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Efficacy of MRP8/14 as a Marker of Disease Activity in Rheumatoid Arthritis

Open Journal of Rheumatology and Autoimmune Diseases 2016年第2期6卷 34-39页

作者： Tetsuro Yamasaki Ryo Oda Kan Imai Daigo Taniguchi Shogo Toyama Takahiro Seno Yuji Arai kazuya ikoma Hiroyoshi Fujiwara Daisaku Tokunaga Yutaka Kawahito Toshikazu Kubo Department of Orthopaedics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan Department of Inflammation and Immunology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan

Objective: Early and accurate evaluation of the presence and activity of synovitis is extremely important in the diagnosis and treatment of rheumatoid arthritis. Myeloid related protein 8/14 (MRP8/14), also known as calprotectin or S100A8/A9 is considered as a sensitive marker for local inflammatory activity in rheumatoid arthritis. The aim of this study is to demonstrate the efficacy of MRP8/14 as a marker of disease activity in RA. Methods: Thirty-one patients with diagnosis of RA who received treatment without biological drugs at our institution were included in this study. Serum MRP8/14, CRP and MMP-3 were tested in all patients. Disease activity was evaluated using DAS28-CRP and SDAI. Ultrasonography was performed on the wrists and MCP joints of both hands using semi-quantitative scale of power Doppler signal. The sum of scales in joints was calculated as the PD score. The correlation of MRP8/14 with serum biomarkers, disease activity and ultrasonography examination was investigated. Result: Serum MRP8/14 was strongly correlated with CRP (r = 0.63) and MMP-3 (r = 0.69). A correlation was observed between serum MRP8/14 and DAS28-CRP (r = 0.53) and SDAI (r = 0.66). No significant correlation was found between PD scores and MRP8/14. Conclusion: This study demonstrated that MRP8/14 is correlated with evaluated disease activity and markers of serum inflammatory response in patients not using biological drugs. MRP8/14 is considered an effective new method for objective evaluation of synovitis in RA.

关键词： Rheumatoid Arthritis Myeloid Related Protein 8/14 (MRP8/14) Calprotectin Disease Activity

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