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Surgical resection for pulmonary recurrence of esophageal cancer after curative esophagectomy

Journal of Cancer Metastasis and Treatment 2021年第1期7卷 412-421页

作者： Masaru Morita Manabu Yamamoto Yuichiro Nakashima Keiichi Shiokawa Yuki Shin Yoshiaki Fujimoto Tomonori Nakanoko Hideo Uehara Masahiko Sugiyama Mitsuhiko ota Yohei Mano Keishi Sugimachi Tatsuro Okamoto Yasushi Toh Department of Gastroenterological Surgery National Hospital Organization Kyushu Cancer CenterFukuoka 811-1395Japan Department of Hepatobiliary-Pancreatic Surgery National Hospital Organization Kyushu Cancer CenterFukuoka 811-1395Japan Department of Thoracic Oncology National Hospital Organization Kyushu Cancer CenterFukuoka 811-1395Japan.

Aim:To clarify the significance of surgical resection for pulmonary recurrence after curative esophagectomy for esophageal ***:Clinical details,such as the recurrence site,timing,and contents of therapies for recurrence,and the prognosis,were examined in 14 patients who underwent surgical resection for pulmonary recurrence that developed after curative ***:The median disease-free interval after esophagectomy was 17.2 *** patients underwent pulmonary resection two times,and in one patient,three *** pulmonary resections were performed when other extra-pulmonary recurrences had been controlled,and R0 resection was *** and/or radiotherapy were additionally performed for pulmonary metastasis in 13 *** median survival time after initial pulmonary resection was 45.5 months,and the 1-,3-,and 5-year overall survival rates were 93%,68%,and 43%,*** 5-year overall survival rate after initial pulmonary resection was 13%in patients with Stage III or IV esophageal cancer and 100%in those with Stage I or II disease(P=0.010).The rate was 56%in patients with tumors<20 mm in size,while all 5 patients with lesions≥20 mm in size died within 3 years(P=0.005).Conclusion:Surgical resection along with systemic therapy is a promising treatment strategy for pulmonary recurrence after curative esophagectomy when it is solitary and *** factors,such as the esophageal cancer stage and the size of the pulmonary metastasis,are useful for deciding on the surgical indication.

关键词： Esophageal cancer pulmonary metastasis recurrence surgical resection

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One Case of Suspected Angiostenosis Revealed by MRA Following Carotid Endarterectomy Due to a Rare Cause

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Open Journal of Modern Neurosurgery 2018年第3期8卷 276-281页

作者： Yuji Endo Naoki Sato Hidekazu Takahashi Mamoru ota Toshihito Ishikawa Katsuhiro Endo Kenichi Ebihara Department of Neurosurgery Masu Memorial Hospital Fukushima Japan Department of Neurosurgery Ageo Central General Hospital Saitama Japan

We herein report on a case in which magnetic resonance angiography (MRA) following carotid endarterectomy revealed the appearance of angiostenosis due to an artifact of metallic powder, which was thought to have come from an old surgical instrument. The patient was a 77-year-old male. Carotid endarterectomy (CEA) was performed for stenosis in the internal carotid artery of his left neck (82%). Upon observing a decline in renal function following CEA surgery, a postoperative cervical MRA revealed the appearance of high-grade stenosis at the common carotid artery on which surgery was performed. No stenosis was revealed upon carotid ultrasonography and angiography. In the original MRA image, an orbicular low intensity area was observed in concordance with the narrow segment. 3D computed tomography (3D-CT) revealed a metallic finding, suggesting it was an artifact caused by metal powder. Close inspection of the metal surgical instruments used during surgery revealed slight damage to a suture snare which had been used for 30 years. Going forward, it is necessary to pay attention to old surgical instruments, introduce a system by which the number of years and the frequency of use of each surgical instrument can be learned, and replace them with new equipment as necessary.

关键词： Carotid Endarterectomy Operation Metal Artifact Surgical Instruments

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Performance Evaluation of Super-Resolution Methods Using Deep-Learning and Sparse-Coding for Improving the Image Quality of Magnified Images in Chest Radiographs

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Open Journal of Medical Imaging 2017年第3期7卷 100-111页

作者： Kensuke Umehara Junko ota Naoki Ishimaru Shunsuke Ohno Kentaro Okamoto Takanori Suzuki Takayuki Ishida Department of Medical Physics and Engineering Graduate School of Medicine Osaka University Suita Japan

Purpose: To detect small diagnostic signals such as lung nodules in chest radiographs, radiologists magnify a region-of-interest using linear interpolation methods. However, such methods tend to generate over-smoothed images with artifacts that can make interpretation difficult. The purpose of this study was to investigate the effectiveness of super-resolution methods for improving the image quality of magnified chest radiographs. Materials and Methods: A total of 247 chest X-rays were sampled from the JSRT database, then divided into 93 training cases with non-nodules and 154 test cases with lung nodules. We first trained two types of super-resolution methods, sparse-coding super-resolution (ScSR) and super-resolution convolutional neural network (SRCNN). With the trained super-resolution methods, the high-resolution image was then reconstructed using the super-resolution methods from a low-resolution image that was down-sampled from the original test image. We compared the image quality of the super-resolution methods and the linear interpolations (nearest neighbor and bilinear interpolations). For quantitative evaluation, we measured two image quality metrics: peak signal-to-noise ratio (PSNR) and structural similarity (SSIM). For comparative evaluation of the super-resolution methods, we measured the computation time per image. Results: The PSNRs and SSIMs for the ScSR and the SRCNN schemes were significantly higher than those of the linear interpolation methods (p p p Conclusion: Super-resolution methods provide significantly better image quality than linear interpolation methods for magnified chest radiograph images. Of the two tested schemes, the SRCNN scheme processed the images fastest;thus, SRCNN could be clinically superior for processing radiographs in terms of both image quality and processing speed.

关键词： Deep Learning Super-Resolution Super-Resolution Convolutional Neural Network (SRCNN) Sparse-Coding Super-Resolution (ScSR) Chest X-Ray

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有限空间的多重体验——DURAS日本台场店

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现代装饰 2010年第7期 34-39页

作者： Takumi ota（摄影） Emma（翻译）

Duras Ambient品牌成立于2000年,是日本著名的High Fashion Style品牌,品牌设计师擅长把不同流行元素放到作品中,为自信、成熟的女性提供保持原有独特魅力的服饰,鼓励女性“大胆”做自己,追求自己想要的生活。这样的理念也被贯彻到了品... 详细信息

Duras Ambient品牌成立于2000年,是日本著名的High Fashion Style品牌,品牌设计师擅长把不同流行元素放到作品中,为自信、成熟的女性提供保持原有独特魅力的服饰,鼓励女性“大胆”做自己,追求自己想要的生活。这样的理念也被贯彻到了品牌产品设计、

关键词：有限空间日本多重流行元素独特魅力产品设计品牌设计师

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尘嚣孤屿

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建筑实践 2009年第5期 110-115页

作者：查方兴 Takumi ota Isolation Unit

热浪焦灼,人头攒动,都市的红绿灯口,随波逐流已是一种习惯。在这步调一致的麻木中,谁不是在独立与群体的制衡之间,同时追求着自我与安全?

关键词：美发沙龙集装箱包装箱设计师大理石石料连锁店连锁商店零售商店

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Byrsocarpus coccineus Schumach.&Thonn.(Connaraceae)叶子提取物的降血糖和抗氧化活性(英文)

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中国天然药物 2013年第6期11卷 628-637页

作者： Oluwakemi K.Dada Abidemi J.Akindele Olufemi A.Morakinyo Margaret O.Sofidiya Duncan ota Department of Pharmacology Faculty of Basic Medical SciencesCollege of MedicineUniversity of Lagos Department of Physiology Faculty of Basic Medical SciencesCollege of MedicineUniversity of Lagos Department of Pharmacognosy Faculty of PharmacyUniversity of Lagos

AIM: Diabetes Mellitus is associated with significant morbidity and mortality worldwide. The need for enhanced efficacy and safety, and cheaper and more readily available new drugs has increased the search for new antidiabetic drugs from plants. This study was conducted to investigate the antidiabetic activity of the hydroethanolic leaf extract of B. coccineus in rats. METHODS: The effect of B. coccineus extract(100–800 mg·kg–1, p.o.) on blood glucose levels in normal and glucose loaded rats, and alloxan-induced diabetic rats was determined. After 10 days of treatment, blood samples were collected from rats for lipid and insulin profiling. Animals were thereafter sacrificed and the kidneys, heart, and liver were harvested for antioxidant indices assay. RESULTS: In normal rats, B. coccineus did not cause significant reduction in blood glucose. At the dose of 800 mg·kg–1, significant increase in blood glucose level was not observed 30 min. after glucose load. B. coccineus administered acutely did not generally produce significant reduction in blood glucose level in diabetic rats. Administered subacutely, the extract significantly reduced blood glucose level in diabetic rats from the 3rdday with peak effect observed at the dose of 800 mg·kg–1on the 10thday. The extract generally preserved in vivo antioxidant levels in the kidneys, heart, and liver, increased the level of high density lipoprotein and insulin, and reduced the level of triglycerides and low density lipoprotein compared to diabetic control. CONCLUSION: The findings in this study suggest that the hydroethanolic leaf extract Byrsocarpus coccineus possesses antidiabetic activity possibly mediated through inhibition of intestinal glucose absorption, in vivo antioxidant activity, and enhancement of regeneration of beta cells of the pancreas and insulin secretion.

关键词： Byrsocarpus coccineus Connaraceae Hypoglycemic activity Antioxidant activity Diabetes

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Successful Surgical Treatment of Metachronous Oligometastases from Non-B, Non-C Hepatocellular Carcinoma

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Open Journal of Thoracic Surgery 2016年第2期6卷 7-11页

作者： Haruchika Yamamoto Yuji Hirami Tomohiro Toji Yoko Shinno Tetsuya ota Minoru Naito Akio Andou Department of General Thoracic Surgery National Hospital Organization Okayama Medical Center Okayama Japan Department of Pathology National Hospital Organization Okayama Medical Center Okayama Japan Department of General and Gastroenterological Surgery National Hospital Organization Okayama Medical Center Okayama Japan

Hepatocellular Carcinoma (HCC) rarely metastasizes to bone or mediastinum. In some patients, surgical treatment of oligometastatic lesions from colorectal cancer, breast cancer, or non-small cell lung cancer results in satisfactory survival. However, data concerning oligometastatic lesions from HCC are scarce. We report the case of a patient with long-term survival after resection of metachronous oligometastases of HCC. A 54-year-old woman underwent hepatic resection for non-B, non-C HCC. A solitary left tenth rib tumor was detected 20 months after initial surgery and was surgically resected. A solitary mediastinal tumor was detected 6 months after the second operation and the patient again underwent surgical resection. Histopathological examination of both lesions confirmed metastasis of HCC. The patient has had no further recurrence 7 years after initial surgery without chemotherapy or radiotherapy.

关键词： Hepatocellular Carcinoma Mediastinal Metastases Rib Metastases Oligometastases

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第三部分海陆对比 300000年以来的海平面变化

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第四纪研究 1992年第2期 160-161页

作者： Yoko ota John Chappell Brad Pmllans 顾兆炎横滨国立大学地理系澳大利亚国立大学生物地理与地貌系惠灵顿维多利亚大学地质系日本澳大利亚新西兰

对于海岸演化,海平面变化是最重要的控制因素之一。300 000年以来海平面历史的建立,对于理解中、晚第四纪年代学,海岸演化对现代海岸特征的影响和测量沿海地区第四纪新构造运动都是特别重要的。这个专题讨论会的目的就是根据新发展的测... 详细信息

对于海岸演化,海平面变化是最重要的控制因素之一。300 000年以来海平面历史的建立,对于理解中、晚第四纪年代学,海岸演化对现代海岸特征的影响和测量沿海地区第四纪新构造运动都是特别重要的。这个专题讨论会的目的就是根据新发展的测年手段和具有不同构造特征的各种沿海地带地貌和地质的调查,建立海平面波动的年代和幅度以

关键词：海平面变化铀系质谱铀镭系粒子谱抬升速率测年

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Incidence of <i>Clostridium difficile</i>-associated diarrhea in patients using proton pump inhibitors: A Japanese study

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Open Journal of Gastroenterology 2013年第5期3卷 276-280页

作者： Takatoshi Kitazawa Yusuke Yoshino Ichiro Koga Akari Isono Takatsugu Yamamoto Yasushi Kuyama Yasuo ota Department of Internal Medicine Teikyo University School of Medicine Tokyo Japan

Objective: The incidence of Clostridium difficile-associated diarrhea (CDAD) has increased in many developed countries. In addition to previous use of antimicrobials, use of proton pump inhibitors (PPIs) is thought to increase the incidence of CDAD. However, most previous studies that showed a positive relationship between PPI use and CDAD were conducted retrospectively in Western countries. We investigated whether the use of PPIs increases the incidence of CDAD in Japan. Methods: The study was carried out with all the patients admitted to the department of internal medicine of Teikyo University Hospital from April 2009 to June 2009. Clinical data were obtained from medical records. CDAD was defined as detection of CD toxin from stool samples in diarrheal patients. PPI users were defined as patients that were prescribed with PPI for more than 30 days at the detection of CD toxin. The results of Clostridium difficile (CD) toxin were collected until April 2011. Results: A total of 793 patients were included, and PPIs were prescribed to 489 patients (59.8%). The average age of PPI users was higher than that of PPI nonusers (68.9 vs. 63.1 years). Among the 489 PPI users, 19 patients developed CDAD, while 4 developed CDAD among the 304 PPI nonusers. The relative risk of PPI use on the incidence of CDAD was 3.20 in univariate analysis (95% confidence interval, 1.10 to 9.32, p = 0.04), although the hazard ratio in multivariate analysis was 1.23 (95% confidence interval, 0.35 to 3.83, p = 0.82). Conclusions: There was no association between CDAD occurrence and PPI use in patients in Japan.

关键词： Clostridium difficile-Associated Diarrhea Proton Pump Inhibitors Risk Factor

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Experience of a Videoconference System with Medical Information Desktop Sharing for Radiation Therapy and Evaluation of Its Usefulness

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2014年第1期3卷 20-24页

作者： Shohei Kawashiro Yasuhito Hagiwara Ibuki ota Mayumi Ichikawa Misako Miwa Yuuki Kuroda Kenji Nemoto Department of Radiation Oncology Yamagata Uni-versity Faculty of Medicine Yamagata Japan

Purpose: To present our videoconference system with medical information desktop sharing for radiation therapy and report initial experience using the system and its usefulness. Materials and Methods: A videoconference system for radiation therapy enables radiation oncologists sent to affiliated hospitals to consult a more experienced board-certified doctor at our institution while sharing the same display showing a patient’s information, radiology information system (RIS), and radiation therapy planning (RTP) system. We evaluated cases discussed in videoconferences to determine the influence of the system on treatment policies and radiation therapy plans. Results: From December 2012 to March 2013, treatment policies for 56 cases and radiation therapy plans for 50 cases were discussed in videoconferences. As for treatment policies, no change was made in treatment policy for 33 cases (59%), and minor and major changes were made for 16 (29%) cases and 7 (12%) cases, respectively. Radiation therapy plans for 50 cases were checked. No change was needed for 32 cases (64%), and minor and major changes were needed for 17 (34%) cases and 1 (2%) case, respectively. Conclusion: The videoconference system can be effective for improving the quality of radiation therapy.

关键词： Radiation Therapy Shortage of Radiation Oncologists Videoconference Desktop Sharing Telemedicine

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