检索结果-南通市图书馆

Molecular mechanism of peritoneal dissemination in gastric cancer

Journal of Cancer Metastasis and Treatment 2018年第1期4卷 451-458页

作者： Qing-Jiang Hu Shuhei Ito kazuyoshi yanagihara Koshi Mimori Department of Surgery Kyushu University Beppu HospitalBeppu 874-0838Japan Department of Surgery and Science Kyushu University HospitalFukuoka 812-8582Japan Division of Biomarker Discovery Exploratory Oncology Research&Clinical Trial CenterNational Cancer CenterKashiwa 277-8577Japan

Peritoneal dissemination(PD)is the most common cause of metastasis in gastric cancer(GC).Because there are no standard treatments for PD,it is associated with a poor prognosis.Although clinicians have performed intraperitoneal chemotherapy for GC with PD,the outcome remains unsatisfactory.Therefore,the development of novel treatments and diagnostic tools for PD is expected to improve the prognosis of GC patients with PD.Notably,it is essential to elucidate the molecular mechanisms involved in the development of PD in GC.In this review,the molecular mechanisms of PD(three steps:detachment from the primary tumor,adaptation to the microenvironment of the peritoneal cavity,and attachment to peritoneal mesothelial cells)and new topics in GC are highlighted.

关键词： Gastric cancer peritoneal dissemination molecular mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CD21-independent Infection of Epstein-Barr Virus in Human Signet Ring Gastric Carcinoma Cell Line

引用

Journal of Microbiology and Immunology 2003年第1期1卷 17-24页

作者：罗兵 Masanao Murakami Makoto Fukuta kazuyoshi yanagihara Takeshi Sairenji Department of Microbiology Medical College of Qingdao University Qingdao 266021China Department of Biosignaling School of Life Science Faculty of Medicine Tottori University Yonago 683-8505 Japan Central Animal Laboratory National Cancer Center Research Institute Tokyo 104-0045 Japan

To study the mechanism of infection of Epstein-Barr virus (EBV) in gastric carcinoma cells, the Akata and P3HR-1 strains of EBV were used as the test strains of viruses, and the signet ring cell line HSC-39 of gastric carcinoma cells was used as the target cells of infection. The virus-infected cell clones were isolated by limited dilution method. It was found that the EBV-encoded small RNA (EBER) could be detected in the infected cells. The Akata and P3HR-1 EBV infected parental cells and most of clones expressed EBNA1, but not EBNA2. Latent membrane protein (LMP-1) and LMP-2, and the Q promoter (p), but not the Cp/Wp for EBNA gene transcription was active in the infected parental cells as well as all the clones. Uninfected HSC-39 cells did not express CD21, however, Akata but not P3HR-1 EBV-infected clones expressed low level of CD21 mRNA. These results demonstrate that HSC-39 cells are susceptible to both EBV strains and EBV infects HSC-39 cells through the CD21-independent pathway. This study defines a signet ring type of gastric carcinoma cells line as a unique target cells for the study of EBV infection mechanism.

关键词： CD21-传染病爱泼斯坦-巴尔病毒胃癌癌细胞系统 EBV

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：