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Journal of Civil Engineering and Architecture 2024年第2期18卷 51-59页

作者： Yasushi Uematsu kazuya takahashi New Industry Creation Hatchery Center Tohoku UniversitySendai 980-8579Japan Engineering Headquarters Shimizu CorporationChuo-kuTokyo 104-8370Japan

The present paper first investigates the collapse behavior of a conventional pipe-framed greenhouse under snow loading based on a 3-D finite element analysis,in which both geometrical and material non-linearities are considered.Three snow load distribution patterns related to the wind-driven snow particle movement are used in the analysis.It is found that snow load distribution affects the deformation and collapse behavior of the pipe-framed greenhouse significantly.The results obtained in this study are consistent with the actual damage observed.Next,discussion is made of the effects of reinforcements by adding members to the basic frame on the strength of the whole structure,in which seven kinds of reinforcement methods are examined.A buckling analysis is also carried out.The results indicate that the most effective reinforcement method depends on the snow load distribution pattern.

关键词： Pipe-framed greenhouse snow loading collapse buckling finite element analysis

Diversion colitis and pouchitis: A mini-review

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World Journal of Gastroenterology 2018年第16期24卷 1734-1747页

作者： Kentaro Tominaga Kenya Kamimura kazuya takahashi Junji Yokoyama Satoshi Yamagiwa Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

Diversion colitis is characterized by inflammation of the mucosa in the defunctioned segment of the colon after colostomy or ileostomy. Similar to diversion colitis, diversion pouchitis is an inflammatory disorder occurring in the ileal pouch, resulting from the exclusion of the fecal stream and a subsequent lack of nutrients from luminal bacteria. Although the vast majority of patients with surgically-diverted gastrointestinal tracts remain asymptomatic, it has been reported that diversion colitis and pouchitis might occur in almost all patients with diversion. Surgical closure of the stoma, with reestablishment of gut continuity, is the only curative intervention available for patients with diversion disease. Pharmacologic treatments using short-chain fatty acids, mesalamine, or corticosteroids are reportedly effective for those who are not candidates for surgical reestablishment; however, there are no established assessment criteria for determining the severity of diversion colitis, and no management strategies to date. Therefore, in this mini-review, we summarize and review various recently-reported treatments for diversion disease. We are hopeful that the information summarized here will assist physicians who treat patients with diversion colitis and pouchitis, leading to better case management.

关键词： Diversion colitis Diversion pouchitis Ileitis Inflammatory bowel disease

Collapse and Reinforcement of Pipe-Framed Greenhouse under Static Wind Loading

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Journal of Civil Engineering and Architecture 2020年第11期14卷 583-594页

作者： Yasushi Uematsu kazuya takahashi National Institute of Technology(KOSEN) Akita CollegeAkita 011-8511Japan Engineering Headquarters Shimizu CorporationChuo-kuTokyo 104-8370Japan

The present paper investigates the collapse process of a pipe-framed greenhouse under static wind loading based on a non-linear finite element analysis.The purpose is to establish a more reasonable wind resistant design method for such structures.The structures are so flexible that the fluid-structure interaction(FSI)is considered in the analysis.In practice,iterative analyses of the structure’s response and the wind pressure distribution on the deformed structure are made.The wind direction is normal to the ridge.Computational fluid dynamics(CFD)analysis with a RANS turbulence model is used for evaluating the time-averaged wind pressure coefficient distribution on the structure.Both the geometric and the material non-linearity are considered in the structural analysis.The collapse behavior obtained is consistent with the practical one often observed in damage investigations.Based on the results,discussion is made of the validity of the current design guideline commonly used in Japan.The same analysis is carried out for various reinforced models.The effect of each reinforcement method on the improvement of wind resistance of the structure is investigated on the basis of the allowable stress and deformation limits specified in the current design guideline.

关键词： Pipe-framed greenhouse static wind loading collapse process reinforcement FSI CFD finite element method(FEM)

Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis

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World Journal of Gastroenterology 2017年第13期23卷 2414-2423页

作者： Hiroki Sato Nao Nakajima kazuya takahashi Go Hasegawa Ken-ichi Mizuno Satoru Hashimoto Satoshi Ikarashi Kazunao Hayashi Yutaka Honda Junji Yokoyama Yuichi Sato Shuji Terai Division of Gastroenterology and Hepatology Niigata University Medical and Dental Hospital Division of Gastroenterology and Hepatology Saiseikai Niigata Daini Hospital Division of Cellular and Molecular Pathology Department of Cellular FunctionNiigata University Graduate School of Medical and Dental Sciences

AIM To define clinical criteria to differentiate eosinophilic gastrointestinal disorder(Eo GD) in the esophagus. METHODS Our criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis(Eo E), subepithelial eosinophilic esophagitis(s Eo E) and eosinophilic esophageal myositis(Eo EM), identified by endoscopy, manometry and serum immunoglobulin E levels(s-Ig E), in combination with histological and polymerase chain reaction analyses on esophageal tissue samples.RESULTS In five patients with Eo E, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with s Eo E and four with Eo EM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with Eo E and s Eo E with some variation, while Eo EM was associated with hypercontractile or hypertensive peristalsis, with elevated s-Ig E. Histology revealed the following eosinophils per high-power field values. Eo E = 41.4 ± 7.9 in the epithelium and 2.3 ± 1.5 in the subepithelium; s Eo E = 3 in the epithelium and 35 in the subepithelium(conventional biopsy); Eo EM = none in the epithelium, 10.7 ± 11.7 in the subepithelium(conventional biopsy or endoscopic mucosal resection) and 46.8 ± 16.5 in the muscularis propria(peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to Eo E. Eotaxin-3, IL-5 and IL-13 were overexpressed in Eo E.CONCLUSION Based on clinical and histological data, we identified criteria, which differentiated between Eo E, s Eo E and Eo EM, and reflected a different pathogenesis between these esophageal Eo GDs.

关键词：嗜曙红的食道炎嗜曙红的食道的肌炎 Peroral 内视镜的肌切开术手提钻食管 Achalasia Peroral 食道的肌肉活体检视

Vonoprazan 20 mg vs lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers

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World Journal of Gastrointestinal Endoscopy 2016年第19期8卷 716-722页

作者： kazuya takahashi Yuichi Sato Junji Kohisa Jun Watanabe Hiroki Sato Kenichi Mizuno Satoru Hashimoto Shuji Terai Department of Endoscopy Niigata University Medical and Dental Hospital Division of Gastroenterology and Hepatology Sado General Hospital Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata University Division of Gastroenterology and Hepatology Nagaoka Red Cross Hospital

AIM To compare the healing effects of vonoprazan and lansoprazole on gastric ulcers induced by endoscopic submucosal dissection(ESD).METHODS Data were obtained from a total of 26 patients.Fourteen patients were randomized to the vonoprazan group and 12 were randomized to the lansoprazole group.Patients were administered either 20 mg vonoprazan or 30 mg lansoprazole per day after ESD.Endoscopic images just after ESD,on day 8,and on day 28 were used for the evaluation of the shrinking rate of ESD ulcers.The shrinking rates and the incidence of delayed bleeding were compared between the 2 groups.RESULTS The shrinking rates of ESD ulcers on day 8 [vonoprazangroup: 61.8%(range: 24.0%-91.1%),lansoprazole group: 71.3%(range: 25.2%-88.6%)] and on day 28 [vonoprazan group: 95.3%(range: 76.2%-100%),lansoprazole group: 97.2%(range: 81.1%-99.8%)] were not statistically different between the 2 groups.On day 28,most of the ulcers in both groups healed to more than 90%,whereas 3 of 14(21.4%) in the vonoprazan group and 1 of 12(8.3%) in the lansoprazole group had delayed ulcer healing,which was not statistically different(P = 0.356).The frequency of delayed bleeding was 0 in the both groups.Taken together,there were no significant differences between the two drug groups.CONCLUSION Our study indicates that vonoprazan is potent for the management of ESD ulcers although lansoprazole is also sufficient and cost-effective.

关键词： Lansoprazole 胃的癌症内视镜的 submucosal 解剖钾竞争的酸 blocker 质子泵禁止者 Vonoprazan

Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor

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World Journal of Gastrointestinal Endoscopy 2017年第12期9卷 583-589页

作者： Kazunao Hayashi Kenya Kamimura Kazunori Hosaka Satoshi Ikarashi Junji Kohisa kazuya takahashi Kentaro Tominaga Kenichi Mizuno Satoru Hashimoto Junji Yokoyama Satoshi Yamagiwa kazuyasu Takizawa Toshifumi Wakai Hajime Umezu Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University Division of Digestive and General Surgery Graduate School of Medical and Dental Sciences Niigata University Department of Pathology Niigata University Medical and Dental Hospital

Duodenal gastrointestinal stromal tumors(GISTs) are extremely rare disease entities, and the extraluminal type is difficult to diagnose. These tumors have been misdiagnosed as pancreatic tumors; hence, pancreaticoduodenectomy has been performed, although partial duodenectomy can be performed if accurately diagnosed. Developing a diagnostic methodology including endoscopic ultrasonography(EUS) and fine-needle aspiration(FNA) has allowed us to diagnose the tumor directly through the duodenum. Here, we present a case of a 50-year-old woman with a 27-mm diameter tumor in the pancreatic uncus on computed tomography scan. EUS showed a well-defined hypoechoic mass in the pancreatic uncus that connected to the duodenal proper muscular layer and was followed by endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA). Histological examination showed spindle-shaped tumor cells positively stained for c-kit. Based on these findings, the tumor was finally diagnosed as a duodenal GIST of the extraluminal type, and the patient underwent successful mass resection with partial resection of the duodenum. This case suggests that EUS and EUS-FNA are effective for diagnosing the extraluminal type of duodenal GISTs, which is difficult to differentiate from pancreatic head tumor, and for performing the correct surgical procedure.

关键词： Gastrointestinal stromal tumor Duodenum Extraluminal type Pancreatic head tumor Endoscopic ultrasonography Endoscopic ultrasound-guided fineneedle aspiration Partial resection

Genetic diversity in Japanese populations of the Eurasian Collared Dove

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Avian Research 2020年第2期11卷 133-138页

作者： kazuya Nagai Yusuke takahashi Ken‑ichi Tokita Tomomi Anzai Kiyoshi Uchida Fumihito Nakayama Faculty of Agriculture Iwate UniversityMoriokaIwate 020‑8550Japan Research and Education Centre for Natural Sciences Keio UniversityYokohamaKanagawa 223‑8521Japan Japan Wildlife Research Centre KotoTokyo 130‑8606Japan Satoyama Natural History Study Group AbikoChiba 270‑1153Japan.

Background:Eurasian Collared Dove(Streptopelia decaocto)is a species distributed in the Eurasian continent and North Africa,and inhabiting mainly in Saitama Prefecture in Japan.Eurasian Collared Dove is one of the most prosper-ous invaders in the world,and Japanese Eurasian Collared Dove has also been introduced from overseas.The Japa-nese population has declined to one-hundredth over 30 years and is being protected.In this study,we analyzed its genetic diversity in order to understand the genetic differences between wild populations of Eurasian Collared Dove and those bred in zoos.Methods:A sequence of about 1.9 kb mtDNA was determined for 20 wild Eurasian Collared Doves living in Saitama,Japan and 20 zoo-bred Eurasian Collared Doves,and population genetic analysis was performed.Results:In the COI gene,778 bp had the same sequence in all the 40 individuals examined,and no mutation sites could be confirmed.In the control region,two base substitution sites were confirmed in 1140 bp long sequence.Three haplotypes were detected in 20 individuals in wild,whereas all 20 zoo-bred individuals possessed the same haplotypes possessed in the wild population.Conclusion:Haplotypes of zoo-bred individuals were also retained among the wild individuals,confirming that no genetic problems could occur if the zoo-bred individuals were released to the wild for the Japanese Eurasian Collared Dove propagation program.

关键词： COI Control region Eurasian Collared Dove Genetic diversity mtDNA Phylogeography