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Tumor size discrepancy between endoscopic and pathological evaluations in colorectal endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 136-147页

作者： Takeshi Onda Osamu Goto Toshiaki Otsuka Yoshiaki Hayasaka Shun Nakagome Tsugumi Habu Yumiko Ishikawa Kumiko Kirita Eriko Koizumi Hiroto Noda kazutoshi Higuchi Jun Omori Naohiko Akimoto Katsuhiko Iwakiri Department of Gastroenterology Nippon Medical SchoolGraduate School of MedicineBunkyo-ku 113-8603TokyoJapan Endoscopy Center Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Hygiene and Public Health Nippon Medical SchoolBunkyoku 113-8603TokyoJapan Center for Medical Education Nippon Medical SchoolBunkyo-ku 113-8603TokyoJapan

BACKGROUND Tumor size impacts the technical difficulty and histological curability of colorectal endoscopic submucosal dissection(ESD);however,the preoperative evaluation of tumor size is often different from histological *** influential factors on failure to obtain an accurate tumor size evaluation could help prepare optimal conditions for safer and more reliable *** This was a retrospective study conducted at a single institution.A total of 377 lesions removed by colorectal ESD at our hospital between April 2018 and March 2022 were *** first assessed the difference in size with an absolute per-centage of the scaling ***,we compared the clinicopatho-logical characteristics of the correct scaling group(>-33%and33%),which was further subdivided into the underscaling group(-33%or less of the discrepancy)and overscaling group(33%or more of the discrepancy),*** secondary outcome measures,parameters on size estimation were compared between the underscaling and correct scaling groups,as well as between the overscaling and correct scaling ***,multivariate analysis was performed in terms of the following relevant parameters on size estimation:Pathological size,location,and possible influential factors(P<0.1)in the univariate *** The mean of absolute percentage in the scaling discordance was 21%,and 91 lesions were considered to be incorrectly estimated in *** incorrect scaling was significantly remarkable in larger lesions(40 mm vs 28 mm;P<0.001)and less experience(P<0.001),and these two factors were influential on the underscaling(75 lesions;P<0.001).Conversely,compared with the correct scaling group,16 lesions in the overscaling group were significantly small(20 mm vs 28 mm;P<0.001),and the small lesion size was influential on the overscaling(P=0.002).CONCLUSION Lesions indicated for colorectal ESD tended to be underestimate

关键词： Endoscopic submucosal dissection Colorectal tumor Tumor size Size estimation Size discrepancy

Recent development of Faith conjecture

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Frontiers of Mathematics in China 2016年第4期11卷 933-947页

作者： kazutoshi KOIKE Kiyoichi OSHIRO Okinawa National College of Technology Okinawa Japan Yamaguchi University Yamaguchi Japan

Is a semiprimary right self-injective ring a quasi-Frobenius ring？ Almost half century has passed since Faith raised this problem. He first conjectured “No” in his book Algebra II. Ring Theory in 1976, but changing his mind, he conjectured “Yes” in his article “When self-injective rings are QF： a report on a problem” in 1990. In this paper, we describe recent studies of this problem based on authors works and raise related problems.

关键词： Semiprimary right self-injective ring Faith conjecture division algebra D (D,D)-space ErdSs-Kaplansky's theorem quasi-Frobenius ring Nakayama permutation

Nickel Electroplating

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材料热处理学报 2004年第5B期25卷 1122-1125页

作者： Toru Murakami Yasuo Uchikoshiki kazutoshi Komori C.Uyemura. & Co. Ltd. Osaka JapanUyemura-Solar(Shenzhen)Co.Ltd Shenzhen ChinaUyemura(Shanghai)Co.Ltd Shanghai China

Nickel electroplating has been used practically for decades, is easy to plate, but there is an unknown interest in it. Nickel electroplating as a basis of surface treatment is shown practically from basics to the applied electronics use. At first the basics of nickel electroplating, for example, purpose, use, merit & demerit, nickel plating solution, current efficiency, limiting current density, additional agents and their behaviors are surveyed. And the points of nickel deposition already practically used such as decorative nickel plating, satin nickel plating and functional nickel plating, which has very high throwing power and has been used for electronics, are described in detail.

关键词：镍电镀电积能力表面处理应用

Antarctic Radiosonde Observations Reduce Uncertainties and Errors in Reanalyses and Forecasts over the Southern Ocean:An Extreme Cyclone Case

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Advances in Atmospheric Sciences 2020年第5期37卷 431-440页

作者： kazutoshi SATO Jun INOUE Akira YAMAZAKI Naohiko HIRASAWA Konosuke SUGIURA Kyohei YAMADA Kitami Institute of Technology Kitami 090-8507Japan Application Laboratory Japan Agency for Marine-Earth Science and TechnologyYokohama 236-0001Japan National Institute of Polar Research Tachikawa 190-8518Japan SOKENDAI(Graduate University for Advanced Studies) Hayama 240-0193Japan University of Toyama Toyama 930-8555Japan

Cyclones with strong winds can make the Southern Ocean and the Antarctic a dangerous *** weather forecasts are essential for safe shipping in the Southern Ocean and observational and logistical operations at Antarctic research *** study investigated the impact of additional radiosonde observations from Research Vessel"Shirase"over the Southern Ocean and Dome Fuji Station in Antarctica on reanalysis data and forecast experiments using an ensemble data assimilation system comprising the Atmospheric General Circulation Model for the Earth Simulator and the Local Ensemble Transform Kalman Filter Experimental Ensemble Reanalysis,version 2.A 63-member ensemble forecast experiment was conducted focusing on an unusually strong Antarctic cyclonic *** data with(observing system experiment)and without(control)additional radiosonde data were used as initial *** observing system experiment correctly captured the central pressure of the cyclone,which led to the reliable prediction of the strong winds and moisture transport near the ***,the control experiment predicted lower wind speeds because it failed to forecast the central pressure of the cyclone *** were found in cyclone predictions of operational forecast systems with and without assimilation of radiosonde observations from Dome Fuji Station.

关键词： radiosonde data assimilation TIGGE Antarctica weather forecast

Genetic polymorphisms in glutathione S-transferase T1 affect the surgical outcome of varicocelectomies in infertile patients

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Asian Journal of Andrology 2009年第3期11卷 333-341页

作者： Kentaro Ichioka Kanji Nagahama kazutoshi Okubo Takeshi Soda Osamu Ogawa Hiroyuki Nishiyama Department of Urology Kyoto University Graduate School of Medicine Kyoto 606-8507 Japan

Glutathione S-transferases （GSTs）, superoxide dismutase 2 （SOD2） and NAD（P）H：quinone oxidoreductase 1 （NQO1） are anti-oxidant enzyme genes. Polymorphisms of GSTs, SOD2 and NQO1 have been reported to influence individual susceptibility to various diseases. In an earlier study, we obtained preliminary findings that a subset of glutathione S-transferase 7：1 （GSTT1）-wt patients with varicocele may exhibit good response to varicocelectomy. In this study, we extended the earlier study to determine the distribution of genotype of each gene in the infertile population and to evaluate whether polymorphism of these genes affects the results of surgical treatment of varicocele. We analyzed 72 infertile varicocele patients, 202 infertile patients without varicocele and 101 male controls. Genotypes of GSTs were determined by polymerase chain reaction （PCR）. Genotyping of SOD2 and NQO1 was performed using the PCR-restriction fragment length polymorphism （PCR-RFLP） method. A significantly better response to varicocelectomy was found in patients with the GSTTI-wt genotype （63.2%） and NQO1-Ser/Ser genotype （80.0%） than in those with GSTTI-null genotype （35.3%） and NQO1-Pro/Pro or NQO1- Pro/Ser genotype （45.2%）, respectively. The frequencies of glutathione S-transferase M1/T1, SOD2 and NQO1 genotypes did not differ significantly among the varicocele patients, idiopathic infertile patients and male controls. GSTT1 genotype is associated with improvement of semen parameters after varicocelectomy. As the number of patients with NQO1-Ser/Ser genotype was not sufficient to reach definite conclusions, the association of NQO1 genotype with varicocelectomy requires further investigation.

关键词： genetic polymorphism GSTM1 GSTT1 male infertility NQO1 SOD2 varicocele testis

Genetic variants involved in gallstone formation and capsaicin metabolism,and the risk of gallbladder cancer in Chilean women

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World Journal of Gastroenterology 2010年第3期16卷 372-378页

作者： Sergio Báez Yasuo Tsuchiya Alfonso Calvo Martha Pruyas kazutoshi Nakamura Chikako Kiyohara Mari Oyama Masaharu Yamamoto Department of Surgery Sótero del Río Hospital Department of Community Preventive Medicine Niigata University Graduate School of Medical and Dental Sciences Department of Anatomic Pathology Sótero del Río Hospital Department of Preventive Medicine Graduate School of Medical SciencesKyushu University Faculty of Health Sciences Niigata University of Health and Welfare

AIM:To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC).METHODS: A total of 57 patients with GBC, 119 patients with gallstones, and 70 controls were enrolled in this study. DNA was extracted from their blood or paraffi n block sample using standard commercial kits. The statuses of the genetic variants were assayed using Taqman SNP Genotyping Assays or Custom Taqman SNP Genotyping ***:The non-ancestral T/T genotype of apolipoprotein B rs693 polymorphism was associated with a decreased risk of GBC (OR:0.14,95% CI:0.03-0.63). The T/T genotype of cholesteryl ester transfer protein (CETP) rs708272 polymorphism was associated with an increased risk of GBC (OR:5.04,95% CI:1.43-17.8).CONCLUSION: Genetic variants involved in gallstone formation such as the apolipoprotein B rs693 and CETP rs 708272 polymorphisms may be related to the risk of developing GBC in Chilean women.

关键词： Genetic risk factor Gallbladder cancer Gallstone Genetic polymorphism Apolipoprotein B Cholesteryl ester transfer protein

Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?

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World Journal of Gastroenterology 2009年第34期15卷 4290-4297页

作者： Katsuhiro Mabe Mikako Takahashi Haruhumi Oizumi Hideaki Tsukuma Akiko Shibata kazutoshi Fukase Toru Matsuda Hiroaki Takeda Sumio Kawata Division of Gastroenterology KKR Sapporo Medical Center Internal Medicine Tsuruoka Kyoritsu Hospital Internal Medicine Oizumi Medical Clinic Department of Cancer Control and Statistics Osaka Medical Center for Cancer and Cardiovascular Diseases Yamagata Prefectural Medical Center for Cancer and Lifestyle-Related Disease Internal Medicine Yamagata Prefectural Central Hospital Yamagata Prefectural Shonai Public Health Center Department of Gastroenterology Faculty of MedicineYamagata University

AIM:To investigate the effects of Helicobacter pylori (H pylori)eradication therapy for treatment of peptic ulcer on the incidence of gastric cancer. METHODS:A multicenter prospective cohort study was conducted between November 2000 and December 2007 in Yamagata Prefecture,*** study included patients with H pylori-positive peptic ulcer who decided themselves whether to receive H pylori eradication(eradication group)or conventional antacid therapy(non-eradication group).Incidence of gastric cancer in the two groups was determined based on the results of annual endoscopy and questionnaire surveys,as well as Yamagata Prefectural Cancer Registry data,and was compared between the two groups and by results of H pylori ***:A total of 4133 patients aged between 13 and 91 years(mean 52.9 years)were registered,and 56 cases of gastric cancer were identified over a mean follow-up of 5.6 *** sex-and age-adjusted incidence ratio of gastric cancer in the eradication group, as compared with the non-eradication group,was 0.58 (95%CI:0.28-1.19)and ratios by follow-up period(3 years)were 1.16(0.27-5.00),0.50 (0.17-1.49),and 0.34(0.09-1.28),*** follow-up tended to be associated with better prevention of gastric cancer,although not to a significant *** significant difference in incidence of gastric cancer was observed between patients with successful eradication therapy(32/2451 patients,1.31%)and those with treatment failure(11/639 patients,1.72%).Among patients with duodenal ulcer,which is known to be more prevalent in younger individuals,the incidence of gastric cancer was significantly less in those with successful eradication therapy(2/845 patients,0.24%)than in those with treatment failure(3/216 patients,1.39%). CONCLUSION:H pylori eradication therapy for peptic ulcer patients with a mean age of 52.9 years at registration did not significantly decrease the incidence of gastric cancer.

关键词：胃癌临床治疗 HETODS

Effect of electro-acupuncture on the expression of heat shock protein-70 gene in rat spinal cords following spinal cord injury

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Neural Regeneration Research 2007年第12期2卷 722-726页

作者： Zean Zhang Qiangli Wang Yuzhu Zhi Jie Li Hiroko Nonaka kazutoshi Sibuya Department of Histology and Embryology Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Department of Surgical Pathology Toho University School of Medicine Tokyo 143-8540 Japan

BACKGROUND： It is generally believed that the mechanism by which heat shock protein-70 （HSP70） protects cells is related to its effectiveness in maintaining the normal stereochemical structure of intracellular proteins, and in participating in the process of cell apoptosis. Whether electro-acupuncture participates in HSP70 expression and produces neuroprotective effects remain unclear. OBJECTIVE： This study aimed at detecting HSP70 expression after electro-acupuncture in rats with transected spinal cord, in order to further validate the mechanism of electro-acupuncture-induced effects in the treatment of spinal cord injury. DESIGN： A controlled observational experiment. SETTING： Shanghai University of Traditional Chinese Medicine and Toho University, School of Medicine. MATERIALS： Seventy adult male Sprague-Dawley rats of SPF grade, weighing 200± 20 g, were provided by the Laboratory Animal Center of Shanghai University of Traditional Chinese Medicine, with permission No. SYXK （hu） 2004 - 2005. The animals were handled in accordance with the requests from Animal Ethics Committees for guidance. A G6805-2 multiple purpose treatment machine was used （Shanghai Medical Instruments High-Tech Co.,Ltd., Shanghai, China）. METHODS： This study was carried out in the state level laboratories of Shanghai University of Traditional Chinese Medicine and Toho University, School of Medicine between January 2005 and July 2007. The rats were randomly divided into the electro-acupuncture treated group, which received electro-acupuncture treatment in addition to spinal cord surgery and the control group, which received only spinal cord surgery, with 35 rats in each group. All the rats underwent the same surgery consisting of spinal cord transection at the T10 level. If the spinal cord was completely transected and the two posterior limbs were completely paralyzed, then the surgery was considered successful and the animal was kept for further analysis and testing. After surgery,

关键词： electro-acupuncture spinal cord injury heat shock protein-70 rats

Serum Neutrophil Gelatinase-associated Lipocalin(NGAL)Is Elevated in Patients with Asthma and Airway Obstruction

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Current Medical Science 2021年第2期41卷 323-328页

作者： Junichiro Kawagoe Yuta Kono Yuki Togashi Mayuko Ishiwari kazutoshi Toriyama Chika Yajima Hideaki Nakayama Satoshi Kasagi Shinji Abe Yasuhiro Setoguchi Deparment of Respiralory Medicine Tokyo Medical UniversityTokyo 160-0023Japan Department of Respiratory Medicine Toranomon HospitalTokyo 105-8470Japan Deparment of Respiratory Medicine Tokyo Medical and Dental UnriversityTokyo 113-8510Japan

Neutrophilic airway inflammation is one of the features of severe *** gelatinase-associated lipocalin(NGAL),or lipocalin-2,is a glycoprotein associated with neutrophilic inflammation and can be detected in ***,blood NGAL levels have been reported to be elevated in chronic obstructive pulmonary ***,the clinical significance of serum NGAL levels in patients with asthma has not been *** aim of this study was to explore the association between serum NGAL level and clinical parameters in patients with *** non-smoking people with stable asthma were enrolled in this *** patients underwent blood ollction and pulmonary function *** associations between serum NGAL levels and clinical parameters were analyzed *** NGAL levels in patients with asthma and obstructive ventilatory defect were higher than those in patients with asthma without obstructive ventilatory defect(76.4±51.4 ng/mL vs.39.3±27.4 ng/mL,P=0.0019).Serum NGAL levels were correlated with forced expired flow at 50%of vital capacity%predicted and forced expired flow at 75%of vital capacity%predicted(r=-0.3373,P=0.0078 and r=0.2900,P=0.0234,respectively).Results of a multiple regression analysis demonstrated that serum NGAL level was independently associated with obstructive ventilatory *** NGAL levels were elevated in patients with asthma and obstructive ventilatory *** may be involved in airway remodeling possibly mediated by neutrophilic inflammation in asthma.

关键词： asthma airflow obstruction neutrophil gelatinase-associated lipocalin airway remodeling