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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 77-82页

作者： Wen-Jian Mao Jing Zhou Guo-Fu Zhang fa.Xi Chen Jing-Zhu Zhang Bai-Qiang Li Lu ke Wei-Qin Li Department of Critical Care Medicine Jinling HospitalNanjing Medical UniversityNanjing 210002China Department of Critical Care Medicine Jinling HospitalMedical School of Nanjing UniversityNanjing 210002China National Institute of Healthcare Data Science Nanjing UniversityNanjing 210010China

Background:Early systemic anticoagulation(SAC)is a common practice in acute necrotizing pancreatitis(ANP),and its impact on in-hospital clinical outcomes had been ***,whether it affects long-term outcomes is *** study aimed to evaluate the effect of SAC on 90-day readmission and other long-term outcomes in ANP ***:During January 2013 and December 2018,ANP patients admitted within 7 days from the onset of abdominal pain were *** primary outcome was 90-day readmission after *** proportional-hazards regression model and mediation analysis were used to define the relationship between early SAC and 90-day ***:A total of 241 ANP patients were enrolled,of whom 143 received early SAC during their hospitalization and 98 did *** who received early SAC experienced a lower incidence of splanchnic venous thrombosis(SVT)[risk ratio(RR)=0.40,95%CI:0.26-0.60,Pfa.tor for 90-day readmission after adjusting for potential confounders with a hazard ratio of 0.57(95%CI:0.34-0.96,P=0.04).Mediation analysis showed that SVT mediated 37.0%of the early SAC-90-day readmission ***:The application of early SAC may reduce the risk of 90-day readmission in the survivors of ANP patients,and reduced SVT incidence might be the primary contributor.

关键词： Anticoagulation Splanchnic venous thrombosis Acute necrotizing pancreatitis Readmission Long-term outcomes

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二维中温气流热电测量的研究

工程热物理学报 1981年第1期 95-97页

作者：岑可法许冀森茹浩良浙江大学

在热力工程的试验中,应用气力式探针测量风速、风向虽有一定的准确度,但较难自动、迅速测量,低速灵敏度较差。本文采用了有方向罩的旋转热柱法,自动记下风速和方向,实验室和工程现场均可使用

关键词：热柱风速

Carotid versus axillary artery cannulation for descending aorta remodeling in type A acute aortic dissection

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World Journal of Cardiology 2024年第10期16卷 564-573页

作者： Qin Jiang Tao Yu ke-Li Huang ke Liu Xi Li Sheng-Shou Hu Department of Cardiac Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Cardiac Surgery Center Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Arterial cannulation sites for the surgical repair of type A aortic dissection(AAD)have evolved from right axillary artery(AA)cannulation to bilateral carotid artery(CA)based of femoral artery(fa.*** descending aorta remodeling is closely linked to the fa.se lumen area ratio(FLAR),defined as fa.se lumen area/aortic area,as well as to the incidence of renal replacement therapy(RRT).AIM To investigate the effect of the updated arterial cannulation strategy on descending aortic *** A total of 443 AAD patients who received fa.combined cannulation between March 2015 and March 2023 were included in the *** these,209 received right AA cannulation and 234 received bilateral CA *** primary outcome was the change in FLAR,as calculated from computed tomography angiography in three segments of the descending aorta:Thoracic(S1),upper abdominal(S2),and lower abdominal(S3).Secondary outcomes were the incidence of RRT and the serum inflammation response,as observed by the levels of high sensitivity C reaction protein(hs-CRP)and Interleukin-6(IL-6).RESULTS The postoperative/preoperative ratio of FLAR in S2 and S3 was higher in the AA group compared to the CA group(S2:0.80±0.08 vs 0.75±0.07,P<0.001;S3:0.57±0.12 vs 0.50±0.12,P<0.001,respectively).The AA group also had a significantly higher incidence of RRT(19.1%vs 8.5%,P=0.001;odds ratio:2.533,95%CI:1.427-4.493)and higher levels of inflammation cytokines 24 h after the procedure[hr-CRP:117±17 vs 104±15 mg/L;IL-6:129(103,166)vs 83(69,101)pg/mL;both P<0.001]compared to the CA *** The CA cannulation strategy was associated with better abdominal aorta remodeling after AAD repair compared to AA cannulation,as observed by a greater change in FLAR and lower incidence of RRT.

关键词： Acute type A aortic dissection Bilateral carotid arterial cannulation Descending aortic remodeling fa.se lumen area ratio Prognosis

Growth History of Complex fa.lt System and Syn- to Post-rift Transition in the Wushi East Subsag， Beibuwan Basin

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Journal of Earth Science 2024年

作者： Zheng Wang ke Xu Dianjun Tong College of Marine Science and Technology， China University of Geosciences School of Geosciences， Yangtze University

The Wushi sag is located in the central part of the Beibuwan Basin， northern South China Sea. Above the thick oily shale unit in the Wushi East Subsag， a suite of terrace-like extensional décollement fa.lt systems exists， which， in conjunction with the No.7 boundary fa.lt， control a complex fa.lt system. This study integrates the high-resolution 3D seismic data and quantitative analysis of fa.lt displacement to analyze the growth history of the complex fa.lt system and to establish a model of fa.lt system evolution in the Wushi East Subsag. The findings reveal two phases of fa.lt growth northward migration during the rifting process. The first phase occurred between the rift I phase and the décollement I phase， witnessing fa.lt activity migrating northward from the No.7 boundary fa.lt to the décollement fa.lts (Fd and Fe) in the hangingwall. The second phase occurred between the décollement I phase and the décollement II phase， with fa.lt activity migrating further northward from Fd and Fe to fa. Fb and Fd. By the end of the Oligocene， basin inversion controlled the syn- to post-rift transition of the Wushi East Subsag. This study bears significant implications for hydrocarbon exploration and for understanding the mechanism underlying the syn- to post-rift process in the north continental marginal basins of the South China Sea.

关键词：

Scintillation Arc from FRB 20220912A

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 134-142页

作者： Zi-Wei Wu Robert AMain Wei-Wei Zhu Bing Zhang Peng Jiang Jia-Rui Niu Jin-Lin Han Di Li ke-Jia Lee Dong-Zi Li Yuan-Pei Yang fa.Yin Wang Rui Luo Pei Wang Chen-Hui Niu Heng Xu Bo-Jun Wang Wei-Yang Wang Yong-Kun Zhang Yi Feng De-Jiang Zhou Yong-Hua Xu Can-Min Deng Yu-Hao Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Max-Planck-Institut für Radioastronomie Bonn 53121Germany Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Nevada Center for Astrophysics and Department of Physics and Astronomy University of NevadaLas VegasNV 89154USA CAS key Laboratory of fa.T National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy University of Chinese Academy of SciencesBeijing 100049China NAOC-UKZN Computational Astrophysics Centre University of KwaZulu-NatalDurban 4000South Africa Department of Astronomy Peking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Cahill Center for Astronomy and Astrophysics California Institute of TechnologyPasadena 91125USA South-Western Institute For Astronomy Research Yunnan UniversityKunming 650504China School of Astronomy and Space Science Nanjing UniversityNanjing 210093China key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210023China CSIRO Space and Astronomy Epping 1710Australia Department of Astronomy School of Physics and Materials ScienceGuangzhou UniversityGuangzhou 510006China Research Center for Intelligent Computing Platforms Zhejiang LaboratoryHangzhou 311100China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Guangxi key Laboratory for Relativistic Astrophysics Department of PhysicsGuangxi UniversityNanning 530004China

We present the interstellar scintillation analysis of fa.t radio burst(FRB)20220912A during its extremely active episode in 2022using data from the Five-hundred-meter Aperture Spherical Radio Telescope(fa.T).We detect a scintillation arc in the FRB’s secondary spectrum,which describes the power in terms of the scattered FRB signals’time delay and Doppler *** arc indicates that the scintillation is caused by a highly localized *** analysis fa.ors a Milky Way origin of the ionized interstellar medium(IISM)for the localized scattering medium but cannot rule out a host galaxy *** present our method for detecting the scintillation arc,which can be applied generally to sources with irregularly spaced bursts or *** methods could help shed light on the complex interstellar environment surrounding the FRBs and in our Galaxy.

关键词： fa.t radio burst scintillation FRB 20220912A

Mitochondria-targeted nanoparticles overcome chemoresistance via downregulating BACH1/CD47 axis in ovarian carcinoma

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Chinese Chemical Letters 2024年第5期35卷 344-350页

作者： ke Gong Jinghan Liao Jiangtao Lin Quan Wang Zhihua Wu Liting Wang Jiali Zhang Yi Dong Yourong Duan Jianhua Chen State key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200032China Department of Ultrasound Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Department of Oncology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

The platinum-based chemotherapy is a routine strategy for the treatment of ovarian cancer,while it is prone to chemoresistance in clinical,which hinders the ***,it is urgently needed to elucidate the underlying mechanism of drug resistance and form the appropriate *** sequencing results showed that cisplatin(DDP)resistant ovarian cancer overexpressed BTB and CNC homology 1(BACH1),and up-regulated the“don’t eat me”signal *** identified that hemin,a BACH1 inhibitor,could effectively down-regulate BACH1 and simultaneously inhibit ***,hemin has a synergistic effect with *** designed a pH-responsive nanoparticle(H/D@fa.CaP-NPs)in which folic acid(fa.ensured targeting of ovarian cancer cells,while hemin inhibited BACH1 as well as down-regulated CD47,achieving the promotion of apoptosis of tumor cells and inducing phagocytosis of tumors by ***,hemin has a synergistic effect with DDP to promote apoptosis of tumor ***,hemin and DDP was encapsulated within hydrophobic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine(DSPE)to form a tight core,and hydrophilic polyethylene glycol 2000(PEG2000)and calcium phosphate(CaP)formed the outside shell,and fa.was modified on the surfa.e of *** terms of function,(a)fa.enhanced the active targeting of nanoparticles to tumors;(b)NPs targeted mitochondria to induce reactive oxygen species(ROS)production;(c)hemin encapsulated in nanoparticles could specifically target BACH1,thereby down regulating CD47;(d)hemin had a synergistic effect with DDP,thus augmenting the ***,mitochondria-targeted nanoparticles H/D@fa.CaP-NPs promoted tumor apoptosis and mobilized phagocytosis to treat tumor,providing a novel scheme for clinical treatment of cisplatin-resistant ovarian carcinoma.

关键词： Cisplatin-resistant Hemin BACH1 CD47 Phagocytosis ROS Synergistic effect

基于动态能力视角的品牌生态圈形成过程机制研究——以仁和集团为例

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管理案例研究与评论 2024年第1期17卷 89-104页

作者：余可发高劲章汪华林江西财经大学工商管理学院南昌330013

在数字经济时代,品牌生态圈的构建为品牌可持续发展提供了强大支撑,但对其形成过程的内在机理研究不足。基于动态能力视角,选取仁和集团作为研究对象,通过纵向解构其多年品牌发展历程,总结品牌生态圈的形成过程机制。研究发现:(1)品牌... 详细信息

在数字经济时代,品牌生态圈的构建为品牌可持续发展提供了强大支撑,但对其形成过程的内在机理研究不足。基于动态能力视角,选取仁和集团作为研究对象,通过纵向解构其多年品牌发展历程,总结品牌生态圈的形成过程机制。研究发现:(1)品牌生态圈本质上是一个以核心品牌企业为中心、以数字技术平台为基础的产业链体系完整、多方利益相关者紧密合作、品牌族群协同发展的闭环开放生态系统;(2)品牌生态圈的形成过程会出现“点—线—面”即“品牌核心圈培育(市场破局)—品牌产业圈发展(产业链整合)—品牌生态圈形成(价值共创)”的成长特征;(3)在品牌生态圈形成过程中,企业的动态能力呈现出“市场破局能力—产业链整合能力—价值共创能力”等从低阶能力向高阶能力的演变。最终形成的理论框架可为数字经济时代企业品牌生态圈的构建提供一定的参考。

关键词：品牌生态圈动态能力仁和集团案例研究

重点国有林区现代化的内涵、特征及评价体系建构

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中国林业经济 2024年第1期 11-22页

作者：万深玮柯水发中国人民大学农业与农村发展学院北京100872

首先对重点国有林区的三生空间进行了建构并明确了其与五大文明和五大振兴之间的关系,进而引出三生空间与重点国有林区现代化之间的关系,从而探索出重点国有林区现代化应当涵盖林业经济发展的现代化、森工企业的现代化、林人自身的现代... 详细信息

首先对重点国有林区的三生空间进行了建构并明确了其与五大文明和五大振兴之间的关系,进而引出三生空间与重点国有林区现代化之间的关系,从而探索出重点国有林区现代化应当涵盖林业经济发展的现代化、森工企业的现代化、林人自身的现代化、林区公共服务与基础设施建设的现代化与林区生态文明的现代化五个维度;其次,通过梳理现有研究明确了建构中国式现代化的必要性,强调了建构重点国有林区现代化应当坚持服务中国式现代化与世界共识兼备、真实反映与数据可得性兼备、全面性与突出重点兼备三项原则;最后,从重点国有林区的现实情况与改革的实践经验出发,选取符合五个维度的36项指标构成重点国有林区现代化评价指标体系,并基于现实情况,借助三生空间的框架提出在林业生产上重视森林数量与质量并举、在林人生活上重视居民共同富裕、在林区生态上重视资源可持续利用等三条启示,以期对重点国有林区现代化进行学理性阐释并建构一套适用于中国重点国有林区的现代化评价体系,促使重点国有林区现代化能够更好地服务于中国式现代化总目标,并为中国式重点国有林区的现代化提供理论依据和政策参考。

关键词：中国式现代化重点国有林区森工企业三生空间林区现代化

A Finite Element Based Study on Lowering Operation of Subsea Massive Structure

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China Ocean Engineering 2017年第5期31卷 646-652页

作者： WANG fa.cheng WANG Jun TANG ke Department of Civil Engineering Tsinghua University COTEC Offshore Engineering Solutions

Subsea production system has been increasingly used in recent South China Sea offshore developments. With deepwater applications, constituent parts of subsea systems become more complicated and enlarged. Increases on the weight and geometry of each component bring challenges to installations. A recent accomplished deployment on a subsea massive jumper shows the weight and length have been up to 120 tons and 90 m, respectively with sophi- sticated geometry. It is considerably difficult to install heavy and large subsea structures, especially in South China Sea where severe environmental conditions are common. In addition, deepwater deployment may alter natural frequency of the hoisting system and the altered frequency may be close to possible environmental conditions. To deal with the above two issues, traditionally, engineers need to carry out series of complicated numerical analyses which are on case basis and significantly time-consuming. Existing studies focus on the optimization on analysis techniques by conducting laboratory testing and numerical simulations. However, easy-to-use guidance on massive subsea structure installation are somewhat limited. The studies presented in this paper aim to achieve a simplified guidance which can briefly screen the cases subject to axial resonance and provide visible correlations between hoisting system integrity and key installation parameters.

关键词： subsea massive saucture sensitivity analysis DAF

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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Science China(Life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia Xue-Feng Wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei Wang En-Tao Li Chang-fa.fa. ke Song Yuan-Guo Li Run-Ze Ye fa.g-Xu Li Dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi Ming-Zhu Zhang Liang-Jing Li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu Lin Zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu Jiang Yan-Ling Hu Na Jia Yu-Wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China Life Sciences Institute Guangxi Medical UniversityNanning 530020China College of Life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice