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Role of the Lung Microbiome in the Pathogenesis of Chronic Obstructive Pulmonary Disease

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Chinese Medical Journal 2017年第17期130卷 2107-2111页

作者： Lei Wang ke hao Ting Yang Chen Wang Department of Pulmonary and Critical Care Medicine Xuanwu Hospital Capital Medical University Beijing 100069 China Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York 10001 USA Department of Pulmonary and Critical Care Medicine China-Japan Friendship Hospital Beijing 100029 China

Objective：The development of culture-independent techniques for microbiological analysis shows that bronchial tree is not sterile in either healthy or chronic obstructive pulmonary disease （COPD） *** the advance of sequencing technologies,lung microbiome has become a new frontier for pulmonary disease research,and such advance has led to better understanding of the lung microbiome in *** review aimed to summarize the recent advances in lung microbiome,its relationships with COPD,and the possible mechanisms that microbiome contributed to COPD *** Sources：Literature search was conducted using PubMed to collect all available studies concerning lung microbiome in *** search terms were ＆quot;microbiome＆quot; and ＆quot;chronic obstructive pulmonary disease＆quot;,or ＆quot;microbiome＆quot; and ＆quot;lung/pulmonary＆quot;.Study Selection：The papers in English about lung microbiome or lung microbiome in COPD were selected,and the type of articles was not ***：The lung is a complex microbial ecosystem;the microbiome in lung is a collection of viable and nonviable microbiota （bacteria,viruses,and fungi） residing in the bronchial tree and parenchymal tissues,which is important for *** following types of respiratory samples are often used to detect the lung microbiome：sputum,bronchial aspirate,bronchoalveolar lavage,and bronchial *** bacterial microbiome is participated in pathogenesis of COPD;there are also dynamic changes in microbiota during COPD *** microbiome may contribute to the pathogenesis of COPD by manipulating inflammatory and/or immune ***：Normal lung microbiome could be useful for prophylactic or therapeutic management in COPD,and the changes of lung microbiome could also serve as biomarkers for the evaluation of COPD.

关键词： Chronic Obstructive Pulmonary Disease Lung Microbiome Pathogenesis

A Novel Approach for Trajectory Tracking Control of an Under-Actuated Quad-Rotor UAV

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 2030-2032页

作者： ke Shao Kang Huang Shengchao Zhen hao Sun Rongrong Yu School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072 School of Mechanical Engineering Hefei University of TechnologyHefei 230009China

Dear Editor,This letter presents a novel Udwadia-Kalaba(U-K)approach for the trajectory tracking control of a quad-rotor unmanned aerial vehicle(UAV).Compared to conventional control approaches,the desired trajectorie... 详细信息

关键词： letter desired constraints

Axial enantiomers with donor-regulated TADF feature for multicolor circularly polarized electroluminescence

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Science China Chemistry 2024年第6期67卷 2039-2045页

作者： Chen-hao Guo Wen-Long Zhao ke-ke Tan Wei-Chen Guo Liheng Feng Chuan-Feng Chen Meng Li School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

This study optimized the TADF feature of axial chiral enantiomers through precise donor engineering,and multicolor CP-TADFwas achieved in the axial chiral *** pairs of axial enantiomers with donor-regulated TADF feature,namely(R/S)-TPCBD,(R/S)-DPCBD,and(R/S)-DPACBD,were synthesized by introducing carbazole donors with different substituents onto biphenyl cyanide *** the electron-donating ability of donors increases,the emission of these axial enantiomers ranges from 455,476 to 552 nm,their singlet-triplet energy gaps(ΔE_(ST))gradually decrease from 0.30,0.22 to 0.02 e V,accompanied by an increasement in the transition rate(k_(RISC))of RISC process,and the k_(RISC)of DPACBD could reach up to 7.16×10^(5)s^(-1).These axial enantiomers also exhibit mirror-image CD and circularly polarized luminescence(CPL)***,OLEDs based on TPCBD,DPCBD,and DPACBD as emitter were then fabricated,which displayed blue,green,and orange electroluminescence with EQE_(max)of 13.0%,16.4%,and 25.0%,*** results also exhibited a phenomenon of device efficiency increasing with the enhancement of donor ***,the CP-OLEDs using(R/S)-TPCBD,(R/S)-DPCBD and(R/S)-DPACBD as emitters displayed intense CPEL signals with g_(EL)values of 3.4×10^(-3)/-4.1×10^(-3),3.2×10^(-3)/-3.1×10^(-3)and2.3×10^(-3)/-2.1×10^(-3),*** convenient molecular engineering of donor regulation in the same molecular skeleton,CP-TADF materials with multicolor CPEL and improved device performance could be conveniently achieved.

关键词： axial chirality thermally activated delayed fluorescence circularly polarized luminescence electroluminescence organic light-emitting diodes

角蛋白凝胶新型制备技术及对重金属离子吸附性能研究

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纺织科学与工程学报 2024年第1期41卷 52-57,67页

作者：杨美慧陈柯好沈艳琴武海良李博西安工程大学纺织科学与工程学院陕西西安710048 西安工程大学服装与艺术设计学院陕西西安710048 西安工程大学功能性纺织材料及制品教育部重点实验室陕西西安710048

毛纺产业每年会产生大量废弃纤维及废旧制品,这些资源若无法有效处理将会造成资源浪费及环境污染等诸多问题。提取羊毛纤维中富含的角蛋白并制备为再生凝胶材料,是实现废弃资源高值化循环利用的重要途径之一。但由于羊毛复杂的化学结构... 详细信息

毛纺产业每年会产生大量废弃纤维及废旧制品,这些资源若无法有效处理将会造成资源浪费及环境污染等诸多问题。提取羊毛纤维中富含的角蛋白并制备为再生凝胶材料,是实现废弃资源高值化循环利用的重要途径之一。但由于羊毛复杂的化学结构及加工技术的不足,现有研究中角蛋白凝胶普遍存在制备率低或机械性能差等缺陷,难以实现产业化生产。基于此,对羊毛角蛋白的提取技术和凝胶制备方法进行了探究,并将制得的凝胶用于重金属离子吸附研究。实验中利用“还原预处理-甲酸法”提取角蛋白多肽,对还原预处理的工艺进行了优化。研究结果表明还原预处理工艺最优条件为TCEP质量分数100 g/L,浴比1∶10,处理时间2 h,处理温度80℃。经该工艺预处理后,纤维在甲酸中的溶解率可高达70%。随后,利用“透析-冷冻法”制得孔隙结构较均匀的角蛋白凝胶并将其用于铜离子和锌离子的吸附性能研究。结果显示在特定条件下,凝胶材料对两种重金属离子的吸附量和去除率均可达到0.06 mg/g以及40%左右,具有一定的研究和开发价值。

关键词：羊毛角蛋白凝胶材料重金属离子废水净化

敲除TSP-1对小鼠急性肝损伤保护作用的机制

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广东医学 2024年第2期45卷 152-158页

作者：吴敏冯伟珂占一姗王剑巧曾金娣李科浩张守华陶强占敏江西省儿童医院普外科江西南昌330038 九江学院附属医院江西九江332000 井冈山大学附属医院江西吉安343000

目的研究敲除血小板反应蛋白1(thrombospondin 1,TSP-1)在四氯化碳(CCl_(4))所致小鼠急性肝损伤中的保护作用。方法选取C57BL/6J小鼠16只,TSP-1基因敲除小鼠8只:C57BL/6J小鼠分为WT组和WT+CCl_(4)组,TSP-1基因敲除小鼠为TSP-1^(-/-)+CCl_(4)组;WT+CCl_(4)和TSP-1^(-/-)+CCl_(4)组给予0.5 mL CCl_(4)+9.5 mL/kg橄榄油进行腹腔注射建立急性肝损伤模型,WT组注射橄榄油10 mL/kg作为对照。通过HE染色以及血清中丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)观察各组小鼠肝脏损伤情况及炎症反应程度;同时检测肝组织丙二醛(MDA)和谷胱甘肽(GSH)的含量并通过免疫组化和TUNEL检测凋亡的变化。结果敲除TSP-1对CCl4诱导的急性肝损伤具有明显的改善作用,表现为血清AST、ALT、IL-6和TNF-α的降低和肝细胞坏死的减少,以及降低MDA含量和升高GSH含量,减少肝组织中凋亡及caspase-3的表达。结论敲除TSP-1对CCl_(4)诱导的小鼠急性肝损伤具有明显的保护作用,其机制可能与抑制炎症、氧化应激和细胞凋亡相关。

关键词：血小板反应蛋白1 四氯化碳急性肝损伤

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多维度新型光电传感系统分析

光电技术应用 2024年第4期39卷 28-31页

作者：杨莲莲郝克徐昕阳张洁何鑫侯瑞鹏中国电子科技集团公司光电研究院天津电磁空间安全全国重点实验室天津

信息获取能力日益重要,随着人工智能等新一代信息技术的快速发展,世界各国争相发展新一代智能化光电传感系统,利用多维信息和智能算法进行光电传感系统的迭代升级,进一步提高全电磁频谱探测能力。主要概述了智能化光电传感系统的发展需... 详细信息

信息获取能力日益重要,随着人工智能等新一代信息技术的快速发展,世界各国争相发展新一代智能化光电传感系统,利用多维信息和智能算法进行光电传感系统的迭代升级,进一步提高全电磁频谱探测能力。主要概述了智能化光电传感系统的发展需求和典型项目,分析了RAIVEN智能传感系统的关键技术。

关键词：智能化多维度光电传感

Impact of Annealing on the Melt Recrystallization of a-PDLA/α-PLLA Double-layered Films

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Chinese Journal of Polymer Science 2024年第2期42卷 230-238,I0009页

作者： Yun-Peng Li hao-Ran Shen Shao-Juan Wang hao Zhang Jian Hu Rui Xin Xiao-Li Sun Shou-ke Yan key Laboratory of Rubber-Plastics Ministry of Education/Shandong Provincial Key Laboratory of Rubber-plasticsQingdao University of Science&TechnologyQingdao266042China State key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China

Poly(lactic acid)(PLA) as a bio-based polymer with biodegradability and biocompatibility has attracted much attention. To manipulate its properties for different applications, regulation of crystal structure and crystalline morphology becomes an attractive research topic. In this work, the structure evolution of layered samples containing an amorphous poly(D-lactide)(PDLA) layer and a crystalline poly(L-lactide)(PLLA)layer with highly oriented edge-on α lamellar crystals after annealing at 150 ℃ or/and after melt-recrystallization has been studied by AFM, FTIR,and TEM combined with electron diffraction. The results demonstrate that melt recrystallization of the as-prepared sample leads to the formation of abundant randomly oriented PLA stereo-complex(PLA SC) crystals. Annealing at 150 ℃ results in the formation of a small amount of oriented PLA SC crystals at the interface. These PLA SC crystals show great impact on the recrystallization behavior of sample after melting at 190 ℃ and then crystallizing at 90 ℃. First, they impede the mutual diffusion of the overlying PDLA and underlying PLLA, and thus reduce their stereocomplexation ability as manifested by the decreased amount of PLA SC crystals. Second, they act as substrate to initiate the epitaxial crystallization of the overlying PDLA and underlying PLLA, which ensures the production of a highly oriented structure of PDLA and PLLA after melt recrystallization again.

关键词： Poly(L-lactide) Poly(D-lactide) Double layer Stereocomplex

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呼吸亚重症病房大规模供氧方案研究

医院管理论坛 2024年第7期41卷 81-85页

作者：赵伊楠王金良袁星杨浩克高伟翔北京大学第三医院

突发公共卫生事件导致出现大量呼吸危重症患者,发热门诊和急诊量激增,呼吸亚重症病房大量投入使用,实现最大限度收治患者。这对医用氧气的持续供应带来极大挑战,因此如何保证大规模供氧的安全稳定成为工作难点。本文结合某三甲医院的实... 详细信息

突发公共卫生事件导致出现大量呼吸危重症患者,发热门诊和急诊量激增,呼吸亚重症病房大量投入使用,实现最大限度收治患者。这对医用氧气的持续供应带来极大挑战,因此如何保证大规模供氧的安全稳定成为工作难点。本文结合某三甲医院的实际情况,采用系统工程的研究思路,从氧源储备、安全管理、氧气分配及人力配置几个方面开展研究,探索大规模供氧方案,有效保障医院呼吸亚重症病房大规模收治病人的供氧需求。

关键词：呼吸亚重症病房氧气供给安全管理

Effect of Heat Treatment on Gradient Microstructure and Tensile Property of Laser Powder Bed Fusion Fabricated 15-5 Precipitation Hardening Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 181-195页

作者： Sheng Cao Hongyu Liu Jin Jiang ke He Binghua Lv hao Zhang Lujie Zhang Jingrong Meng hao Deng Xiaodong Niu Department of Mechanical Engineering College of EngineeringShantou UniversityShantou515063China China State Shipbuilding Co. Ltd.Huangpu Wenchong Shipbuilding Company Ltd.Guangzhou510715China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing100080China Shantou Ruixiang Mould Co. Ltd.Shantou515041China Military Representative Office X of Unit 93147 Deyang618000China China National Erzhong Group Co. Deyang Wanhang Die Forging Co.Ltd.Deyang618013China

This work investigated the gradient microstructure evolution and tensile property of LPBF fabricated 15-5 precipitation hardening stainless steel in post-process direct ageing(DA)and solution treating&ageing(STA).The varied microstructures for austenite and small-sized oxide inclusions at different sample heights in the as-built(AB)condition was generally preserved after DA ***,austenite was almost disappeared,and oxide particle grew significantly after the STA *** a result,the tensile property differences in sample top and bottom for AB and DA conditions did not occur in the STA *** the influence of post-process heat treatment,the STA condition had the highest yield strength due to the highest volume fraction of nano-sized Cu ***,the DA specimen had the highest ultimate tensile strength and elongation owing to the considerable amount of austenite phase and associated transformation induced plasticity effect.

关键词： 15-5 PH stainless steel Laser powder bed fusion Heat treatment Gradient microstructures Tensile properties