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Oral manifestation in inflammatory bowel disease:A review

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World Journal of Gastroenterology 2013年第46期19卷 8571-8579页

作者： Kamran B lankarani Gholam Reza Sivandzadeh Shima Hassanpour Department of Internal Medicine Healthcare Policy Research Center Shiraz University of Medical Sciences Department of Internal Medicine Gastroenterohepatology Research Center Namazi Hospital Shiraz University of Medical Sciences Gastroenterohepatology Research Center Namazi Hospital Shiraz University of Medical Sciences

Inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis, not only affect the intestinal tract but also have an extraintestinal involvement within the oral cavity. These oral manifestations may assist in the diagnosis and the monitoring of disease activity, whilst ignoring them may lead to an inaccurate diagnosis and useless and expensive workups. Indurated tag-like lesions, cobblestoning, and mucogingivitis are the most common specific oral findings encountered in CD cases. Aphthous stomatitis and pyostomatitis vegetans are among non-specific oral manifestations of IBD. In differential diagnosis, side effects of drugs, infections, nutritional deficiencies, and other inflammatory conditions should also be considered. Treatment usually involves managing the underlying intestinal disease. In severe cases with local symptoms, topical and/or systemic steroids and immunosuppressive drugs might be used.

关键词： Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Extra-intestinal manifestations, Pyostomatitis vegetans, Aphthous stomatitis, Cobblestoning, Mucogingivitis, Oral manifestation

Association of risky driving behavior with psychiatric disorders among Iranian drivers:A case-control study

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中华创伤杂志:英文版 2023年第5期26卷 290-296页

作者： Kiana Khatami Yaser Sarikhani Reza Fereidooni Mohammad Salehi-Marzijarani Maryam Akabri Leila Khabir Arash Mani Mahsa Yaghikosh Afsaneh Haghdel Seyed Taghi Heydari Kamran Bagheri lankarani Health Policy Research Center Institute of HealthShiraz University of Medical SciencesShirazIran Research Center for Social Determinants of Health Jahrom University of Medical SciencesJahromIran Research Center for Psychiatry and Behavioral Sciences Shiraz University of Medical SciencesShirazIran Department of Psychology Shiraz BranchIslamic Azad UniversityShirazIran

Purpose:This study aimed to investigate the possible association between psychological disorders and riskydriving behavior(RDB)in ***:This case-control study conducted in Shiraz,Iran in *** case group included drivers with psychological disorders and the control group included those without any *** inclusion criteria for selecting patients were:active driving at the time of the study,being 18-65 years old,having a driving license,having a psychological disorder including depression,bipolar disorder,anxiety spectrum disorder,or psychotic disorder spectrum confirmed by a psychiatrist,and completing an informed consent *** exclusion criterion was the existence of conditions that interfered with answering and understanding the *** inclusion criteria for selecting the healthy cases were:active driving at the time of the study,being 18-65 years old,having a driving license,lack of any past or present history of psychiatric problems,and completing an informed consent *** data were gathered using a researcher-made checklist and Manchester driving behavior ***,partition around medoids method was used to extract clusters of ***,backward logistic regression was applied to investigate the association between the independent variables and the clusters of ***:The sample comprised of 344(153 with psychological disorder and 191 without confirmed psychological disorder)*** elimination logistic regression on total data revealed that share of medical expenditure≤10%of total household expenditure(OR=3.27,95%Cl:1.48-7.24),psychological disorder(OR=3.08,95%Cl:1.67-5.70),and substance abuse class(OR=6.38,95%CI:3.55-11.48)wereassociatedwithhighlevelof ***:Substance abuse,psychological illnesses,and share of medical costs from total household expenditure were found to be main predictors of *** investigations are necessary to explain the impact of different psychological illnesses on driv

关键词： Risky driving behavior Psychological disorder Manchesterdriving behaviorquestionnaire Iran

Association of H pylori cagA and vacA genotypes and IL-8 gene polymorphisms with clinical outcome of infection in Iranian patients with gastrointestinal diseases

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World Journal of Gastroenterology 2006年第32期12卷 5205-5210页

作者： Eskandar Kamali-Sarvestani Abdulah Bazargani Malihe Masoudian Kamran lankarani Ali-Reza Taghavi Mehdi Saberifiroozi Department of Immunology and Autoimmune Diseases Research Center Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of Bacteriology and virology Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of cellular and molecular sciences Khatam University TehranIran Gastrointestinal and Hepatology Research center Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of Internal medicine Shiraz Medical School Shiraz University of Medical SciencesShirazIran

AIM： To find out if a functional promoter polymorphism in the IL-8 gene along with cagA status and polymorphisms in vacA gene influence the type of diseases in Iranian patients infected by Hpylori. METHODS： IL-8 -251 A/T polymorphism was genotyped by oligonucleotide allele specific PCR （ASO-PCR） in a sample of 233 patients with Hpylori infection undergoing upper gastrointestinal endoscopy. The presence of cagA gene and polymorphisms in vacA gene was also determined by PCR. Association of these genetic polymorphisms with the development of gastritis, peptic ulcers as well as gastric cancer was tested. RESULTS： When the patients with different clinical manifestations were compared according to the presence of cagA gene or various vacA genotypes, only the vacA genotypes were significantly different among gastritis, peptic ulcer and gastric cancer patients （χ^2= 17.8; P=0.001）. Furthermore, there was a significant difference in the frequency of IL-8 -251 A/T genotypes between patients with gastric cancer and benign diseases （χ^2=10.47;P=0.005） CONCLUSION： The IL-8 -251 A/T polymorphism and the polymorphisms in H pylor/ vacA gene are involved in limiting the infection outcome to gastritis and peptic ulcer or in favoring cancer onset in Iranian patients.

关键词： Interleukin 8 Hpylori Gastric cancer Peptic ulcer Polymorphism

Distinct Placenta Increta and Percreta in the Setting of Dichorionic Diamniotic Twin Gestation: A Unique Histological Finding

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Open Journal of Obstetrics and Gynecology 2022年第7期12卷 610-615页

作者： Conway Xu Cassandra Presti Sebastian Nasrallah Saeid Movahedi-lankarani John C. Elkas Alfred Khoury Ankit Shah Department of Obstetrics and Gynecology Inova Fairfax Hospital Falls Church VA USA Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology Inova Fairfax Hospital Falls Church VA USA Department of Pathology Inova Fairfax Hospital Falls Church VA USA Mid Atlantic Gynecologic Oncology and Pelvic Surgery Associates Fairfax VA USA Perinatal Associates of Northern Virginia Fairfax VA USA

Multiple gestations have been reported as a risk factor for placenta accreta spectrum (PAS) but the evidence is limited. Previous reports showed that PAS degrees (creta, increta, percreta) were similar in multiple gestation placentas. To our knowledge, there have been no reports of PAS in dichorionic placentas with different degrees of invasion. Here, we report dichorionic diamniotic placentas with two different degrees of invasion, one increta and another percreta.

关键词： Placenta Accreta Spectrum Increta Percreta Differential Placental Invasion Twin

Process of becoming a mother in women receiving donated egg: Based on the grounded theory

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Asian pacific Journal of Reproduction 2020年第4期9卷 182-191页

作者： Mitra Zandi Sahar Dabaghi Narges Bagheri-lankarani Reza Omani-Samani Mojtaba Naderi-Taheri Nursing Department School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehranIran Department of Epidemiology and Reproductive Health Reproductive Biomedicine Research CenterRoyan Institute for Reproductive BiomedicineACECRTehranIran Department of Community Health and Geriatric Nursing School of Nursing and MidwiferyUniversity of Medical SciencesTehranIran

Objective:To elucidate theoretically the safety and identity of mothers receiving egg and the process of becoming a ***:This study was conducted during 7 months from July 2018 to January 2019 by using a grounded theory *** women at the gestational age who received oocyte were selected with purposive sampling method and then entered the study using theoretical *** who had not decided definitely to participate and had not started the treatment course yet were excluded from the *** participating mothers were 28-44 years old with a mean age of(37.00±2.49)years.A total of 30 interviews were *** were collected by unstructured deep interviews and field *** interview duration ranged between 19 to 74 min with a mean time of 40 min and they were performed ***:Data analysis showed that"feeling of insecurity in personal and familial identity"formed in the context of"exposure to socio-cultural constraints"was the main problem of mothers receiving donated *** led to a set of coping strategies as"gradual acceptance","attempts to maintain the marital life","sensitivity in selecting donor","sensitivity in fetal care","seeking information and consultation","challenging the internal restlessness",and"treatment follow-up",all indicating the concept of"protection of personal and familial identity"as the core ***:The challenge faced by Iranian mothers receiving donated oocyte in the constrained sociocultural context forms a multilateral and all-inclusive insecurity.

关键词： Infertility Motherhood process Donated egg Identity insecurity Grounded theory Nursing Iran

An epidemiologic survey of road traffic accidents in Iran： analysis of driver-related factors

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Chinese Journal of Traumatology 2013年第3期16卷 140-144页

作者： Ghasem Moafian Mohammad Reza Aghabeigi Seyed Taghi Heydari Amin Hoseinzadeh Kamran Bagheri lankarani Yaser Sarikhani Health Policy Research Center School of MedicineShiraz University of Medical Sciences Shiraz Iran

ObjectiveRoad 交通事故(RTA ) 和它的相关损害在伊朗贡献疾病的负担的重要部分。这份报纸在 countryMethodsThis 探索在司机相关的因素和 RTA 之间的协会代表性的学习从 2010 年 3 月 20 日关于 RTA 在伊朗和所有数据被进行到 2010 年... 详细信息

ObjectiveRoad 交通事故(RTA ) 和它的相关损害在伊朗贡献疾病的负担的重要部分。这份报纸在 countryMethodsThis 探索在司机相关的因素和 RTA 之间的协会代表性的学习从 2010 年 3 月 20 日关于 RTA 在伊朗和所有数据被进行到 2010 年 6 月 10 日从交通警察部门被获得。我们包括了 538 588 RTA 记录，它被分类为主要 confounders 控制：事故类型，事故的最后的原因，事故的时间和司机相关的因素。司机相关的因素包括了性，教育水平，许可证类型，损害的类型，在事故之间的持续时间并且得到驾驶执照和 538 588 位司机的 driver’s 错误 *** 总数(91.83% 男性，几乎 13:1 的性比率) 涉及 RTA。在他们之中 423 (78.71%) 932 是未受损伤的；224 (41.74%) 818 有证书度。等级 2 驾驶执照代表了所有驾驶执照的最高的比例(290 811， 54.00%) 。事故的最大的数字发生在 12:00-13:59 (75 024， 13.93%) 。涉及 RTA 的司机的比例在在 10 以后得到一个驾驶执照到 3.13% 的第一年里从 15.90% 减少了； years’驾驶经验。规定的疏忽是交通碰撞的最普通的原因(345 589， 64.17%) 。到前面的优先级和疏忽的违反是死亡的最经常的最后的原因(138 175， 25.66% 和 129 352， 24.02% ，分别地) 。我们发现了在事故和性的类型之间的重要协会，教育，许可证类型，事故的时间，事故的最后的原因，在事故之间的 driver’s 错误以及持续时间并且得到驾驶执照(所有 P ；< ； 0.001 ) .ConclusionOur 结果将改进交通法律实施措施，它将改变司机的不恰当的行为并且保护最不富有经验的道路用户。

关键词： Accidents, traffic Automobile driving Wounds and injuries Mortality Iran

Educational level and age as contributing factors to road traffic accidents

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Chinese Journal of Traumatology 2013年第5期16卷 281-285页

作者： Ashkan Sami Ghasem Moafian Arman Najafi Mohammad Reza Aghabeig Navid Yamin Seyed Taghi Heydari Kamran B lankarani Department of Computer Science and Engineering School of Electrical Engineering and Computer ShirazUniversity Shiraz Iran Health Policy Research Center Shiraz University ofMedical Sciences Shiraz Iran Department of Biostatistics Jahrom University of Medi-cal Sciences Jahrom Iran

Objective： This research analyzes data on road traffic accidents （RTA） in Fars province, whose roads are among the highly dangerous ones in Iran. It inves- tigates educational level and age involved in RTA in order to discover patterns that can prevent or decrease accidents. Methods： This research made use of data visualization techniques to find hidden patterns. The data included mor- tality rate related to RTA in Fars province and were obtained from Fars Forensic Medicine Registry covering a period of 1 year from March 21, 2010 to March 21, 2011. All data were analyzed using SPSS 11.5. The results were reported as de- scriptive indices such as frequency （percentage）. The Chi- square test was applied to the data concerning educational level and age. P value less than 0.05 was considered significant. Results： In the mentioned period, 1 831 people were killed, out of whom un/lowly educated people （69.6%） ac- counted for the highest mortality rate. The significant rela- tionship between educational level and mortality rate was found （X2=275.98, P〈0.0001）. Also three was a significant association between age and mortality rate （X2=371.20, P〈0.0001）. Young people （age between 20 and 29 years） contribute to higher RTA mortality rate compared with other age groups. Conclusion： The educational level and age are signifi- cantly correlated to mortality rate. The youth and un/lowly educated people suffer more fatal RTA.

关键词： Accidents, traffic Mortality Education Data mining Iran

Burden of traffic accidents among pedestrians of Fars province, southern Iran; estimate of years of life lost in a sample of Iranian population from 2009 to 2013

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Chinese Journal of Traumatology 2017年第5期20卷 259-263页

作者： Yaser Sarikhani Seyed Taghi Heydari Saeed Gholamzadeh Maryam Mazloom Payam Peymani Kamran Bagheri lankarani Ahmad Kalateh Sadati Reza Tabrizi Maryam Akbari ahrom University of Meclical Sciences Jahrom Iran Health Policy Research Center Institute of Health Shiraz University of Medical Sciences Shiraz Iran Legal Medicine Research Center Legal Medicine Organization Tehran Iran Department of Sociology Yazd University Yazd Iran

Purpose： Traffic injuries are among the leading causes of mortality and morbidity worldwide. Pedestrians have been considered as a high-risk group among road users, especially in middle- or low-income communities. This study attempted to determine the burden of pedestrians＇ fatalities in Fars, the southern province of Iran using years of life lost （YLL） approach. Methods： The data used in this study were retrieved from Fars Forensic Medicine Organization database on pedestrian traffic accidents. The YLL from 2009 to 2013 was estimated using the method presented by World Health organization. Some epidemiological characteristics of pedestrians＇ fatalities were analyzed by SPSS. Results： Although YLL among 1000 male pedestrians decreased from 2.5 in 2009 to 1.5 in 2013, it increased from 0.9 to 2.1 among 1000 females during the same period. Higher proportion of death was found in female, illiterate, and married pedestrians {p 〈 0.001 ）. In addition, mortality was higher in pedestrians living the cities, during daytime, at home, and in hospitals （p 〈 0.001 ）. Conclusion： Consistent with the global trends, burden of pedestrian accidents in Fats was also excep- tionally high. Considering the national and cultural aspects of different countries, improving the safety of pedestrians demands a multi-dimensional approach with interventional factors concerning policies, rules, pedestrians, motor vehicles and environmental conditions taken into consideration.

关键词： Accidents traffic Pedestrians Burden of disease Years of potential life lost

COVID-19 infection and liver injury:Clinical features,biomarkers,potential mechanisms,treatment,and management challenges

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World Journal of Clinical Cases 2021年第22期9卷 6178-6200页

作者： Gholam Reza Sivandzadeh Hassan Askari Ali Reza Safarpour Fardad Ejtehadi Ehsan Raeis-Abdollahi Armaghan Vaez Lari Mohammad Foad Abazari Firoozeh Tarkesh Kamran Bagheri lankarani Gastroenterohepatology Research Center Shiraz University of Medical SciencesShiraz ***Iran Department of Medical Sciences Qom Medical BranchIslamic Azad UniversityQom ***Iran Department of Physiology School of MedicineAhvaz Jundishapur University of Medical ScienceAhvaz ***Iran Research Center for Clinical Virology Tehran University of Medical SciencesTehran ***Iran Health Policy Research Center Shiraz University of Medical SciencesShiraz 71348-45794Iran

It is hypothesized that liver impairment caused by coronavirus disease 2019(COVID-19)infection might play a central role in severe clinical *** injury is closely associated with severe disease and,even with antiviral drugs,have a poor prognosis in COVID-19 *** addition to the common hepatobiliary disorders caused by COVID-19,patients with pre-existing liver diseases demand special considerations during the current ***,it is vital that upon clinical presentation,patients with concurrent pre-existing liver disease associated with metabolic dysfunction and COVID-19 be managed properly to prevent liver *** monitoring and early detection of liver damage through biomarkers after hospitalization for COVID-19 is underscored in all cases,particularly in those with pre-existing metabolic liver *** purpose of this study was to determine most recent evidence regarding causality,potential risk factors,and challenges,therapeutic options,and management of COVID-19 infection in vulnerable patients with pre-existing liver *** review aims to highlight the current frontier of COVID-19 infection and liver injury and the direction of liver injury in these patients.

关键词： Liver injury COVID-19 SARS-CoV-2 Inflammation Management