing Institute of Pharmacology and Toxicology,Beijing 100850,China Beijing Institute of Pharmacology and Toxicology Beijing China

Aim:To comparatively study the pharmacological profiles of 3-methyl-3-azabicyclo(3,3,1)nonanyl-9-α-yl-α-cyclopentyl-α-phenyl-α-glycolate(phencynonatehydrochloride,CPG),an anticholinergic agent,and its enantiomers[R(-)-andS(+)-CPG].Methods:The affinity and relative efficacy were tested usingradioligand-binding assay with muscarinic acetylcholine receptors from rat cere-bral *** pharmacological activities were assessed in three individual experi-ments:(1)potentiating the effect of subthreshold hypnotic dose of sodiumpentobarbital;(2)inhibiting oxotremorine-induced salivation;and(3)inhibitingthe contractile response to ***:The order of potency of phency-nonate hydrochloride and its optical isomers to inhibit the binding of[~3H]quinucli-dinyl benzilate([~3H]QNB)was R(-)-CPG(Ki=46.49±1.27nmol/L)>CPG(Ki=271.37±72.30 nmol/L)>S(+)-CPG(Ki=1263.12±131.64 nmol/L).The results showed thatR(-)-CPG had the highest affinity to central muscarinic receptors among the threecompounds,but did not show any central depressant effects at dose from 10.00 to29.15 mg/*** increased the effects of subthreshold hypnotic dose of sodiumpentobarbital induced-sleeping[the ED50±95% LC value was 21.06±3.04 mg/kg].CPGand R(-)-CPG displayed nearly equipotent effect in depressing oxotremorine-induced salivation[the ED50±95% LC for R(-)and CPG were 1.10±0.28 and 1.07±0.15 mg/kg,respectively],and the contractile response to carbachol(pA2valuesfor R(-)and CPG were 6.84 and 6.80,respectively).S(+)-CPG presented the lówestanticholinergic profiles,but could potentate effects of its enantiomers in ***:These data suggested that R(-)-CPG acted as an eutomerin racemate and a competitive antagonist to acetylcholine muscarinic receptors,but S(+)-CPG was less active in comparison to R(-)-CPG and its *** depressant effects of R(-)-CPG and S(+)-CPG were lower in comparison toits racemate.

关键词： optical isomers muscarinic acetylcholinic receptors pharmacological profiles radioligand binding assay

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肽核酸的合成、修饰和应用

有机化学 2005年第3期25卷 254-263页

作者：褚征刘克良军事医学科学院毒物药物研究所北京100850

肽核酸是寡核苷酸模拟物,它的糖-磷酸骨架被N-(2-氨基乙基)甘氨酸骨架所代替.为了优化肽核酸的性质,各种结构的肽核酸(PNA)单体被合成出来.综述了肽核酸的合成、结构修饰及应用.

关键词：肽核酸合成修饰应用

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尿有形成分的识别与检查方法的选择

中华检验医学杂志 2005年第6期28卷 572-575页

作者：顾可梁江苏大学医学技术学院镇江市212001

尿有形成分检查又称尿沉渣检查(examination of urinary sediments),是将新鲜尿离心后,经显微镜检查尿沉淀物中各种有形成分的检查方法[1].由于仪器分析进展,现代的尿有形成分检查可采用不离心法,用激光荧光染色及流式分析的分析方法,(S... 详细信息

尿有形成分检查又称尿沉渣检查(examination of urinary sediments),是将新鲜尿离心后,经显微镜检查尿沉淀物中各种有形成分的检查方法[1].由于仪器分析进展,现代的尿有形成分检查可采用不离心法,用激光荧光染色及流式分析的分析方法,(Sysmex UF50,UF100)或使用计算机图像自动识别系统(Iris IQ200)来计数尿中各种颗粒,因而又可称为尿中颗粒计数法(particle analysis)[2].目前国内大多数医院实验室仍习惯于传统的普通显微镜检查法,由于在尿中可存在多种有形成分如细胞类、管型类、微生物类、结晶类等,为了进一步识别及鉴别这些成分除用普通光学显微镜外还有相差显微镜、偏光显微镜、荧光显微镜、干涉显微镜及电子显微镜等检查,而在普通显微镜检查又可分为染色法及非染色法。

关键词：尿有形成分查方 analysis) 自动识别系统尿沉渣检查显微镜检查计算机图像分析进展荧光染色离心后新鲜尿沉淀物离心法计数法颗粒

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尿液有形成分检查的难点与疑点

中华检验医学杂志 2009年第6期32卷 605-608页

作者：顾可梁江苏大学医学技术学院镇江212001

尿液有形成分检查是肾疾病诊断中重要的检查方法，显微镜检查或自动化仪器分析法均不够完善，干化学检查也并不可信，染色法是鉴别尿有形成分的有效方法，做好分析前、分析中、分析后质量控制是完成这一工作的有力保证。

关键词：尿分析显微镜检查自动分析染色与标记质量控制