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Chinese Journal of Cancer 2016年第8期35卷 410-415页

作者： Hironori Shiozaki Yusuke Shimodaira Elena Elimova Roopma Wadhwa Kazuki Sudo kazuto Harada Jeannelyn S.Estrella Prajnan Das Brian Badgwell Jaffer A.Ajani Department of Gastrointestinal Medical Oncology Unit 426The University of Texas MD Anderson Cancer Center1515 Holcombe BlvdHoustonTX 77030USA National Cancer Center Hospital Tokyo 104-0045Japan Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Surgical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Surgical management of gastric cancer improves ***,for some time,surgeons have had diverse opinions about the extent of *** have conducted many clinical studies,making slow but steady progress in determining the optimal surgical *** extent of lymph node dissection has been one of the major issues in surgery for gastric *** trials demonstrated that D2 dissection resulted in greater morbidity and mortality than D1 ***,long-term outcomes demonstrated that D2 dissection resulted in longer survival than D1 *** 2004,the Japan Clinical Oncology Group reported a pivotal trial which was performed to determine whether para-aortic lymph node dissection combined with D2 dissection was superior to D2 dissection alone and found no benefit of the additional *** with pancreatectomy,splenectomy,and bursectomy was initially recommended as part of the D2 ***,pancreas-preserving total gastrectomy with D2 dissection is standard,and ongoing trials are addressing the role of ***,the feasibility and safety of laparoscopic gastrectomy are well *** and quality of life are increasingly recognized as the most important *** this review,we present perspectives on surgical techniques and important trials of these techniques in gastric cancer patients.

关键词： Gastric cancer Gastrectomy Laparoscopic gastrectomy Lymph node dissection

Effects of Improving Durability of Concrete by AQUA CURTAIN Curing and Its Application m Development of the New Wet Curing Method

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Journal of Civil Engineering and Architecture 2012年第5期6卷 574-585页

作者： Yukinori Furukawa kazuto Fukudome Yasuhiro Mitani Civil Engineering Division Hazama Corporation Tokyo Japan Department of Civil and Structural Engineering Graduate School of Engineering Kyushu University Fukuoka Japan

We report a wet curing system developed and made suitable for practical application to curing the interior and verticalconcrete surfaces of tunnel linings after the formwork has been removed. In this system, air is evacuated from the gap between the curing sheet and the concrete surface to create a close contact, and by supplying water to the space between the contacting surfaces, a water film is formed over the concrete surface. This enables the wet curing of vertical concrete surfaces and interior surfaces of tunnel linings after the formwork has been removed, a process that has to date been difficult. In this paper, the effects of wet curing on improving the durability of concrete are verified, and examples of the application of wet curing to actual structures are presented.

关键词： Wet curing freeze-thaw resistance carbonation resistance pore structure tunnel lining concrete.

Intra-abdominal ectopic bronchogenic cyst with a mucinous neoplasm harboring a GNAS mutation: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8709-8717页

作者： Takashi Murakami Hiroaki Shimizu kazuto Yamazaki Hiroyuki Nojima Akihiro Usui Chihiro Kosugi KiyohikoShuto Shuntaro Obi Takahisa Sato Masato Yamazaki Keiji Koda Department of Surgery Teikyo University Chiba Medical CenterIchihara 299-0111ChibaJapan Department of Pathology Teikyo University Chiba Medical CenterIchihara 299-0111ChibaJapan Department of Internal Medicine Teikyo University Chiba Medical CenterIchihara 299-0111ChibaJapan

BACKGROUND Bronchogenic cysts are congenital cysts caused by abnormal sprouting from the ventral foregut during fetal *** usually occur in the mediastinum or lung,but there are very rare cases of ectopic bronchogenic cysts that develop in the abdominal cavity.A unique intra-abdominal ectopic bronchogenic cyst with a mucinous neoplasm that was producing carcinoembryonic antigen(CEA),harboring a GNAS mutation,is *** present case may contribute to clarifying the mechanism of tumorigenesis and malignant transformation of ectopic bronchogenic *** SUMMARY In 2007,a man in his 50s was incidentally found to have an intra-abdominal cystic mass,8 cm in *** resection was recommended,but he preferred to remain under *** 2020,his serum CEA level increased to 26.7 ng/mL,and abdominal computed tomography showed a 15 cm×12 cm,multifocal,cystic mass located predominantly on the lesser curvature of the *** malignancy could not be ruled out,he finally underwent surgical ***,the cystic wall was lined by ciliated columnar epithelium,accompanied by bronchial gland-like tissue,bronchial cartilage,and smooth *** of the cyst consisted of atypical columnar epithelium with an MIB-1 index of 5%and positive for ***,a GNAS mutation(p.R201C)was detected in the atypical epithelium,leading to a diagnosis of an ectopic bronchogenic cyst with a low-grade mucinous *** patient is currently undergoing outpatient follow-up without *** An extremely rare case of an abdominal bronchogenic cyst with a low-grade mucinous neoplasm harboring a GNAS mutation was reported.

关键词： Congenital,hereditary,and neonatal diseases and abnormalities Ectopic bronchogenic cyst Abdominal neoplasms GNAS mutation Carcinoembryonic antigen Case report

Diagnosis of intestinal tuberculosis using a monoclonal antibody to Mycobacterium tuberculosis

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World Journal of Gastroenterology 2012年第47期18卷 6974-6980页

作者： Yasushi Ihama Akira Hokama Kenji Hibiya kazuto Kishimoto Manabu Nakamoto Tetsuo Hirata Nagisa Kinjo Haley L Cash Futoshi Higa Masao Tateyama Fukunori Kinjo Jiro Fujita Department of Infectious Respiratoryand Digestive MedicineFaculty of MedicineUniversity of the RyukyusOkinawa 903-0215Japan Department of Endoscopy Ryukyu University HospitalOkinawa 903-0215Japan

AIM:To investigate the utility of immunohistochemical(IHC) staining with an antibody to Mycobacterium tuberculosis(***) for the diagnosis of intestinal tuberculosis(TB).METHODS:We retrospectively identified 10 patients(4 males and 6 females;mean age = 65.1 ± 13.6 years) with intestinal *** characteristics,including age,gender,underlying disease,and symptoms were *** radiograph and laboratory tests,including sputum Ziehl-Neelsen(ZN) staining,*** culture,and sputum polymerase chain reaction(PCR) for tubercle bacilli DNA,as well as Tuberculin skin test(TST) and QuantiFERON-TB gold test(QFT),were *** records recorded on the basis of Sato's classification were also reviewed,in addition to data from intestinal biopsies examined for histopathological findings,including hematoxylin and eosin staining,and ZN staining,as well as *** culture,and PCR for tubercle bacilli *** the present study,archived formalin-fixed paraffin-embedded(FFPE) intestinal tissue samples were immunohistochemically stained using a commercially available species-specific monoclonal antibody to the 38-kDa antigen of the *** *** sections were also stained with the pan-macrophage marker CD68 ***:From the clinical data,we found that no patients were immunocompromised,and that the main symptoms were diarrhea and weight *** patients displayed active pulmonary TB,six patients(60%) had a positive TST,and 4 patients(40%) had a positive *** findings revealed that all patients had type 1 findings(linear ulcers in a circumferential arrangement or linear ulcers arranged circumferentially with mucosa showing multiple nodules),all of which were located in the right hemicolon and/or terminal *** patients(70%) had concomitant healed lesions in the ileocecal *** acid-fast bacilli were detected with ZN staining of the intestinal tissue samples,and both *** culture and PCR

关键词： Colonoscopy Intestinal tuberculosis Immunohistochemistry Monoclonal antibody Mycobacterium tuberculosis

Clinical and radiological feature of lymphoepithelial cyst of the pancreas

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World Journal of Gastroenterology 2014年第45期20卷 17247-17253页

作者： Hirofumi Terakawa Isamu Makino Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro Tajima Hirohisa Kitagawa Takashi Fujimura Dai Inoue kazuto Kozaka Toshifumi Gabata Tetsuo Ohta Department of Gastroenterologic surgery Graduate School of Medical Science Kanazawa University Department of Radiology Graduate School of Medical Science Kanazawa University

A lymphoepithelial cyst(LEC)of the pancreas is a rare benign *** patients with LEC of the pancreas have a good prognosis,it is important that these lesions are accurately differentiated from other more aggressive pancreatic neoplasms for an appropriate treatment *** studies have reported that a definitive diagnosis of LEC often cannot be obtained based solely on the findings of preoperative imaging(e.g.,Computed tomography or Magnetic resonance imaging).In this study,we reviewed four cases of pancreatic LECs to investigate the feature of *** reviewed these cases with regard to symptoms,imaging findings,surgical procedures,and other clinical *** found that LEC was associated with unique characteristics on imaging findings.A preoperative diagnosisof LEC may be possible by comprehensively evaluating its clinical and imaging findings.

关键词： Lymphoepithelial cyst Preoperative diagno-sis Magnetic resonance imaging

Refractory case of ulcerative colitis with idiopathic thrombocytopenic purpura successfully treated by Janus kinase inhibitor tofacitinib:A case report

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World Journal of Clinical Cases 2020年第24期8卷 6389-6395页

作者： Yoriaki Komeda Toshiharu Sakurai Arito Hashimoto Tomoyuki Nagai Satoru Hagiwara Masatoshi Kudo Kazuko Sakai kazuto Nishio Yasuyoshi Morita Itaru Matsumura Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka 589-8511Japan Department of Genome Biology Kindai University Faculty of MedicineOsaka 589-8511Japan Department of Hematology and Rheumatology Kindai University Faculty of MedicineOsaka 589-8511Japan

BACKGROUND Concomitant ulcerative colitis (UC) and idiopathic thrombocytopenic purpura(ITP) is a rare phenomenon. The management of UC with ITP can be challenging,since a decreased platelet count augments *** SUMMARY A 24-year-old man with UC and steroid-resistant ITP experienced UC *** continuous infusion of cyclosporine was initiated, UC did not *** administration of tofacitinib subsequently led to the induction of *** patient has maintained remission of UC and ITP for over one year ontofacitinib treatment. Whole transcriptomic sequencing was performed forinflamed rectal mucosae obtained before and after the initiation of Janus kinase(JAK) inhibitor, suggesting that distinct molecular signatures seemed to beregulated by JAK inhibitors and other conventional therapies including tumornecrosis factor *** Tofacitinib should be considered in refractory cases of UC with ITP.

关键词： Ulcerative colitis Idiopathic thrombocytopenic purpura Tofacitinib Whole transcriptome analysis Case report Predictive biomarker

Dietary characteristics of the Malayan Night Heron (Gorsachius melanolophus) in the Yaeyama Islands,southern Japan

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Chinese Birds 2011年第2期02卷 87-93页

作者： kazuto KAWAKAMI Masaki FUJITA Motohiro HASEGAWA Hiroshi MAKIHARA Forestry and Forest Products Research Institute Okinawa Prefectural Museum and Art Museum

The Malayan Night Heron (Gorsachius melanolophus) inhabits a range of tropical and subtropical zones in South,Southeast and East *** this heron breeds singularly in dense forests,its detailed ecology is not well known and only piecemeal information on its diet is ***,we quantitatively estimated its diet menu with an analysis of pellets and stomach contents in the subtropical Yaeyama Islands of southern *** results showed that the heron frequently foraged on land snails,arachnids,freshwater crabs and insects;no fish were *** the earthworm was believed to be a primary dietary source of this species,it was not detected in our results,as it does not remain in pellets due to its high *** indicated that this bird dominantly depends on soil animals that inhabit humid forest *** the heron does not directly utilize aquatic habitats,they likely prefer moist forests caused by watery environments such as streams and *** forests should be conserved for maintaining populations of this heron species.

关键词： diet Gorsachius melanolophus pellet analysis soil animal

Liver physiology and liver diseases in the elderly

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World Journal of Gastroenterology 2013年第46期19卷 8459-8467页

作者： kazuto Tajiri Yukihiro Shimizu Third Department of Internal Medicine Toyama University Hospital Gastroenterology Unit Nanto Municipal Hospital

The liver experiences various changes with aging that could affect clinical characteristics and outcomes in patients with liver *** liver volume and blood flow decrease significantly with *** changes and decreased cytochrome P450 activity can affect drug metabolism,increasing susceptibility to drug-induced liver *** responses against pathogens or neoplastic cells are lower in the elderly,although these individuals may be predisposed to autoimmunity through impairment of dendritic cell maturation and reduction of regulatory T *** changes in immune functions could alter the pathogenesis of viral hepatitis and autoimmune liver diseases,as well as the development of hepatocellular ***,elderly patients have significantly decreased reserve functions of various organs,reducing their tolerability to treatments for liver ***,aged patients show various changes of the liver and other organs that could affect the clinical characteristics and management of liver diseases in these patients.

关键词： Liver disease Aging Physiology Immunology

Effect of Composts Combined with Chemical N Fertilizer on Nitrogen Uptake by Italian Ryegrass and N Transformation in Soil

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Journal of Agricultural Chemistry and Environment 2015年第2期4卷 37-47页

作者： Nguyen Thanh Binh Hoang Thi Quynh kazuto Shima Department of Environmental Ecology Graduate School of Environmental and Life Science Okayama University Okayama Japan Department of Soil Agro-Chemistry Faculty of Agronomy Nonglam University Ho Chi Minh City Vietnam Vietnam Institute of Meteorology Hydrology and Climate Change (IMHEN) Hanoi Vietnam

Combining compost with sufficient chemical N fertilizer (CF) in agricultural lands is a popular practice to reduce the amount of inorganic nitrogen and accumulation of non-nutrient constituents in soils. A pot culture experiment was conducted to study the effects of 130 mg N of either solids waste compost (Scomp) or biosolids waste compost (Bcomp) complemented with 130 mg (CF, 1N) and 260 mg·N·pot-1 (CF, 2N) as 15N labeled (NH4)2SO4 (13.172 atom %) on growth and N uptake by Italian ryegrass. A separate soil incubation without plants was set up by only blends of Scomp and CF. The results from pot culture experiment show that total plant biomass and N uptake from Bcomp were significantly higher than Scomp alone. Scomp combined with CF improved yield and N uptake over those of Scomp alone. For Scomp + 1N treatment, plant nitrogen uptake derived from compost and CF accounted for 29% and 56% of added N from Scomp and CF, respectively. The incubation study indicates that 16.08 - 29.62 mg·N·kg-1·soil·day-1 from inorganic-N were immobilized into organic pools, while only 0.40 - 0.66 mg·N·kg-1·soil·day-1 from organic-N were mineralized to inorganic pools. Because a part of additional N could be tied up in organic form, combining solids compost with chemical N fertilizer therefore need to consider the effective use of compost-N.

关键词： Solids Biosolids Compost 15N Nitrogen Uptake Mineralization Immobilization