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Y chromosome microdeletion screening using a new molecular diagnostic method in 1030 Japanese males with infertility

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Asian Journal of Andrology 2020年第4期22卷 368-371页

作者： Masashi Iijima kazuyoshi Shigehara Hideki Igarashi Koichi Kyono Yasuo Suzuki Yuji tsuji Yoshitomo Kobori Hideyuki Kobayashi Atsushi Mizokami Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical ScienceKanazawa 920-8641Japan Kyono ART Clinic Sendai 980-0014Japan Kyono ART Clinic TakanawaTokyo 108-0074Japan Suzuki Lady's Hospital Kanazawa 921-8033Japan Ebisu tsuji Clinic Tokyo 150-0021Japan Tenjin tsuji Clinic Fukuoka 810-0001Japan Dokkyo Medical University Koshigaya Hospital Saitama 343-8555Japan Department of Urology Faculty of MedicineToho UniversityTokyo 143-8541Japan

The azoospermia factor(AZF)region is important for spermatogenesis,and deletions within these regions are a common cause of oligozoospermia and *** several studies have reported this cause,the present research,to the best of our knowledge,is the first large-scale study assessing this factor in *** this study,1030 male patients with infertility who were examined for Y chromosome microdeletion using the polymerase chain reaction-reverse sequence-specific oligonucleotide(PCR-rSSO)method,a newly developed method for Y chromosome microdeletion screening,were *** study enrolled 250 patients with severe oligospermia and 717 patients with *** the 1030 patients,4,4,10,and 52 had AZFa,AZFb,AZFb+c,and AZFc deletions,*** sperm recovery rate(SRR)of microdissection testicular sperm extraction in patients with AZFc deletions was significantly higher than that in those without AZF deletions(60.0%vs 28.7%,P=0.04).In patients with gr/gr deletion,SRR was 18.7%,which was lower than that in those without gr/gr deletion,but was not statistically *** conclusion,our study showed that the frequency of Y chromosome microdeletion in male patients in Japan was similar to that reported in patients from other countries,and SRR was higher in patients with AZFc deletion.

关键词： azoospermia factor Japanese infertile men sperm recovery rate Y chromosome microdeletion

Preoperative endoscopic diagnosis of superficial non-ampullary duodenal epithelial tumors, including magnifying endoscopy

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World Journal of Gastroenterology 2015年第41期21卷 11832-11841页

作者： Shigetsugu tsuji Hisashi Doyama Kunihiro tsuji Sho Tsuyama Kei Tominaga Naohiro Yoshida Kenichi Takemura Shinya Yamada Hideki Niwa kazuyoshi Katayanagi Hiroshi Kurumaya Toshihide Okada Department of Gastroenterology Ishikawa Prefectural Central Hospital Kanazawa Department of Diagnostic Pathology Ishikawa Prefectural Central Hospital Kanazawa

Superficial non-ampullary duodenal epithelial tumor(SNADET) is defined as a sporadic tumor that is confined to the mucosa or submucosa that does not arise from Vater's papilla, and it includes adenoma a n d a d e n o c a r c i n o m a. R e c e n t d e v e l o p m e n t s i n endoscopic technology, such as high-resolution endoscopy and image-enhanced endoscopy, may increase the chances of detecting SNADET lesions. However, because SNADET is rare, little is known about its preoperative endoscopic diagnosis. The use of endoscopic resection for SNADET, which has no risk of metastasis, is increasing, but the incidence of complications, such as perforation, is significantly higher than in any other part of the digestive tract. A preoperative diagnosis is required to distinguish between lesions that should be followed up and those that require treatment. Retrospective studies have revealed certain endoscopic findings that suggest malignancy. In recent years, several new imaging modalities have been developed and explored for realtime diagnosis of these lesion types. Establishing an endoscopic diagnostic tool to differentiate between adenoma and adenocarcinoma in SNADET lesions is required to select the most appropriate treatment. This review describes the current state of knowledge about preoperative endoscopic diagnosis of SNADETs, such as duodenal adenoma and duodenal adenocarcinoma. Newer endoscopic techniques, including magnifying endoscopy, may help to guide these diagnostics, but their additional advantages remain unclear, and further studies are required to clarify these issues.

关键词： Endoscopy Duodenoscopy Duodenal neoplasms Narrow b

Numerical Simulation of Deflecting Flow in a Symmetric Enlarged Channel

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Journal of Thermal Science 2007年第4期16卷 353-359页

作者： HiroyukiYOSHIKAWA MizueMUNEKATA HidekiOHBA kazuyoshi ICHINOMIYA Department of Mechanical System Engineering Kumamoto University2-39-1 KurokamiKumamoto860-8555 Japan Graduate School of Science and Technology Kumamoto University2-39-1 KurokamiKumamoto860-8555 Japan

Numerical results of three-dimensional separated flow and heat transfer in a rectangular channel with a sudden expansion are presented in this paper. Numerical simulations of Navier-Stokes and energy equations are carried out using the finite difference method. The results of three-dimensional calculations are compared with the two-dimensional ones, and effects of the aspect ratio of channel upon the flow are shown. The transition from symmetric to asymmetric flow appears at lower Reynolds number as increasing the aspect ratio. The details of local heat transfer characteristics in two different separated flow regions on two downstream walls are clarified. Two-dimensionality of the flow and heat transfer almost disappears for the aspect ratio considered.

关键词： Separated and reattached flow symmetric enlarged channel deflecting flow heat transfer

Hierarchically porous monoliths based on low-valence transition metal (Cu, Co, Mn) oxides:gelation and phase separation

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National Science Review 2020年第11期7卷 1656-1666页

作者： Xuanming Lu kazuyoshi Kanamori Kazuki Nakanishi Department of Chemistry Graduate School of ScienceKyoto University Institute for Integrated Cell-Material Sciences Kyoto University Institute for Advanced StudyKyoto University Division aof Materials Research Institute of Materials and Systems for Sustainability Nagoya University

Hierarchically porous monoliths based on copper (Cu), cobalt (Co) and manganese (Mn) oxides with three-dimensionally (3D) interconnected macropores and open nanopores were prepared using metal bromides as precursors via a sol–gel process accompanied by phase separation. The difficulty of gelation for low-valence metal cation was overcome by introducing a highly electronegative Br atom near to the metal atom to control the rates of hydrolysis and polycondensation. The 3D interconnected macropores were obtained using appropriate polymers to induce phase separation. The domain sizes of macropores and skeletons can be controlled by reaction parameters such as concentration and/or average molecular weight of polymers, and the amount of hydrochloric acid. The crystalline metal oxide monoliths with their 3D interconnected macroporous structure preserved were obtained after heat treatment in air.

关键词： hierarchically porous monolith low-valence transition metal oxide 3D interconnected macropore sol–gel process phase separation

Uncertainty in solid precipitation and snow depth prediction for Siberia using the Noah and Noah-MP land surface models

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Frontiers of Earth Science 2018年第4期12卷 672-682页

作者： kazuyoshi SUZUKI Milija ZUPANSKI Institute of Arctic Climate and Environment Change Research (IACE) Japan Agency for Marine-Earth Science and Technology (JAMSTEC)Yokohama236-0001Japan Cooperative Institute for Research in the Atmosphere Colorado State UniversityFort CollinsCO 80523-1375USA

In this study, we investigate the uncertainties associated with land surface processes in an ensemble predication context. Specifically, we compare the uncertainties produced by a coupled atmosphere-land modeling system with two different land surface models, the Noah- MP land surface model (LSM) and the Noah LSM, by using the Maximum Likelihood Ensemble Filter (MLEF) data assimilation system as a platform for ensemble prediction. We carried out 24-hour prediction simulations in Siberia with 32 ensemble members beginning at 00:00 UTC on 5 March 2013. We then compared the model prediction uncertainty of snow depth and solid precipitation with observation-based research products and evaluated the standard deviation of the ensemble spread. The prediction skill and ensemble spread exhibited high positive correlation for both LSMs, indicating a realistic uncertainty estimation. The inclusion of a multiple snowlayer model in the Noah-MP LSM was beneficial for reducing the uncertainties of snow depth and snow depth change compared to the Noah LSM, but the uncertainty in daily solid precipitation showed minimal difference between the two LSMs. The impact of LSM choice in reducing temperature uncertainty was limited to surface layers of the atmosphere. In summary, we found that the more sophisticated Noah-MP LSM reduces uncertainties associated with land surface processes compared to the Noah LSM. Thus, using prediction models with improved skill implies improved predictability and greater certainty of prediction.

关键词： ensemble simulation land-atmosphere interaction ensemble spread vertical temperature snow prediction

Numerical Analysis of Thermal Convections in a Three-dimensional Cavity: Influence of Difference in Approximation Models on Numerical Solutions

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Journal of Thermal Science 2004年第3期13卷 283-288页

作者： kazuyoshi MATSUZAKI Hideki OHBA Mizue MUNEKATA Mechanical Engineering and Materials Science Kumamoto University 2-39-1 Kurokami Kumamoto 860-8555 JapanMechanical Engineering and Materials Science Kumamoto University 2-39-1 Kurokami Kumamoto 860-8555 JapanMechanical Engineering and Materials Science Kumamoto University 2-39-1 Kurokami Kumamoto 860-8555 Japan

In order to develop the practical approximation models suitable to flow fields at low Mach number with large temperature difference, the influence of difference in approximation models on numerical solutions was investigated by solving the natural convection in the 3-D enclosures with vertical sidewalls differentially heated and the heated bottom wall using 3 approximation models, that is Boussinesq approximation, low Mach Number approximation and approximation model proposed by Mlaouah. As results of the simulation, the effects of the differences in the three approximation models on the numerical solutions become clear.

关键词： thermal convection approximation model numerical analysis 3-D cavity.

Theoretical study of current-voltage characteristics of carbon nanotube wire functionalized with hydrogen atoms

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Science China Chemistry 2012年第5期55卷 796-801页

作者： FUENO Hiroyuki KOBAYASHI Yoshikazu TANAKA kazuyoshi Department of Molecular Engineering Graduate School of Engineering Kyoto University Nishikyo-ku Kyoto 615-8510 Japan

A functionalized single-walled carbon nanotube (SWCNT) of a finite length with a ring-like hydrogenation around its surface is designed toward fabrication of a molecular field-effect transistor (FET) device. The molecular wire thus designed is equipped with a quantum dot inside, which is confirmed by theoretical analysis for electronic transport. In particular, the current-voltage (I-V) characteristics under influence of the gate voltage are discussed in detail.

关键词： single-walled carbon nanotube molecular field-effect transistor molecular wire electron transport

A Study on Viscoelastic Fluid Flow in a Square-Section 90-Degrees Bend

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Journal of Thermal Science 2003年第4期12卷 337-343页

作者： Mizue Munekata kazuyoshi Matsuzaki Hideki Ohba Dept. of Mechanical Engineering and Materials Science Kumamoto University Kurokami 2-39-1 Kumamoto JapanDept. of Mechanical Engineering and Materials Science Kumamoto University Kurokami 2-39-1 Kumamoto JapanDept. of Mechanical Engineering and Materials Science Kumamoto University Kurokami 2-39-1 Kumamoto Japan

It is well known that the drag-reducing effect is obtained in a surfactant solution flow in a straight pipe. We investigate about a viscoelastic fluid flow such as a surfactant solution flow in a square-section 90° bend. In the experimental study, drag-reducing effect and velocity field in a surfactant solution flow are investigated by measurements of wall pressure loss and LDV measurements. For the numerical method, LES with FENE-P model is used in the viscoelastic fluid flow in the bend. The flow characteristics of viscoelastic fluid are discussed compared with that of a Newtonian fluid.

关键词： non-Newtonian flow viscoelastic fluid drag reduction bend flow LES LDV.

Effect of Non-Newtonian Viscosity for Surfactant Solutions on Vortex Characteristics in a Swirling Pipe Flow

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Journal of Thermal Science 2005年第4期14卷 357-361,356页

作者： Mizue MUNEKATA Hidefumi TAKAKI Hideki OHBA kazuyoshi MATSUZAKI Kumamoto University 2-39-1 KurokamiKumamoto 860-8555Japan Tokyo Electron LTD. 650 Mitsuzawa Hosaka-cho NirasakiYamanashi 407-0192Japan

Effects of non-Newtonian viscosity for surfactant solution on the vortex characteristics and drag-reducing rate in a swirling pipe flow are investigated by pressure drop measurements, velocity profile measurements and viscosity measurements. Non-Newtonian viscosity is represented by power-law model （t= kD^π）. Surfactant solution used has shear-thinning viscosity with n 〈 1.0. The swirling flow in this study has decay of swirl and vortex-type change from Rankin＇s combined vortex to forced vortex. It is shown that the effect of shear-thinning viscosity on the decay of swirl intensity is different by vortex category and the critical swirl number with the vortex-type change depends on shear-thinning viscosity.

关键词： swirling flow drag reduction surfactant solution non-Newtonian fluid vortex LDV.