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Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis C virus: A novel technique

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World Journal of Gastroenterology 2016年第26期22卷 6057-6064页

作者： Hidekatsu Kuroda Tamami Abe Keisuke Kakisaka Yudai Fujiwara Yuichi Yoshida Akio Miyasaka kazuyuki ishida Hideaki ishida Tamotsu Sugai Yasuhiro Takikawa Division of Hepatology Department of Internal Medicine Iwate Medical University School of Medicine Department of Molecular Diagnostic Pathology Iwate Medical University Center of Diagnostic Ultrasound Akita Red Cross Hospital

AIM: To identify the hepatic vascular architecture of patients with hepatitis C virus (HCV) using superb microvascular imaging (SMI) and investigate the use of SMI in the evaluation of liver ***: SMI was performed in 100 HCV patients. SMI images were classified into five types according to the vascular pattern, and these patterns were compared with the fibrosis stage. Moreover, the images were analyzed to examine vascularity by integrating the number of SMI signals in the region of interest ROI [number of vascular trees (VT)]. The number of VT, fibrosis stage, serum parameters of liver function, and CD34 expression were ***: There was a significant difference between SMI distribution pattern and fibrosis stage (P < 0.001). The mean VT values in each of the fibrosis stages were as follows: 26.69 ± 7.08 in F0, 27.72 ± 9.32 in F1, 36.74 ± 9.23 in F2, 37.36 ± 5.32 in F3, and 58.14 ± 14.08 in F4. The VT showed excellent diagnostic ability for F4 [area under the receiver operator characteristic (AUROC): 0.911]. The VT was significantly correlated with the CD34 labeling index (r = 0.617, P < 0.0001).CONCLUSION: SMI permitted the detailed delineation of the vascular architecture in chronic liver disease. SMI appears to be a reliable tool for noninvasively detecting significant fibrosis or cirrhosis in HCV patients.

关键词： Superb microvascular imaging Number of vascular trees Chronic liver disease Ultrasound Liver fibrosis CD34

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Association between white opaque substance under magnifying colonoscopy and lipid droplets in colorectal epithelial neoplasms

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World Journal of Gastroenterology 2017年第47期23卷 8367-8375页

作者： Keisuke Kawasaki Makoto Eizuka Shotaro Nakamura Masaki Endo Shunichi Yanai Risaburo Akasaka Yosuke Toya Yasuko Fujita Noriyuki Uesugi kazuyuki ishida Tamotsu Sugai Takayuki Matsumoto Division of Gastroenterology Department of Internal MedicineIwate Medical University Department of Diagnostic Pathology Iwate Medical University Kaiunbashi Endoscopy Clinic

AIM To examine the association between white opaque substance(WOS) and histologically verified lipiddroplets in colorectal epithelial *** We reviewed colonoscopy records at our institution from 2014 to 2016 and identified cases of endoscopically or surgically resected colorectal epithelial neoplasms observed by magnifying narrow-band imaging(M-NBI) colonoscopy. Immunohistochemistry was used to stain tumors with a monoclonal antibody specific to adipophilin as a marker of lipids. The expression and distribution of adipophilin were compared between WOS-positive and WOS-negative lesions and among tumors classified by histologic type and depth of *** Under M-NBI colonoscopy, 81 lesions were positive for WOS and 48 lesions were negative for WOS. The rate of adipophilin expression was significantly higher in WOS-positive lesions(95.1%) than in WOS-negative lesions(68.7%)(P = 0.0001). The incidence of deep adipophilin expression was higher in WOS-positive lesions(24.7%) than in WOS-negative lesions(4.2%)(P = 0.001). The incidence of deep expression was predominant among cancers with massive submucosal invasion(62.5%) compared to adenoma(7.2%) and high-grade dysplasia or cancers with slight submucosal invasion(12.7%)(P = 0.0001).CONCLUSION The distribution of lipid droplets may be closely associated with the visibility of WOS under M-NBI colonoscopy, and with histologic grade and depth of tumor invasion.

关键词： White opaque substance Adipophilin Magnifying narrow-band imaging Colorectal neoplasm Magnifying endoscopy

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Case of gastric neuroendocrine carcinoma showing an interesting tumorigenic pathway

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World Journal of Clinical Cases 2017年第11期5卷 397-402页

作者： Noriyuki Uesugi Ryo Sugimoto Makoto Eizuka Yasuko Fujita Mitsumasa Osakabe Keisuke Koeda Takashi Kosaka Shunichi Yanai kazuyuki ishida Akira Sasaki Takayuki Matsumoto Tamotsu Sugai Department of Diagnostic Molecular Pathology School of MedicineIwate Medical University Department of Surgery School of MedicineIwate Medical University Division of Gastroenterology Department of Internal MedicineSchool of MedicineIwate Medical University

Here, we report a case of gastric neuroendocrine carcinoma showing an interesting tumorigenic pathway. A 57-year-old Japanese woman presented with epigastric tenderness, and distal gastrectomy was performed. In the surgical specimen, histologically, the tumor tissue was composed of three subtypes of tumor components showing different histological architecture and cellular atypia, diagnosed as neuroendocrine tumor(NET) G2, NET G3, and neuroendocrine carcinoma(NEC) components. Immunohistochemically, the Ki-67-positive rates of NET G2, NET G3, and NEC components were 6.5%, 99.5% and 88.1%, respectively. Although allelic imbalance(AI) on chromosomes 1p, 3p, 8q, TP53, 18q and 22 q was commonly found in all components, AI of 4p was found in NET G3 and NEC components(but not in the NET G2 component). In contrast, AIs of 5q and 9p were found in only the NEC component. Thus, we showed the progression from NET G2 to NEC, via NET G3, within the same tumor.

关键词： stomach neuroendocrine tumor G2 neuroendocrine tumor G3 neuroendocrine carcinoma

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Granular cell tumor of the pancreas:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2010年第2期2卷 121-124页

作者： Atsushi Kanno Kennichi Satoh Morihisa Hirota Shin Hamada Jun Umino Hiromichi Itoh Atsushi Masamune Shinichi Egawa Fuyuhiko Motoi Michiaki Unno kazuyuki ishida Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Department of Hepatobiliary-pancreatic surgery Tohoku University Graduate School of Medicine Department of Pathology Tohoku University Graduate School of Medicine

Granular cell tumors,also called Abrikossof's tumors,were originally described by Abrikossof A in *** f irst case of a pancreatic granular cell tumor was described in 1975 and only 6 cases have been *** describe a case of granular cell tumor in the pancreas showing pancreatic duct *** imaging studies showed f indings compatible with those of pancreatic carcinoma,the patient underwent distal *** examination showed that the tumor consisted of a nested growth of large tumor cells with ample granular cytoplasm and small round *** tumor cells expressed S-100 protein and were stained with neuron-specific enolase and periodic acid-Schiff,but were negative for desmin,vimentin,and *** resected tumor was diagnosed as a granular cell *** our knowledge,this is the seventh case of Granular cell tumor of the pancreas to be reported.

关键词： Granular cell tumor Pancreas Diagnosis Distal pancreatectomy

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Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma

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World Journal of Gastroenterology 2009年第10期15卷 1267-1272页

作者： Takayuki Kogure Yoshiyuki Ueno Satoshi Sekiguchi kazuyuki ishida Takehiko Igarashi Yuta Wakui Takao Iwasaki Tooru Shimosegawa Division of Gastroenterology Graduate School of MedicineTohoku UniversitySendai 980-8574Japan Division of Advanced Surgical Science and Technology Graduate School of MedicineTohoku University Sendai 980-8574Japan Department of Pathology Tohoku University HospitalSendai 980-8574Japan Division of Gastroenterology Osaki Citizen Hospital Furukawa 989-6183Japan

A liver tumor 35 mm in diameter was found incidentally in a 40-year-old woman who had no history of liver diseases or the use of oral *** diagnostics showed the typical findings of liver cell adenoma(LCA).Dynamic computed tomography revealed that the tumor showed a homogenous enhancement in the arterial phase and almost the same enhancement as the surrounding liver parenchyma in the delayed *** tumor was found to contain fat on magnetic resonance imaging.A benign fat containing liver tumor was ***,radiological findings altered,which caused us to suspect that a welldifferentiated hepatocellular carcinoma(HCC)containing fat was becoming *** hepatectomy was performed and the pathological findings showed the typical findings of *** case was an extremely rare LCA,which had no background of risk for LCA and developed the sequential alteration of the radiological findings to suspect well-differentiated HCC.

关键词： Liver cell adenoma Hepatocellularcarcinoma Diagnosis Hepatectomy

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日本地方政府预算研究与启示

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中南财经政法大学学报 2007年第6期 91-95页

作者：东晓石田和之武汉大学政治与公共管理学院湖北武汉430072 日本国立德岛大学综合科学部

日本以地方财政计划作为地方政府预算的中心环节,并将地方税返还制度列入该计划,以保障和调整地方财源,满足地方公共支出需要。针对目前出现的地方财力不足,以及中央财政对地方财政补充不足的现实状况,日本正在进行三位一体的地方分权... 详细信息

日本以地方财政计划作为地方政府预算的中心环节,并将地方税返还制度列入该计划,以保障和调整地方财源,满足地方公共支出需要。针对目前出现的地方财力不足,以及中央财政对地方财政补充不足的现实状况,日本正在进行三位一体的地方分权改革与财政体制改革。日本地方政府预算制度与改革的经验与教训对于切实推进中国的分税制改革,发挥地方政府财政计划功能、改革政府财政架构、建立公开透明的政府财政预算体系以及制定科学的地方财政保证方法等方面有着重要的启示作用。

关键词：日本地方政府预算财政分权

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Molecular Integral for the Double Electron-Repulsion Potential： A Closed Form Underived for Forty Years

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Chinese Physics Letters 2005年第12期22卷 3052-3053页

作者： Kazuhiro ishida Department of Chemistry and Frontier Research Centre for Computational Sciences Faculty of ScienceTokyo University of Science Shinjuku-ku Tokyo 162-8601 Japan

A closed form of the title integral formula over the Gaussian-type orbitals is derived for the first time. The present closed form is analytical as the multiple hyper-geometric function of five variables.

关键词： 3-BODY INTERACTION INTEGRALS MATHEMATICAL METHODS SHELL ATOMS IONS

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Linear nonadiabatic pulsation models of the double-mode Cepheid V371 Per

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Research in Astronomy and Astrophysics 2017年第6期17卷 11-16页

作者： Toshihito ishida Center for Astronomy Institute of Natural and Environmental Science University of Hyogo Sayo-cho Hyogo 679-5313 Japan

A recently found double-mode Cepheid with the shortest known period in our Galaxy and abnormal period ratio, V371 Per, is investigated by linear nonadiabatic pulsation models. V371 Per is likely to be crossing the instability strip for the first time, because the mass derived from pulsation models is larger than the evolution mass for the second or higher crossing objects. This result seems to support the conclusion obtained from spectroscopic observation. We also found that models with observed period and period ratio of V371 Per need to have mass and Teff in a narrow range which shifts as heavy element abundance Z changes. We have checked the agreement between Teffranges estimated observationally and derived from pulsation models using observational Z. We found that those ranges overlap marginally. We need more spectroscopic estimations of Teff and [Fe/H], and more photometric monitoring to estimate the evolutional period change for confirmation of our result.

关键词： stars: oscillations (including pulsations) - stars variables Cepheids - stars individual (V371 Per)

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Velocity and Size of Droplets in Dense Region of Diesel Fuel Spray on Transient Needle Opening Condition

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Journal of Thermal Science 2005年第2期14卷 181-186页

作者： Hironobu UEKI Masahiro ishida Daisaku SAKAGUCHI Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521JapanNagasaki University 1-14 Bunkyo-machiNagasaki 852-8521JapanNagasaki University 1-14 Bunkyo-machiNagasaki 852-8521Japan

In order to investigate the effect of transient needle opening on early stage of spray behavior, simultaneous measurements of velocity and size of droplet were conducted by a newly developed laser 2-focus velocimeter (L2F). The micro-scale probe of the L2F was consisted of two foci with a distance of 36μm. The tested nozzle had a single hole with a diameter of 0.2 mm. The measurements of injection pressure, needle lift, and crank angle were synchronized with the spray measurement by the L2F at the position 10 mm downstream from the nozzle exit. It has been clearly shown that the velocity and size of droplet increase with needle valve opening and that the probability density distribution of droplet size can be fitted to the Nukiyama-Tanasawa distribution under the transient needle opening condition.

关键词： droplet disintegration optical characterization laser 2-focus velocimeter.

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Unified interpretation of scalegenesis in conformally extended standard models:a dynamical origin of Higgs portal

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Chinese Physics C 2020年第11期44卷 7-13页

作者： Hiroyuki ishida Shinya Matsuzaki Ruiwen Ouyang Theory Center IPNSKEKTsukubaIbaraki 305-0801Japan Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Laboratory of High Energy and Computational Physics National Institute of Chemical Physics and BiophysicsRavala pst.1010143 TallinnEstonia

We present a universal interpretation of a class of conformal extended standard models that include Higgs portal interactions as realized in low-energy effective *** scale generation mechanism in this class(scalegenesis)arises along the(nearly)conformal/flat direction for breaking scale symmetry,where the electroweak symmetry-breaking structure arises similarly as in the standard model.A dynamical origin for the Higgs portal coupling can provide the discriminator for the low-energy“universality class,”to be probed in forthcoming collider experiments.

关键词： beyond standard model hidden QCD conformal symmetry

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