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Coordinated Control of Multi-Agent Systems with a Varying-Velocity Leader and Input Saturation

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Communications in Theoretical Physics 2009年第9期52卷 449-456页

作者： PENG ke SU hou-Sheng YANG Yu-Pu Department of Automation Shanghai Jiao Tong University Shanghai 200240 China

In this paper,we investigate a leader-following tracking problem for multi-agent systems with *** propose a distributed bounded protocol for each follower to track a leader whose states may not be *** theoretically prove that each agent can follow the leader with estimable track ***,somenumerical simulations are presented to illustrate our theoretical results.

关键词： consensus coordinated control multi-agent system networked system input saturation switching topology

Heparanase-1 activities in the development of laser induced choroidal neovascularization

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 131-135页

作者： Wei-Qiang Tang Bao-ke hou Department of Ophthalmology the First Affiliated Hospital of General Hospital of People's Liberation Army General Hospital of People's Liberation Army

AIM: To investigate the role of heparanase-1 in laser-induced choroidal neovascularization (CNV). METHODS: Experimental CNV was induced by krypton laser photocoagulation in 15 male Brown Norway rats. Fundus fluorescein angiography and histopathological examination were performed in observing the CNV development. The expression and distribution of heparanase-1 protein in the laser lesions were determined by immunohistochemistry and western blotting analysis. RESULTS: The success rate of laser induced CNV was approximately 75% on 3-4 weeks after laser photo-coagulation. The protein levels of heparanase-1 increased significantly in the retina-choroidal complex of CNV models when compared to normal rat eyes (P < 0.01). Immunostaining confirmed strong heparanase-1 expressions in all laser lesions, and it displayed to be highest at the newly formed blood vessels within the fibrovascular complex in the subretinal space. CONCLUSION: Heparanase-1 is closely involved in the development of laser induced CNV.

关键词： choroidal neovascularization immunohistochemistry western blotting heparanase-1

Optimizing slope safety factor prediction via stacking using sparrow search algorithm for multi-layer machine learning regression models

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Journal of Mountain Science 2023年第10期20卷 2852-2868页

作者： SHUI Kuan hou ke-peng hou Wen-wen SUN Jun-long SUN Hua-fen Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093China Yunnan key Laboratory of Sino-German Blue Mining and Utilization of Special Underground Space Kunming 650093China College of Water Resource and Hydropower Sichuan UniversityChengdu 610065China

The safety factor is a crucial quantitative index for evaluating slope ***,the traditional calculation methods suffer from unreasonable assumptions,complex soil composition,and inadequate consideration of the influencing factors,leading to large errors in their ***,a stacking ensemble learning model(stacking-SSAOP)based on multi-layer regression algorithm fusion and optimized by the sparrow search algorithm is proposed for predicting the slope safety *** this method,the density,cohesion,friction angle,slope angle,slope height,and pore pressure ratio are selected as characteristic parameters from the 210 sets of established slope sample *** Forest,Extra Trees,AdaBoost,Bagging,and Support Vector regression are used as the base model(inner loop)to construct the first-level regression algorithm layer,and XGBoost is used as the meta-model(outer loop)to construct the second-level regression algorithm layer and complete the construction of the stacked learning model for improving the model prediction *** sparrow search algorithm is used to optimize the hyperparameters of the above six regression models and correct the over-and underfitting problems of the single regression model to further improve the prediction *** mean square error(MSE)of the predicted and true values and the fitting of the data are compared and *** MSE of the stacking-SSAOP model was found to be smaller than that of the single regression model(MSE=0.03917).Therefore,the former has a higher prediction accuracy and better data *** study innovatively applies the sparrow search algorithm to predict the slope safety factor,showcasing its advantages over traditional ***,our proposed stacking-SSAOP model integrates multiple regression algorithms to enhance prediction *** model not only refines the prediction accuracy of the slope safety factor but also offers a fresh approach to handling the intricate

关键词： Multi-layer regression algorithm fusion Stacking gensemblelearning Sparrow search algorithm Slope safety factor Data prediction

Chemokine ligand 20 enhances progression of hepatocellular carcinoma via epithelial-mesenchymal transition

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World Journal of Gastroenterology 2015年第2期21卷 475-483页

作者： ke-Zhu hou Zhi-Qiang Fu Hua Gong Department of First General Surgery Shidong Hospital

AIM: To identify the mechanisms of chemokine ligand 20(CCL20)-induced hepatocellular carcinoma(HCC) metastasis and evaluate it as a prognostic marker. METHODS: Expression of CCL20 was evaluated by immunohistochemistry in HCC tissues from 62 patients who underwent curative resection. The relationship between CCL20 expression and clinicopathologic features was analyzed. Univariate and multivariate analyses were performed to evaluate its predictive value for recurrence and survival of HCC patients. The expression levels ofepithelial-mesenchymal transition(EMT)-and signaling pathway-related proteins were evaluated by Western blotting and immunocytochemistry. The effects of CCL20 on HCC cell proliferation and migration were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenoltetrazolium bromide(MTT) and Transwell assays. RESULTS: CCL20 immunoreactivity was detected in all 62 patient specimens. CCL20 expression was associated with preoperative alpha-fetoprotein level(P = 0.043), tumor size(P = 0.000), tumor number(P = 0.008), vascular invasion(P = 0.014), and tumor differentiation(P = 0.007). Patients with high CCL20 expression had poorer recurrence-free and overall survivals compared to those with low CCL20 expression(both P ke changes in HCC cells and increased their proliferation and migration ability(P ke phenotype in HCC cells, and increased expression of phosphorylated AKT, β-catenin and vimentin, and decreased E-cadherin expression(P < 0.05). The correlation analysis revealed that high CCL20 expression in HCC tissue specimens was negatively correlated with E-cadherin expression(13.33%, 4/30), and positively correlated with vimentin(90.0%, 27/30), β-catenin(96.67%, 29/30) and p-AKT(76.67%, 23/30) ***: CCL20 expression is associated with HCC recurrence and patient survival and promotes HCC cell proliferation and migration by in

关键词： Chemokine ligand 20 Phosphoinositide kinase-3/AKT

Synthesis, characterization and theoretical study of 2-azido-4-nitroimidazole-based energetic salts

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Chinese Chemical Letters 2014年第3期25卷 438-440页

作者： ke-Hui hou Cong-Ming Ma Zu-Liang Liu School of Chemical Engineering Nanjing University of Science and Technology

The 2-azido-4-nitroimidazole-based energetic salts were synthesized in a simple and straightforward manner. The structures of these new salts were determined by IR, 1H NMR and 13C NMR spectroscopy and elemental analysis. These salts also exhibited high positive enthalpies of formation, high nitrogen content, and moderate detonation properties.

关键词： SynthesisEnergetic compoundsHeats of formation2-Azido-4-nitroimidazole

Synthesis of micron-sized hollow silica spheres with a novel mesoporous shell of MCF

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Chinese Chemical Letters 2009年第7期20卷 852-856页

作者： An Feng Zhang Yong Chun Zhang Na Xing ke ke hou Jing Wang Xin Wen Guo State key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian 116012 China

Micron-sized hollow silica spheres whose shells are made up of mesocellular silica foams （MCFs） have been synthesized by one-pot sol-gel method in benzene/water/P123 emulsion. The material is characterized with SEM, TEM, BET and ^29Si MAS NMR. The results show that the MCFs of the unique shell of hollow silica spheres were connected by large windows with a narrow distribution of - 10 nm in diameter, the inner space of the hollow sphere is accessible. And the formation mechanism of the hollow silica spheres is proposed. C 2009 Xin Wen Guo. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Hollow spheres MCF Mesoporous material

Ultra-stable silica-coated chiral Au-nanorod assemblies： Core-shell nanostructures with enhanced chiroptical properties

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Nano Research 2016年第2期9卷 451-457页

作者： Bing Han Lin Shi Xiaoqing Gao Jun Guo ke hou Yonglong Zheng Zhiyong Tang Laboratory of Nanomaterials National Center for Nanoscience and Technology Beijing 100190 China

Chiral nano-assemblies with amplified optical activity have attracted particular interest for their potential application in photonics, sensing and catalysis. Yet it still remains a great challenge to realize their real applications because of the instability of these assembled nanostructures. Herein, we demonstrate a facile and efficient method to fabricate ultra-stable chiral nanostructures with strong chiroptical properties. In these novel chiral nanostructures, side-by-side assembly of chiral cysteine-modified gold nanorods serves as the core while mesoporous silica acts as the shell. The chiral core-shell nanostructures exhibit an evident plasmonic circular dichroism （CD） response originating from the chiral core. Impressively, such plasmonic CD signals can be easily manipulated by changing the number as well as the aspect ratio of Au nanorods in the assemblies located at the core. In addition, because of the stabilization effect of silica shells, the chiroptical performance of these core-shell nanostructures is significantly improved in different chemical environments.

关键词： chiral core-shell nanostructure plasmonic circular dichroism gold nanorods self-assembly high stability

Characteristics of ZnO Particles Prepared by Au-catalyzed Phase Transport Technique

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Chemical Research in Chinese Universities 2010年第5期26卷 675-677页

作者： HU Shi-qi HUANG ke-ke hou Chang-min YUAN Hong-ming HU Bin FENG Shou-hua State key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 P R. China

ZnO particles were prepared by Au-catalyzed vapor phase transport method on silicon substrate. Scanning electron microscopy（SEM） images show many ZnO particles were formed on the sample surface. They grew up layer by layer along the c-axis, which was confirmed by the results of X-ray diffraction（XRD）. The morphology of ZnO particles is close to hemisphere and its formation process could be seen from the SEM image. The room temperature photoluminescence（PL） measurement revealed a narrow UV emission peak at 3.27 eV and a broad green emission peak at 2.45 eV, which was caused by the near-band-edge and deep-level emissions.

关键词： ZnO Au-catalyzed Vapor phase transport Photoluminescence

Coordination-responsive drug release inside gold nanorod @ metal-organic framework core-shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy

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Nano Research 2018年第6期11卷 3294-3305页

作者： Yantao Li Jun Jin Dawei Wang Jiawei Lv ke hou Yaling Liu Chunying Chen Zhiyong Tang CAS key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China

Multifunctional core-shell nanostructures formed by integration of distinct components have received wide attention as promising biological platforms in recent years. In this work, crystalline zeolitic imidazolate framework-8 （ZIF-8）, a typical metal-organic framework （MOF）, is coated onto single gold nanorod （AuNR） core for successful realization of synergistic photothermal and chemotherapy triggered by near-infrared （NIR） light. Impressivel）~ high doxorubicin hydrochloride （DOX） loading capacity followed by pH and NIR light dual stimuli-responsive DOX release can be easily implemented through formation and breakage of coordination bonds in the system. Moreover, under NIR laser irradiation at 808 nm, these novel AuNR@MOF core-shell nanostructures exhibit effective synergistic chemo-photothermal therapy both in vitro and in vivo, confirmed by cell treatment and tumor ablation via intravenous injection.

关键词： core-shell nanostructures coordination bonds dual stimuli response synergistic cancer therapy