检索结果-南通市图书馆

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura Akira Yamaguchi kazuyuki ishihara Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Algorithm Selection Method Based on Coupling Strength for Partitioned Analysis of Structure-Piezoelectric-Circuit Coupling

引用

Computer Modeling in Engineering & Sciences 2024年第2期138卷 1237-1258页

作者： Daisuke ishihara Naoto Takayama Department of Intelligent and Control Systems Kyushu Institute of TechnologyIizuka820-8502Japan

In this study, we propose an algorithm selection method based on coupling strength for the partitioned analysis ofstructure-piezoelectric-circuit coupling, which includes two types of coupling or inverse and direct piezoelectriccoupling and direct piezoelectric and circuit coupling. In the proposed method, implicit and explicit formulationsare used for strong and weak coupling, respectively. Three feasible partitioned algorithms are generated, namely(1) a strongly coupled algorithm that uses a fully implicit formulation for both types of coupling, (2) a weaklycoupled algorithm that uses a fully explicit formulation for both types of coupling, and (3) a partially stronglycoupled and partially weakly coupled algorithm that uses an implicit formulation and an explicit formulation forthe two types of coupling, *** examples using a piezoelectric energy harvester,which is a typicalstructure-piezoelectric-circuit coupling problem, demonstrate that the proposed method selects the most costeffectivealgorithm.

关键词： Multiphysics coupling strength partitioned algorithm structure-piezoelectric-circuit coupling strongly coupled algorithm weakly coupled algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hybrid Strategy of Partitioned and Monolithic Methods for Solving Strongly Coupled Analysis of Inverse and Direct Piezoelectric and Circuit Coupling

引用

Computer Modeling in Engineering & Sciences 2024年第8期140卷 1371-1386页

作者： Daisuke ishihara Syunnosuke Nozaki Tomoya Niho Naoto Takayama Department of Intelligent and Control Systems Kyushu Institute of TechnologyFukuokaJapan

The inverse and direct piezoelectric and circuit coupling are widely observed in advanced electro-mechanical systems such as piezoelectric energy *** strongly coupled analysis methods based on direct numerical modeling for this phenomenon can be classified into partitioned or monolithic *** formulation has its advantages and disadvantages,and the choice depends on the characteristics of each coupled *** study proposes a new option:a coupled analysis strategy that combines the best features of the existing formulations,namely,the hybrid partitioned-monolithic *** analysis of inverse piezoelectricity and the monolithic analysis of direct piezoelectric and circuit interaction are strongly coupled using a partitioned iterative hierarchical *** a typical benchmark problem of a piezoelectric energy harvester,this research compares the results from the proposed method to those from the conventional strongly coupled partitioned iterative method,discussing the accuracy,stability,and computational *** proposed hybrid concept is effective for coupled multi-physics problems,including various coupling conditions.

关键词： Structure-piezoelectric-circuit interaction energy harvesting partitioned method monolithic method hybrid method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Basic peptide protamine exerts antimicrobial activity against periodontopathic bacteria——Growth inhibition of periodontopathic bacteria by protamine

引用

Journal of Biomedical Science and Engineering 2010年第11期3卷 1069-1072页

作者： Tadashi Miura Keishi Iohara Tetsuo Kato kazuyuki ishihara Masao Yoshinari 不详

Protamine was investigated for its antibacterial activity against the periodontal pathogens, Porphyromonas gingivalis, Prevotella intermedia and Aggregatibacter actinomycetemcomitans. We determined the minimum inhibitory concentrations of protamine and its hydrolysate and their bactericidal activity. Protamine inhibited the growth of all periodontopathic bacteria tested on agar plates. Protamine, which MIC was 6.3 × 10-7 g L-1, was most effective against P. gingivalis. The antibacterial effect of native protamine was higher than that of its hydrolysate. An ATP bioluminescence assay revealed that protamine showed bactericidal activity against P. gingivalis in a time-dependent manner. These results indicate that protamine could be candidate peptide for prevention of P. gingivalis infection.

关键词： Antimicrobial Peptide Periodontopathic Bacteria Implantitis Protamine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic ultrasonography for optimizing treatment position in superior mesenteric artery syndrome:Two case reports and review of literature

引用

World Journal of Gastroenterology 2024年第5期30卷 499-508页

作者： Nobuaki Hasegawa Akihiko Oka Muyiwa Awoniyi Yuri Yoshida Hiroshi Tobita Norihisa Ishimura Shunji ishihara Department of Internal Medicine II Shimane University Faculty of MedicineIzumo 693-8501ShimaneJapan Department of Gastroenterology Hepatology and NutritionDigestive Disease and Surgery InstituteHepatology SectionCleveland ClinicClevelandOH 44195United States Clinical Laboratory Division Shimane University HospitalIzumo 693-8501ShimaneJapan Division of Hepatology Shimane University HospitalIzumo 693-8501Japan

BACKGROUND Superior mesenteric artery(SMA)syndrome is a rare cause of duodenal obstruction by extrinsic compression between the SMA and the aorta(SMA-Ao).Although the left lateral recumbent position is considered effective in the treatment of SMA syndrome,individual variations in the optimal patient position have been *** this report,we present two elderly cases of SMA syndrome that exhibited rapid recovery due to ultrasonographic dynamic evaluation of the optimal position for each *** SUMMARY Case 1:A 90-year-old man with nausea and *** diagnosis of SMA syndrome by computed tomography(CT),ultrasonography(US)revealed the SMA-Ao distance in the supine position(4 mm),which slightly improved in the lateral position(5.7–7.0 mm)without the passage of duodenal ***,in the sitting position,the SMA-Ao distance was increased to 15 mm accompanied by improved content ***,US indicated enhanced passage upon abdominal massage on the right *** day 2,the patient could eat comfortably with the optimal position and *** 2:An 87-year-old woman with *** the diagnosis of SMA syndrome and aspiration pneumonia by CT,dynamic US confirmed the optimal position(SMA-Ao distance was improved to 7 mm in forward-bent position,whereas it remained at 5 mm in the supine position).By day 7 when her pneumonia recovered,she could eat with the optimal *** The optimal position for SMA syndrome varies among *** US appears to be a valuable tool in improving patient outcomes.

关键词： Superior mesenteric artery syndrome Wilkie’s syndrome Cast syndrome Aorto-mesenteric compass syndrome Ultrasonography Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Co-infection with Neisseria mucosa in a patient with tuberculous otitis media

引用

Journal of Otology 2024年第1期19卷 1-4页

作者： Tatsuya Hioki Kazuaki Soejima Yuki Goto Makoto Sugiura Takumi Umemura Yoshimi ishihara Yoshikazu Mutoh Daisuke Sakanashi Hiroshige Mikamo Department of Clinical Laboratory Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Respiratory Medicine and Allergy Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Otolaryngology Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Infection Control Team Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Infectious Diseases Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Infection Prevention and Control Aichi Medical University Hospital1-1 YazakokarimataNagakuteAichi480-1195Japan Department of Clinical Infectious Diseases Aichi Medical University1-1 YazakokarimataNagakuteAichi480-1195Japan

Tuberculous otitis media(TOM) is a rare manifestation caused by Mycobacterium tuberculosis with low incidence rates among extrapulmonary tuberculosis cases. Diagnosis is often delayed because of the presence of several clinical manifestations and the high prevalence of secondary bacterial infections. Few reports have attributed secondary bacterial infections in patients with TOM to commensal Neisseria. Thus, understanding the pathogenic mechanisms and clinical features of commensal Neisseria is important, considering its recent presentation as an infection-causing pathogen. Neisseria mucosa is a commensal inhabitant in humans and is generally considered non-pathogenic but can cause infection in rare cases. Here, we report an atypical secondary infection caused by Neisseria mucosa in an 81-year-old woman with TOM being treated for pulmonary tuberculosis. Direct purulent otorrhea smear microscopy revealed no acid-fast bacilli using Ziehl-Neelsen staining, whereas the phagocytosis of gram-negative cocci by white blood cells was confirmed using Gram staining. Otorrhea culture revealed the growth of N. mucosa. Subsequently, M. tuberculosis infection in the otorrhea was identified using a culture-based method. Vigilance is critical for the early detection of TOM to prevent further complications. This report raises awareness regarding TOM and provides insight into the pathogenicity of N. mucosa in otitis media.

关键词： Commensal neisseria Miliary tuberculosis Mycobacterium tuberculosis Neisseria mucosa Tuberculous otitis media

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

桃源乡

引用

风景园林 2018年第2期25卷 96-98页

作者：石原和幸马嘉王培严陈瑞万静柯

《桃花源记》是一篇描写世外桃源的中国文学，展现了居住在世外桃源里的人们所创造的自然风景。这些通过亲近自然获得美好生活的人们，是北京世园会生态学理念目标的先驱者。

关键词：桃花源自然风景近自然生态学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Importance of Three-Dimensional Piezoelectric Coupling Modeling in Quantitative Analysis of Piezoelectric Actuators

引用

Computer Modeling in Engineering & Sciences 2023年第8期136卷 1187-1206页

作者： Daisuke ishihara Prakasha Chigahalli Ramegowda Shoichi Aikawa Naoki Iwamaru Department of Intelligent and Control Systems Kyushu Institute of TechnologyIizukaFukuoka820-8502Japan Institute of Microelectronics Agency for ScienceTechnology and ResearchInnovis Tower138634Singapore

This paper demonstrates the importance of three-dimensional(3-D)piezoelectric coupling in the electromechanical behavior of piezoelectric devices using three-dimensional finite element analyses based on weak and strong coupling models for a thin cantilevered piezoelectric bimorph *** is found that there is a significant difference between the strong and weak coupling solutions given by coupling direct and inverse piezoelectric effects(i.e.,piezoelectric coupling effect).In addition,there is significant longitudinal bending caused by the constraint of the inverse piezoelectric effect in the width direction at the fixed end(i.e.,3-D effect).Hence,modeling of these effects or 3-D piezoelectric coupling modeling is an electromechanical basis for the piezoelectric devices,which contributes to the accurate prediction of their behavior.

关键词： Piezoelectric coupling effect piezoelectric bimorph actuator weak coupling strong coupling three-dimensional finite element analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liposome-Encapsulated Hemoglobin Vesicle Improves Persistent Anti-arrhythmogenesis through Improving Myocardial Electrical Remodeling and Modulating Cardiac Autonomic Activity in a Hemorrhagic Shock-Induced Rat Heart Model

引用

Current Medical Science 2023年第2期43卷 232-245页

作者： Bonpei Takase Yuko Higashimura Haruka Asahina Masayuki ishihara Hiromi Sakai Department of Intensive Care Medicine National Defense Medical CollegeTokorozawa359-8513Japan Division of Traumatology Research Institute National Defense Medical College Research InstituteTokorozawa359-8513Japan Division of Biomedical Engineering National Defense Medical College Research InstituteTokorozawa359-8513Japan Department of Chemistry School of MedicineNara Medical UniversityNara634-8521Japan

Objective Shock heart syndrome(SHS)is associated with lethal arrhythmias(ventricular tachycardia/ventricular fibrillation,VT/VF).We investigated whether liposome-encapsulated human hemoglobin vesicles(HbVs)has comparable persistent efficacy to washed red blood cells(wRBCs)for improving arrhythmogenesis in the subacute to chronic phase of *** Optical mapping analysis(OMP),electrophysiological study(EPS),and pathological examinations were performed on blood samples from Sprague-Dawley rats following induction of hemorrhagic *** hemorrhagic shock,the rats were immediately resuscitated by transfusing 5%albumin(ALB),HbV,or *** rats survived for 1 *** and EPS were performed on Langendorff-perfused *** arrhythmias and heart rate variability(HRV)were evaluated using awake 24-h telemetry,cardiac function by echocardiography,and pathological examination of *** OMP showed significantly impaired action potential duration dispersion(APDd)in the left ventricle(LV)in the ALB group whereas APDd was substantially preserved in the HbV and wRBCs *** VT/VF was easily provoked by EPS in the ALB *** VT/VF was induced in the HbV and wRBCs ***,spontaneous arrhythmias,and cardiac function were preserved in the HbV and wRBCs *** showed myocardial cell damage and Connexin43 degradation in the ALB group,all of which were attenuated in the HbV and wRBCs *** LV remodeling after hemorrhagic shock caused VT/VF in the presence of impaired *** to wRBCs,HbV persistently prevented VT/VF by inhibiting persistent electrical remodeling,preserving myocardial structures,and ameliorating arrhythmogenic modifying factors in the subacute to chronic phase of hemorrhagic shock-induced SHS.

关键词： artificial oxygen carrier hemorrhage lethal arrhythmia resuscitation heart rate variability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ultrafast reorientation of the Néel vector in antiferromagnetic Dirac semimetals

引用

npj Computational Materials 2021年第1期7卷 1562-1568页

作者： Atsushi Ono Sumio ishihara Department of Physics Tohoku UniversitySendai 980-8578Japan

Antiferromagnets exhibit distinctive characteristics such as ultrafast dynamics and robustness against perturbative fields,thereby attracting considerable interest in fundamental physics and technological ***,it was revealed that the Néel vector can be switched by a current-induced staggered(Néel)spin-orbit torque in antiferromagnets with the parity-time symmetry,and furthermore,a nonsymmorphic symmetry enables the control of Dirac ***,the real-time dynamics of the magnetic and electronic structures remain largely ***,we propose a theory of the ultrafast dynamics in antiferromagnetic Dirac semimetals and show that the Néel vector is rotated in the picosecond timescale by the terahertz-pulse-induced Néel spin-orbit torque and other torques originating from magnetic *** reorientation accompanies the modulation of the mass of Dirac fermions and can be observed in real time by the magneto-optical *** results provide a theoretical basis for emerging ultrafast antiferromagnetic spintronics combined with the topological aspects of materials.

关键词： materials Dirac metals

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：