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Efficacy and safety of perioperative therapy for locally resectable gastric cancer:A network meta-analysis of randomized clinical trials

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1046-1058页

作者： Zi-Yu Kuang Qian-Hui Sun Lu-Chang Cao xin-Yi Ma Jia-Xi Wang ke-xin liu Jie Li Graduate College Beijing University of Traditional Chinese MedicineBeijing 100029China Oncology Department Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND Gastric cancer(GC)is the fifth most commonly diagnosed malignancy worldwide,with over 1 million new cases per year,and the third leading cause of cancer-related *** To determine the optimal perioperative treatment regimen for patients with locally resectable *** A comprehensive literature search was conducted,focusing on phase II/III randomized controlled trials(RCTs)assessing perioperative chemotherapy and chemoradiotherapy in treating locally resectable *** R0 resection rate,overall survival(OS),disease-free survival(DFS),and incidence of grade 3 or higher nonsurgical severe adverse events(SAEs)associated with various perioperative regimens were analyzed.A Bayesian network meta-analysis was performed to compare treatment regimens and rank their *** Thirty RCTs involving 8346 patients were included in this *** XELOX plus neoadjuvant radiotherapy and neoadjuvant CF were found to significantly improve the R0 resection rate compared with surgery alone,and the former had the highest probability of being the most effective option in this *** plus adjuvant FLOT was associated with the highest probability of being the best regimen for improving *** to limited data,no definitive ranking could be determined for *** nonsurgical SAEs,FLO has emerged as the safest treatment *** This study provides valuable insights for clinicians when selecting perioperative treatment regimens for patients with locally resectable *** studies are required to validate these findings.

关键词： Gastric cancer Perioperative treatment Network meta-analysis Efficacy and safety

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Adaptive Control of Accumulative Error for Nonlinear Chaotic Systems

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International Journal of Automation and computing 2014年第5期11卷 527-535页

作者： Fang-Fang Zhang Shu-Tang liu ke-xin liu School of Electrical Engineering and Automation Qilu University of Technology College of Control Science and Engineering Shandong University

We present an adaptive control scheme of accumulative error to stabilize the unstable fixed point for chaotic systems which only satisfies local Lipschitz condition, and discuss how the convergence factor affects the convergence and the characteristics of the final control strength. We define a minimal local Lipschitz coefficient, which can enlarge the condition of chaos control. Compared with other adaptive methods, this control scheme is simple and easy to implement by integral circuits in practice. It is also robust against the effect of noise. These are illustrated with numerical examples.

关键词： Adaptive control accumulative error chaotic systems fixed point convergence Lipschitz coefficient

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High-temperature nodal ring semimetal in two-dimensional honeycomb-kagome Mn_(2)N_(3) lattice

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Chinese Physics B 2022年第12期31卷 477-483页

作者： xin-ke liu xin-Yang Li Miao-Juan Ren Pei-Ji Wang Chang-Wen Zhang School of Physics and Technology University of JinanJinan 250022China

The search for two-dimensional(2D)nodal ring semimetallic materials is a current research hotspot in spintronics,and designing a 2D nodal ring(NR)material with high Curie temperature(TC)and strong robustness to spin-orbit coupling(SOC)is an even greater ***,based on the first-principles calculations and symmetry analysis,we predict that 2D Mn_(2)N_(3)is a nodal ring semimetal(NRSM)with three energy bands near the Fermi energy level consisting of electrons in the same spin *** electron-like energy band and two hole-like energy bands near the Fermi plane cross to form two NRs centered at the pointΓ.Symmetry analysis shows that the spin-polarized NR semimetal is robust to SOC due to the conservation of horizontal mirror ***-Carlo simulations further demonstrate that the TCof the 2D Mn_(2)N_(3)reaches 530 K,well above the room ***,the 2D Mn_(2)N_(3)remains an NRSM on h-BN *** results not only reveal a general framework for designing 2D NR materials,but also promote further research in the direction of multifunctional quantum devices for spintronics.

关键词： first-principles calculation semi-metal nodal ring Curie temperature

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Frontier applications of electrostatic accelerators

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Frontiers of physics 2013年第5期8卷 564-576页

作者： ke-xin liu Yu-Gang Wang Tie-Shuan Fan Guo-Hui Zhang Jia-Er Chen Institute of Heavy Ion Physics School of Physics ~ State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China

Electrostatic accelerator is a powerflfl tool in many research fields, such as nuclear physics, radiation biology, material science *** and earth sciences. Two electrostatic accelerators, one is the single stage Vail de Gi＇aaff with terminal voltage of 4.5 MV and another one is tile EN tamteIn with terminal voltage of 6 MV, were installed in 1980s and had been put into operation since the early 1990s at tile Institute of Heavy Ion Physics. Marly applications have been carried out since then. These two accelerators are described and summaries of the most important applications on neutron physics and technology, radiation biology and material science, as well as accelerator mass spectrometry （AMS） are presented.

关键词： electrostatic accelerator application neutron radiation biology material science,accelerator mass spectrometry (AMS)

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A new compound from the fruit of Amorpha fruticosa and activity against acetaminophen-induced hepatotoxicity

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Chinese Chemical Letters 2009年第8期20卷 942-944页

作者： Yun Peng Diao Kun Li Shan Shan Huang ke xin liu Ting Guo Kang College of Pharmacy Dalian Medical University Dalian 116044 China College of Pharmacy Liaoning University of Traditional Chinese Medicine Dalian 116001 China College of Chemistry and Chemical Engineering Liaoning Normal University Dalian 116029. China

A new isoflavone was obstained from the medicinal herb Amorpha fruticosa. It was elucidated asbenzopyran- 12-one, 1,4,10,11 - tetrahydro-6′-[8′-（hydroxymethy1）etheny1]-2,3-dimethoxy-8′-O-β-glucopyranosy1-O-α-D-arabinoside by spectroscopic methods including UV, IR, 1D NMR and 2D NMR techniques. And the activity against acetaminophen-induced hepatotoxicity of this compound was also studied, and found this compound can protect liver obviously from hepatotoxicity induced by acetaminophen （AAP）. ？2009 Ting Guo Kang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Amorpha fruticosa Isoflavone Activity against AAP

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A new ent-labdane diterpenoid lactone from Andrographis paniculata

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Chinese Chemical Letters 2010年第5期21卷 587-589页

作者： Xiao Chi Ma Zhan Ping Gou Chang Yuan Wang Ji Hong Yao Xiu Lan xin Yuan Lin ke xin liu School of Pharmacy Dalian Medical UniversityDalian 116044China School of Pharmacology Guangdong Medical CollegeDongguan 523808China Biotechnology Application Center Beijing Vocational College of Electronic Science and TechnologyBeijing 100029China

A new ent-labdane diterpenoid lactone was isolated from Andrographis *** structure was identified on the basis of spectral data including 2D NMR.

关键词： Andrographis paniculata Ent-labdane diterpenoid Lactone

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A new ent-labdane eiterpenoid lactone from Andrographis paniculata

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Chinese Chemical Letters 2009年第3期20卷 317-319页

作者： Xiao Chi Ma Bao Jing Zhang Sha Deng Shan Shan Huang ke xin liu Jing Ming Jia School of Pharmaceutical Sciences Dalian Medical University Dalian 116027 PR China School of Traditional Chinese Medicines Shenyang Pharmaceutical University Shengyang 110016 China

A new ent-labdane diterpenoid lactone with a new natural product was isolated from Andrographis paniculata. Their structures were elucidated on the basis of spectral evidences including 2D NMR.

关键词： Andrographis paniculata Ent-labdane diterpenoid Acanthaceae Lactone

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Construction of multifunctional lanthanum manganese mixed nanoparticles mediated by ionic liquids for selective aerobic oxidation of cyclohexane

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Rare Metals 2024年第5期43卷 2205-2221页

作者： Hao Li Rui-Rui Zhang ke-xin Li Shuang Wei Yu-Mei liu Rui-Xia liu Beijing key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and EngineeringState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Selective oxidation of alkanes to produce highvalue chemicals is an essential strategy and means to realize efficient utilization of *** this work,a strategy of lanthanum manganese mixed metal oxides(LMMO)regulated via a facile ionic liquid(IL)-assisted hydrothermal method was proposed to construct the multifunctional catalysts,which exhibited excellent catalytic performance in the selective aerobic oxidation of *** 8.9%cyclohexane conversion with 90%KA oi(cyclohexanol and cyclohexanone)selectivity was achieved over the optimal LMMO catalyst under mild *** effects of anion type,carbon chain length and concentration of ILs on the structure and properties of catalysts were investigated through various characterizations,indicating the structure-directing and template effect of ILs on the multifunctional *** formation of self-assembled spherical nanoparticles followed the"dissolution-nucleation-proliferation"mechanism with the introduction of 1-butyl-3-methylimidazolium hydrogen sulfate,ascribing the synergistic effect between the microenvironment of ILs and the hydrothermal ***,the high reactive oxygen concentration redox capacity,and suitable basic sites of LMMO catalysts mediated by ILs enhance the activation of C-H bonds and molecular oxygen,simultaneously influencing the adsorption and desorption of the substrate.A comprehensive understanding of the high KA oil selectivity and radical reaction mechanism was elucidated based on in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)and radical trapping *** recycling and regeneration experiments further illuminated that the removal of adsorbed cyclohexanone acting on the LMMO catalyst was the key to achieve high KA oil selectivity.

关键词： Ionic liquids Nanoparticle Multifunctional catalyst Cyclohexane oxidation

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Love wave propagation in one-dimensional piezoelectric quasicrystal multilayered nanoplates with surface effects

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 619-632页

作者： xin FENG Liaoliang ke Yang GAO College of Science China Agricultural UniversityBeijing 100083China School of Mechanical Engineering Tianjin UniversityTianjin 300350China

The exact solutions for the propagation of Love waves in one-dimensional(1D)hexagonal piezoelectric quasicrystal(PQC)nanoplates with surface effects are *** electro-elastic model is developed to investigate the anti-plane strain problem of Love wave *** introducing three shape functions,the wave equations and electric balance equations are decoupled into three uncorrelated *** the boundary conditions of the top surface on the covering layer,the interlayer interface,and the matrix,a dispersive equation with the influence of multi-physical field coupling is provided.A surface PQC model is developed to investigate the surface effects on the propagation behaviors of Love waves in quasicrystal(QC)multilayered structures with nanoscale thicknesses.A novel dispersion relation for the PQC structure is derived in an explicit closed form according to the non-classical mechanical and electric boundary *** examples are given to reveal the effects of the boundary conditions,stacking sequence,characteristic scale,and phason fluctuation characteristics on the dispersion curves of Love waves propagating in PQC nanoplates with surface effects.

关键词： piezoelectric quasicrystal(PQC)material multilayered plate dispersion characteristic surface effect

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Strong Edge Coloring of Outerplane Graphs with Independent Crossings

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 467-477页

作者： ke-Jie LI xin ZHANG School of Mathematics and Statistics Xidian UniversityXi’an 710071China

The strong chromatic index of a graph is the minimum number of colors needed in a proper edge coloring so that no edge is adjacent to two edges of the same *** outerplane graph with independent crossings is a graph embedded in the plane in such a way that all vertices are on the outer face and two pairs of crossing edges share no common end *** is proved that every outerplane graph with independent crossings and maximum degreeΔhas strong chromatic index at most 4Δ-6 if Δ≥4,and at most 8 ifΔ≤*** bounds are sharp.

关键词： outer-1-planar graph IC-planar graph strong edge coloring crossing

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